Abstract: Co-crystal is believed to improve the solubility and
dissolution rates and thus, enhanced the bioavailability of poor water
soluble drugs particularly during the oral route of administration.
With the existing of poorly soluble drugs in pharmaceutical industry,
the screening of co-crystal formation using carbamazepine (CBZ) as
a model drug compound with dicarboxylic acids co-crystal formers
(CCF) namely fumaric (FA) and succinic (SA) acids in ethanol has
been studied. The co-crystal formations were studied by varying the
mol ratio values of CCF to CBZ to access the effect of CCF
concentration on the formation of the co-crystal. Solvent evaporation,
slurry and cooling crystallization which representing the solution
based method co-crystal screening were used. Based on the
differential scanning calorimetry (DSC) analysis, the melting point of
CBZ-SA in different ratio was in the range between 188oC-189oC.
For CBZ-FA form A and CBZ-FA form B the melting point in
different ratio were in the range of 174oC-175oC and 185oC-186oC
respectively. The product crystal from the screening was also
characterized using X-ray powder diffraction (XRPD). The XRPD
pattern profile analysis has shown that the CBZ co-crystals with FA
and SA were successfully formed for all ratios studied. The findings
revealed that CBZ-FA co-crystal were formed in two different
polymorphs. It was found that CBZ-FA form A and form B were
formed from evaporation and slurry crystallization methods
respectively. On the other hand, in cooling crystallization method,
CBZ-FA form A was formed at lower mol ratio of CCF to CBZ and
vice versa. This study disclosed that different methods and mol ratios
during the co-crystal screening can affect the outcome of co-crystal
produced such as polymorphic forms of co-crystal and thereof. Thus,
it was suggested that careful attentions is needed during the screening
since the co-crystal formation is currently one of the promising
approach to be considered in research and development for
pharmaceutical industry to improve the poorly soluble drugs.
Abstract: This paper argues nation-building theories that
prioritize democratic governance best explain the successful postindependence
development of Botswana. Three main competing
schools of thought exist regarding the sequencing of policies that
should occur to re-build weakened or failed states. The first posits
that economic development should receive foremost attention, while
democratization and a binding sense of nationalism can wait. A
second group of experts identified constructing a sense of nationalism
among a populace is necessary first, so that the state receives popular
legitimacy and obedience that are prerequisites for development.
Botswana, though, transitioned into a multi-party democracy and
prosperous open economy due to the utilization of traditional
democratic structures, enlightened and accountable leadership, and an
educated technocratic civil service. With these political foundations
already in place when the discovery of diamonds occurred, the
resulting revenues were spent wisely on projects that grew the
economy, improved basic living standards, and attracted foreign
investment. Thus democratization preceded, and therefore provided
an accountable basis for, economic development that might otherwise
have been squandered by greedy and isolated elites to the detriment
of the greater population. Botswana was one of the poorest nations in
the world at the time of its independence in 1966, with little
infrastructure, a dependence on apartheid South Africa for trade, and
a largely subsistence economy. Over the next thirty years, though, its
economy grew the fastest of any nation in the world. The transparent
and judicious use of diamond returns is only a partial explanation, as
the government also pursued economic diversification, mass
education, and rural development in response to public needs.
As nation-building has become a project undertaken by nations
and multilateral agencies such as the United Nations and the North
Atlantic Treaty Organization, Botswana may provide best practices
that others should follow in attempting to reconstruct economically
and politically unstable states.
Abstract: Chitosan has been an attractive biopolymer for
decades, but its processability is lowered by its poor solubility,
especially in physiological pH values. Freeze concentrated reactions
of chitosan with several organic acids including acrylic, citraconic,
itaconic, and maleic acid revealed improved solubility and
morphological properties. Solubility traits were assessed with a
modified ninhydrin test. Chitosan derivatives were characterized by
ATR-FTIR and morphological characteristics were determined by
SEM. This study is a unique approach to chemically modify chitosan
to enhance water solubility.
Abstract: This research was conducted in the Mae Sot
Watershed where located in the Moei River Basin at the Upper
Salween River Basin in Tak Province, Thailand. The Mae Sot
Municipality is the largest urban area in Tak Province and situated in
the midstream of the Mae Sot Watershed. It usually faces flash flood
problem after heavy rain due to poor flood management has been
reported since economic rapidly bloom up in recent years. Its
catchment can be classified as ungauged basin with lack of rainfall
data and no any stream gaging station was reported. It was attached
by most severely flood events in 2013 as the worst studied case for
all those communities in this municipality. Moreover, other problems
are also faced in this watershed, such shortage water supply for
domestic consumption and agriculture utilizations including a
deterioration of water quality and landslide as well. The research
aimed to increase capability building and strengthening the
participation of those local community leaders and related agencies to
conduct better water management in urban area was started by mean
of the data collection and illustration of the appropriated application
of some short period rainfall forecasting model as they aim for better
flood relief plan and management through the hydrologic model
system and river analysis system programs. The authors intended to
apply the global rainfall data via the integrated data viewer (IDV)
program from the Unidata with the aim for rainfall forecasting in a
short period of 7-10 days in advance during rainy season instead of
real time record. The IDV product can be present in an advance
period of rainfall with time step of 3-6 hours was introduced to the
communities. The result can be used as input data to the hydrologic
modeling system model (HEC-HMS) for synthesizing flood
hydrographs and use for flood forecasting as well. The authors
applied the river analysis system model (HEC-RAS) to present flood
flow behaviors in the reach of the Mae Sot stream via the downtown
of the Mae Sot City as flood extents as the water surface level at
every cross-sectional profiles of the stream. Both models of HMS and
RAS were tested in 2013 with observed rainfall and inflow-outflow
data from the Mae Sot Dam. The result of HMS showed fit to the
observed data at the dam and applied at upstream boundary discharge
to RAS in order to simulate flood extents and tested in the field, and
the result found satisfying. The product of rainfall from IDV was fair
while compared with observed data. However, it is an appropriate
tool to use in the ungauged catchment to use with flood hydrograph
and river analysis models for future efficient flood relief plan and
management.
Abstract: Our goal is development of an algorithm capable of
predicting the directional trend of the Standard and Poor’s 500 index
(S&P 500). Extensive research has been published attempting to
predict different financial markets using historical data testing on an
in-sample and trend basis, with many authors employing excessively
complex mathematical techniques. In reviewing and evaluating these
in-sample methodologies, it became evident that this approach was
unable to achieve sufficiently reliable prediction performance for
commercial exploitation. For these reasons, we moved to an out-ofsample
strategy based on linear regression analysis of an extensive
set of financial data correlated with historical closing prices of the
S&P 500. We are pleased to report a directional trend accuracy of
greater than 55% for tomorrow (t+1) in predicting the S&P 500.
Abstract: Microbial fuel cells (MFCs) represent a promising
technology for simultaneous bioelectricity generation and wastewater
treatment. Catalysts are significant portions of the cost of microbial
fuel cell cathodes. Many materials have been tested as aqueous
cathodes, but air-cathodes are needed to avoid energy demands for
water aeration. The sluggish oxygen reduction reaction (ORR) rate at
air cathode necessitates efficient electrocatalyst such as carbon
supported platinum catalyst (Pt/C) which is very costly. Manganese
oxide (MnO2) was a representative metal oxide which has been
studied as a promising alternative electrocatalyst for ORR and has
been tested in air-cathode MFCs. However the single MnO2 has poor
electric conductivity and low stability. In the present work, the MnO2
catalyst has been modified by doping Pt nanoparticle. The goal of the
work was to improve the performance of the MFC with minimum Pt
loading. MnO2 and Pt nanoparticles were prepared by hydrothermal
and sol gel methods, respectively. Wet impregnation method was
used to synthesize Pt/MnO2 catalyst. The catalysts were further used
as cathode catalysts in air-cathode cubic MFCs, in which anaerobic
sludge was inoculated as biocatalysts and palm oil mill effluent
(POME) was used as the substrate in the anode chamber. The asprepared
Pt/MnO2 was characterized comprehensively through field
emission scanning electron microscope (FESEM), X-Ray diffraction
(XRD), X-ray photoelectron spectroscopy (XPS), and cyclic
voltammetry (CV) where its surface morphology, crystallinity,
oxidation state and electrochemical activity were examined,
respectively. XPS revealed Mn (IV) oxidation state and Pt (0)
nanoparticle metal, indicating the presence of MnO2 and Pt.
Morphology of Pt/MnO2 observed from FESEM shows that the
doping of Pt did not cause change in needle-like shape of MnO2
which provides large contacting surface area. The electrochemical
active area of the Pt/MnO2 catalysts has been increased from 276 to
617 m2/g with the increase in Pt loading from 0.2 to 0.8 wt%. The
CV results in O2 saturated neutral Na2SO4 solution showed that
MnO2 and Pt/MnO2 catalysts could catalyze ORR with different
catalytic activities. MFC with Pt/MnO2 (0.4 wt% Pt) as air cathode
catalyst generates a maximum power density of 165 mW/m3, which
is higher than that of MFC with MnO2 catalyst (95 mW/m3). The
open circuit voltage (OCV) of the MFC operated with MnO2 cathode
gradually decreased during 14 days of operation, whereas the MFC
with Pt/MnO2 cathode remained almost constant throughout the
operation suggesting the higher stability of the Pt/MnO2 catalyst.
Therefore, Pt/MnO2 with 0.4 wt% Pt successfully demonstrated as an
efficient and low cost electrocatalyst for ORR in air cathode MFC with higher electrochemical activity, stability and hence enhanced
performance.
Abstract: This paper examines how “Zakat” provides fair
income redistribution and aids the struggle against poverty. Providing
fair income redistribution and combating poverty constitutes some of
the fundamental tasks performed by countries all over the world.
Each country seeks a solution for these problems according to their
political, economic and administrative styles through applying
various economic and financial policies. The same situation can be
handled via “zakat” association in Islam. Nowadays, we observe
different versions of “zakat” in developed countries. Applications
such as negative income tax denote merely a different form of
“zakat” that is being applied almost in the same way but under
changed names. However, the minimum values to donate under zakat
(e.g. 85 gr. gold and 40 animals) get altered and various amounts are
put into practice. It might be named as negative income tax instead of
zakat, nonetheless, these applications are based on the Holy Koran
and the hadith released 1400 years ago. Besides, considering the
savage and slavery in the world at those times, we might easily
recognize the true value of the zakat being applied for the first time
then in the Islamic system. Through zakat, governments are able to
transfer incomes to the poor as a means of enabling them achieve the
minimum standard of living required. With regards to who benefits
from the Zakat, an objective and fair criteria was used to determine
who benefits from the zakat contrary to the notion that it was based
on peoples’ own choices. Since the zakat is obligatory, the transfers
do not get forwarded directly but via the government and get
distributed, which requires vast governmental organizations. Through
the application of Zakat, reduced levels of poverty can be achieved
and also ensure the fair income redistribution.
Abstract: Solar energy is a good option among renewable
energy resources due to its easy availability and abundance. The
simplest and most efficient way to utilize solar energy is to convert it
into thermal energy and this can be done with the help of solar
collectors. The thermal performance of such collectors is poor due to
less heat transfer from the collector surface to air. In this work,
experimental investigations of single pass solar air heater having
triangular duct and provided with roughness element on the underside
of the absorber plate. V-shaped ribs are used for investigation having
three different values of relative roughness pitch (p/e) ranges from 4-
16 for a fixed value of angle of attack (α), relative roughness height
(e/Dh) and a relative gap distance (d/x) values are 60°, 0.044 and 0.60
respectively. Result shows that considerable augmentation in heat
transfer has been obtained by providing roughness.
Abstract: Background: With the perceived pain and poor
function experienced following knee arthroplasty, patients usually
feel un-satisfied. Yet, a controversy still persists on the appropriate
operative technique that doesn’t affect proprioception much.
Purpose: This study compared the effects of Cruciate Retaining
(CR) and Posterior Stabilized (PS) total knee arthroplasty (TKA on
dynamic balance, pain and functional performance following
rehabilitation.
Methods: Thirty patients with CRTKA (group I), thirty with
PSTKA (group II) and fifteen indicated for arthroplasty but weren’t
operated on yet (group III) participated in the study. The mean age
was 54.53±3.44, 55.13±3.48 and 55.33±2.32 years and BMI
35.7±3.03, 35.7±1.99 and 35.73±1.03 kg/m2 for groups I, II and III
respectively. The Berg Balance Scale (BBS), WOMAC pain subscale
and Timed Up-and-Go (TUG) and Stair-Climbing (SC) tests were
used for assessment. Assessments were conducted four weeks preand
post-operatively, three, six and twelve months post-operatively
with the control group being assessed at the same time intervals. The
post-operative rehabilitation involved hospitalization (1st week),
home-based (2nd-4th weeks), and outpatient clinic (5th-12th weeks)
programs, follow-up to all groups for twelve months.
Results: The Mixed design MANOVA revealed that group I had
significantly lower pain scores and SC time compared with group II
three, six and twelve months post-operatively. Moreover, the BBS
scores increased significantly and the pain scores and TUG and SC
time decreased significantly six months post-operatively compared
with four weeks pre- and post-operatively and three months postoperatively
in groups I and II with the opposite being true four weeks
post-operatively. But no significant differences in BBS scores, pain
scores and TUG and SC time between six and twelve months postoperatively
in groups I and II.
Interpretation/Conclusion: CRTKA is preferable to PSTKA,
possibly due to the preserved human proprioceptors in the un-excised
PCL.
Abstract: Conventional educational practices, do not offer all
the required skills for teachers to successfully survive in today’s
workplace. Due to poor professional training, a big gap exists across
the curriculum plan and the teacher practices in the classroom. As
such, raising the quality of teaching through ICT-enabled training and
professional development of teachers should be an urgent priority.
‘Mobile Learning’, in that vein, is an increasingly growing field of
educational research and practice across schools and work places. In
this paper, we propose a novel Mobile learning system that allows the
users to learn through an intelligent mobile learning in cooperatively
every-time and every-where. The system will reduce the training cost
and increase consistency, efficiency, and data reliability. To establish
that our system will display neither functional nor performance
failure, the evaluation strategy is based on formal observation of
users interacting with system followed by questionnaires and
structured interviews.
Abstract: In and around Erode District, it is estimated that more
than 1250 chemical and allied textile processing fabric industries are
affected, partially closed and shut off for various reasons such as poor
management, poor supplier performance, lack of planning for
productivity, fluctuation of output, poor investment, waste analysis,
labor problems, capital/labor ratio, accumulation of stocks, poor
maintenance of resources, deficiencies in the quality of fabric, low
capacity utilization, age of plant and equipment, high investment and
input but low throughput, poor research and development, lack of
energy, workers’ fear of loss of jobs, work force mix and work ethic.
The main objective of this work is to analyze the existing conditions
in textile fabric sector, validate the break even of Total Productivity
(TP), analyze, design and implement fuzzy sets and mathematical
programming for improvement of productivity and quality
dimensions in the fabric processing industry. It needs to be
compatible with the reality of textile and fabric processing industries.
The highly risk events from productivity and quality dimension were
found by fuzzy systems and results are wrapped up among the textile
fabric processing industry.
Abstract: This study presents synthesis of novel block
copolymers of thienyl end capped ethoxylated nonyl phenol and
pyrrole via chemical oxidative polymerization. Ethoxylated nonyl
phenol (ENP) was reacted with 2-thiophenecarbonyl chloride in order
to synthesize a macromonomer containing thienyl end-group (ENPThC).
Then copolymers of ENP-ThC and pyrrole were synthesized
by chemical oxidative polymerization using iron (III) chloride as an
oxidant. ENP-ThC served both as a macromonomer and an emulsifier
for pyrrole with poor solubility in water.
The synthesized block copolymers (ENP-ThC-b-PPy) were
characterized by spectroscopic analysis and the electrical
conductivities were investigated with 4-point probe technique.
Abstract: Cost of governance in Nigeria has become a challenge
to development and concern to practitioners and scholars alike in the
field of business and social science research. In the 2010 national
budget of NGN4.6 trillion or USD28.75billion for instance, only a
pantry sum of NGN1.8trillion or USD11.15billion was earmarked for
capital expenditure. Similarly, in 2013, out of a total national budget
of NGN4.92trillion or USD30.75billion, only the sum of
NGN1.50trllion or USD9.38billion was voted for capital expenditure.
Therefore, based on the data sourced from the Nigerian Office of
Statistics, Central bank of Nigeria Statistical Bulletin as well as from
the United Nations Development Programme, this study examined
the causes of high cost of governance in Nigeria. It found out that the
high cost of governance in the country is in the interest of the ruling
class, arising from their unethical behaviour – corrupt practices and
the poor management of public resources. As a result, the study
recommends the need to intensify the war against corruption and
mismanagement of public resources by government officials as
possible solution to overcome the high cost of governance in Nigeria.
This could be achieved by strengthening the constitutional powers of
the various anti-corruption agencies in the area of arrest, investigation
and prosecution of offenders without the interference of the executive
arm of government either at the local, state or federal level.
Abstract: Currently, thorium fuel has been especially noticed
because of its proliferation resistance than long half-life alpha emitter
minor actinides, breeding capability in fast and thermal neutron flux
and mono-isotopic naturally abundant. In recent years, efficiency of
minor actinide burning up in PWRs has been investigated. Hence, a
minor actinide-contained thorium based fuel matrix can confront both
proliferation resistance and nuclear waste depletion aims. In the
present work, minor actinide depletion rate in a CANDU-type nuclear
core modeled using MCNP code has been investigated. The obtained
effects of minor actinide load as mixture of thorium fuel matrix on
the core neutronics has been studied with comparing presence and
non-presence of minor actinide component in the fuel matrix.
Depletion rate of minor actinides in the MA-contained fuel has been
calculated using different power loads. According to the obtained
computational data, minor actinide loading in the modeled core
results in more negative reactivity coefficients. The MA-contained
fuel achieves less radial peaking factor in the modeled core. The
obtained computational results showed 140 kg of 464 kg initial load
of minor actinide has been depleted in during a 6-year burn up in 10
MW power.
Abstract: Systems Engineering plays a key role during industrial
product development of complex technical systems. The need for
systems engineers in industry is growing. But there is a gap between
the industrial need and the academic education. Normally the
academic education is focused on the domain specific design,
implementation and testing of technical systems. Necessary systems
engineering expertise like knowledge about requirements analysis,
product cost estimation, management or social skills are poorly
taught. Thus there is the need of new academic concepts for teaching
systems engineering skills. This paper presents a project-orientated
training concept to prepare students from different technical degree
programs for systems engineering activities. The training concept has
been initially implemented and applied in the industrial engineering
master program of the University of Applied Sciences Offenburg.
Abstract: The final step to complete the “Analytical Systems
Engineering Process” is the “Allocated Architecture” in which all
Functional Requirements (FRs) of an engineering system must be
allocated into their corresponding Physical Components (PCs). At
this step, any design for developing the system’s allocated
architecture in which no clear pattern of assigning the exclusive
“responsibility” of each PC for fulfilling the allocated FR(s) can be
found is considered a poor design that may cause difficulties in
determining the specific PC(s) which has (have) failed to satisfy a
given FR successfully. The present study utilizes the Axiomatic
Design method principles to mathematically address this problem and
establishes an “Axiomatic Model” as a solution for reaching good
alternatives for developing the allocated architecture. This study
proposes a “loss Function”, as a quantitative criterion to monetarily
compare non-ideal designs for developing the allocated architecture
and choose the one which imposes relatively lower cost to the
system’s stakeholders. For the case-study, we use the existing design
of U. S. electricity marketing subsystem, based on data provided by
the U.S. Energy Information Administration (EIA). The result for
2012 shows the symptoms of a poor design and ineffectiveness due to
coupling among the FRs of this subsystem.
Abstract: Solar air heater is a type of heat exchanger which
transforms solar radiation into heat energy. The thermal performance
of conventional solar air heater has been found to be poor because of
the low convective heat transfer coefficient from the absorber plate to
the air. It is attributed to the formation of a very thin boundary layer
at the absorber plate surface commonly known as viscous sub-layer.
Thermal efficiency of solar air heater can be improved by providing
the artificial roughness on absorber plate is the most efficient
technique. In this paper an attempt is made to provide artificial
roughness by incorporating inclined multiple V-ribs in the underside
of the absorber plate. 60˚V – ribs are arranged inclined to the
direction of air flow. Performance of collector estimated theoretically
and experimentally. Results of the investigation reveal that thermal
efficiency of collector with multiple V-ribs increased by 14%.
Abstract: This paper focuses on the dynamic behavior of
reinforced concrete (RC) slabs. Therefore, the theoretical modal
analysis was performed using two different types of boundary
conditions. Modal analysis method is the most important dynamic
analyses. The analysis would be modal case when there is no external
force on the structure. By using this method in this paper, the effects
of freely and simply supported boundary conditions on the
frequencies and mode shapes of RC square slabs are studied. ANSYS
software was employed to derive the finite element model to
determine the natural frequencies and mode shapes of the slabs.
Then, the obtained results through numerical analysis (finite element
analysis) would be compared with the exact solution. The main goal
of the research study is to predict how the boundary conditions
change the behavior of the slab structures prior to performing
experimental modal analysis. Based on the results, it is concluded
that simply support boundary condition has obvious influence to
increase the natural frequencies and change the shape of the mode
when it is compared with freely supported boundary condition of
slabs. This means that such support conditions have the direct
influence on the dynamic behavior of the slabs. Thus, it is suggested
to use free-free boundary condition in experimental modal analysis to
precisely reflect the properties of the structure. By using free-free
boundary conditions, the influence of poorly defined supports is
interrupted.
Abstract: In oases, the surface water resources are becoming
increasingly scarce and groundwater resources, which generally have
a poor quality due to the high levels of salinity, are often
overexploited. Water saving have therefore become imperative for
better oases sustainability. If drip irrigation is currently recommended
in Morocco for saving water and valuing, its use in the sub-desert
areas does not keep water safe from high evaporation rates. An
alternative to this system would be the use of subsurface drip
irrigation. This technique is defined as an application of water under
the soil surface through drippers, which deliver water at rates
generally similar to surface drip irrigation. As subsurface drip
irrigation is a recently introduced in Morocco, a better understanding
of the infiltration process around a buried source, in local conditions,
and its impact on plant growth is necessarily required. This study
aims to contribute to improving the water use efficiency by testing
the performance of subsurface irrigation system, especially in areas
where water is a limited source. The objectives of this research are
performance evaluation in arid conditions of the subsurface drip
irrigation system for young date palms compared to the surface drip.
In this context, an experimental test is installed at a farmer’s field in
the area of Erfoud (Errachidia Province, southeastern Morocco),
using the subsurface drip irrigation system in comparison with the
classic drip system for young date palms. Flow measurement to
calculate the uniformity of the application of water was done through
two methods: a flow measurement of drippers above the surface and
another one underground. The latter method has also helped us to
estimate losses through evaporation for both irrigation techniques. In
order to compare the effect of two irrigation modes, plants were
identified for each type of irrigation to monitor certain agronomic
parameters (cumulative numbers of palms and roots development).
Experimentation referred to a distribution uniformity of about 88%;
considered acceptable for subsurface drip irrigation while it is around
80% for the surface drip irrigation. The results also show an increase
in root development and in the number of palm, as well as a
substantial water savings due to lower evaporation losses compared
to the classic drip irrigation.
The results of this study showed that subsurface drip irrigation is
an efficient technique, which allows sustainable irrigation in arid
areas.
Abstract: Particles are the most common and cheapest
reinforcement producing discontinuous reinforced composites with
isotropic properties. Conventional fabrication methods can be used to
produce a wide range of product forms, making them relatively
inexpensive. Optimising composite development must include
consideration of all the fundamental aspect of particles including
their size, shape, volume fraction, distribution and mechanical
properties. Research has shown that the challenges of low fracture
toughness, poor crack growth resistance and low thermal stability can
be overcome by reinforcement with particles. The unique properties
exhibited by micro particles reinforced ceramic composites have
made them to be highly attractive in a vast array of applications.