Abstract: Most of the drugs used for pharmaceutical purposes
are poorly water-soluble drugs. About 40% of all newly discovered
drugs are lipophilic and the numbers of lipophilic drugs seem to
increase more and more. Drug delivery systems such as
nanoparticles, micelles or liposomes are applied to improve their
solubility and thus their bioavailability. Besides various techniques of
solubilization, oil-in-water emulsions are often used to incorporate
lipophilic drugs into the oil phase. To stabilize emulsions surface
active substances (surfactants) are generally used. An alternative
method to avoid the application of surfactants was of great interest.
One possibility is to develop O/W-emulsion without any addition of
surface active agents or the so called “surfactant-free emulsion or
SFE”. The aim of this study was to develop and characterize SFE as a
drug carrier by varying the production conditions. Lidocaine base
was used as a model drug. The injection method was developed.
Effects of ultrasound as well as of temperature on the properties of
the emulsion were studied. Particle sizes and release were
determined. The long-term stability up to 30 days was performed.
The results showed that the surfactant-free O/W emulsions with
pharmaceutical oil as drug carrier can be produced.
Abstract: Open Agent System platform based on High Level
Architecture is firstly proposed to support the application involving
heterogeneous agents. The basic idea is to develop different wrappers
for different agent systems, which are wrapped as federates to join a
federation. The platform is based on High Level Architecture and the
advantages for this open standard are naturally inherited, such as
system interoperability and reuse. Especially, the federal architecture
allows different federates to be heterogeneous so as to support the
integration of different agent systems. Furthermore, both implicit
communication and explicit communication between agents can be
supported. Then, as the wrapper RTI_JADE an example, the
components are discussed. Finally, the performance of RTI_JADE is
analyzed. The results show that RTI_JADE works very efficiently.
Abstract: Recently research on human wayfinding has focused
mainly on mental representations rather than processes of
wayfinding. The objective of this paper is to demonstrate the
rationality behind applying multi-agent simulation paradigm to the
modeling of rescuer team wayfinding in order to develop
computational theory of perceptual wayfinding in crisis situations
using image schemata and affordances, which explains how people
find a specific destination in an unfamiliar building such as a
hospital. The hypothesis of this paper is that successful navigation is
possible if the agents are able to make the correct decision through
well-defined cues in critical cases, so the design of the building
signage is evaluated through the multi-agent-based simulation. In
addition, a special case of wayfinding in a building, finding one-s
way through three hospitals, is used to demonstrate the model.
Thereby, total rescue time for rescue operation during building fire is
computed. This paper discuses the computed rescue time for various
signage localization and provides experimental result for
optimization of building signage design. Therefore the most
appropriate signage design resulted in the shortest total rescue time in
various situations.
Abstract: The effects of irrigation with dairy factory wastewater on soil properties were investigated at two sites that had received irrigation for > 60 years. Two adjoining paired sites that had never received DFE were also sampled as well as another seven fields from a wider area around the factory. In comparison with paired sites that had not received effluent, long-term wastewater irrigation resulted in an increase in pH, EC, extractable P, exchangeable Na and K and ESP. These changes were related to the use of phosphoric acid, NaOH and KOH as cleaning agents in the factory. Soil organic C content was unaffected by DFE irrigation but the size (microbial biomass C and N) and activity (basal respiration) of the soil microbial community were increased. These increases were attributed to regular inputs of soluble C (e.g. lactose) present as milk residues in the wastewater. Principal component analysis (PCA) of the soils data from all 11sites confirmed that the main effects of DFE irrigation were an increase in exchangeable Na, extractable P and microbial biomass C, an accumulation of soluble salts and a liming effect. PCA analysis of soil bacterial community structure, using PCR-DGGE of 16S rDNA fragments, generally separated individual sites from one another but did not group them according to irrigation history. Thus, whilst the size and activity of the soil microbial community were increased, the structure and diversity of the bacterial community remained unaffected.
Abstract: In this article, we synthesize a novel chitosan -based
superabsorbent hydrogel via graft copolymerization of mixtures
acrylic acid (AA) and N-vinyl pyrollidon onto chitosan backbones.
The polymerization reaction was carried out in an aqueous medium
and in the presence of ammonium persulfate (APS) as an initiator and
N,N'-methylene bisacrylamide (MBA) as a crosslinker.The hydrogel
structures were confirmed by FTIR spectroscopy. The swelling
behavior of these absorbent polymers was also investigated in
various salt solutions. Results indicated that the swelling capacity
decreased with an increase in the ionic strength of the swelling
medium. Furthermore, the swelling of superabsorbing hydrogels was
examined in solutions with pH values ranging between 1.0 and 13.0.
It showed a reversible pH-responsive behavior at pHs 2.0 and 8.0.
This on-off switching behavior makes the synthesized hydrogels as
an excellent candidate for controlled delivery of bioactive agents.
Abstract: This paper presents an economic game for sybil
detection in a distributed computing environment. Cost parameters
reflecting impacts of different sybil attacks are introduced in the sybil
detection game. The optimal strategies for this game in which both
sybil and non-sybil identities are expected to participate are devised.
A cost sharing economic mechanism called Discriminatory
Rewarding Mechanism for Sybil Detection is proposed based on this
game. A detective accepts a security deposit from each active agent,
negotiates with the agents and offers rewards to the sybils if the latter
disclose their identity. The basic objective of the detective is to
determine the optimum reward amount for each sybil which will
encourage the maximum possible number of sybils to reveal
themselves. Maintaining privacy is an important issue for the
mechanism since the participants involved in the negotiation are
generally reluctant to share their private information. The mechanism
has been applied to Tor by introducing a reputation scoring function.
Abstract: According to the mobility of the satellite network nodes and the characteristic of management domain dynamic partition in the satellite network, the login and logout mechanism of the satellite network dynamic management domain partition was proposed in the paper. In the mechanism, a ground branch-station sends the packets of login broadcasting to satellites in view. After received the packets, the SNMP agents on the satellites adopt link-delay test to respond. According to the mechanism, the SNMP primitives were extended, and the new added primitives were as follows: broadcasting, login, login confirmation,delay_testing, test responses, and logout. The definition of primitives, which followed RFC1157 criterion, could be encoded by the BER coding. The policy of the dynamic management domain partition on the basis of the login and logout mechanism, which was supported by the SNMP protocol, was realized by the design of the extended primitives.
Abstract: In this paper, a Bayesian Network (BN) based system
is presented for providing clinical decision support to healthcare
practitioners in rural or remote areas of India for young infants or
children up to the age of 5 years. The government is unable to
appoint child specialists in rural areas because of inadequate number
of available pediatricians. It leads to a high Infant Mortality Rate
(IMR). In such a scenario, Intelligent Pediatric System provides a
realistic solution. The prototype of an intelligent system has been
developed that involves a knowledge component called an Intelligent
Pediatric Assistant (IPA); and User Agents (UA) along with their
Graphical User Interfaces (GUI). The GUI of UA provides the
interface to the healthcare practitioner for submitting sign-symptoms
and displaying the expert opinion as suggested by IPA. Depending
upon the observations, the IPA decides the diagnosis and the
treatment plan. The UA and IPA form client-server architecture for
knowledge sharing.
Abstract: Wireless sensor networks are consisted of hundreds or
thousands of small sensors that have limited resources.
Energy-efficient techniques are the main issue of wireless sensor
networks. This paper proposes an energy efficient agent-based
framework in wireless sensor networks. We adopt biologically
inspired approaches for wireless sensor networks. Agent operates
automatically with their behavior policies as a gene. Agent aggregates
other agents to reduce communication and gives high priority to nodes
that have enough energy to communicate. Agent behavior policies are
optimized by genetic operation at the base station. Simulation results
show that our proposed framework increases the lifetime of each node.
Each agent selects a next-hop node with neighbor information and
behavior policies. Our proposed framework provides self-healing,
self-configuration, self-optimization properties to sensor nodes.
Abstract: We introduce, a new interactive 3D simulation system of ocular motion and expressions suitable for: (1) character animation applications to game design, film production, HCI (Human Computer Interface), conversational animated agents, and virtual reality; (2) medical applications (ophthalmic neurological and muscular pathologies: research and education); and (3) real time simulation of unconscious cognitive and emotional responses (for use, e.g., in psychological research). The system is comprised of: (1) a physiologically accurate parameterized 3D model of the eyes, eyelids, and eyebrow regions; and (2) a prototype device for realtime control of eye motions and expressions, including unconsciously produced expressions, for application as in (1), (2), and (3) above. The 3D eye simulation system, created using state-of-the-art computer animation technology and 'optimized' for use with an interactive and web deliverable platform, is, to our knowledge, the most advanced/realistic available so far for applications to character animation and medical pedagogy.
Abstract: One of the most important aspects expected from an
ERP system is to mange user\administrator manual documents
dynamically. Since an ERP package is frequently changed during its
implementation in customer sites, it is often needed to add new
documents and/or apply required changes to existing documents in
order to cover new or changed capabilities. The worse is that since
these changes occur continuously, the corresponding documents
should be updated dynamically; otherwise, implementing the ERP
package in the organization encounters serious risks. In this paper, we
propose a new architecture which is based on the agent oriented
vision and supplies the dynamic document generation expected from
ERP systems using several independent but cooperative agents.
Beside the dynamic document generation which is the main issue of
this paper, the presented architecture will address some aspects of
intelligence and learning capabilities existing in ERP.
Abstract: Researchers have been applying artificial/ computational intelligence (AI/CI) methods to computer games. In this research field, further researchesare required to compare AI/CI methods with respect to each game application. In thispaper, we report our experimental result on the comparison of evolution strategy, genetic algorithm and their hybrids, applied to evolving controller agents for MarioAI. GA revealed its advantage in our experiment, whereas the expected ability of ES in exploiting (fine-tuning) solutions was not clearly observed. The blend crossover operator and the mutation operator of GA might contribute well to explore the vast search space.
Abstract: This paper introduces our first efforts of developing a
new team for RoboCup Middle Size Competition. In our robots we
have applied omni directional based mobile system with omnidirectional
vision system and fuzzy control algorithm to navigate
robots. The control architecture of MRL middle-size robots is a three
layered architecture, Planning, Sequencing, and Executing. It also
uses Blackboard system to achieve coordination among agents.
Moreover, the architecture should have minimum dependency on low
level structure and have a uniform protocol to interact with real
robot.
Abstract: The purpose of the paper is to develop an informationcontrol environment for overall management and self-reconfiguration of the reconfigurable multifunctional machine tool for machining both rotation and prismatic parts and high concentration of different technological operations - turning, milling, drilling, grinding, etc. For the realization of this purpose on the basis of defined sub-processes for the implementation of the technological process, architecture of the information-search system for machine control is suggested. By using the object-oriented method, a structure and organization of the search system based on agents and manager with central control are developed. Thus conditions for identification of available information in DBs, self-reconfiguration of technological system and entire control of the reconfigurable multifunctional machine tool are created.
Abstract: Sudoku is a kind of logic puzzles. Each puzzle consists
of a board, which is a 9×9 cells, divided into nine 3×3 subblocks
and a set of numbers from 1 to 9. The aim of this puzzle is to
fill in every cell of the board with a number from 1 to 9 such
that in every row, every column, and every subblock contains each
number exactly one. Sudoku puzzles belong to combinatorial problem
(NP complete). Sudoku puzzles can be solved by using a variety of
techniques/algorithms such as genetic algorithms, heuristics, integer
programming, and so on. In this paper, we propose a new approach for
solving Sudoku which is by modelling them as block-world problems.
In block-world problems, there are a number of boxes on the table
with a particular order or arrangement. The objective of this problem
is to change this arrangement into the targeted arrangement with the
help of two types of robots. In this paper, we present three models
for Sudoku. We modellized Sudoku as parameterized multi-agent
systems. A parameterized multi-agent system is a multi-agent system
which consists of several uniform/similar agents and the number of
the agents in the system is stated as the parameter of this system. We
use Temporal Logic of Actions (TLA) for formalizing our models.
Abstract: One of the most challenges for hard surface cleaning product is to get rid of soap scum, a filmy sticky layer in the bathroom. The deposits of soap scum can be removed by using a proper surfactant solution with chelating agent. Unfortunately, the conventional chelating agent, ethylenediamine tetraacetic acid (EDTA), has low biodegradability, which can be tolerance in water resources and harmful to aquatic animal and microorganism. In this study, two biodegradable chelating agents, ethylenediamine disuccinic acid (EDDS) and glutamic acid diacetic acid (GLDA) were introduced as a replacement of EDTA. The result shows that using GLDA with amphoteric surfactant gave the highest equilibrium solubility of soap scum.
Abstract: This paper shows possibility of extraction Social,
Group and Individual Mind from Multiple Agents Rule Bases. Types
those Rule bases are selected as two fuzzy systems, namely
Mambdani and Takagi-Sugeno fuzzy system. Their rule bases are
describing (modeling) agent behavior. Modifying of agent behavior
in the time varying environment will be provided by learning fuzzyneural
networks and optimization of their parameters with using
genetic algorithms in development system FUZNET. Finally,
extraction Social, Group and Individual Mind from Multiple Agents
Rule Bases are provided by Cognitive analysis and Matching
criterion.
Abstract: In order to answer the general question: “What does a simple agent with a limited life-time require for constructing a useful representation of the environment?" we propose a robot platform including the simplest probabilistic sensory and motor layers. Then we use the platform as a test-bed for evaluation of the navigational capabilities of the robot with different “brains". We claim that a protocognitive behavior is not a consequence of highly sophisticated sensory–motor organs but instead emerges through an increment of the internal complexity and reutilization of the minimal sensory information. We show that the most fundamental robot element, the short-time memory, is essential in obstacle avoidance. However, in the simplest conditions of no obstacles the straightforward memoryless robot is usually superior. We also demonstrate how a low level action planning, involving essentially nonlinear dynamics, provides a considerable gain to the robot performance dynamically changing the robot strategy. Still, however, for very short life time the brainless robot is superior. Accordingly we suggest that small organisms (or agents) with short life-time does not require complex brains and even can benefit from simple brain-like (reflex) structures. To some extend this may mean that controlling blocks of modern robots are too complicated comparative to their life-time and mechanical abilities.
Abstract: The demand for autonomous resource
management for distributed systems has increased in recent
years. Distributed systems require an efficient and powerful
communication mechanism between applications running on
different hosts and networks. The use of mobile agent
technology to distribute and delegate management tasks
promises to overcome the scalability and flexibility limitations
of the currently used centralized management approach. This
work proposes a multiagent system that adopts mobile agents
as a technology for tasks distribution, results collection, and
management of resources in large-scale distributed systems. A
new mobile agent-based approach for collecting results from
distributed system elements is presented. The technique of
artificial intelligence based on intelligent agents giving the
system a proactive behavior. The presented results are based
on a design example of an application operating in a mobile
environment.
Abstract: This paper presents a novel method that allows an
agent host to delegate its signing power to an anonymous mobile
agent in such away that the mobile agent does not reveal any information about its host-s identity and, at the same time, can be authenticated by the service host, hence, ensuring fairness of service
provision. The solution introduces a verification server to verify the
signature generated by the mobile agent in such a way that even if colluding with the service host, both parties will not get more information than what they already have. The solution incorporates
three methods: Agent Signature Key Generation method, Agent
Signature Generation method, Agent Signature Verification method.
The most notable feature of the solution is that, in addition to allowing secure and anonymous signature delegation, it enables
tracking of malicious mobile agents when a service host is attacked. The security properties of the proposed solution are analyzed, and the solution is compared with the most related work.