Abstract: Periodic vortex shedding in pulsating flow inside wavy
channel and the effect it has on heat transfer are studied using the
finite volume method. A sinusoidally-varying component is superimposed
on a uniform flow inside a sinusoidal wavy channel and
the effects on the Nusselt number is analyzed. It was found that a
unique optimum value of the pulsation frequency, represented by the
Strouhal number, exists for Reynolds numbers ranging from 125 to
1000. Results suggest that the gain in heat transfer is related to the
process of vortex formation, movement about the troughs of the wavy
channel, and subsequent ejection/destruction through the converging
section. Heat transfer is the highest when the frequencies of the
pulsation and vortex formation approach being in-phase. Analysis of
Strouhal number effect on Nu over a period of pulsation substantiates
the proposed physical mechanism for enhancement. The effect of
changing the amplitude of pulsation is also presented over a period
of pulsation, showing a monotonic increase in heat transfer with
increasing amplitude. The 60% increase in Nusselt number suggests
that sinusoidal fluid pulsation can an effective method for enhancing
heat transfer in laminar, wavy-channel flows.
Abstract: Intravitreal injection (IVI) is the most common treatment for eye posterior segment diseases such as endopthalmitis, retinitis, age-related macular degeneration, diabetic retinopathy, uveitis, and retinal detachment. Most of the drugs used to treat vitreoretinal diseases, have a narrow concentration range in which they are effective, and may be toxic at higher concentrations. Therefore, it is critical to know the drug distribution within the eye following intravitreal injection. Having knowledge of drug distribution, ophthalmologists can decide on drug injection frequency while minimizing damage to tissues. The goal of this study was to develop a computer model to predict intraocular concentrations and pharmacokinetics of intravitreally injected drugs. A finite volume model was created to predict distribution of two drugs with different physiochemical properties in the rabbit eye. The model parameters were obtained from literature review. To validate this numeric model, the in vivo data of spatial concentration profile from the lens to the retina were compared with the numeric data. The difference was less than 5% between the numerical and experimental data. This validation provides strong support for the numerical methodology and associated assumptions of the current study.