Abstract: A spectrophotometric method was developed for simultaneous quantification of pseudoephedrine hydrochloride (PSE) triprolidine hydrochloride (TRI) using second derivative method (zero-crossing technique). The second derivative amplitudes of PSE and TRI were measured at 271 and 321 nm, respectively. The calibration curves were linear in the range of 200 to 1,000 g/ml for PSE and 10 to 50 g/ml for TRI. The method was validated for specificity, accuracy, precision, limit of detection and limit of quantitation. The proposed method was applied to the assaying and dissolution of PSE and TRI in commercial tablets without any chemical separation. The results were compared with those obtained by the official USP31 method and statistical tests showed that there is no significant between the methods at 95% confidence level. The proposed method is simple, rapid and suitable for the routine quality control application. KeywordsTriprolidine, Pseudoephedrine, Derivative spectrophotometry, Dissolution testing.
Abstract: The seismic vulnerability of an urban area is of a great
deal for local authorities especially those facing earthquakes. So, it is
important to have an efficient tool to assess the vulnerability of
existing buildings. The use of the VIP (Vulnerability Index Program)
and the GIS (Geographic Information System) let us to identify the
most vulnerable districts of an urban area.
The use of the vulnerability index method lets us to assess the
vulnerability of the center town of Blida (Algeria) which is a
historical town and which has grown enormously during the last
decades. In this method, three levels of vulnerability are defined. The
GIS has been used to build a data base in order to perform different
thematic analyses. These analyses show the seismic vulnerability of
Blida.