Abstract: The main perspective of the present study aims at overcoming solubility problems by using the technique of solid dispersion. Repaglinide is a BCS Class II drug, having low aqueous solubility and therefore, low bioavailability. Solid dispersions of repaglinide with different carriers Polyvinyl Pyrrolidone (PVP) and Ethyl Cellulose (EC) in different ratios were prepared by suspending method and Dissolving methods. In vitro release studies revealed that the F7 formulation showed extended drug release. So, the dissolution profile of solid dispersion containing EC and PVP K30 (1: 3) was selected as the best formulation because of its extended drug release among all formulations. In conclusion, solid dispersions of Repaglinide in PVP have shown to be a promising approach to improve the bioavailability of Repaglinide.
Abstract: This paper describes a new method for affine parameter
estimation between image sequences. Usually, the parameter
estimation techniques can be done by least squares in a quadratic
way. However, this technique can be sensitive to the presence
of outliers. Therefore, parameter estimation techniques for various
image processing applications are robust enough to withstand the
influence of outliers. Progressively, some robust estimation functions
demanding non-quadratic and perhaps non-convex potentials adopted
from statistics literature have been used for solving these. Addressing
the optimization of the error function in a factual framework for
finding a global optimal solution, the minimization can begin with
the convex estimator at the coarser level and gradually introduce nonconvexity
i.e., from soft to hard redescending non-convex estimators
when the iteration reaches finer level of multiresolution pyramid.
Comparison has been made to find the performance of the results
of proposed method with the results found individually using two
different estimators.
Abstract: This paper explains a project based learning method where autonomous mini-robots are developed for research, education and entertainment purposes. In case of remote systems wireless sensors are developed in critical areas, which would collect data at specific time intervals, send the data to the central wireless node based on certain preferred information would make decisions to turn on or off a switch or control unit. Such information transfers hardly sums up to a few bytes and hence low data rates would suffice for such implementations. As a robot is a multidisciplinary platform, the interfacing issues involved are discussed in this paper. The paper is mainly focused on power supply, grounding and decoupling issues.