Abstract: Computer modeling has played a unique role in
understanding electrocardiography. Modeling and simulating cardiac
action potential propagation is suitable for studying normal and
pathological cardiac activation. This paper presents a 2-D Cellular
Automata model for simulating action potential propagation in
cardiac tissue. We demonstrate a novel algorithm in order to use
minimum neighbors. This algorithm uses the summation of the
excitability attributes of excited neighboring cells. We try to
eliminate flat edges in the result patterns by inserting probability to
the model. We also preserve the real shape of action potential by
using linear curve fitting of one well known electrophysiological
model.
Abstract: This paper attempts to explain response components of Electrovestibulography (EVestG) using a computer simulation of a three-canal model of the vestibular system. EVestG is a potentially new diagnostic method for Meniere's disease. EVestG is a variant of Electrocochleography (ECOG), which has been used as a standard method for diagnosing Meniere's disease - it can be used to measure the SP/AP ratio, where an SP/AP ratio greater than 0.4-0.5 is indicative of Meniere-s Disease. In EVestG, an applied head tilt replaces the acoustic stimulus of ECOG. The EVestG output is also an SP/AP type plot, where SP is the summing potential, and AP is the action potential amplitude. AP is thought of as being proportional to the size of a population of afferents in an excitatory neural firing state. A simulation of the fluid volume displacement in the vestibular labyrinth in response to various types of head tilts (ipsilateral, backwards and horizontal rotation) was performed, and a simple neural model based on these simulations developed. The simple neural model shows that the change in firing rate of the utricle is much larger in magnitude than the change in firing rates of all three semi-circular canals following a head tilt (except in a horizontal rotation). The data suggests that the change in utricular firing rate is a minimum 2-3 orders of magnitude larger than changes in firing rates of the canals during ipsilateral/backward tilts. Based on these results, the neural response recorded by the electrode in our EVestG recordings is expected to be dominated by the utricle in ipsilateral/backward tilts (It is important to note that the effect of the saccule and efferent signals were not taken into account in this model). If the utricle response dominates the EVestG recordings as the modeling results suggest, then EVestG has the potential to diagnose utricular hair cell damage due to a viral infection (which has been cited as one possible cause of Meniere's Disease).
Abstract: In this research we show that the dynamics of an action potential in a cell can be modeled with a linear combination of the dynamics of the gating state variables. It is shown that the modeling error is negligible. Our findings can be used for simplifying cell models and reduction of computational burden i.e. it is useful for simulating action potential propagation in large scale computations like tissue modeling. We have verified our finding with the use of several cell models.
Abstract: In this paper a new approach to face recognition is
presented that achieves double dimension reduction, making the
system computationally efficient with better recognition results and
out perform common DCT technique of face recognition. In pattern
recognition techniques, discriminative information of image
increases with increase in resolution to a certain extent, consequently
face recognition results change with change in face image resolution
and provide optimal results when arriving at a certain resolution
level. In the proposed model of face recognition, initially image
decimation algorithm is applied on face image for dimension
reduction to a certain resolution level which provides best
recognition results. Due to increased computational speed and feature
extraction potential of Discrete Cosine Transform (DCT), it is
applied on face image. A subset of coefficients of DCT from low to
mid frequencies that represent the face adequately and provides best
recognition results is retained. A tradeoff between decimation factor,
number of DCT coefficients retained and recognition rate with
minimum computation is obtained. Preprocessing of the image is
carried out to increase its robustness against variations in poses and
illumination level. This new model has been tested on different
databases which include ORL , Yale and EME color database.
Abstract: Emerging Bio-engineering fields such as Brain
Computer Interfaces, neuroprothesis devices and modeling and
simulation of neural networks have led to increased research activity
in algorithms for the detection, isolation and classification of Action
Potentials (AP) from noisy data trains. Current techniques in the field
of 'unsupervised no-prior knowledge' biosignal processing include
energy operators, wavelet detection and adaptive thresholding. These
tend to bias towards larger AP waveforms, AP may be missed due to
deviations in spike shape and frequency and correlated noise
spectrums can cause false detection. Also, such algorithms tend to
suffer from large computational expense.
A new signal detection technique based upon the ideas of phasespace
diagrams and trajectories is proposed based upon the use of a
delayed copy of the AP to highlight discontinuities relative to
background noise. This idea has been used to create algorithms that
are computationally inexpensive and address the above problems.
Distinct AP have been picked out and manually classified from
real physiological data recorded from a cockroach. To facilitate
testing of the new technique, an Auto Regressive Moving Average
(ARMA) noise model has been constructed bases upon background
noise of the recordings. Along with the AP classification means this
model enables generation of realistic neuronal data sets at arbitrary
signal to noise ratio (SNR).
Abstract: We created the tool, which combines the powerful
GENESIS (GEneral NEural SImulation System) simulation language
with the up-to-date visualisation and internet techniques. Our
solution resides in the connection between the simulation output from
GENESIS, which is converted to the data-structure suitable for
WWW browsers and VRML (Virtual Reality Modelling Language)
viewers. The selected GENESIS simulations are once exported into
the VRML code, and stored in our neurovisualisation portal
(webserver). There, the loaded models, demonstrating mainly the
spread of electrical signal (action potentials, postsynaptic potentials)
along the neuronal membrane (axon, dendritic tree, neuron) could be
displayed in the client-s VRML viewer, without interacting with
original GENESIS environment. This enables the visualisation of
basic neurophysiological phenomena designed for GENESIS
simulator on the independent OS (operation system).