Abstract: Modeling and simulation of biochemical reactions is of great interest in the context of system biology. The central dogma of this re-emerging area states that it is system dynamics and organizing principles of complex biological phenomena that give rise to functioning and function of cells. Cell functions, such as growth, division, differentiation and apoptosis are temporal processes, that can be understood if they are treated as dynamic systems. System biology focuses on an understanding of functional activity from a system-wide perspective and, consequently, it is defined by two hey questions: (i) how do the components within a cell interact, so as to bring about its structure and functioning? (ii) How do cells interact, so as to develop and maintain higher levels of organization and functions? In recent years, wet-lab biologists embraced mathematical modeling and simulation as two essential means toward answering the above questions. The credo of dynamics system theory is that the behavior of a biological system is given by the temporal evolution of its state. Our understanding of the time behavior of a biological system can be measured by the extent to which a simulation mimics the real behavior of that system. Deviations of a simulation indicate either limitations or errors in our knowledge. The aim of this paper is to summarize and review the main conceptual frameworks in which models of biochemical networks can be developed. In particular, we review the stochastic molecular modelling approaches, by reporting the principal conceptualizations suggested by A. A. Markov, P. Langevin, A. Fokker, M. Planck, D. T. Gillespie, N. G. van Kampfen, and recently by D. Wilkinson, O. Wolkenhauer, P. S. Jöberg and by the author.
Abstract: Classifying biomedical literature is a difficult and
challenging task, especially when a large number of biomedical
articles should be organized into a hierarchical structure. In this paper,
we present an approach for classifying a collection of biomedical text
abstracts downloaded from Medline database with the help of
ontology alignment. To accomplish our goal, we construct two types
of hierarchies, the OHSUMED disease hierarchy and the Medline
abstract disease hierarchies from the OHSUMED dataset and the
Medline abstracts, respectively. Then, we enrich the OHSUMED
disease hierarchy before adapting it to ontology alignment process for
finding probable concepts or categories. Subsequently, we compute
the cosine similarity between the vector in probable concepts (in the
“enriched" OHSUMED disease hierarchy) and the vector in Medline
abstract disease hierarchies. Finally, we assign category to the new
Medline abstracts based on the similarity score. The results obtained
from the experiments show the performance of our proposed approach
for hierarchical classification is slightly better than the performance of
the multi-class flat classification.
Abstract: Today, building automation is advancing from simple
monitoring and control tasks of lightning and heating towards more
and more complex applications that require a dynamic perception
and interpretation of different scenes occurring in a building. Current
approaches cannot handle these newly upcoming demands. In this
article, a bionically inspired approach for multimodal, dynamic scene
perception and interpretation is presented, which is based on neuroscientific
and neuro-psychological research findings about the perceptual
system of the human brain. This approach bases on data from diverse
sensory modalities being processed in a so-called neuro-symbolic
network. With its parallel structure and with its basic elements being
information processing and storing units at the same time, a very
efficient method for scene perception is provided overcoming the
problems and bottlenecks of classical dynamic scene interpretation
systems.
Abstract: This paper aims at to develop a robust optimization methodology for the mechatronic modules of machine tools by considering all important characteristics from all structural and control domains in one single process. The relationship between these two domains is strongly coupled. In order to reduce the disturbance caused by parameters in either one, the mechanical and controller design domains need to be integrated. Therefore, the concurrent integrated design method Design For Control (DFC), will be employed in this paper. In this connect, it is not only applied to achieve minimal power consumption but also enhance structural performance and system response at same time. To investigate the method for integrated optimization, a mechatronic feed drive system of the machine tools is used as a design platform. Pro/Engineer and AnSys are first used to build the 3D model to analyze and design structure parameters such as elastic deformation, nature frequency and component size, based on their effects and sensitivities to the structure. In addition, the robust controller,based on Quantitative Feedback Theory (QFT), will be applied to determine proper control parameters for the controller. Therefore, overall physical properties of the machine tool will be obtained in the initial stage. Finally, the technology of design for control will be carried out to modify the structural and control parameters to achieve overall system performance. Hence, the corresponding productivity is expected to be greatly improved.
Abstract: Safety, river environment, and sediment utilization are the elements of the target of sediment management. As a change in an element by sediment management, may affect the other two elements, and the priority among three elements depends on stakeholders. It is necessary to develop a method to evaluate the effect of sediment management on each element and an integrated evaluation method for socio-economic effect. In this study, taking Mount Merapi basin as an investigation field, the method for an active volcanic basin was developed. An integrated evaluation method for sediment management was discussed from a socio-economic point on safety, environment, and sediment utilization and a case study of sediment management was evaluated by means of this method. To evaluate the effect of sediment management, some parameters on safety, utilization, and environment have been introduced. From a utilization point of view, job opportunity, additional income of local people, and tax income to local government were used to evaluate the effectiveness of sediment management. The risk degree of river infrastructure was used to describe the effect of sediment management on a safety aspect. To evaluate the effects of sediment management on environment, the mean diameter of grain size distribution of riverbed surface was used. On the coordinate system designating these elements, the direction of change in basin condition by sediment management can be predicted, so that the most preferable sediment management can be decided. The results indicate that the cases of sediment management tend to give the negative impacts on sediment utilization. However, these sediment managements will give positive impacts on safety and environment condition. Evaluation result from a social-economic point of view shows that the case study of sediment management reduces job opportunity and additional income for inhabitants as well as tax income for government. Therefore, it is necessary to make another policy for creating job opportunity for inhabitants to support these sediment managements.
Abstract: This paper considers a scheduling problem in flexible
flow shops environment with the aim of minimizing two important
criteria including makespan and cumulative tardiness of jobs. Since
the proposed problem is known as an Np-hard problem in literature,
we have to develop a meta-heuristic to solve it. We considered
general structure of Genetic Algorithm (GA) and developed a new
version of that based on Data Envelopment Analysis (DEA). Two
objective functions assumed as two different inputs for each Decision
Making Unit (DMU). In this paper we focused on efficiency score of
DMUs and efficient frontier concept in DEA technique. After
introducing the method we defined two different scenarios with
considering two types of mutation operator. Also we provided an
experimental design with some computational results to show the
performance of algorithm. The results show that the algorithm
implements in a reasonable time.
Abstract: Nowadays companies strive to survive in a
competitive global environment. To speed up product
development/modifications, it is suggested to adopt a collaborative
product development approach. However, despite the advantages of
new IT improvements still many CAx systems work separately and
locally. Collaborative design and manufacture requires a product
information model that supports related CAx product data models. To
solve this problem many solutions are proposed, which the most
successful one is adopting the STEP standard as a product data model
to develop a collaborative CAx platform. However, the improvement
of the STEP-s Application Protocols (APs) over the time, huge
number of STEP AP-s and cc-s, the high costs of implementation,
costly process for conversion of older CAx software files to the STEP
neutral file format; and lack of STEP knowledge, that usually slows
down the implementation of the STEP standard in collaborative data
exchange, management and integration should be considered. In this
paper the requirements for a successful collaborative CAx system is
discussed. The STEP standard capability for product data integration
and its shortcomings as well as the dominant platforms for supporting
CAx collaboration management and product data integration are
reviewed. Finally a platform named LAYMOD to fulfil the
requirements of CAx collaborative environment and integrating the
product data is proposed. The platform is a layered platform to enable
global collaboration among different CAx software
packages/developers. It also adopts the STEP modular architecture
and the XML data structures to enable collaboration between CAx
software packages as well as overcoming the STEP standard
limitations. The architecture and procedures of LAYMOD platform
to manage collaboration and avoid contradicts in product data
integration are introduced.
Abstract: Linearization of graph embedding has been emerged
as an effective dimensionality reduction technique in pattern
recognition. However, it may not be optimal for nonlinearly
distributed real world data, such as face, due to its linear nature. So, a
kernelization of graph embedding is proposed as a dimensionality
reduction technique in face recognition. In order to further boost the
recognition capability of the proposed technique, the Fisher-s
criterion is opted in the objective function for better data
discrimination. The proposed technique is able to characterize the
underlying intra-class structure as well as the inter-class separability.
Experimental results on FRGC database validate the effectiveness of
the proposed technique as a feature descriptor.
Abstract: In the present paper the results of a numerical study are presented, numerical models were developed to simulate the behaviour of vertical massive dikes. The proposed models were developed according to the geometry, boundary conditions, loading conditions and initial conditions of a physical model taken as reference. The results obtained were compared to the experimental data. As far as the overall behaviour, the displacements and the failure mechanisms of the dikes is concerned, the numerical results were in good agreement with the experimental results, which clearly indicates a good quality of numerical modelling. The validated numerical models were used in a parametric study were the displacements and failure mechanisms were fully investigated. Out of the results obtained, some conclusions and recommendations related to the design of massive dikes are proposed.
Abstract: Hydrodynamic pressures acting on upstream of concrete dams during an earthquake are an important factor in designing and assessing the safety of these structures in Earthquake regions. Due to inherent complexities, assessing exact hydrodynamic pressure is only feasible for problems with simple geometry. In this research, the governing equation of concrete gravity dam reservoirs with effect of fluid viscosity in frequency domain is solved and then compared with that in which viscosity is assumed zero. The results show that viscosity influences the reservoir-s natural frequency. In excitation frequencies near the reservoir's natural frequencies, hydrodynamic pressure has a considerable difference in compare to the results of non-viscose fluid.
Abstract: The present project was conducted with the
circumferential-fuel-jets inverse diffusion flame (CIDF) burner
burning liquefied petroleum gas (LPG) enriched with 50% of
hydrogen fuel (H2). The range of stable operation of the CIDF burner
in terms of Reynolds number (from laminar to turbulent flow regions),
equivalence ratio and fuel jet velocity of LPG of the 50% H2-LPG
mixed fuel was identified. Experiments were also carried out to
investigate the flame structures of the LPG flame and LPG enriched H2
flame. Experimental results obtained from these two flames were
compared to fully explore the influence of hydrogen addition on flame
stability. Flame heights obtained by burning these two kinds of fuels at
various equivalence ratios were compared and correlated with the
Global Momentum Ratio (GMR).
Abstract: Swedish truck industry is investigating the possibility
for implementing the use of Compacted Graphite Iron (CGI) in their
heavy duty diesel engines. Compared to the alloyed gray iron used
today, CGI has superior mechanical properties but not as good
machinability. Another issue that needs to be addressed when
implementing CGI is the inhomogeneous microstructure when the
cast component has different section thicknesses, as in cylinder
blocks. Thinner sections results in finer pearlite, in the material, with
higher strength. Therefore an investigation on its influence on
machinability was needed. This paper focuses on the effect that
interlamellar distance in pearlite has on CGI machinability and
material physical properties. The effect of pearlite content and
nodularity is also examined. The results showed that interlamellar
distance in pearlite did not have as large effect on the material
physical properties or machinability as pearlite content. The paper
also shows the difficulties of obtaining a homogeneous
microstructure in inhomogeneous workpieces.
Abstract: High voltage generators are being subject to higher
voltage rating and are being designed to operate in harsh conditions.
Stator windings are the main component of generators in which
Electrical, magnetical and thermal stresses remain major failures for
insulation degradation accelerated aging. A large number of
generators failed due to stator winding problems, mainly insulation
deterioration. Insulation degradation assessment plays vital role in the
asset life management. Mostly the stator failure is catastrophic
causing significant damage to the plant. Other than generation loss,
stator failure involves heavy repair or replacement cost. Electro
thermal analysis is the main characteristic for improvement design of
stator slot-s insulation. Dielectric parameters such as insulation
thickness, spacing, material types, geometry of winding and slot are
major design consideration. A very powerful method available to
analyze electro thermal performance is Finite Element Method
(FEM) which is used in this paper. The analysis of various stator coil
and slot configurations are used to design the better dielectric system
to reduce electrical and thermal stresses in order to increase the
power of generator in the same volume of core. This paper describes
the process used to perform classical design and improvement
analysis of stator slot-s insulation.
Abstract: Economic freedoms, most emphasized issue in the recent years, are considered to affect economic growth and performance via institutional structure. In this context, a model that includes Turkey and Middle East Countries, and where the effects of economic freedom on growth are examined, was formed. For the groups of countries determined, in the study carried out by using the dataset belonging the period of 2004 - 2009, between economic freedoms and growth, a negative relationship was observed as group. In the sense of individual effects, it was identified that there was a positive relationship in terms of some Middle East Countries and Turkey.
Abstract: Noble metal participation in nanostructured
semiconductor catalysts has drawn much interest because of their
improved properties. Recently, it has been discussed by many
researchers that Ag participation in TiO2, CuO, ZnO semiconductors
showed improved photocatalytic and optical properties. In this
research, Ag/ZnO nanocomposite particles were prepared by
Ultrasonic Spray Pyrolysis(USP) Method. 0.1M silver and zinc
nitrate aqueous solutions were used as precursor solutions. The
Ag:Zn atomic ratio of the solution was selected 1:1. Experiments
were taken place under constant air flow of 400 mL/min at 800°C
furnace temperature. Particles were characterized by X-Ray
Diffraction (XRD), Scanning Electron Microscope (SEM) and
Energy Dispersive Spectroscopy (EDS). The crystallite sizes of Ag
and ZnO in composite particles are 24.6 nm, 19.7 nm respectively.
Although, spherical nanocomposite particles are in a range of 300-
800 nm, these particles are formed by the aggregation of primary
particles which are in a range of 20-60 nm.
Abstract: Several methods are available for weight and shape
optimization of structures, among which Evolutionary Structural
Optimization (ESO) is one of the most widely used methods. In ESO,
however, the optimization criterion is completely case-dependent.
Moreover, only the improving solutions are accepted during the
search. In this paper a Simulated Annealing (SA) algorithm is used
for structural optimization problem. This algorithm differs from other
random search methods by accepting non-improving solutions. The
implementation of SA algorithm is done through reducing the
number of finite element analyses (function evaluations).
Computational results show that SA can efficiently and effectively
solve such optimization problems within short search time.
Abstract: This paper presents an exact pruning algorithm with
adaptive pruning interval for general dynamic neural networks
(GDNN). GDNNs are artificial neural networks with internal dynamics.
All layers have feedback connections with time delays to the
same and to all other layers. The structure of the plant is unknown, so
the identification process is started with a larger network architecture
than necessary. During parameter optimization with the Levenberg-
Marquardt (LM) algorithm irrelevant weights of the dynamic neural
network are deleted in order to find a model for the plant as
simple as possible. The weights to be pruned are found by direct
evaluation of the training data within a sliding time window. The
influence of pruning on the identification system depends on the
network architecture at pruning time and the selected weight to be
deleted. As the architecture of the model is changed drastically during
the identification and pruning process, it is suggested to adapt the
pruning interval online. Two system identification examples show
the architecture selection ability of the proposed pruning approach.
Abstract: International competitiveness receives much attention
nowadays, but up to now its assessment has been heavily based on
manufacturing industry statistics. This paper addresses the need for
competitiveness indicators that cover the service sector and sets out a
multilevel framework for measuring international services trade
competitiveness. The approach undertaken here aims at
comparatively examining the international competitiveness of the
EU-25 (the twenty-five European Union member states before the 1st
of January 2007), Romanian and Bulgarian services trade, as well as
the last two countries- structure of specialization on the EU-25
services market. The primary changes in the international
competitiveness of three major services sectors – transportation,
travel and other services - are analyzed. This research attempts to
determine the ability of the two recent European Union (EU) member
states to contend with the challenges that might arise from the hard
competition within the enlarged EU, in the field of services trade.
Abstract: A novel and versatile numerical technique to solve a self-stress equilibrium state is adopted herein as a form-finding procedure for an irregular tensegrity structure. The numerical form-finding scheme of a tensegrity structure uses only the connectivity matrix and prototype tension coefficient vector as the initial guess solution. Any information on the symmetrical geometry or other predefined initial structural conditions is not necessary to get the solution in the form-finding process. An eight-node initial condition example is presented to demonstrate the efficiency and robustness of the proposed method in the form-finding of an irregular tensegrity structure. Based on the conception from the form-finding of an eight-node irregular tensegrity structure, a monumental object is designed by considering the real world situation such as self-weight, wind and earthquake loadings.
Abstract: The main goal of this seminal paper is to introduce the
application of Wireless Sensor Networks (WSN) in long distance
infrastructure monitoring (in particular in pipeline infrastructure
monitoring) – one of the on-going research projects by the Wireless
Communication Research Group at the department of Electronic and
Computer Engineering, Nnamdi Azikiwe University, Awka. The
current sensor network architectures for monitoring long distance
pipeline infrastructures are previewed. These are wired sensor
networks, RF wireless sensor networks, integrated wired and wireless
sensor networks. The reliability of these architectures is discussed.
Three reliability factors are used to compare the architectures in
terms of network connectivity, continuity of power supply for the
network, and the maintainability of the network. The constraints and
challenges of wireless sensor networks for monitoring and protecting
long distance pipeline infrastructure are discussed.