Abstract: New developed approach for Functional Cost Analysis (FCA) based on virtual prototyping (VP) models in CAD/CAE environment, applicable and necessary in developing new products is presented. It is instrument for improving the value of the product while maintaining costs and/or reducing the costs of the product without reducing value. Five broad classes of VP methods are identified. Efficient use of prototypes in FCA is a vital activity that can make the difference between successful and unsuccessful entry of new products into the competitive word market. Successful realization of this approach is illustrated for a specific example using press joint power tool.
Abstract: The computer aided for design, analysis, control, visualization and simulation of robotized workcells is very interesting in this time. Computer Aided Robot Control (CARC) is a subsystem of the system CIM including the computer aided systems of all activities connected with visualization and working of robotized workcells. There are three basic ideas: current CAD/CAM/CAE systems for design and 3D visualization, special PC based control and simulation systems and Augmented Reality Aided Manufacturing (ARAM) systems. This paper describes example of Open Source software application that can to be utilized at planning of the robotized workcells, visualization and off-line programming the automated processes realized by authors.
Abstract: The design of a landing gear is one of the fundamental aspects of aircraft design. The need for a light weight, high strength, and stiffness characteristics coupled with techno economic feasibility are a key to the acceptability of any landing gear construction. In this paper, an approach for analyzing two different designed landing gears for an unmanned aircraft vehicle (UAV) using advanced CAE techniques will be applied. Different landing conditions have been considered for both models. The maximum principle stresses for each model along with the factor of safety are calculated for every loading condition. A conclusion is drawing about better geometry.
Abstract: Neonatal lupus erythematous (NLE) is a rare disease marked by clinical characteristic and specific maternal autoantibody. Many cutaneous, cardiac, liver, and hematological manifestations could happen with affect of one organ or multiple. In this case, both babies were premature, low birth weight (LBW), small for gestational age (SGA) and born through caesarean section from a systemic lupus erythematous (SLE) mother. In the first case, we found a baby girl with dyspnea and grunting. Chest X ray showed respiratory distress syndrome (RDS) great I and echocardiography showed small atrial septal defect (ASD) and ventricular septal defect (VSD). She also developed anemia, thrombocytopenia, elevated C-reactive protein, hypoalbuminemia, increasing coagulation factors, hyperbilirubinemia, and positive blood culture of Klebsiella pneumonia. Anti-Ro/SSA and Anti-nRNP/sm were positive. Intravenous fluid, antibiotic, transfusion of blood, thrombocyte concentrate, and fresh frozen plasma were given. The second baby, male presented with necrotic tissue on the left ear and skin rashes, erythematous macula, athropic scarring, hyperpigmentation on all of his body with various size and facial haemorrhage. He also suffered from thrombocytopenia, mild elevated transaminase enzyme, hyperbilirubinemia, anti-Ro/SSA was positive. Intravenous fluid, methyprednisolone, intravenous immunoglobulin (IVIG), blood, and thrombocyte concentrate transfution were given. Two cases of neonatal lupus erythematous had been presented. Diagnosis based on clinical presentation and maternal auto antibody on neonate. Organ involvement in NLE can occur as single or multiple manifestations.
Abstract: This work presents a study on the abrasive water jet
(AWJ) machining. An explicit finite element analysis (FEA) of
single abrasive particle impact on stainless steel 1.4304 (AISI 304) is
conducted. The abrasive water jet machining is modeled by FEA
software ABAQUS/CAE. Shapes of craters in FEM simulation
results were used and compared with the previous experimental and
FEM works by means of crater sphericity. The influence of impact
angle and particle velocity was observed. Adaptive mesh domain is
used to model the impact zone. Results are in good agreement with
those obtained from the experimental and FEM simulation. The
crater-s depth is also obtained for different impact angle and abrasive
particle velocities.
Abstract: This research studied the hypoglycemic effect of
water soluble polysaccharide (WSP) extracted from yam (Dioscorea
hispida) tuber by three different methods: aqueous extraction, papain
assisted extraction, and tempeh inoculums assisted extraction. The
two later extraction methods were aimed to remove WSP binding
protein to have more pure WSP. The hypoglycemic activities were
evaluated by means in vivo test on alloxan induced hyperglycemic
rats, glucose response test (GRT), in situ glucose absorption test
using everted sac, and short chain fatty acids (SCFAs) analysis. All
yam WSP extracts exhibited ability to decrease blood glucose level in
hyperglycemia condition as well as inhibited glucose absorption and
SCFA formation. The order of hypoglycemic activity was tempeh
inoculums assisted- >papain assisted- >aqueous WSP extracts. GRT
and in situ glucose absorption test showed that order of inhibition
was papain assisted- >tempeh inoculums assisted- >aqueous WSP
extracts. Digesta of caecum of yam WSP extracts oral fed rats had
more SCFA than control. Tempeh inoculums assisted WSP extract
exhibited the most significant hypoglycemic activity.
Abstract: The main objective of the paper has been represented
by the identification of the changes that occurred in the competitive
environment and their impact on the strategic marketing management
of companies in B2B market. At Romania-s level there has not yet
been done a similar research that studies change management in
crises on business to business field. In order to answer to the paper-s
objectives, a qualitative marketing research (in-depth structured
interview) was conducted, within the top management of 27
companies in Romanian business to business field. The main results
of the research highlight the necessity of a management of change, as
a result of the crises, as follows: changes in the corporate objectives
(from development objectives to maintaining objectives), changes
market segmentation and in competitive advantages, changes at the
level of market strategies and of the marketing mix.
Abstract: This study shows palynomorphological description of
pollen grains of Lamium garganicum, species of the family Labiatae.
Fresh material of this plant is taken in Mount Llogara, in Albania. By
comparison made between palinomorphological characteristics of
pollen grains of Lamium garganicum with those of Lamium
maculatum and Lamium purpureum, showed that granules have
similarities in the number of furrows. The pollen grains of Lamium
garganicum were larger in length and width than those of Lamium
maculatum and almost equal with those of Lamium purpureum.
Furrows are longer than those of pollen grains in Lamium maculatum
and shorter than those of Lamium purpureum. The layer of exine of
Lamium garganicum was thinner than that of two others. The
sculpture of exine was fine reticulate, where reticulas were uniform
whereas in Lamium purpureum was verrucate, with small verrucae; in
Lamium maculatum was reticulate.
Abstract: Bean common mosaic necrosis virus (BCMNV) is a
potyvirus with a worldwide distribution. This virus causes serious
economic losses in Iran in many leguminoses. During 20008,
samples were collected from soybeans fields in Tehran Province.
Four isolates (S1, S2 and S3) were inoculated on 15 species of
Cucurbitaceae, Chenopodiaceae, Solanacae and Leguminosae.
Chenopodium quinoa and C. amaranticolor.
Did not developed any symptoms.all isolates caused mosaic
symptoms on Phaseolus vulgaris cv. Red Kidney and P. vulgaris cv.
Bountiful. The molecular weights of coat protein using SDS-PAGE
and western blotting were estimated at 33 kDa. Reverse transcription
polymerase chain reaction (RT-PCR) was performed using one
primer pairs designed by L. XU et al. An approximately 920 bp
fragment was amplified with a specific primer.
Abstract: Hyperglycaemia is a key factor that contributes to the
development of diabetes-related microvascular disease and a major
risk factor for endothelial dysfunction. In the current study, we have
explored glucose-induced abnormal intracellular calcium (Ca2+
i)
homeostasis in mouse microvessel endothelial cells (MMECs) in
high glucose (HG) (40mmol/L) versus control (low glucose, LG) (11
mmol/L). We demonstrated that the exposure of MMECs to HG for 3
days did not change basal Ca2+
i, however, there was a significant
increase of acetylcholine-induced Ca2+ entry. Western blots
illustrated that exposure to HG also increased STIM1 (Stromal
Interaction Molecule 1), but not Orai1 (the pore forming subunit),
protein expression levels. Although the link between HG-induced
changes in STIM1 expression, enhanced Ca2+ entry and endothelial
dysfunction requires further study, the current data are suggestive
that targeting these pathways may reduce the impact of HG on
endothelial function.
Abstract: Improvement in CAE methods has an important role for shortening of the vehicle product development time. It is provided that validation of the design and improvements in terms of durability can be done without hardware prototype production. In recent years, several different methods have been developed in order to investigate fatigue damage of the vehicle. The intended goal among these methods is prediction of fatigue damage in a short time with reduced costs. This study developed a new fatigue damage prediction method in the automotive sector using power spectrum densities of accelerations. This study also confirmed that the weak region in vehicle can be easily detected with the method developed in this study which results were compared with conventional method.
Abstract: The incidence of mechanical fracture of an
automobile piston rings prompted development of fracture analysis
method on this case. The three rings (two compression rings and one
oil ring) were smashed into several parts during the power-test (after
manufacturing the engine) causing piston and liner to be damaged.
The radial and oblique cracking happened on the failed piston rings.
The aim of the fracture mechanics simulations presented in this paper
was the calculation of particular effective fracture mechanics
parameters, such as J-integrals and stress intensity factors. Crack
propagation angles were calculated as well. Two-dimensional
fracture analysis of the first compression ring has been developed in
this paper using ABAQUS CAE6.5-1 software. Moreover, SEM
fractography was developed on fracture surfaces and is discussed in
this paper. Results of numerical calculations constitute the basis for
further research on real object.
Abstract: This paper presents an optimization of the hull
separation, i.e. transverse clearance. The main objective is to identify
the feasible speed ranges and find the optimum transverse clearance
considering the minimum wave-making resistance. The dimensions
and the weight of hardware systems installed in the catamaran
structured fuel cell powered USV (Unmanned Surface Vehicle) were
considered as constraints. As the CAE (Computer Aided Engineering)
platform FRIENDSHIP-Framework was used. The hull surface
modeling, DoE (Design of Experiment), Tangent search optimization,
tool integration and the process automation were performed by
FRIENDSHIP-Framework. The hydrodynamic result was evaluated
by XPAN the potential solver of SHIPFLOW.
Abstract: This study has investigated the antidiabetic and
antioxidant potential of Pseudovaria macrophylla bark extract on
streptozotocin–nicotinamide induced type 2 diabetic rats. LCMSQTOF
and NMR experiments were done to determine the chemical
composition in the methanolic bark extract. For in vivo experiments,
the STZ (60 mg/kg/b.w, 15 min after 120 mg/kg/1 nicotinamide, i.p.)
induced diabetic rats were treated with methanolic extract of
Pseuduvaria macrophylla (200 and 400 mg/kg·bw) and
glibenclamide (2.5 mg/kg) as positive control respectively.
Biochemical parameters were assayed in the blood samples of all
groups of rats. The pro-inflammatory cytokines, antioxidant status
and plasma transforming growth factor βeta-1 (TGF-β1) were
evaluated. The histological study of the pancreas was examined and
its expression level of insulin was observed by
immunohistochemistry. In addition, the expression of glucose
transporters (GLUT 1, 2 and 4) were assessed in pancreas tissue by
western blot analysis. The outcomes of the study displayed that the
bark methanol extract of Pseuduvaria macrophylla has potentially
normalized the elevated blood glucose levels and improved serum
insulin and C-peptide levels with significant increase in the
antioxidant enzyme, reduced glutathione (GSH) and decrease in the
level of lipid peroxidation (LPO). Additionally, the extract has
markedly decreased the levels of serum pro-inflammatory cytokines
and transforming growth factor beta-1 (TGF-β1). Histopathology
analysis demonstrated that Pseuduvaria macrophylla has the
potential to protect the pancreas of diabetic rats against peroxidation
damage by downregulating oxidative stress and elevated
hyperglycaemia. Furthermore, the expression of insulin protein,
GLUT-1, GLUT-2 and GLUT-4 in pancreatic cells was enhanced.
The findings of this study support the anti-diabetic claims of
Pseudovaria macrophylla bark.
Abstract: The cDNA encoding the 326 amino acids of a Class I
basic chitinase gene from Leucaena leucocephala de Wit (KB3,
Genbank accession: AAM49597) was cloned under the control of
CaMV35S promoter in pCAMBIA 1300 and transferred to
Koshihikari. Calli of Koshihikari rice was transformed with
agrobacterium with this construct expressing the chitinase and β-
glucouronidase (GUS). The frequencies of calli 90 % has been
obtained from rice seedlings cultured on NB medium. The high
regeneration frequencies, 74% was obtained from calli cultured on
regeneration medium containing 4 mg/l BAP, and 7 g/l phytagel at
25°C. Various factors were studied in order to establish a procedure
for the transformation of Koshihikari Agrobacterium tumefaciens.
Supplementation of 50 mM acetosyringone to the medium during
coculivation was important to enhance the frequency to transient
transformation. The 4 week-old scutellum-derived calli were
excellent starting materials. Selection medium based on NB medium
supplement with 40 mg/l hygromycin and 400 mg/l cefotaxime were
an optimized medium for selection of transformed rice calli. The
percentage of transformation 70 was obtained. Recombinant calli and
regenerated rice plants were checked the expression of chitinase and
gus by PCR, northern blot gel, southern blot gel, and gus assay.
Chitinase and gus were expressed in all parts of recombinant rice.
The rice line expressing the KB3 chiitnase was more resistant to the
blast fungus Fusarium monoliforme than control line.
Abstract: Eukaryotic protein-coding genes are interrupted by spliceosomal introns, which are removed from the RNA transcripts before translation into a protein. The exon-intron structures of different eukaryotic species are quite different from each other, and the evolution of such structures raises many questions. We try to address some of these questions using statistical analysis of whole genomes. We go through all the protein-coding genes in a genome and study correlations between the net length of all the exons in a gene, the number of the exons, and the average length of an exon. We also take average values of these features for each chromosome and study correlations between those averages on the chromosomal level. Our data show universal features of exon-intron structures common to animals, plants, and protists (specifically, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Cryptococcus neoformans, Homo sapiens, Mus musculus, Oryza sativa, and Plasmodium falciparum). We have verified linear correlation between the number of exons in a gene and the length of a protein coded by the gene, while the protein length increases in proportion to the number of exons. On the other hand, the average length of an exon always decreases with the number of exons. Finally, chromosome clustering based on average chromosome properties and parameters of linear regression between the number of exons in a gene and the net length of those exons demonstrates that these average chromosome properties are genome-specific features.
Abstract: The experiment was conducted to evaluate
digestibility quantities of protein in Canola Meals (CMs) between
caecectomised and intact adult Rhode Island Red (RIR) cockerels
with using conventional addition method (CAM) for 7 d: a 4-d
adaptation and a 3-d experiment period on the basis of a completely
randomized design with 4 replicates. Results indicated that
caecectomy decreased (P
Abstract: The evaluation of non-conventional water resources
on seed germination and seedling growth performance at early
growth stages is still in progress especially in forage crops. This
study was designed to test the effect of four types of water qualities
(treated wastewater (TWW), industrial water (IW), grey water (GW),
and Distilled water (DW)) on germination and early seedling vigor of
Leucaena leucocephala. The results showed that the germination
was not significantly affected by the different water qualities. Seed
germination reached maximum after 17, 14, 14, and 21 days under
GW, IW, TWW, and DW treatments, respectively. The highest mean
of shoot length was scored under the GW treatment. And, the highest
mean of root length was scored under DW which was not significant
from GW treatment. The means of shoot fresh was the highest under
the TWW. The means of root fresh weight was not significantly
different from each other's under different treatments. The growth
performance was in progress with no mortality during 21 days of
growth. Thus, the best non-conventional water qualities alternatives
based on the cleanness, nutrients, and toxicity are the GW, TWW and
IW, respectively.
Abstract: The changes in quality properties and nutritional
components in two fermented mugworts (Artemisia capillaries
Thumberg, Artemisiaeasiaticae Nakai) were characterized followed
by the rapid pattern analysis of volatile flavor compounds by Electric
Nose based on SAW(Surface Acoustic Wave) sensor in GC system.
There were remarkable decreases in the pH and small changes in the
total soluble solids after fermentation. The L (lightness) and b
(yellowness) values in Hunter's color system were shown to be
decreased, whilst the a (redness) value was increased by fermentation.
The HPLC analysis demonstrated that total amino acids were
increased in quantity and the essential amino acids were contained
higher in A. asiaticaeNakai than in A. capillaries Thumberg. While
the total polyphenol contents were not affected by fermentation, the
total sugar contents were dramatically decreased. Scopoletinwere
highly abundant in A. capillarisThumberg, however, it was not
detected in A. asiaticaeNakai. Volatile flavor compounds by Electric
Nose showed that the intensity of several peaks were increased much
and seven additional flavor peaks were newly produced after
fermentation. The flavor differences of two mugworts were clearly
distinguished from the image patterns of VaporPrintTM which indicate
that the fermentation enables the two mugworts to have subtle flavor
differences.
Abstract: This study was carried out to evaluate concentration
of micro minerals (Zn, Fe, Mn, Cu and Se) of forages and their
distribution in fiber fraction (neutral detergent fiber/NDF and acid
detergent fiber/ADF) in South Sumatra during dry and rainy seasons.
Seven species of commonly forages namely Axonopus compressus,
Panicum maximum, Pennisetum purpuphoides, Leucaena
leucocephala, Centrocema pubescens, Calopogonium mucunoides
and Acacia mangium were collected at native pasture during rainy
and dry seasons. The results showed that micro minerals
concentration of forages and their distribution in fiber fraction varied
among species and season. In general, concentration of micro
minerals was slightly higher in rainy season compared to dry season
either in grass or legumes forages. In grass, concentration of Fe and
Mn were above the critical level, while 33.3 %, 100 % and 16.7 % of
evaluated grass were deficient in Zn, Cu and Se. Data on legume
forages show that 75 % of legumes were deficient in Zn and Mn, 62.5
% deficient in Cu and 50 % deficient in Se. There was no species of
legume deficient in Fe. Distribution of micro minerals in NDF and
ADF were also significantly affected by species and season and
depends on the kinds of element measured. Generally, micro minerals
were associated in fiber fractions much higher during dry season
compared to rainy season. Iron (Fe) and selenium (Se) in forages
were the highest elements associated in NDF and ADF, while the
lowest was found in Copper (Cu).