Abstract: Most of the drugs used for pharmaceutical purposes
are poorly water-soluble drugs. About 40% of all newly discovered
drugs are lipophilic and the numbers of lipophilic drugs seem to
increase more and more. Drug delivery systems such as
nanoparticles, micelles or liposomes are applied to improve their
solubility and thus their bioavailability. Besides various techniques of
solubilization, oil-in-water emulsions are often used to incorporate
lipophilic drugs into the oil phase. To stabilize emulsions surface
active substances (surfactants) are generally used. An alternative
method to avoid the application of surfactants was of great interest.
One possibility is to develop O/W-emulsion without any addition of
surface active agents or the so called “surfactant-free emulsion or
SFE”. The aim of this study was to develop and characterize SFE as a
drug carrier by varying the production conditions. Lidocaine base
was used as a model drug. The injection method was developed.
Effects of ultrasound as well as of temperature on the properties of
the emulsion were studied. Particle sizes and release were
determined. The long-term stability up to 30 days was performed.
The results showed that the surfactant-free O/W emulsions with
pharmaceutical oil as drug carrier can be produced.
Abstract: EPC Class-1 Generation-2 UHF tags, one of Radio
frequency identification or RFID tag types, is expected that most
companies are planning to use it in the supply chain in the short term
and in consumer packaging in the long term due to its inexpensive
cost. Because of the very cost, however, its resources are extremely
scarce and it is hard to have any valuable security algorithms in it. It
causes security vulnerabilities, in particular cloning the tags for
counterfeits. In this paper, we propose a product authentication
solution for anti-counterfeiting at application level in the supply chain
and mobile RFID environment. It aims to become aware of
distribution of spurious products with fake RFID tags and to provide a
product authentication service to general consumers with mobile
RFID devices like mobile phone or PDA which has a mobile RFID
reader. We will discuss anti-counterfeiting mechanisms which are
required to our proposed solution and address requirements that the
mechanisms should have.
Abstract: This paper describes an efficient and practical method
for economic dispatch problem in one and two area electrical power
systems with considering the constraint of the tie transmission line
capacity constraint. Direct search method (DSM) is used with some
equality and inequality constraints of the production units with any
kind of fuel cost function. By this method, it is possible to use several
inequality constraints without having difficulty for complex cost
functions or in the case of unavailability of the cost function
derivative. To minimize the number of total iterations in searching,
process multi-level convergence is incorporated in the DSM.
Enhanced direct search method (EDSM) for two area power system
will be investigated. The initial calculation step size that causes less
iterations and then less calculation time is presented. Effect of the
transmission tie line capacity, between areas, on economic dispatch
problem and on total generation cost will be studied; line
compensation and active power with reactive power dispatch are
proposed to overcome the high generation costs for this multi-area
system.
Abstract: The ever increasing product diversity and competition on the market of goods and services has dictated the pace of growth in the number of advertisements. Despite their admittedly diminished effectiveness over the recent years, advertisements remain the favored method of sales promotion. Consequently, the challenge for an advertiser is to explore every possible avenue of making an advertisement more noticeable, attractive and impellent for consumers. One way to achieve this is through invoking celebrity endorsements. On the one hand, the use of a celebrity to endorse a product involves substantial costs, however, on the other hand, it does not immediately guarantee the success of an advertisement. The question of how celebrities can be used in advertising to the best advantage is therefore of utmost importance. Celebrity endorsements have become commonplace: empirical evidence indicates that approximately 20 to 25 per cent of advertisements feature some famous person as a product endorser. The popularity of celebrity endorsements demonstrates the relevance of the topic, especially in the context of the current global economic downturn, when companies are forced to save in order to survive, yet simultaneously to heavily invest in advertising and sales promotion. The issue of the effective use of celebrity endorsements also figures prominently in the academic discourse. The study presented below is thus aimed at exploring what qualities (characteristics) of a celebrity endorser have an impact on the ffectiveness of the advertisement in which he/she appears and how.
Abstract: Nowadays there is a growing interest in biofuel production in most countries because of the increasing concerns about hydrocarbon fuel shortage and global climate changes, also for enhancing agricultural economy and producing local needs for transportation fuel. Ethanol can be produced from biomass by the hydrolysis and sugar fermentation processes. In this study ethanol was produced without using expensive commercial enzymes from sugarcane bagasse. Alkali pretreatment was used to prepare biomass before enzymatic hydrolysis. The comparison between NaOH, KOH and Ca(OH)2 shows NaOH is more effective on bagasse. The required enzymes for biomass hydrolysis were produced from sugarcane solid state fermentation via two fungi: Trichoderma longibrachiatum and Aspergillus niger. The results show that the produced enzyme solution via A. niger has functioned better than T. longibrachiatum. Ethanol was produced by simultaneous saccharification and fermentation (SSF) with crude enzyme solution from T. longibrachiatum and Saccharomyces cerevisiae yeast. To evaluate this procedure, SSF of pretreated bagasse was also done using Celluclast 1.5L by Novozymes. The yield of ethanol production by commercial enzyme and produced enzyme solution via T. longibrachiatum was 81% and 50% respectively.
Abstract: Segmentation, filtering out of measurement errors and
identification of breakpoints are integral parts of any analysis of
microarray data for the detection of copy number variation (CNV).
Existing algorithms designed for these tasks have had some successes
in the past, but they tend to be O(N2) in either computation time or
memory requirement, or both, and the rapid advance of microarray
resolution has practically rendered such algorithms useless. Here we
propose an algorithm, SAD, that is much faster and much less thirsty
for memory – O(N) in both computation time and memory requirement
-- and offers higher accuracy. The two key ingredients of SAD are the
fundamental assumption in statistics that measurement errors are
normally distributed and the mathematical relation that the product of
two Gaussians is another Gaussian (function). We have produced a
computer program for analyzing CNV based on SAD. In addition to
being fast and small it offers two important features: quantitative
statistics for predictions and, with only two user-decided parameters,
ease of use. Its speed shows little dependence on genomic profile.
Running on an average modern computer, it completes CNV analyses
for a 262 thousand-probe array in ~1 second and a 1.8 million-probe
array in 9 seconds
Abstract: The article contains results of the flour and bread
quality assessment from the grains of spring spelt, also called as an
ancient wheat. Spelt was cultivated on heavy and medium soils
observing principles of organic farming. Based on flour and bread
laboratory studies, as well as laboratory baking, the technological
usefulness of studied flour has been determined. These results were
referred to the standard derived from common wheat cultivated in the
same conditions. Grain of spring spelt is a good raw material for
manufacturing bread flour, from which to get high-quality bakery
products, but this is strictly dependent on the variety of ancient
wheat.
Abstract: Tubular process equipment is often damaged in
industrial processes. The damage occurs both on devices working at
high temperatures and also on less exposed devices. In case of sudden
damage of key equipment a shutdown of the whole production unit
and resulting significant economic losses are imminent. This paper
presents a solution of several types of tubular process equipment. The
causes of damage and suggestions of correction actions are discussed
in all cases. Very important part is the analysis of operational
conditions, determination of unfavourable working states decreasing
lifetime of devices and suggestions of correction actions. Lately very
popular numerical methods are used for analysis of the equipment.
Abstract: This study examines the use of the persuasive strategy
of deixis and personalization in advertising slogans. This rhetorical/
stylistic and linguistic strategy has been found to be widely used in
advertising slogans for over a century. A total of five hundred
advertising slogans of multinational companies in both product and
service sectors were obtained. The analysis reveals the 3 main
components of this strategy as being deictic words, absolute
uniqueness and personal pronouns. The percentage and mean of the
use of the 3 components are tabulated. The findings show that
advertisers have used this persuasive strategy in creative ways to
persuade consumers to buy their products and services.
Abstract: In industry, on of the most important subjects is die
and it's characteristics in which for cutting and forming different
mechanical pieces, various punch and matrix metal die are used.
whereas the common parts which form the main frame die are not
often proportion with pieces and dies therefore using a part as socalled
common part for frames in specified dimension ranges can
decrease the time of designing, occupied space of warehouse and
manufacturing costs. Parts in dies with getting uniform in their shape
and dimension make common parts of dies. Common parts of punch
and matrix metal die are as bolster, guide bush, guide pillar and
shank. In this paper the common parts and effective parameters in
selecting each of them as the primary information are studied,
afterward for selection and design of mechanical parts an
introduction and investigation based on the Mech. Desk. software is
done hence with developing this software can standardize the metal
common parts of punch and matrix. These studies will be so useful
for designer in their designing and also using it has with very much
advantage for manufactures of products in decreasing occupied
spaces by dies.
Abstract: In order to meet environmental norms, Indian fuel
policy aims at producing ultra low sulphur diesel (ULSD) in near
future. A catalyst for meeting such requirements has been developed
and kinetics of this catalytic process is being looked into. In the
present investigations, effect of mass transfer on kinetics of ultra deep
hydrodesulphurization (UDHDS) to produce ULSD has been studied
to determine intrinsic kinetics over a pre-sulphided catalyst.
Experiments have been carried out in a continuous flow micro reactor
operated in the temperature range of 330 to 3600C, whsv of 1 hr-1 at a
pressure of 35 bar, and its parameters estimated. Based on the derived
rate expression and estimated parameters optimum operation range
has been determined for this UDHDS catalyst to obtain ULSD
product.
Abstract: Corporate identity, which has several advantages such
that the employees become integrated with their corporations,
corporation is distinguished from its competitors and it is recognized
by the masses, is the total of the distinctive corporate features that
and corporation has. That the information takes part in production as
a more important component than labor and capital has required that
the corporations are reorganized as information-based. Therefore,
information and its management have reached a basic and prevalent
position in having sustainable competitive advantage. Thanks to the
information management which regulates the information and makes
it reachable and available, information will be produced in line with a
specific purpose in the corporations and be used in all the corporate
processes. As an auxiliary power for increase in the economic
potential, efficiency and productivity of the corporation, corporate
identity consists of four components. These are corporate philosophy,
corporate design, corporate behavior and corporate communication.
In this study, the effects of the information management on corporate
identity are discussed from the point of these four elements.
Abstract: This study endeavors to evaluate the effects of farmers’ training program on the adoption of improved farming practices, the output of rice farming, and the income as well as the profit from rice farming by employing an ex-post non-experimental data in Sierra Leone. It was established that participating in farmers’ training program increased the possibility of adoption of the improved farming activities that were implemented in the study area. Through the training program also, the proceeds from rice production was also established to have increased considerably. These results were in line with the assumption that one of the main constraints on the growth in agricultural output particularly rice cultivation in most African states is the lack of efficient extension programs.
Abstract: Iran is one of the greatest producers of date in the
world. However due to lack of information about its viscoelastic
properties, much of the production downgraded during harvesting
and postharvesting processes. In this study the effect of temperature
and moisture content of product were investigated on stress
relaxation characteristics. Therefore, the freshly harvested date
(kabkab) at tamar stage were put in controlled environment chamber
to obtain different temperature levels (25, 35, 45, and 55 0C) and
moisture contents (8.5, 8.7, 9.2, 15.3, 20, 32.2 %d.b.). A texture
analyzer TAXT2 (Stable Microsystems, UK) was used to apply
uniaxial compression tests. A chamber capable to control temperature
was designed and fabricated around the plunger of texture analyzer to
control the temperature during the experiment. As a new approach a
CCD camera (A4tech, 30 fps) was mounted on a cylindrical glass
probe to scan and record contact area between date and disk.
Afterwards, pictures were analyzed using image processing toolbox
of Matlab software. Individual date fruit was uniaxially compressed
at speed of 1 mm/s. The constant strain of 30% of thickness of date
was applied to the horizontally oriented fruit. To select a suitable
model for describing stress relaxation of date, experimental data were
fitted with three famous stress relaxation models including the
generalized Maxwell, Nussinovitch, and Pelege. The constant in
mentioned model were determined and correlated with temperature
and moisture content of product using non-linear regression analysis.
It was found that Generalized Maxwell and Nussinovitch models
appropriately describe viscoelastic characteristics of date fruits as
compared to Peleg mode.
Abstract: Lean production (or lean management respectively)
gained popularity in several waves. The last three decades have been
filled with numerous attempts to apply these concepts in companies.
However, this has only been partially successful. The roots of lean
production can be traced back to Toyota-s just-in-time production.
This concept, which according to Womack-s, Jones- and Roos-
research at MIT was employed by Japanese car manufacturers,
became popular under its international names “lean production",
“lean-manufacturing" and was termed “Schlanke Produktion" in
Germany. This contribution shows a review about lean production in
Germany over the last thirty years: development, trial & error and
implementation as well.
Abstract: In the recent past, there has been an increasing interest
in applying evolutionary methods to Knowledge Discovery in
Databases (KDD) and a number of successful applications of Genetic
Algorithms (GA) and Genetic Programming (GP) to KDD have been
demonstrated. The most predominant representation of the
discovered knowledge is the standard Production Rules (PRs) in the
form If P Then D. The PRs, however, are unable to handle
exceptions and do not exhibit variable precision. The Censored
Production Rules (CPRs), an extension of PRs, were proposed by
Michalski & Winston that exhibit variable precision and supports an
efficient mechanism for handling exceptions. A CPR is an
augmented production rule of the form:
If P Then D Unless C, where C (Censor) is an exception to the rule.
Such rules are employed in situations, in which the conditional
statement 'If P Then D' holds frequently and the assertion C holds
rarely. By using a rule of this type we are free to ignore the exception
conditions, when the resources needed to establish its presence are
tight or there is simply no information available as to whether it
holds or not. Thus, the 'If P Then D' part of the CPR expresses
important information, while the Unless C part acts only as a switch
and changes the polarity of D to ~D.
This paper presents a classification algorithm based on evolutionary
approach that discovers comprehensible rules with exceptions in the
form of CPRs.
The proposed approach has flexible chromosome encoding, where
each chromosome corresponds to a CPR. Appropriate genetic
operators are suggested and a fitness function is proposed that
incorporates the basic constraints on CPRs. Experimental results are
presented to demonstrate the performance of the proposed algorithm.
Abstract: Earthmoving operations are a major part of many
construction projects. Because of the complexity and fast-changing
environment of such operations, the planning and estimating are
crucial on both planning and operational levels. This paper presents
the framework ofa microscopic discrete-event simulation system for
modeling earthmoving operations and conducting productivity
estimations on an operational level.A prototype has been developed
to demonstrate the applicability of the proposed framework, and this
simulation system is presented via a case study based on an actual
earthmoving project. The case study shows that the proposed
simulation model is capable of evaluating alternative operating
strategies and resource utilization at a very detailed level.
Abstract: This paper and its companion (Part 2) deal with
modeling and optimization of two NP-hard problems in production
planning of flexible manufacturing system (FMS), part type selection
problem and loading problem. The part type selection problem and
the loading problem are strongly related and heavily influence the
system-s efficiency and productivity. The complexity of the problems
is harder when flexibilities of operations such as the possibility of
operation processed on alternative machines with alternative tools are
considered. These problems have been modeled and solved
simultaneously by using real coded genetic algorithms (RCGA)
which uses an array of real numbers as chromosome representation.
These real numbers can be converted into part type sequence and
machines that are used to process the part types. This first part of the
papers focuses on the modeling of the problems and discussing how
the novel chromosome representation can be applied to solve the
problems. The second part will discuss the effectiveness of the
RCGA to solve various test bed problems.
Abstract: Improving performance measures in the construction
processes has been a major concern for managers and decision
makers in the industry. They seek for ways to recognize the key
factors which have the largest effect on the process. Identifying such
factors can guide them to focus on the right parts of the process in
order to gain the best possible result. In the present study design of
experiment (DOE) has been applied to a computer simulation model
of brick laying process to determine significant factors while
productivity has been chosen as the response of the experiment. To
this end, four controllable factors and their interaction have been
experimented and the best factor level has been calculated for each
one. The results indicate that three factors, namely, labor of brick,
labor of mortar and inter arrival time of mortar along with interaction
of labor of brick and labor of mortar are significant.
Abstract: The paper presents an optimization study based on
genetic algorithms (GA-s) for a radio-frequency applicator used in
heating dielectric band products. The weakly coupled electro-thermal
problem is analyzed using 2D-FEM. The design variables in the
optimization process are: the voltage of a supplementary “guard"
electrode and six geometric parameters of the applicator. Two
objective functions are used: temperature uniformity and total active
power absorbed by the dielectric. Both mono-objective and multiobjective
formulations are implemented in GA optimization.