Abstract: It is shown that the relationship of tick-borne
encephalitis virus with the human body comes in two ways, the
development of acute infection with the outcome in convalescence
and long stay by the virus in the body, its persistence in the nervous
tissue with periodic reactivation and prolonged circulating
immunoglobulin M. In spite of the fact that tick-borne encephalitis
virus has a tropism for nerve tissue, involvement in the process of
blood cells is an integral component of the infection. Comprehensive
study of the relation of factors of innate and adaptive immunity in the
tick-borne encephalitis providing insight into the features of chronic
disease.