Experimental Study on Capturing of Magnetic Nanoparticles Transported in an Implant Assisted Cylindrical Tube under Magnetic Field
Targeted drug delivery is a method of delivering
medication to a patient in a manner that increases the concentration
of the medication in some parts of the body relative to others.
Targeted drug delivery seeks to concentrate the medication in the
tissues of interest while reducing the relative concentration of the
medication in the remaining tissues. This improves efficacy of the
while reducing side effects. In the present work, we investigate the
effect of magnetic field, flow rate and particle concentration on the
capturing of magnetic particles transported in a stent implanted
fluidic channel. Iron oxide magnetic nanoparticles (Fe3O4)
nanoparticles were synthesized via co-precipitation method. The
synthesized Fe3O4 nanoparticles were added in the de-ionized (DI)
water to prepare the Fe3O4 magnetic particle suspended fluid. This
fluid is transported in a cylindrical tube of diameter 8 mm with help
of a peristaltic pump at different flow rate (25-40 ml/min). A
ferromagnetic coil of SS 430 has been implanted inside the
cylindrical tube to enhance the capturing of magnetic nanoparticles
under magnetic field. The capturing of magnetic nanoparticles was
observed at different magnetic magnetic field, flow rate and particle
concentration. It is observed that capture efficiency increases from
47-67% at magnetic field 2-5kG, respectively at particle
concentration 0.6mg/ml and at flow rate 30 ml/min. However, the
capture efficiency decreases from 65 to 44% by increasing the flow
rate from 25 to 40 ml/min, respectively. Furthermore, it is observed
that capture efficiency increases from 51 to 67% by increasing the
particle concentration from 0.3 to 0.6 mg/ml, respectively.
[1] V. P. Torchilin, "Drug targeting." Eur J. Pharm Sci, Vol. 11, 2000, pp.
81.
[2] D. J. A Crommelin, G. Scherphof, G. Storm, "Active targeting with
particulate carrier systems in the blood compartment." Adv drug deliver
rev, Vol. 17, 1995, pp. 49.
[3] M. O. Avilés, A. D. Ebner, J. A. Ritter "In vitro study of magnetic
particle seeding for implants assisted-magnetic drug targeting." J. Magn.
Magn.Mater., Vol. 320, 2008, pp. 2640.
[4] M. O. Avilés, A. D. Ebner, J. A. Ritter "In vitro study of magnetic
particle seeding for implant-assisted-magnetic drug targeting: Seed and
magnetic drug carrier particle capture." J. Magn. Magn.Mater.,Vol. 321,
2009, pp. 1586.
[5] J. A. Ritter, J. A. D. Ebner, K. D. Daniel, K. Stewart"Application of high
gradient magnetic separation principles to magnetic drug targeting" J.
Magn. Magn.Mater., Vol. 280, 2004, pp. 184.
[6] A. D. Grief, G. Richardson "Mathematical modelling of magnetically
targeted drug delivery" J. Magn. Magn.Mater., Vol. 293, 2005, pp. 455.
[7] M. Babincová, D. Leszczynska, P. Sourivong, P. Babinec, "Lysis of
photosensitized erythrocytes in an alternating magnetic field"J.
magn.Magn.mater., Vol. 225, 2001, pp. 194.
[8] G. H. Iacob, O. Rotariu, H. Chiriac "A possibility for local targeting of
magnetic carriers" J. Optoelectron. Adv. M, Vol. 6, 2004, pp. 713.
[9] G. Iacob,O. Rotariu, N. J. C Strachan, U.O. Hafeli "Magnetizable
needles and wires-modeling an efficient way to target magnetic
microspheres in vivo." Biorheology, Vol. 41, 2004, pp. 599.
[10] B. B. Yellen, Z. G. Forbes, D. S. Halverson, G. Fridman, K. A. Barbee,
M. Chorny, G. Friedman"Targeted drug delivery to magnetic implants
for therapeutic applications." J. magn.Magn.mater., Vol. 293, 2005, pp.
647.
[11] O. Rotariu, N. J. C. Strachan "Modelling magnetic carrier particle
targeting in the tumor microvasculature for cancer treatment." J. Magn.
Magn. Mater, Vol. 293, 2005, pp. 639.
[12] H. Chen, A. D. Ebner, A. J. Rosengart, M. D. Kaminski, J. A. Ritter,
"Analysis of magnetic drug carrier particle capture by a magnetizable
intravascular stent: 1. Parametric study with single wire correlation." J.
magn.Magn.Mater. Vol. 284, 2004, pp. 181.
[13] H. Chen, A. D. Ebner, A. J. Rosengart, M. D. Kaminski, J. A. Ritter
"Analysis of magnetic drug carrier particle capture by a magnetizable
intravascular stent—2: parametric study with multi-wire twodimensional
model." J. magn.Magn.Mater., Vol. 293, 2005, pp. 616.
[14] M. O. Avilés, A. D. Ebner, H. Chen, A. J. Rosengart, M. D. Kaminski, J.
A Ritter, "Theoretical analysis of a transdermal ferromagnetic implant
for retention of magnetic drug carrier particles." J.
magn.Magn.Mater., Vol. 293, 2005, pp. 605.
[15] M. O. Avilés,A. D. Ebner, J. A. Ritter "Ferromagnetic seeding for the
magnetic targeting of drugs and radiation in capillary beds."J.
magn.Magn.Mater., Vol. 310, 2007, pp. 131
[16] M. O. Avilés, A. D. Ebner, H. Chen, A. J. Rosengart, M. D. Kaminski, J.
A Ritter" In vitro study of ferromagnetic stents for implant assistedmagnetic
drug targeting" J. Magn. Magn.Mater., Vol. 311,2007, pp. 306.
[17] M. O. Avilés,J. O. Mangual, A. D. Ebner, J. A. Ritter, "Isolated swine
heart ventricle perfusion model for implant assisted-magnetic drug
targeting." Int. j. pharm., Vol. 361, 2008, pp. 202.
[18] Z. G. Forbes, B. B. Yellen, K. Barbee, G. Friedman "An approach to
targeted drug delivery based on uniform magnetic fields." Magnetics,
IEEE Transactions on, Vol. 39, 2003, pp. 3372.
[1] V. P. Torchilin, "Drug targeting." Eur J. Pharm Sci, Vol. 11, 2000, pp.
81.
[2] D. J. A Crommelin, G. Scherphof, G. Storm, "Active targeting with
particulate carrier systems in the blood compartment." Adv drug deliver
rev, Vol. 17, 1995, pp. 49.
[3] M. O. Avilés, A. D. Ebner, J. A. Ritter "In vitro study of magnetic
particle seeding for implants assisted-magnetic drug targeting." J. Magn.
Magn.Mater., Vol. 320, 2008, pp. 2640.
[4] M. O. Avilés, A. D. Ebner, J. A. Ritter "In vitro study of magnetic
particle seeding for implant-assisted-magnetic drug targeting: Seed and
magnetic drug carrier particle capture." J. Magn. Magn.Mater.,Vol. 321,
2009, pp. 1586.
[5] J. A. Ritter, J. A. D. Ebner, K. D. Daniel, K. Stewart"Application of high
gradient magnetic separation principles to magnetic drug targeting" J.
Magn. Magn.Mater., Vol. 280, 2004, pp. 184.
[6] A. D. Grief, G. Richardson "Mathematical modelling of magnetically
targeted drug delivery" J. Magn. Magn.Mater., Vol. 293, 2005, pp. 455.
[7] M. Babincová, D. Leszczynska, P. Sourivong, P. Babinec, "Lysis of
photosensitized erythrocytes in an alternating magnetic field"J.
magn.Magn.mater., Vol. 225, 2001, pp. 194.
[8] G. H. Iacob, O. Rotariu, H. Chiriac "A possibility for local targeting of
magnetic carriers" J. Optoelectron. Adv. M, Vol. 6, 2004, pp. 713.
[9] G. Iacob,O. Rotariu, N. J. C Strachan, U.O. Hafeli "Magnetizable
needles and wires-modeling an efficient way to target magnetic
microspheres in vivo." Biorheology, Vol. 41, 2004, pp. 599.
[10] B. B. Yellen, Z. G. Forbes, D. S. Halverson, G. Fridman, K. A. Barbee,
M. Chorny, G. Friedman"Targeted drug delivery to magnetic implants
for therapeutic applications." J. magn.Magn.mater., Vol. 293, 2005, pp.
647.
[11] O. Rotariu, N. J. C. Strachan "Modelling magnetic carrier particle
targeting in the tumor microvasculature for cancer treatment." J. Magn.
Magn. Mater, Vol. 293, 2005, pp. 639.
[12] H. Chen, A. D. Ebner, A. J. Rosengart, M. D. Kaminski, J. A. Ritter,
"Analysis of magnetic drug carrier particle capture by a magnetizable
intravascular stent: 1. Parametric study with single wire correlation." J.
magn.Magn.Mater. Vol. 284, 2004, pp. 181.
[13] H. Chen, A. D. Ebner, A. J. Rosengart, M. D. Kaminski, J. A. Ritter
"Analysis of magnetic drug carrier particle capture by a magnetizable
intravascular stent—2: parametric study with multi-wire twodimensional
model." J. magn.Magn.Mater., Vol. 293, 2005, pp. 616.
[14] M. O. Avilés, A. D. Ebner, H. Chen, A. J. Rosengart, M. D. Kaminski, J.
A Ritter, "Theoretical analysis of a transdermal ferromagnetic implant
for retention of magnetic drug carrier particles." J.
magn.Magn.Mater., Vol. 293, 2005, pp. 605.
[15] M. O. Avilés,A. D. Ebner, J. A. Ritter "Ferromagnetic seeding for the
magnetic targeting of drugs and radiation in capillary beds."J.
magn.Magn.Mater., Vol. 310, 2007, pp. 131
[16] M. O. Avilés, A. D. Ebner, H. Chen, A. J. Rosengart, M. D. Kaminski, J.
A Ritter" In vitro study of ferromagnetic stents for implant assistedmagnetic
drug targeting" J. Magn. Magn.Mater., Vol. 311,2007, pp. 306.
[17] M. O. Avilés,J. O. Mangual, A. D. Ebner, J. A. Ritter, "Isolated swine
heart ventricle perfusion model for implant assisted-magnetic drug
targeting." Int. j. pharm., Vol. 361, 2008, pp. 202.
[18] Z. G. Forbes, B. B. Yellen, K. Barbee, G. Friedman "An approach to
targeted drug delivery based on uniform magnetic fields." Magnetics,
IEEE Transactions on, Vol. 39, 2003, pp. 3372.
@article{"International Journal of Engineering, Mathematical and Physical Sciences:71346", author = "Anurag Gaur and Nidhi and Shashi Sharma", title = "Experimental Study on Capturing of Magnetic Nanoparticles Transported in an Implant Assisted Cylindrical Tube under Magnetic Field", abstract = "Targeted drug delivery is a method of delivering
medication to a patient in a manner that increases the concentration
of the medication in some parts of the body relative to others.
Targeted drug delivery seeks to concentrate the medication in the
tissues of interest while reducing the relative concentration of the
medication in the remaining tissues. This improves efficacy of the
while reducing side effects. In the present work, we investigate the
effect of magnetic field, flow rate and particle concentration on the
capturing of magnetic particles transported in a stent implanted
fluidic channel. Iron oxide magnetic nanoparticles (Fe3O4)
nanoparticles were synthesized via co-precipitation method. The
synthesized Fe3O4 nanoparticles were added in the de-ionized (DI)
water to prepare the Fe3O4 magnetic particle suspended fluid. This
fluid is transported in a cylindrical tube of diameter 8 mm with help
of a peristaltic pump at different flow rate (25-40 ml/min). A
ferromagnetic coil of SS 430 has been implanted inside the
cylindrical tube to enhance the capturing of magnetic nanoparticles
under magnetic field. The capturing of magnetic nanoparticles was
observed at different magnetic magnetic field, flow rate and particle
concentration. It is observed that capture efficiency increases from
47-67% at magnetic field 2-5kG, respectively at particle
concentration 0.6mg/ml and at flow rate 30 ml/min. However, the
capture efficiency decreases from 65 to 44% by increasing the flow
rate from 25 to 40 ml/min, respectively. Furthermore, it is observed
that capture efficiency increases from 51 to 67% by increasing the
particle concentration from 0.3 to 0.6 mg/ml, respectively.", keywords = "Capture efficiency, Implant assisted-Magnetic drug
targeting (IA-MDT), Magnetic nanoparticles, in vitro study.", volume = "9", number = "9", pages = "566-4", }