Abstract: NFκB activation plays a crucial role in anti-apoptotic responses in response to the apoptotic signaling during tumor necrosis factor (TNFa) stimulation in Multiple Myeloma (MM). Although several drugs have been found effective for the treatment of MM by mainly inhibiting NFκB pathway, there are no any quantitative or qualitative results of comparison assessment on inhibition effect between different single drugs or drug combinations. Computational modeling is becoming increasingly indispensable for applied biological research mainly because it can provide strong quantitative predicting power. In this study, a novel computational pathway modeling approach is employed to comparably assess the inhibition effects of specific single drugs and drug combinations on the NFκB pathway in MM, especially the prediction of synergistic drug combinations.
Abstract: The purposes of this research were 1) to survey the
number of drugstores that unlawful dispense of asthma prescription
drugs, in form of drug combinations in the Phaya Thai district of
Bangkok, 2) to find the steroids contained in that drug combinations,
3) to find a means for informing general public about the dangers of
drugs and for a campaign to stop dispensing them.
Researcher collected drug combinations from 69 drugstores in
Phaya Thai district from Feb 15, 2012 to Mar 15, 2012. The survey
found 30.43%, 21, drug stores, sold asthma drug combinations to
customers without a prescription. These collected samples were
tested for steroid contamination by using Immunochromatography
kits. Eleven samples, 52.38%, were found contaminated with
steroids. In short, there should be control and inspection of
drugstores in the distribution of steroid medications. To improve the
knowledge of self health maintenance and drug usage among public,
Thai Government and Department of Public Health should educate
people about the side effects of using drug combinations and steroids.