Abstract: Today, cancer remains one of the major diseases that
lead to death. The main obstacle in chemotherapy as a main cancer
treatment is the toxicity to normal cells due to Multidrug Resistance
(MDR) after the use of anticancer drugs. Proposed solution to
overcome this problem is the use of MDR efflux inhibitor of cinchona
alkaloids which is delivered together with anticancer drugs
encapsulated in the form of polymeric nanoparticles. The particles
were prepared by the hydration method. The characterization of
nanoparticles was particle size, zeta potential, entrapment efficiency
and in vitro drug release. Combination nanoparticle size ranged 29-45
nm with a neutral surface charge. Entrapment efficiency was above
87% for the use quinine, quinidine or cinchonidine in combination
with etoposide. The release test results exhibited that the cinchona
alkaloids release released faster than that of etoposide. Collectively,
cinchona alkaloids can be packaged along with etoposide in
nanomicelles for better cancer therapy.
Abstract: Computers are being integrated in the various aspects
of human every day life in different shapes and abilities. This fact
has intensified a requirement for the software development
technologies which is ability to be: 1) portable, 2) adaptable, and 3)
simple to develop. This problem is also known as the Pervasive
Computing Problem (PCP) which can be implemented in different
ways, each has its own pros and cons and Context Oriented
Programming (COP) is one of the methods to address the PCP.
In this paper a design for a COP framework, a context aware
framework, is presented which has eliminated weak points of a
previous design based on interpreter languages, while introducing the
compiler languages power in implementing these frameworks.
The key point of this improvement is combining COP and
Dependency Injection (DI) techniques. Both old and new frameworks
are analyzed to show advantages and disadvantages. Finally a
simulation of both designs is proposed to indicating that the practical
results agree with the theoretical analysis while the new design runs
almost 8 times faster.
Abstract: Intravitreal injection (IVI) is the most common treatment for eye posterior segment diseases such as endopthalmitis, retinitis, age-related macular degeneration, diabetic retinopathy, uveitis, and retinal detachment. Most of the drugs used to treat vitreoretinal diseases, have a narrow concentration range in which they are effective, and may be toxic at higher concentrations. Therefore, it is critical to know the drug distribution within the eye following intravitreal injection. Having knowledge of drug distribution, ophthalmologists can decide on drug injection frequency while minimizing damage to tissues. The goal of this study was to develop a computer model to predict intraocular concentrations and pharmacokinetics of intravitreally injected drugs. A finite volume model was created to predict distribution of two drugs with different physiochemical properties in the rabbit eye. The model parameters were obtained from literature review. To validate this numeric model, the in vivo data of spatial concentration profile from the lens to the retina were compared with the numeric data. The difference was less than 5% between the numerical and experimental data. This validation provides strong support for the numerical methodology and associated assumptions of the current study.