Abstract: The motivation of this work was to find a suitable 3D
scanner for human body parts digitalization in the field of prosthetics
and orthotics. The main project objective is to compare the three
hand-held portable scanners (two optical and one laser) and two
optical tripod scanners. The comparison was made with respect of
scanning detail, simplicity of operation and ability to scan directly on
the human body. Testing was carried out on a plaster cast of the
upper limb and directly on a few volunteers. The objective monitored
parameters were time of digitizing and post-processing of 3D data
and resulting visual data quality. Subjectively, it was considered level
of usage and handling of the scanner. The new tripod was developed
to improve the face scanning conditions. The results provide an
overview of the suitability of different types of scanners.
Abstract: The objective of current issue was to develop a model
of testicular herpes simplex virus (HSV) type I infection for
assessment of viral effect on fertility. 56 male mice were inoculated
intraperitoneally with different concentrations of HSV on 8 day post
partum. It was revealed that the optimal dose was 100 plaque
forming units per mice as it provided testicular infection in 100% of
survivors. HSV proteins were detected both in somatic and germ
cells (spermatogonia, spermatocytes, spermatides). Although DNA
load in testis was descending from 3 to 28 days post infection only
12.5% of infected males had offspring after mating with uninfected
females comparing to 87.5% in control (p=0.012). These results are
the first direct evidence for HSV impact in male sterility. Prepuberal
mice appeared to be a suitable model for investigation of
pathogenesis of virus-associated fertility disorders.
Abstract: It is necessary to incorporate technological advances
achieved in the field of engineering into dentistry in order to enhance
the process of diagnosis, treatment planning and enable the doctors to
render better treatment to their patients. To achieve this ultimate goal
long distance collaborations are often necessary. This paper discusses
the various collaborative tools and their applications to solve a few
burning problems confronted by the dentists. Customization is often
the solution to most of the problems. But rapid designing,
development and cost effective manufacturing is a difficult task to
achieve. This problem can be solved using the technique of digital
manufacturing. Cases from 6 major branches of dentistry have been
discussed and possible solutions with the help of state of art
technology using rapid digital manufacturing have been proposed in
the present paper. The paper also entails the usage of existing tools in
collaborative and digital manufacturing area.
Abstract: Bacillus subtilis strain LB5 produced lipopeptide
antibiotic iturin A-2 in liquid medium. Crude extract
from cell-free supernatant of B. subtilis cultivated broth extracted
with n-butanol showed antifungal activity to conidial germination of
Colletotrichum gloeosporioides. The germination of conidia was
completely inhibited by crude extract. The ultrastructure of conidia
after treated with crude extract was found an accumulation of vesiclelike
material between cell wall and plasma membrane while this
accumulation was not observed in untreated and germinated conidia.
Besides, the cell wall was not affected by crude extract.
Abstract: It is shown that the relationship of tick-borne
encephalitis virus with the human body comes in two ways, the
development of acute infection with the outcome in convalescence
and long stay by the virus in the body, its persistence in the nervous
tissue with periodic reactivation and prolonged circulating
immunoglobulin M. In spite of the fact that tick-borne encephalitis
virus has a tropism for nerve tissue, involvement in the process of
blood cells is an integral component of the infection. Comprehensive
study of the relation of factors of innate and adaptive immunity in the
tick-borne encephalitis providing insight into the features of chronic
disease.
Abstract: This study aimed to detect and to identify the main
strains of airborne microorganisms present in the Shanghai Metro
system. Samples were collected using agar plates exposed to the air
and microorganisms were identified using catalase, plasma coagulase
and hymolytic analysis. The results show that the concentration of
mildew present within a newly opened metro line was significantly
higher than for other lines. Differences among underground and
elevated stations can be attributed to differences in passenger flow and
the environment surrounding the stations. Additionally, the
investigation indicated that bacteria reached maximum levels at
different times on weekdays and weekends. The bacteria in the Metro
stations were identified as primarily Gram positive, consisting mainly
of coagulase-negative staphylococcus strains (CNS).
Abstract: Today, cancer remains one of the major diseases that
lead to death. The main obstacle in chemotherapy as a main cancer
treatment is the toxicity to normal cells due to Multidrug Resistance
(MDR) after the use of anticancer drugs. Proposed solution to
overcome this problem is the use of MDR efflux inhibitor of cinchona
alkaloids which is delivered together with anticancer drugs
encapsulated in the form of polymeric nanoparticles. The particles
were prepared by the hydration method. The characterization of
nanoparticles was particle size, zeta potential, entrapment efficiency
and in vitro drug release. Combination nanoparticle size ranged 29-45
nm with a neutral surface charge. Entrapment efficiency was above
87% for the use quinine, quinidine or cinchonidine in combination
with etoposide. The release test results exhibited that the cinchona
alkaloids release released faster than that of etoposide. Collectively,
cinchona alkaloids can be packaged along with etoposide in
nanomicelles for better cancer therapy.