Abstract: The PAX6, a transcription factor, is essential for the morphogenesis of the eyes, brain, pituitary and pancreatic islets. In rodents, the loss of Pax6 function leads to central nervous system defects, anophthalmia, and nasal hypoplasia. The haplo-insufficiency of Pax6 causes microphthalmia, aggression and other behavioral abnormalities. It is also required in brain patterning and neuronal plasticity. In human, heterozygous mutation of Pax6 causes loss of iris [aniridia], mental retardation and glucose intolerance. The 3- deletion in Pax6 leads to autism and aniridia. The phenotypes are variable in peneterance and expressivity. However, mechanism of function and interaction of PAX6 with other proteins during development and associated disease are not clear. It is intended to explore interactors of PAX6 to elucidated biology of PAX6 function in the tissues where it is expressed and also in the central regulatory pathway. This report describes In-silico approaches to explore interacting proteins of PAX6. The models show several possible proteins interacting with PAX6 like MITF, SIX3, SOX2, SOX3, IPO13, TRIM, and OGT. Since the Pax6 is a critical transcriptional regulator and master control gene of eye and brain development it might be interacting with other protein involved in morphogenesis [TGIF, TGF, Ras etc]. It is also presumed that matricelluar proteins [SPARC, thrombospondin-1 and osteonectin etc] are likely to interact during transport and processing of PAX6 and are somewhere its cascade. The proteins involved in cell survival and cell proliferation can also not be ignored.
Abstract: We have developed a database for membrane protein functions, which has more than 3000 experimental data on functionally important amino acid residues in membrane proteins along with sequence, structure and literature information. Further, we have proposed different methods for identifying membrane proteins based on their functions: (i) discrimination of membrane transport proteins from other globular and membrane proteins and classifying them into channels/pores, electrochemical and active transporters, and (ii) β-signal for the insertion of mitochondrial β-barrel outer membrane proteins and potential targets. Our method showed an accuracy of 82% in discriminating transport proteins and 68% to classify them into three different transporters. In addition, we have identified a motif for targeting β-signal and potential candidates for mitochondrial β-barrel membrane proteins. Our methods can be used as effective tools for genome-wide annotations.
Abstract: Power loss reduction is one of the main targets in power industry and so in this paper, the problem of finding the optimal configuration of a radial distribution system for loss reduction is considered. Optimal reconfiguration involves the selection of the best set of branches to be opened ,one each from each loop, for reducing resistive line losses , and reliving overloads on feeders by shifting the load to adjacent feeders. However ,since there are many candidate switching combinations in the system ,the feeder reconfiguration is a complicated problem. In this paper a new approach is proposed based on a simple optimum loss calculation by determining optimal trees of the given network. From graph theory a distribution network can be represented with a graph that consists a set of nodes and branches. In fact this problem can be viewed as a problem of determining an optimal tree of the graph which simultaneously ensure radial structure of each candidate topology .In this method the refined genetic algorithm is also set up and some improvements of algorithm are made on chromosome coding. In this paper an implementation of the algorithm presented by [7] is applied by modifying in load flow program and a comparison of this method with the proposed method is employed. In [7] an algorithm is proposed that the choice of the switches to be opened is based on simple heuristic rules. This algorithm reduce the number of load flow runs and also reduce the switching combinations to a fewer number and gives the optimum solution. To demonstrate the validity of these methods computer simulations with PSAT and MATLAB programs are carried out on 33-bus test system. The results show that the performance of the proposed method is better than [7] method and also other methods.
Abstract: Levan, an exopolysaccharide, was produced by
Microbacterium laevaniformans and its yield was characterized as a
function of concentrations of date syrup, sucrose and the fermentation
time. The optimum condition for levan production from sucrose was
at concentration of 20% sucrose for 48 h and for date syrup was 25%
for 48 h. The results show that an increase in fermentation time
caused a decrease in the levan production at all concentrations of date
syrup tested. Under these conditions after 48 h in sucrose medium,
levan production reached 48.9 g/L and for date syrup reached 10.48
g/L . The effect of pH on the yield of the purified levan was examined
and the optimum pH for levan production was determined to be 6.0.
Levan was composed mainly of fructose residues when analyzed by
TLC and FT-IR spectroscopy. Date syrup is a cheap substrate widely
available in Iran and has potential for levan production. The thermal
stability of levan was assessed by Thermo Gravimetric Analysis
(TGA) that revealed the onset of decomposition near to 49°C for the
levan produced from sucrose and 51°C for the levan from date syrup.
DSC results showed a single Tg at 98°C for levan produced from
sucrose and 206 °C for levan from date syrup.
Abstract: IETF defines mobility support in IPv6, i.e. MIPv6, to
allow nodes to remain reachable while moving around in the IPv6
internet. When a node moves and visits a foreign network, it is still
reachable through the indirect packet forwarding from its home
network. This triangular routing feature provides node mobility but
increases the communication latency between nodes. This deficiency
can be overcome by using a Binding Update (BU) scheme, which let
nodes keep up-to-date IP addresses and communicate with each other
through direct IP routing. To further protect the security of BU, a
Return Routability (RR) procedure was developed. However, it has
been found that RR procedure is vulnerable to many attacks. In this
paper, we will propose a lightweight RR procedure based on
geometric computing. In consideration of the inherent limitation of
computing resources in mobile node, the proposed scheme is
developed to minimize the cost of computations and to eliminate the
overhead of state maintenance during binding updates. Compared with
other CGA-based BU schemes, our scheme is more efficient and
doesn-t need nonce tables in nodes.
Abstract: Nowadays, where most of the leading economies are
service oriented and e-business is being widely used for their
management, supply chain management has become one of the most
studied and practiced fields. Quality has an important role on today-s
business processes, so it is important to understand the impact of IT
service quality on the performance of supply chains. This paper will
start by analyzing the Supply Chain Operations Reference (SCOR)
model and each of its five activities: Plan, Source, Make, Delivery,
and Return. This article proposes a framework for analyzing Effect of
IT Service Quality on Supply Chain Performance. Using the
proposed framework, hypotheses are framed for the direct effect of IT
service quality on Supply Chain Performance and its indirect effect
through effective Supply Chain Management. The framework will be
validated empirically based on the surveys of executives of various
organizations and statistical analyses of the data collected.
Abstract: In this paper, we investigate the study of techniques
for scheduling users for resource allocation in the case of multiple
input and multiple output (MIMO) packet transmission systems. In
these systems, transmit antennas are assigned to one user or
dynamically to different users using spatial multiplexing. The
allocation of all transmit antennas to one user cannot take full
advantages of multi-user diversity. Therefore, we developed the case
when resources are allocated dynamically. At each time slot users
have to feed back their channel information on an uplink feedback
channel. Channel information considered available in the schedulers
is the zero forcing (ZF) post detection signal to interference plus
noise ratio. Our analysis study concerns the round robin and the
opportunistic schemes.
In this paper, we present an overview and a complete capacity
analysis of these schemes. The main results in our study are to give
an analytical form of system capacity using the ZF receiver at the
user terminal. Simulations have been carried out to validate all
proposed analytical solutions and to compare the performance of
these schemes.
Abstract: In this paper a three dimensional thermal model of
high breaking capacity fuse with unequal fuse links is proposed for
both steady-state or transient conditions. The influence of ambient
temperature and electric current on the temperature distribution
inside the fuse, has been investigated. A thermal analysis of the
unbalanced distribution of the electric current through the fuse
elements and their influence on fuse link temperature rise, has been
performed. To validate the three dimensional thermal model, some
experimental tests have been done. There is a good correlation
between experimental and simulation results.
Abstract: This paper demonstrates an effort of a serviceoriented
engineering department in improving the sharing and
transfer of knowledge. Although the department consist of only six
employees, but it provides services in various chemical application in
an oil and gas business. The services provided span across Asia
Pacific region mainly Indonesia, Myanmar, Vietnam, Brunei,
Thailand and Singapore. Currently there are no effective tools or
integrated systems that support the sharing or transfer and
maintenance of knowledge so the department has considered
preserving this valuable knowledge by developing a Knowledge
Management System (KMS). This paper presents the development of
a KMS to support the sharing of knowledge in a service-oriented
engineering department of an oil and gas company. The embedded
features in the KMS like blog and forum will encourage iterative
process of knowledge sharing among the employees in the
department. The information and knowledge being shared, discussed
and communicated will be then achieved for future re-use. The re-use
of the knowledge allows the department to reduce redundant efforts
in providing consistent, up-to-date and cost effective of the best
solution to the its clients.
Abstract: The photonic component industry is a highly
innovative industry with a large value chain. In order to ensure the
growth of the industry much effort must be devoted to road mapping
activities. In such activities demand and price evolution forecasting
tools can prove quite useful in order to help in the roadmap
refinement and update process. This paper attempts to provide useful
guidelines in roadmapping of optical components and considers two
models based on diffusion theory and the extended learning curve for
demand and price evolution forecasting.
Abstract: Almost all universities include some form of assignment in their courses. The assignments are either carried out in either in groups or individually. To effectively manage these submitted assignments, a well-designed assignment submission system is needed, hence the need for an online assignment submission system to facilitate the distribution, and collection of assignments on due dates. The objective of such system is to facilitate interaction of lecturers and students for assessment and grading purposes. The aim of this study was to create a web based online assignment submission system for University of Mauritius. The system was created to eliminate the traditional process of giving an assignment and collecting the answers for the assignment. Lecturers can also create automated assessment to assess the students online. Moreover, the online submission system consists of an automatic mailing system which acts as a reminder for students about the deadlines of the posted assignments. System was tested to measure its acceptance rate among both student and lecturers.
Abstract: This study examines the issue of recommendation
sources from the perspectives of gender and consumers- perceived
risk, and validates a model for the antecedents of consumer online
purchases. The method of obtaining quantitative data was that of the
instrument of a survey questionnaire. Data were collected via
questionnaires from 396 undergraduate students aged 18-24, and a
multiple regression analysis was conducted to identify causal
relationships. Empirical findings established the link between
recommendation sources (word-of-mouth, advertising, and
recommendation systems) and the likelihood of making online
purchases and demonstrated the role of gender and perceived risk as
moderators in this context. The results showed that the effects of
word-of-mouth on online purchase intentions were stronger than those
of advertising and recommendation systems. In addition, female
consumers have less experience with online purchases, so they may be
more likely than males to refer to recommendations during the
decision-making process. The findings of the study will help
marketers to address the recommendation factor which influences
consumers- intention to purchase and to improve firm performances to
meet consumer needs.
Abstract: The purpose of this paper is to elucidate the flow unsteady behavior for moving plug in convergent-divergent variable thrust nozzle. Compressible axisymmetric Navier-Stokes equations are used to study this physical phenomenon. Different velocities are set for plug to investigate the effect of plug movement on flow unsteadiness. Variation of mass flow rate and thrust are compared under two conditions: First, the plug is placed at different positions and flow is simulated to reach the steady state (quasi steady simulation) and second, the plug is moved with assigned velocity and flow simulation is coupled with plug movement (unsteady simulation). If plug speed is high enough and its movement time scale is at the same order of the flow time scale, variation of the mass flow rate and thrust level versus plug position demonstrate a vital discrepancy under the quasi steady and unsteady conditions. This phenomenon should be considered especially from response time viewpoints in thrusters design.
Abstract: This paper discusses a curriculum approach that will
give emphasis on practical portions of teaching network security
subjects in information and communication technology courses. As
we are well aware, the need to use a practice and application oriented
approach in education is paramount. Research on active learning and
cooperative groups have shown that students grasps more and have
more tendency towards obtaining and realizing soft skills like
leadership, communication and team work as opposed to the more
traditional theory and exam based teaching and learning. While this
teaching and learning paradigm is relatively new in Malaysia, it has
been practiced widely in the West. This paper examines a certain
approach whereby students learning wireless security are divided into
and work in small and manageable groups where there will be 2
teams which consist of black hat and white hat teams. The former
will try to find and expose vulnerabilities in a wireless network while
the latter will try their best to prevent such attacks on their wireless
networks using hardware, software, design and enforcement of
security policy and etc. This paper will try to show that the approach
taken plus the use of relevant and up to date software and hardware
and with suitable environment setting will hopefully expose students
to a more fruitful outcome in terms of understanding of concepts,
theories and their motivation to learn.
Abstract: Feeder is one of the airships of the Multibody Advanced Airship for Transport (MAAT) system, under development within the EU FP7 project. MAAT is based on a modular concept composed of two different parts that have the possibility to join; respectively they are the so-called Cruiser and Feeder, designed on the lighter than air principle. Feeder, also named ATEN (Airship Transport Elevator Network), is the smaller one which joins the bigger one, Cruiser, also named PTAH (Photovoltaic modular Transport Airship for High altitude),envisaged to happen at 15km altitude. During the MAAT design phase, the aerodynamic studies of the both airships and their interactions are analyzed. The objective of these studies is to understand the aerodynamic behavior of all the preselected configurations, as an important element in the overall MAAT system design. The most of these configurations are only simulated by CFD, while the most feasible one is experimentally analyzed in order to validate and thrust the CFD predictions. This paper presents the numerical and experimental investigation of the Feeder “conical like" shape configuration. The experiments are focused on the aerodynamic force coefficients and the pressure distribution over the Feeder outer surface, while the numerical simulation cover also the analysis of the velocity and pressure distribution. Finally, the wind tunnel experiment is compared with its CFD model in order to validate such specific simulations with respective experiments and to better understand the difference between the wind tunnel and in-flight circumstances.
Abstract: An optimal solution for a large number of constraint
satisfaction problems can be found using the technique of
substitution and elimination of variables analogous to the technique
that is used to solve systems of equations. A decision function
f(A)=max(A2) is used to determine which variables to eliminate. The
algorithm can be expressed in six lines and is remarkable in both its
simplicity and its ability to find an optimal solution. However it is
inefficient in that it needs to square the updated A matrix after each
variable elimination. To overcome this inefficiency the algorithm is
analyzed and it is shown that the A matrix only needs to be squared
once at the first step of the algorithm and then incrementally updated
for subsequent steps, resulting in significant improvement and an
algorithm complexity of O(n3).
Abstract: Estimation time and cost of work completion in a
project and follow up them during execution are contributors to
success or fail of a project, and is very important for project
management team. Delivering on time and within budgeted cost
needs to well managing and controlling the projects. To dealing with
complex task of controlling and modifying the baseline project
schedule during execution, earned value management systems have
been set up and widely used to measure and communicate the real
physical progress of a project. But it often fails to predict the total
duration of the project. In this paper data mining techniques is used
predicting the total project duration in term of Time Estimate At
Completion-EAC (t). For this purpose, we have used a project with
90 activities, it has updated day by day. Then, it is used regular
indexes in literature and applied Earned Duration Method to
calculate time estimate at completion and set these as input data for
prediction and specifying the major parameters among them using
Clem software. By using data mining, the effective parameters on
EAC and the relationship between them could be extracted and it is
very useful to manage a project with minimum delay risks. As we
state, this could be a simple, safe and applicable method in prediction
the completion time of a project during execution.
Abstract: This paper presents a text clustering system developed based on a k-means type subspace clustering algorithm to cluster large, high dimensional and sparse text data. In this algorithm, a new step is added in the k-means clustering process to automatically calculate the weights of keywords in each cluster so that the important words of a cluster can be identified by the weight values. For understanding and interpretation of clustering results, a few keywords that can best represent the semantic topic are extracted from each cluster. Two methods are used to extract the representative words. The candidate words are first selected according to their weights calculated by our new algorithm. Then, the candidates are fed to the WordNet to identify the set of noun words and consolidate the synonymy and hyponymy words. Experimental results have shown that the clustering algorithm is superior to the other subspace clustering algorithms, such as PROCLUS and HARP and kmeans type algorithm, e.g., Bisecting-KMeans. Furthermore, the word extraction method is effective in selection of the words to represent the topics of the clusters.
Abstract: Numerical studies have been carried out using a
validated two-dimensional RNG k-epsilon turbulence model for the
design optimization of a thrust vector control system using shock
induced supersonic secondary jet. Parametric analytical studies have
been carried out with various secondary jets at different divergent
locations, jet interaction angles, jet pressures. The results from the
parametric studies of the case on hand reveal that the primary nozzle
with a small divergence angle, downstream injections with a distance
of 2.5 times the primary nozzle throat diameter from the primary
nozzle throat location warrant higher efficiency over a certain range
of jet pressures and jet angles. We observed that the supersonic
secondary jet opposing the core flow with jets interaction angle of
40o to the axis far downstream of the nozzle throat facilitates better
thrust vectoring than the secondary jet with same direction as that of
core flow with various interaction angles. We concluded that fixing
of the supersonic secondary jet nozzle pointing towards the throat
direction with suitable angle at a distance 2 to 4 times of the primary
nozzle throat diameter, as the case may be, from the primary nozzle
throat location could facilitate better thrust vectoring for the
supersonic aerospace vehicles.
Abstract: Selective harmonic elimination-pulse width modulation techniques offer a tight control of the harmonic spectrum of a given voltage waveform generated by a power electronic converter along with a low number of switching transitions. Traditional optimization methods suffer from various drawbacks, such as prolonged and tedious computational steps and convergence to local optima; thus, the more the number of harmonics to be eliminated, the larger the computational complexity and time. This paper presents a novel method for output voltage harmonic elimination and voltage control of PWM AC/AC voltage converters using the principle of hybrid Real-Coded Genetic Algorithm-Pattern Search (RGA-PS) method. RGA is the primary optimizer exploiting its global search capabilities, PS is then employed to fine tune the best solution provided by RGA in each evolution. The proposed method enables linear control of the fundamental component of the output voltage and complete elimination of its harmonic contents up to a specified order. Theoretical studies have been carried out to show the effectiveness and robustness of the proposed method of selective harmonic elimination. Theoretical results are validated through simulation studies using PSIM software package.