Abstract: MinC plays an important role in bacterial cell division
system by inhibiting FtsZ assembly. However, the molecular
mechanism of the action is poorly understood. E. coli MinC Nterminus
domain was purified and crystallized using 1.4 M sodium
citrate pH 6.5 as a precipitant. X-ray diffraction data was collected
and processed to 2.3 Å from a native crystal. The crystal belonged to
space group P212121, with the unit cell parameters a = 52.7, b = 54.0,
c = 64.7 Å. Assuming the presence of two molecules in the
asymmetric unit, the Matthews coefficient value is 1.94 Å3 Da-1,
which corresponds to a solvent content of 36.5%. The overall
structure of MinCN is observed as a dimer form through anti-parallel
ß-strand interaction.
Abstract: The inherent iterative nature of product design and development poses significant challenge to reduce the product design and development time (PD). In order to shorten the time to market, organizations have adopted concurrent development where multiple specialized tasks and design activities are carried out in parallel. Iterative nature of work coupled with the overlap of activities can result in unpredictable time to completion and significant rework. Many of the products have missed the time to market window due to unanticipated or rather unplanned iteration and rework. The iterative and often overlapped processes introduce greater amounts of ambiguity in design and development, where the traditional methods and tools of project management provide less value. In this context, identifying critical metrics to understand the iteration probability is an open research area where significant contribution can be made given that iteration has been the key driver of cost and schedule risk in PD projects. Two important questions that the proposed study attempts to address are: Can we predict and identify the number of iterations in a product development flow? Can we provide managerial insights for a better control over iteration? The proposal introduces the concept of decision points and using this concept intends to develop metrics that can provide managerial insights into iteration predictability. By characterizing the product development flow as a network of decision points, the proposed research intends to delve further into iteration probability and attempts to provide more clarity.
Abstract: The aim of the present study is to analyze the generation of osteoporotic vertebral bone induced by lack of calcium during growth period and analyze its effects for disc degeneration, based on biomechanical and histomorphometrical study. Mechanical and histomorphological characteristics of lumbar vertebral bones and discs of rats with calcium free diet (CFD) were detected and tracked by using high resolution in-vivo micro-computed tomography (in-vivo micro-CT), finite element (FE) and histological analysis. Twenty female Sprague-Dawley rats (6 weeks old, approximate weight 170g) were randomly divided into two groups (CFD group: 10, NOR group: 10). The CFD group was maintained on a refmed calcium-controlled semisynthetic diet without added calcium, to induce osteoporosis. All lumbar (L 1-L6) were scanned by using in vivo micro-CT with 35i.un resolution at 0, 4, 8 weeks to track the effects of CFD on the generation of osteoporosis. The fmdings of the present study indicated that calcium insufficiency was the main factor in the generation of osteoporosis and it induced lumbar vertebral disc degeneration. This study is a valuable experiment to firstly evaluate osteoporotic vertebral bone and disc degeneration induced by lack of calcium during growth period from a biomechanical and histomorphometrical point of view.
Abstract: Digital watermarking has become an important technique for copyright protection but its robustness against attacks remains a major problem. In this paper, we propose a normalizationbased robust image watermarking scheme. In the proposed scheme, original host image is first normalized to a standard form. Zernike transform is then applied to the normalized image to calculate Zernike moments. Dither modulation is adopted to quantize the magnitudes of Zernike moments according to the watermark bit stream. The watermark extracting method is a blind method. Security analysis and false alarm analysis are then performed. The quality degradation of watermarked image caused by the embedded watermark is visually transparent. Experimental results show that the proposed scheme has very high robustness against various image processing operations and geometric attacks.
Abstract: Star graphs are Cayley graphs of symmetric groups of permutations, with transpositions as the generating sets. A star graph is a preferred interconnection network topology to a hypercube for its ability to connect a greater number of nodes with lower degree. However, an attractive property of the hypercube is that it has a Hamiltonian decomposition, i.e. its edges can be partitioned into disjoint Hamiltonian cycles, and therefore a simple routing can be found in the case of an edge failure. The existence of Hamiltonian cycles in Cayley graphs has been known for some time. So far, there are no published results on the much stronger condition of the existence of Hamiltonian decompositions. In this paper, we give a construction of a Hamiltonian decomposition of the star graph 5-star of degree 4, by defining an automorphism for 5-star and a Hamiltonian cycle which is edge-disjoint with its image under the automorphism.
Abstract: Several works regarding facial recognition have dealt with methods which identify isolated characteristics of the face or with templates which encompass several regions of it. In this paper a new technique which approaches the problem holistically dispensing with the need to identify geometrical characteristics or regions of the face is introduced. The characterization of a face is achieved by randomly sampling selected attributes of the pixels of its image. From this information we construct a set of data, which correspond to the values of low frequencies, gradient, entropy and another several characteristics of pixel of the image. Generating a set of “p" variables. The multivariate data set with different polynomials minimizing the data fitness error in the minimax sense (L∞ - Norm) is approximated. With the use of a Genetic Algorithm (GA) it is able to circumvent the problem of dimensionality inherent to higher degree polynomial approximations. The GA yields the degree and values of a set of coefficients of the polynomials approximating of the image of a face. By finding a family of characteristic polynomials from several variables (pixel characteristics) for each face (say Fi ) in the data base through a resampling process the system in use, is trained. A face (say F ) is recognized by finding its characteristic polynomials and using an AdaBoost Classifier from F -s polynomials to each of the Fi -s polynomials. The winner is the polynomial family closer to F -s corresponding to target face in data base.
Abstract: Numerical study of a plane jet occurring in a vertical
heated channel is carried out. The aim is to explore the influence of
the forced flow, issued from a flat nozzle located in the entry section
of a channel, on the up-going fluid along the channel walls. The
Reynolds number based on the nozzle width and the jet velocity
ranges between 3 103 and 2.104; whereas, the Grashof number based
on the channel length and the wall temperature difference is 2.57
1010. Computations are established for a symmetrically heated
channel and various nozzle positions. The system of governing
equations is solved with a finite volumes method. The obtained
results show that the jet-wall interactions activate the heat transfer,
the position variation modifies the heat transfer especially for low
Reynolds numbers: the heat transfer is enhanced for the adjacent
wall; however it is decreased for the opposite one. The numerical
velocity and temperature fields are post-processed to compute the
quantities of engineering interest such as the induced mass flow rate,
and the Nusselt number along the plates.
Abstract: In the context of computer numerical control (CNC) and computer aided manufacturing (CAM), the capabilities of programming languages such as symbolic and intuitive programming, program portability and geometrical portfolio have special importance. They allow to save time and to avoid errors during part programming and permit code re-usage. Our updated literature review indicates that the current state of art presents voids in parametric programming, program portability and programming flexibility. In response to this situation, this article presents a compiler implementation for EGCL (Extended G-code Language), a new, enriched CNC programming language which allows the use of descriptive variable names, geometrical functions and flow-control statements (if-then-else, while). Our compiler produces low-level generic, elementary ISO-compliant Gcode, thus allowing for flexibility in the choice of the executing CNC machine and in portability. Our results show that readable variable names and flow control statements allow a simplified and intuitive part programming and permit re-usage of the programs. Future work includes allowing the programmer to define own functions in terms of EGCL, in contrast to the current status of having them as library built-in functions.
Abstract: A high energy dual-wavelength extracavity KTA
optical parametric oscillator (OPO) with excellent stability and beam
quality, which is pumped by a Q-switched single-longitudinal-mode
Nd:YAG laser, has been demonstrated based on a type II noncritical
phase matching (NCPM) KTA crystal. The maximum pulse energy of
10.2 mJ with the output stability of better than 4.1% rms at 3.467 μm is
obtained at the repetition rate of 10 Hz and pulse width of 2 ns, and the
11.9 mJ of 1.535 μm radiation is obtained simultaneously. This
extracavity NCPM KTA OPO is very useful when high energy, high
beam quality and smooth time domain are needed.
Abstract: Effective evaluation of software development effort is an important aspect of successful project management. Based on a large database with 4106 projects ever developed, this study statistically examines the factors that influence development effort. The factors found to be significant for effort are project size, average number of developers that worked on the project, type of development, development language, development platform, and the use of rapid application development. Among these factors, project size is the most critical cost driver. Unsurprisingly, this study found that the use of CASE tools does not necessarily reduce development effort, which adds support to the claim that the use of tools is subtle. As many of the current estimation models are rarely or unsuccessfully used, this study proposes a parsimonious parametric model for the prediction of effort which is both simple and more accurate than previous models.
Abstract: Software reliability, defined as the probability of a
software system or application functioning without failure or errors
over a defined period of time, has been an important area of research
for over three decades. Several research efforts aimed at developing
models to improve reliability are currently underway. One of the
most popular approaches to software reliability adopted by some of
these research efforts involves the use of operational profiles to
predict how software applications will be used. Operational profiles
are a quantification of usage patterns for a software application. The
research presented in this paper investigates an innovative multiagent
framework for automatic creation and management of
operational profiles for generic distributed systems after their release
into the market. The architecture of the proposed Operational Profile
MAS (Multi-Agent System) is presented along with detailed
descriptions of the various models arrived at following the analysis
and design phases of the proposed system. The operational profile in
this paper is extended to comprise seven different profiles. Further,
the criticality of operations is defined using a new composed metrics
in order to organize the testing process as well as to decrease the time
and cost involved in this process. A prototype implementation of the
proposed MAS is included as proof-of-concept and the framework is
considered as a step towards making distributed systems intelligent
and self-managing.
Abstract: The use of electronic sensors in the electronics
industry has become increasingly popular over the past few years,
and it has become a high competition product. The frequency
adjustment process is regarded as one of the most important process
in the electronic sensor manufacturing process. Due to inaccuracies
in the frequency adjustment process, up to 80% waste can be caused
due to rework processes; therefore, this study aims to provide a
preliminary understanding of the role of parameters used in the
frequency adjustment process, and also make suggestions in order to
further improve performance. Four parameters are considered in this
study: air pressure, dispensing time, vacuum force, and the distance
between the needle tip and the product. A full factorial design for
experiment 2k was considered to determine those parameters that
significantly affect the accuracy of the frequency adjustment process,
where a deviation in the frequency after adjustment and the target
frequency is expected to be 0 kHz. The experiment was conducted on
two levels, using two replications and with five center-points added.
In total, 37 experiments were carried out. The results reveal that air
pressure and dispensing time significantly affect the frequency
adjustment process. The mathematical relationship between these
two parameters was formulated, and the optimal parameters for air
pressure and dispensing time were found to be 0.45 MPa and 458 ms,
respectively. The optimal parameters were examined by carrying out
a confirmation experiment in which an average deviation of 0.082
kHz was achieved.
Abstract: Prior to the use of detectors, characteristics
comparison study was performed and baseline established. In patient
specific QA, the portal dosimetry mean values of area gamma,
average gamma and maximum gamma were 1.02, 0.31 and 1.31 with
standard deviation of 0.33, 0.03 and 0.14 for IMRT and the
corresponding values were 1.58, 0.48 and 1.73 with standard
deviation of 0.31, 0.06 and 0.66 for VMAT. With ImatriXX 2-D
array system, on an average 99.35% of the pixels passed the criteria
of 3%-3 mm gamma with standard deviation of 0.24 for dynamic
IMRT. For VMAT, the average value was 98.16% with a standard
deviation of 0.86. The results showed that both the systems can be
used in patient specific QA measurements for IMRT and VMAT.
The values obtained with the portal dosimetry system were found to
be relatively more consistent compared to those obtained with
ImatriXX 2-D array system.
Abstract: Aroma forming volatiles are important components of
fermented beverages. The aim of current research is to evaluate the
volatile compounds and phenolic compounds of commercial ciders.
Volatile aroma compounds and TPC of seven commercial ciders
were determined. Extraction of aroma compounds was performed
using solid phase microextraction (DVB/Car/PDMS fibre). Analysis
of volatile aroma compounds was made using a Perkin Elmer Clarus
500 GC/MS. Total phenol content (TPC) was determined according
to the Folin-Ciocalteu spectrophotometric method and results were
expressed as gallic acid equivalents. The highest volatile compounds
were in apple ciders with pear flavor. The highest TPC and lower
content of volatile compounds were detected in French ciders.
Abstract: Functional Magnetic Resonance Imaging(fMRI) is a
noninvasive imaging technique that measures the hemodynamic
response related to neural activity in the human brain. Event-related
functional magnetic resonance imaging (efMRI) is a form of
functional Magnetic Resonance Imaging (fMRI) in which a series of
fMRI images are time-locked to a stimulus presentation and averaged
together over many trials. Again an event related potential (ERP) is a
measured brain response that is directly the result of a thought or
perception. Here the neuronal response of human visual cortex in
normal healthy patients have been studied. The patients were asked
to perform a visual three choice reaction task; from the relative
response of each patient corresponding neuronal activity in visual
cortex was imaged. The average number of neurons in the adult
human primary visual cortex, in each hemisphere has been estimated
at around 140 million. Statistical analysis of this experiment was
done with SPM5(Statistical Parametric Mapping version 5) software.
The result shows a robust design of imaging the neuronal activity of
human visual cortex.
Abstract: Application of projective geometry to the theory of two-ports and cascade circuits with a load change is considered. The equations linking the input and output of a two-port are interpreted as projective transformations which have the invariant as a cross-ratio of four points. This invariant has place for all regime parameters in all parts of a cascade circuit. This approach allows justifying the definition of a regime and its change, to calculate a circuit without explicitly finding the aparameters, to transmit accurately an analogue signal through the unstable two-port.
Abstract: In this paper we introduce an efficient solution
method for the Eigen-decomposition of bisymmetric and per
symmetric matrices of symmetric structures. Here we decompose
adjacency and Laplacian matrices of symmetric structures to submatrices
with low dimension for fast and easy calculation of
eigenvalues and eigenvectors. Examples are included to show the
efficiency of the method.
Abstract: Lake Nasser is one of the largest reservoirs in the
world. Over 120 million metric tons of sediments are deposited in its
dead storage zone every year. The main objective of the present work
was to determine the physical and chemical characteristics of Lake
Nasser sediments. The sample had a relatively low surface area of 2.9
m2/g which increased more than 3-fold upon chemical activation. The
main chemical elements of the raw sediments were C, O and Si with
some traces of Al, Fe and Ca. The organic functional groups for the
tested sample included O-H, C=C, C-H and C-O, with indications of
Si-O and other metal-C and/or metal-O bonds normally associated
with clayey materials. Potentiometric titration of the sample in
different ionic strength backgrounds revealed an alkaline material with
very strong positive surface charge at pH values just a little less than
the pH of zero charge which is ~9. Surface interactions of the
sediments with the background electrolyte were significant. An
advanced surface complexation model was able to capture these
effects, employing a single-site approach to represent protolysis
reactions in aqueous solution, and to determine the significant surface
species in the pH range of environmental interest.
Abstract: The aim of this work is to determine the supersonic
nozzle profiles used in propulsion, for the launchers or embarked
with the satellites. This design has as a role firstly, to give a
important propulsion, i.e. with uniform and parallel flow at exit,
secondly to find a short length profiles without modification of the
flow in the nozzle. The first elaborate program is used to determine
the profile of divergent by using the characteristics method for an
axisymmetric flow. The second program is conceived by using the
finite volume method to determine and test the profile found
connected to a convergent.
Abstract: This paper presents a model for the evaluation of
energy performance and aerodynamic forces acting on a small
straight-bladed Darrieus-type vertical axis wind turbine depending on
blade geometrical section. It consists of an analytical code coupled to
a solid modeling software, capable of generating the desired blade
geometry based on the desired blade design geometric parameters.
Such module is then linked to a finite volume commercial CFD code
for the calculation of rotor performance by integration of the
aerodynamic forces along the perimeter of each blade for a full period
of revolution.After describing and validating the computational
model with experimental data, the results of numerical simulations
are proposed on the bases of two candidate airfoil sections, that is a
classical symmetrical NACA 0021 blade profile and the recently
developed DU 06-W-200 non-symmetric and laminar blade
profile.Through a full CFD campaign of analysis, the effects of blade
geometrical section on angle of attack are first investigated and then
the overall rotor torque and power are analyzed as a function of blade
azimuthal position, achieving a numerical quantification of the
influence of airfoil geometry on overall rotor performance.