Abstract: It is well known that Logistic Regression is the gold
standard method for predicting clinical outcome, especially
predicting risk of mortality. In this paper, the Decision Tree method
has been proposed to solve specific problems that commonly use
Logistic Regression as a solution. The Biochemistry and
Haematology Outcome Model (BHOM) dataset obtained from
Portsmouth NHS Hospital from 1 January to 31 December 2001 was
divided into four subsets. One subset of training data was used to
generate a model, and the model obtained was then applied to three
testing datasets. The performance of each model from both methods
was then compared using calibration (the χ2 test or chi-test) and
discrimination (area under ROC curve or c-index). The experiment
presented that both methods have reasonable results in the case of the
c-index. However, in some cases the calibration value (χ2) obtained
quite a high result. After conducting experiments and investigating
the advantages and disadvantages of each method, we can conclude
that Decision Trees can be seen as a worthy alternative to Logistic
Regression in the area of Data Mining.
Abstract: Bone remodeling occurs by the balanced action of
bone resorbing osteoclasts (OC) and bone-building osteoblasts.
Increased bone resorption by excessive OC activity contributes
to malignant and non-malignant diseases including osteoporosis.
To study OC differentiation and function, OC formed in
in vitro cultures are currently counted manually, a tedious
procedure which is prone to inter-observer differences. Aiming
for an automated OC-quantification system, classification of
OC and precursor cells was done on fluorescence microscope
images based on the distinct appearance of fluorescent nuclei.
Following ellipse fitting to nuclei, a combination of eight
features enabled clustering of OC and precursor cell nuclei.
After evaluating different machine-learning techniques, LOGREG
achieved 74% correctly classified OC and precursor cell
nuclei, outperforming human experts (best expert: 55%). In
combination with the automated detection of total cell areas,
this system allows to measure various cell parameters and most
importantly to quantify proteins involved in osteoclastogenesis.