Abstract: The PAX6, a transcription factor, is essential for the morphogenesis of the eyes, brain, pituitary and pancreatic islets. In rodents, the loss of Pax6 function leads to central nervous system defects, anophthalmia, and nasal hypoplasia. The haplo-insufficiency of Pax6 causes microphthalmia, aggression and other behavioral abnormalities. It is also required in brain patterning and neuronal plasticity. In human, heterozygous mutation of Pax6 causes loss of iris [aniridia], mental retardation and glucose intolerance. The 3- deletion in Pax6 leads to autism and aniridia. The phenotypes are variable in peneterance and expressivity. However, mechanism of function and interaction of PAX6 with other proteins during development and associated disease are not clear. It is intended to explore interactors of PAX6 to elucidated biology of PAX6 function in the tissues where it is expressed and also in the central regulatory pathway. This report describes In-silico approaches to explore interacting proteins of PAX6. The models show several possible proteins interacting with PAX6 like MITF, SIX3, SOX2, SOX3, IPO13, TRIM, and OGT. Since the Pax6 is a critical transcriptional regulator and master control gene of eye and brain development it might be interacting with other protein involved in morphogenesis [TGIF, TGF, Ras etc]. It is also presumed that matricelluar proteins [SPARC, thrombospondin-1 and osteonectin etc] are likely to interact during transport and processing of PAX6 and are somewhere its cascade. The proteins involved in cell survival and cell proliferation can also not be ignored.
Abstract: Gas turbine air inlet cooling is a useful method for
increasing output for regions where significant power demand and
highest electricity prices occur during the warm months. Inlet air
cooling increases the power output by taking advantage of the gas
turbine-s feature of higher mass flow rate when the compressor inlet
temperature decreases. Different methods are available for reducing
gas turbine inlet temperature. There are two basic systems currently
available for inlet cooling. The first and most cost-effective system is
evaporative cooling. Evaporative coolers make use of the evaporation
of water to reduce the gas turbine-s inlet air temperature. The second
system employs various ways to chill the inlet air. In this method, the
cooling medium flows through a heat exchanger located in the inlet
duct to remove heat from the inlet air. However, the evaporative
cooling is limited by wet-bulb temperature while the chilling can cool
the inlet air to temperatures that are lower than the wet bulb
temperature. In the present work, a thermodynamic model of a gas
turbine is built to calculate heat rate, power output and thermal
efficiency at different inlet air temperature conditions. Computational
results are compared with ISO conditions herein called "base-case".
Therefore, the two cooling methods are implemented and solved for
different inlet conditions (inlet temperature and relative humidity).
Evaporative cooler and absorption chiller systems results show that
when the ambient temperature is extremely high with low relative
humidity (requiring a large temperature reduction) the chiller is the
more suitable cooling solution. The net increment in the power output
as a function of the temperature decrease for each cooling method is
also obtained.
Abstract: In recent years, tuned mass damper (TMD) control systems for civil engineering structures have attracted considerable attention. This paper emphasizes on the application of particle swarm application (PSO) to design and optimize the parameters of the TMD control scheme for achieving the best results in the reduction of the building response under earthquake excitations. The Integral of the Time multiplied Absolute value of the Error (ITAE) based on relative displacement of all floors in the building is taken as a performance index of the optimization criterion. The problem of robustly TMD controller design is formatted as an optimization problem based on the ITAE performance index to be solved using the PSO technique which has a story ability to find the most optimistic results. An 11- story realistic building, located in the city of Rasht, Iran is considered as a test system to demonstrate effectiveness of the proposed method. The results analysis through the time-domain simulation and some performance indices reveals that the designed PSO based TMD controller has an excellent capability in reduction of the seismically excited example building.
Abstract: Palm shell obtained from coastal part of southern
India was studied for the removal for the adsorption of Hg (II) ions.
Batch adsorption experiments were carried out as a function of pH,
concentration of Hg (II) ions, time, temperature and adsorbent dose.
Maximum removal was seen in the range pH 4.0- pH 7.0. The palm
shell powder used as adsorbent was characterized for its surface area,
SEM, PXRD, FTIR, ion exchange capacity, moisture content, and
bulk density, soluble content in water and acid and pH. The
experimental results were analyzed using Langmuir I, II, III, IV and
Freundlich adsorption isotherms. The batch sorption kinetics was
studied for the first order reversible reaction, pseudo first order;
pseudo second order reaction and the intra-particle diffusion reaction.
The biomass was successfully used for removal Hg (II) from
synthetic and industrial effluents and the technique appears
industrially applicable and viable.
Abstract: Combinatorial optimization problems arise in many scientific and practical applications. Therefore many researchers try to find or improve different methods to solve these problems with high quality results and in less time. Genetic Algorithm (GA) and Simulated Annealing (SA) have been used to solve optimization problems. Both GA and SA search a solution space throughout a sequence of iterative states. However, there are also significant differences between them. The GA mechanism is parallel on a set of solutions and exchanges information using the crossover operation. SA works on a single solution at a time. In this work SA and GA are combined using new technique in order to overcome the disadvantages' of both algorithms.
Abstract: In this study, a new root-finding method for solving nonlinear equations is proposed. This method requires two starting values that do not necessarily bracketing a root. However, when the starting values are selected to be close to a root, the proposed method converges to the root quicker than the secant method. Another advantage over all iterative methods is that; the proposed method usually converges to two distinct roots when the given function has more than one root, that is, the odd iterations of this new technique converge to a root and the even iterations converge to another root. Some numerical examples, including a sine-polynomial equation, are solved by using the proposed method and compared with results obtained by the secant method; perfect agreements are found.
Abstract: In this paper, we investigate two parallel alternating methods for solving the system of linear equations Ax = b and give convergence theorems for the parallel alternating methods when the coefficient matrix is a nonsingular H-matrix. Furthermore, we give one example to show our results.
Abstract: In this paper we propose a mixture of two different
distributions such as Exponential-Gamma, Exponential-Weibull and
Gamma-Weibull to model heterogeneous survival data. Various
properties of the proposed mixture of two different distributions are
discussed. Maximum likelihood estimations of the parameters are
obtained by using the EM algorithm. Illustrative example based on
real data are also given.
Abstract: A hybrid feature based adaptive particle filter algorithm is presented for object tracking in real scenarios with static camera.
The hybrid feature is combined by two effective features: the Grayscale Arranging Pairs (GAP) feature and the color histogram feature. The GAP feature has high discriminative ability even under conditions of severe illumination variation and dynamic background
elements, while the color histogram feature has high reliability to identify the detected objects. The combination of two features covers the shortage of single feature. Furthermore, we adopt an updating
target model so that some external problems such as visual angles can be overcame well. An automatic initialization algorithm is introduced which provides precise initial positions of objects. The experimental
results show the good performance of the proposed method.
Abstract: While the form of crises may change, their essence
remains the same (such as a cycle of abundant liquidity, rapid credit
growth, and a low-inflation environment followed by an asset-price
bubble). The current market turbulence began in mid-2000s when the
US economy shifted to imbalanced both internal and external
macroeconomic positions. We see two key causes of these problems
– loose US monetary policy in early 2000s and US government
guarantees issued on the securities by government-sponsored
enterprises what was further fueled by financial innovations such as
structured credit products. We have discovered both negative and
positive lessons deriving from this crisis and divided the negative
lessons into three groups: financial products and valuation, processes
and business models, and strategic issues. Moreover, we address key
risk management lessons and exit strategies derived from the current
crisis and recommend policies that should help diminish the negative
impact of future potential crises.
Abstract: In this paper we proposed a method for finding video
frames representing one sign in the finger alphabet. The method is
based on determining hands location, segmentation and the use of
standard video quality evaluation metrics. Metric calculation is
performed only in regions of interest. Sliding mechanism for finding
local extrema and adaptive threshold based on local averaging is used
for key frames selection. The success rate is evaluated by recall,
precision and F1 measure. The method effectiveness is compared
with metrics applied to all frames. Proposed method is fast, effective
and relatively easy to realize by simple input video preprocessing
and subsequent use of tools designed for video quality measuring.
Abstract: This paper presents a novel algorithm of stereo
correspondence with rank transform. In this algorithm we used the
genetic algorithm to achieve the accurate disparity map. Genetic
algorithms are efficient search methods based on principles of
population genetic, i.e. mating, chromosome crossover, gene
mutation, and natural selection. Finally morphology is employed to
remove the errors and discontinuities.
Abstract: The literature reports a large number of approaches for
measuring the similarity between protein sequences. Most of these
approaches estimate this similarity using alignment-based techniques
that do not necessarily yield biologically plausible results, for two
reasons.
First, for the case of non-alignable (i.e., not yet definitively aligned
and biologically approved) sequences such as multi-domain, circular
permutation and tandem repeat protein sequences, alignment-based
approaches do not succeed in producing biologically plausible results.
This is due to the nature of the alignment, which is based on the
matching of subsequences in equivalent positions, while non-alignable
proteins often have similar and conserved domains in non-equivalent
positions.
Second, the alignment-based approaches lead to similarity measures
that depend heavily on the parameters set by the user for the alignment
(e.g., gap penalties and substitution matrices). For easily alignable
protein sequences, it's possible to supply a suitable combination of
input parameters that allows such an approach to yield biologically
plausible results. However, for difficult-to-align protein sequences,
supplying different combinations of input parameters yields different
results. Such variable results create ambiguities and complicate the
similarity measurement task.
To overcome these drawbacks, this paper describes a novel and
effective approach for measuring the similarity between protein
sequences, called SAF for Substitution and Alignment Free. Without
resorting either to the alignment of protein sequences or to substitution
relations between amino acids, SAF is able to efficiently detect the
significant subsequences that best represent the intrinsic properties of
protein sequences, those underlying the chronological dependencies of
structural features and biochemical activities of protein sequences.
Moreover, by using a new efficient subsequence matching scheme,
SAF more efficiently handles protein sequences that contain similar
structural features with significant meaning in chronologically
non-equivalent positions. To show the effectiveness of SAF, extensive
experiments were performed on protein datasets from different
databases, and the results were compared with those obtained by
several mainstream algorithms.
Abstract: E-travel is travel agency-s companies employing internet and website as e-commerce context. This study presents numerous initial key factors of electronic travel model based on small travel agencies perspectives. Browsing previous studies related to website travel activities are conducted. Five small travel agencies in Indonesia has been deeply interviewed in case studies. The finding of this research is identifying numerous characteristics and dimension factors and travel website operations including ownermanager roles, business experiences, characteristically business, and technological aspects. This study is the preliminary research related to travel website adoption in Indonesia. The further study would be conducted in questionnaires of the quantitative research in Indonesia contexts as a developing country.
Abstract: This work proposes a novel market-based air traffic flow control model considering competitive airlines in air traffic network. In the flow model, an agent based framework for resources (link/time pair) pricing is described. Resource agent and auctioneer for groups of resources are also introduced to simulate the flow management in Air Traffic Control (ATC). Secondly, the distributed group pricing algorithm is introduced, which efficiently reflect the competitive nature of the airline industry. Resources in the system are grouped according to the degree of interaction, and each auctioneer adjust s the price of one group of resources respectively until the excess demand of resources becomes zero when the demand and supply of resources of the system changes. Numerical simulation results show the feasibility of solving the air traffic flow control problem using market mechanism and pricing algorithms on the air traffic network.
Abstract: We study in this paper the effect of the scene
changing on image sequences coding system using Embedded
Zerotree Wavelet (EZW). The scene changing considered here is the
full motion which may occurs. A special image sequence is generated
where the scene changing occurs randomly. Two scenarios are
considered: In the first scenario, the system must provide the
reconstruction quality as best as possible by the management of the
bit rate (BR) while the scene changing occurs. In the second scenario,
the system must keep the bit rate as constant as possible by the
management of the reconstruction quality. The first scenario may be
motivated by the availability of a large band pass transmission
channel where an increase of the bit rate may be possible to keep the
reconstruction quality up to a given threshold. The second scenario
may be concerned by the narrow band pass transmission channel
where an increase of the bit rate is not possible. In this last case,
applications for which the reconstruction quality is not a constraint
may be considered. The simulations are performed with five scales
wavelet decomposition using the 9/7-tap filter bank biorthogonal
wavelet. The entropy coding is performed using a specific defined
binary code book and EZW algorithm. Experimental results are
presented and compared to LEAD H263 EVAL. It is shown that if
the reconstruction quality is the constraint, the system increases the
bit rate to obtain the required quality. In the case where the bit rate
must be constant, the system is unable to provide the required quality
if the scene change occurs; however, the system is able to improve
the quality while the scene changing disappears.
Abstract: MATCH project [1] entitle the development of an
automatic diagnosis system that aims to support treatment of colon
cancer diseases by discovering mutations that occurs to tumour
suppressor genes (TSGs) and contributes to the development of
cancerous tumours. The constitution of the system is based on a)
colon cancer clinical data and b) biological information that will be
derived by data mining techniques from genomic and proteomic
sources The core mining module will consist of the popular, well
tested hybrid feature extraction methods, and new combined
algorithms, designed especially for the project. Elements of rough
sets, evolutionary computing, cluster analysis, self-organization maps
and association rules will be used to discover the annotations
between genes, and their influence on tumours [2]-[11].
The methods used to process the data have to address their high
complexity, potential inconsistency and problems of dealing with the
missing values. They must integrate all the useful information
necessary to solve the expert's question. For this purpose, the system
has to learn from data, or be able to interactively specify by a domain
specialist, the part of the knowledge structure it needs to answer a
given query. The program should also take into account the
importance/rank of the particular parts of data it analyses, and adjusts
the used algorithms accordingly.
Abstract: The major part of light weight timber constructions
consists of insulation. Mineral wool is the most commonly used
insulation due to its cost efficiency and easy handling. The fiber
orientation and porosity of this insulation material enables flowthrough.
The air flow resistance is low. If leakage occurs in the
insulated bay section, the convective flow may cause energy losses
and infiltration of the exterior wall with moisture and particles. In
particular the infiltrated moisture may lead to thermal bridges and
growth of health endangering mould and mildew. In order to prevent
this problem, different numerical calculation models have been
developed. All models developed so far have a potential for
completion. The implementation of the flow-through properties of
mineral wool insulation may help to improve the existing models.
Assuming that the real pressure difference between interior and
exterior surface is larger than the prescribed pressure difference in the
standard test procedure for mineral wool ISO 9053 / EN 29053,
measurements were performed using the measurement setup for
research on convective moisture transfer “MSRCMT".
These measurements show, that structural inhomogeneities of
mineral wool effect the permeability only at higher pressure
differences, as applied in MSRCMT. Additional microscopic
investigations show, that the location of a leak within the
construction has a crucial influence on the air flow-through and the
infiltration rate. The results clearly indicate that the empirical values
for the acoustic resistance of mineral wool should not be used for the
calculation of convective transfer mechanisms.
Abstract: In today's day and age, one of the important topics in
information security is authentication. There are several alternatives
to text-based authentication of which includes Graphical Password
(GP) or Graphical User Authentication (GUA). These methods stems
from the fact that humans recognized and remembers images better
than alphanumerical text characters. This paper will focus on the
security aspect of GP algorithms and what most researchers have
been working on trying to define these security features and
attributes. The goal of this study is to develop a fuzzy decision model
that allows automatic selection of available GP algorithms by taking
into considerations the subjective judgments of the decision makers
who are more than 50 postgraduate students of computer science. The
approach that is being proposed is based on the Fuzzy Analytic
Hierarchy Process (FAHP) which determines the criteria weight as a
linear formula.
Abstract: Literature reveals that many investors rely on technical trading rules when making investment decisions. If stock markets are efficient, one cannot achieve superior results by using these trading rules. However, if market inefficiencies are present, profitable opportunities may arise. The aim of this study is to investigate the effectiveness of technical trading rules in 34 emerging stock markets. The performance of the rules is evaluated by utilizing White-s Reality Check and the Superior Predictive Ability test of Hansen, along with an adjustment for transaction costs. These tests are able to evaluate whether the best model performs better than a buy-and-hold benchmark. Further, they provide an answer to data snooping problems, which is essential to obtain unbiased outcomes. Based on our results we conclude that technical trading rules are not able to outperform a naïve buy-and-hold benchmark on a consistent basis. However, we do find significant trading rule profits in 4 of the 34 investigated markets. We also present evidence that technical analysis is more profitable in crisis situations. Nevertheless, this result is relatively weak.