Abstract: The PAX6, a transcription factor, is essential for the morphogenesis of the eyes, brain, pituitary and pancreatic islets. In rodents, the loss of Pax6 function leads to central nervous system defects, anophthalmia, and nasal hypoplasia. The haplo-insufficiency of Pax6 causes microphthalmia, aggression and other behavioral abnormalities. It is also required in brain patterning and neuronal plasticity. In human, heterozygous mutation of Pax6 causes loss of iris [aniridia], mental retardation and glucose intolerance. The 3- deletion in Pax6 leads to autism and aniridia. The phenotypes are variable in peneterance and expressivity. However, mechanism of function and interaction of PAX6 with other proteins during development and associated disease are not clear. It is intended to explore interactors of PAX6 to elucidated biology of PAX6 function in the tissues where it is expressed and also in the central regulatory pathway. This report describes In-silico approaches to explore interacting proteins of PAX6. The models show several possible proteins interacting with PAX6 like MITF, SIX3, SOX2, SOX3, IPO13, TRIM, and OGT. Since the Pax6 is a critical transcriptional regulator and master control gene of eye and brain development it might be interacting with other protein involved in morphogenesis [TGIF, TGF, Ras etc]. It is also presumed that matricelluar proteins [SPARC, thrombospondin-1 and osteonectin etc] are likely to interact during transport and processing of PAX6 and are somewhere its cascade. The proteins involved in cell survival and cell proliferation can also not be ignored.
Abstract: In recent years, tuned mass damper (TMD) control systems for civil engineering structures have attracted considerable attention. This paper emphasizes on the application of particle swarm application (PSO) to design and optimize the parameters of the TMD control scheme for achieving the best results in the reduction of the building response under earthquake excitations. The Integral of the Time multiplied Absolute value of the Error (ITAE) based on relative displacement of all floors in the building is taken as a performance index of the optimization criterion. The problem of robustly TMD controller design is formatted as an optimization problem based on the ITAE performance index to be solved using the PSO technique which has a story ability to find the most optimistic results. An 11- story realistic building, located in the city of Rasht, Iran is considered as a test system to demonstrate effectiveness of the proposed method. The results analysis through the time-domain simulation and some performance indices reveals that the designed PSO based TMD controller has an excellent capability in reduction of the seismically excited example building.
Abstract: We theoretically demonstrate modulation of light
polarization by a crossed rectangular hole array with asymmetric arm
lengths. There are two waveguide modes that can modulate the x- and
y- polarized incident waves independently. A specific structure is
proposed to convert a left-hand incident wave to a right-hand outgoing
wave by transmission.
Abstract: We study in this paper the effect of the scene
changing on image sequences coding system using Embedded
Zerotree Wavelet (EZW). The scene changing considered here is the
full motion which may occurs. A special image sequence is generated
where the scene changing occurs randomly. Two scenarios are
considered: In the first scenario, the system must provide the
reconstruction quality as best as possible by the management of the
bit rate (BR) while the scene changing occurs. In the second scenario,
the system must keep the bit rate as constant as possible by the
management of the reconstruction quality. The first scenario may be
motivated by the availability of a large band pass transmission
channel where an increase of the bit rate may be possible to keep the
reconstruction quality up to a given threshold. The second scenario
may be concerned by the narrow band pass transmission channel
where an increase of the bit rate is not possible. In this last case,
applications for which the reconstruction quality is not a constraint
may be considered. The simulations are performed with five scales
wavelet decomposition using the 9/7-tap filter bank biorthogonal
wavelet. The entropy coding is performed using a specific defined
binary code book and EZW algorithm. Experimental results are
presented and compared to LEAD H263 EVAL. It is shown that if
the reconstruction quality is the constraint, the system increases the
bit rate to obtain the required quality. In the case where the bit rate
must be constant, the system is unable to provide the required quality
if the scene change occurs; however, the system is able to improve
the quality while the scene changing disappears.
Abstract: MATCH project [1] entitle the development of an
automatic diagnosis system that aims to support treatment of colon
cancer diseases by discovering mutations that occurs to tumour
suppressor genes (TSGs) and contributes to the development of
cancerous tumours. The constitution of the system is based on a)
colon cancer clinical data and b) biological information that will be
derived by data mining techniques from genomic and proteomic
sources The core mining module will consist of the popular, well
tested hybrid feature extraction methods, and new combined
algorithms, designed especially for the project. Elements of rough
sets, evolutionary computing, cluster analysis, self-organization maps
and association rules will be used to discover the annotations
between genes, and their influence on tumours [2]-[11].
The methods used to process the data have to address their high
complexity, potential inconsistency and problems of dealing with the
missing values. They must integrate all the useful information
necessary to solve the expert's question. For this purpose, the system
has to learn from data, or be able to interactively specify by a domain
specialist, the part of the knowledge structure it needs to answer a
given query. The program should also take into account the
importance/rank of the particular parts of data it analyses, and adjusts
the used algorithms accordingly.
Abstract: This study is designed to investigate errors emerged in written texts produced by 30 Turkish EFL learners with an explanatory, and thus, qualitative perspective. Erroneous language elements were identified by the researcher first and then their grammaticality and intelligibility were checked by five native speakers of English. The analysis of the data showed that it is difficult to claim that an error stems from only one single factor since different features of an error are triggered by different factors. Our findings revealed two different types of errors: those which stem from the interference of L1 with L2 and those which are developmental ones. The former type contains more global errors whereas the errors in latter type are more intelligible.
Abstract: Kepsut-Dursunbey volcanic field (KDVF) is located
in NW Turkey and contains various products of the post-collisional
Neogene magmatic activity. Two distinct volcanic suites have been
recognized; the Kepsut volcanic suite (KVS) and the Dursunbey
volcanic suite (DVS). The KVS includes basaltic trachyandesitebasaltic
andesite-andesite lavas and associated pyroclastic rocks. The
DVS consists of dacite-rhyodacite lavas and extensive pumice-ash
fall and flow deposits. Petrographical features (i.e. existence of
xenocrysts, glomerocrysts, and mixing-compatible textures) and
mineral chemistry of phenocryst assemblages of both suites provide
evidence for magma mixing/AFC. Calculated crystallization
pressures and temperatures give values of 5.7–7.0 kbar and 927–982
°C for the KVS and 3.7–5.3 kbar and 783-787°C for the DVS,
indicating separate magma reservoirs and crystallization in magma
chambers at deep and mid crustal levels, respectively. These
observations support the establishment and evolution of KDVF
magma system promoted by episodic basaltic inputs which may
generate and mix with crustal melts.
Abstract: Non-viral gene carriers composed of biodegradable
polymers or lipids have been considered as a safer alternative for gene
carriers over viral vectors. We have developed multi-functional
nano-micelles for both drug and gene delivery application.
Polyethyleneimine (PEI) was modified by grafting stearic acid (SA)
and formulated to polymeric micelles (PEI-SA) with positive surface
charge for gene and drug delivery. Our results showed that PEI-SA
micelles provided high siRNA binding efficiency. In addition, siRNA
delivered by PEI-SA carriers also demonstrated significantly high
cellular uptake even in the presence of serum proteins. The
post-transcriptional gene silencing efficiency was greatly improved by
the polyplex formulated by 10k PEI-SA/siRNA. The amphiphilic
structure of PEI-SA micelles provided advantages for multifunctional
tasks; where the hydrophilic shell modified with cationic charges can
electrostatically interact with DNA or siRNA, and the hydrophobic
core can serve as payloads for hydrophobic drugs, making it a
promising multifunctional vehicle for both genetic and chemotherapy
application.
Abstract: EDF (Early Deadline First) algorithm is a very important scheduling algorithm for real- time systems . The EDF algorithm assigns priorities to each job according to their absolute deadlines and has good performance when the real-time system is not overloaded. When the real-time system is overloaded, many misdeadlines will be produced. But these misdeadlines are not uniformly distributed, which usually focus on some tasks. In this paper, we present an adaptive fuzzy control scheduling based on EDF algorithm. The improved algorithm can have a rectangular distribution of misdeadline ratios among all real-time tasks when the system is overloaded. To evaluate the effectiveness of the improved algorithm, we have done extensive simulation studies. The simulation results show that the new algorithm is superior to the old algorithm.
Abstract: In this paper, the effect of atmospheric turbulence on
bit error probability in free-space optical CDMA scheme with
Sequence Inverse Keyed (SIK) optical correlator receiver is analyzed.
Here Intensity Modulation scheme is considered for transmission.
The turbulence induced fading is described by the newly introduced
gamma-gamma pdf[1] as a tractable mathematical model for
atmospheric turbulence. Results are evaluated with Gold and Kasami
code & it is shown that Gold sequence can be used for more
efficient transmission than Kasami sequence in an atmospheric
turbulence channel.
Abstract: Three alumina-supported Pt-Sn catalysts have been
prepared by means of co-impregnation and characterized by XRD and
N2 adsorption. The influence of catalyst composition and reaction
conditions on the conversion and selectivity were investigated in the
hydrogenation of acetic acid in an isothermal integral fixed bed
reactor. The experiments were performed on the temperature interval
468-548 K, liquid hourly space velocity (LHSV) of 0.3-0.7h-1,
pressures between 1.0 and 5.0Mpa. A good compromise of
0.75%Pt-1.5%Sn can act as an optimized acetic acid hydrogenation
catalyst, and the conversion and selectivity can be tuned through the
variation of reaction conditions.
Abstract: We have previously introduced an ultrasonic imaging
approach that combines harmonic-sensitive pulse sequences with a
post-beamforming quadratic kernel derived from a second-order
Volterra filter (SOVF). This approach is designed to produce images
with high sensitivity to nonlinear oscillations from microbubble
ultrasound contrast agents (UCA) while maintaining high levels of
noise rejection. In this paper, a two-step algorithm for computing the
coefficients of the quadratic kernel leading to reduction of tissue
component introduced by motion, maximizing the noise rejection and
increases the specificity while optimizing the sensitivity to the UCA
is presented. In the first step, quadratic kernels from individual
singular modes of the PI data matrix are compared in terms of their
ability of maximize the contrast to tissue ratio (CTR). In the second
step, quadratic kernels resulting in the highest CTR values are
convolved. The imaging results indicate that a signal processing
approach to this clinical challenge is feasible.
Abstract: A simple mobile engine-driven pneumatic paddy
collector made of locally available materials using local
manufacturing technology was designed, fabricated, and tested for
collecting and bagging of paddy dried on concrete pavement. The
pneumatic paddy collector had the following major components:
radial flat bladed type centrifugal fan, power transmission system,
bagging area, frame and the conveyance system. Results showed
significant differences on the collecting capacity, noise level, and fuel
consumption when rotational speed of the air mover shaft was varied.
Other parameters such as collecting efficiency, air velocity,
augmented cracked grain percentage, and germination rate were not
significantly affected by varying rotational speed of the air mover
shaft. The pneumatic paddy collector had a collecting efficiency of
99.33 % with a collecting capacity of 2685.00 kg/h at maximum
rotational speed of centrifugal fan shaft of about 4200 rpm. The
machine entailed an investment cost of P 62,829.25. The break-even
weight of paddy was 510,606.75 kg/yr at a collecting cost of 0.11
P/kg of paddy. Utilizing the machine for 400 hours per year
generated an income of P 23,887.73. The projected time needed to
recover cost of the machine based on 2685 kg/h collecting capacity
was 2.63 year.
Abstract: Information sharing and exchange, rather than
information processing, is what characterizes information
technology in the 21st century. Ontologies, as shared common
understanding, gain increasing attention, as they appear as the
most promising solution to enable information sharing both at
a semantic level and in a machine-processable way. Domain
Ontology-based modeling has been exploited to provide
shareability and information exchange among diversified,
heterogeneous applications of enterprises.
Contextual ontologies are “an explicit specification of
contextual conceptualization". That is: ontology is
characterized by concepts that have multiple representations
and they may exist in several contexts. Hence, contextual
ontologies are a set of concepts and relationships, which are
seen from different perspectives. Contextualization is to allow
for ontologies to be partitioned according to their contexts.
The need for contextual ontologies in enterprise modeling
has become crucial due to the nature of today's competitive
market. Information resources in enterprise is distributed and
diversified and is in need to be shared and communicated
locally through the intranet and globally though the internet.
This paper discusses the roles that ontologies play in an
enterprise modeling, and how ontologies assist in building a
conceptual model in order to provide communicative and
interoperable information systems. The issue of enterprise
modeling based on contextual domain ontology is also
investigated, and a framework is proposed for an enterprise
model that consists of various applications.
Abstract: Heat-inducible gene expression vectors are useful for hyperthermia-induced cancer gene therapy, because the combination
of hyperthermia and gene therapy can considerably improve the therapeutic effects. In the present study, we developed an enhanced
heat-inducible transgene expression system in which a heat-shock
protein (HSP) promoter and tetracycline-responsive transactivator
were combined. When the transactivator plasmid containing the
tetracycline-responsive transactivator gene was co-transfected with
the reporter gene expression plasmid, a high level of heat-induced gene expression was observed compared with that using the HSP
promoter without the transactivator. In vitro evaluation of the
therapeutic effect using HeLa cells showed that heat-induced therapeutic gene expression caused cell death in a high percentage of
these cells, indicating that this strategy is promising for cancer gene therapy.
Abstract: In this paper the behavior of fixed series compensated
extra high voltage transmission lines during faults is simulated. Many
over-voltage protection schemes for series capacitors are limited in
terms of size and performance, and are easily affected by
environmental conditions. While the need for more compact and
environmentally robust equipment is required. use of series
capacitors for compensating part of the inductive reactance of long
transmission lines increases the power transmission capacity.
Emphasis is given on the impact of modern capacitor protection
techniques (MOV protection). The simulation study is performed
using MATLAB/SIMULINK®and results are given for a three phase
and a single phase to ground fault.
Abstract: Due to the complex network architecture, the mobile
adhoc network-s multihop feature gives additional problems to the
users. When the traffic load at each node gets increased, the
additional contention due its traffic pattern might cause the nodes
which are close to destination to starve the nodes more away from the
destination and also the capacity of network is unable to satisfy the
total user-s demand which results in an unfairness problem. In this
paper, we propose to create an algorithm to compute the optimal
MAC-layer bandwidth assigned to each flow in the network. The
bottleneck links contention area determines the fair time share which
is necessary to calculate the maximum allowed transmission rate used
by each flow. To completely utilize the network resources, we
compute two optimal rates namely, the maximum fair share and
minimum fair share. We use the maximum fair share achieved in
order to limit the input rate of those flows which crosses the
bottleneck links contention area when the flows that are not allocated
to the optimal transmission rate and calculate the following highest
fair share. Through simulation results, we show that the proposed
protocol achieves improved fair share and throughput with reduced
delay.
Abstract: There have been different approaches to compute the
analytic instantaneous frequency with a variety of background reasoning
and applicability in practice, as well as restrictions. This paper presents an adaptive Fourier decomposition and (α-counting) based
instantaneous frequency computation approach. The adaptive Fourier
decomposition is a recently proposed new signal decomposition
approach. The instantaneous frequency can be computed through the so called mono-components decomposed by it. Due to the fast energy
convergency, the highest frequency of the signal will be discarded by the adaptive Fourier decomposition, which represents the noise of
the signal in most of the situation. A new instantaneous frequency
definition for a large class of so-called simple waves is also proposed
in this paper. Simple wave contains a wide range of signals for which
the concept instantaneous frequency has a perfect physical sense.
The α-counting instantaneous frequency can be used to compute the highest frequency for a signal. Combination of these two approaches one can obtain the IFs of the whole signal. An experiment is demonstrated the computation procedure with promising results.
Abstract: The power consumption of an Optical Packet Switch
equipped with SOA technology based Spanke switching fabric is
evaluated. Sophisticated analytical models are introduced to evaluate
the power consumption versus the offered traffic, the main
switch parameters, and the used device characteristics. The impact
of Amplifier Spontaneous Emission (ASE) noise generated by a
transmission system on the power consumption is investigated. As
a matter of example for 32×32 switches supporting 64 wavelengths
and offered traffic equal to 0,8, the average energy consumption per
bit is 5, 07 · 10-2 nJ/bit and increases if ASE noise introduced by
the transmission systems is increased.
Abstract: The objective of this paper is to use the Pfaffian
technique to construct different classes of exact Pfaffian solutions and
N-soliton solutions to some of the generalized integrable nonlinear
partial differential equations in (3+1) dimensions. In this paper, I will
show that the Pfaffian solutions to the nonlinear PDEs are nothing but
Pfaffian identities. Solitons are among the most beneficial solutions
for science and technology, from ocean waves to transmission of
information through optical fibers or energy transport along protein
molecules. The existence of multi-solitons, especially three-soliton
solutions, is essential for information technology: it makes possible
undisturbed simultaneous propagation of many pulses in both directions.