Abstract: Sensitive and predictive DILI (Drug Induced Liver
Injury) biomarkers are needed in drug R&D to improve early
detection of hepatotoxicity. The discovery of DILI biomarkers that
demonstrate the predictive power to identify individuals at risk to
DILI would represent a major advance in the development of
personalized healthcare approaches. In this healthy volunteer
acetaminophen study (4g/day for 7 days, with 3 monitored nontreatment
days before and 4 after), 450 serum samples from 32
subjects were analyzed using protein profiling by antibody
suspension bead arrays. Multiparallel protein profiles were generated
using a DILI target protein array with 300 antibodies, where the
antibodies were selected based on previous literature findings of
putative DILI biomarkers and a screening process using pre dose
samples from the same cohort. Of the 32 subjects, 16 were found to
develop an elevated ALT value (2Xbaseline, responders). Using the
plasma profiling approach together with multivariate statistical
analysis some novel findings linked to lipid metabolism were found
and more important, endogenous protein profiles in baseline samples
(prior to treatment) with predictive power for ALT elevations were
identified.
Abstract: The paper deals with determination of electromagnetic
and temperature field distribution of induction heating system used
for pipe brazing. The problem is considered as coupled – time
harmonic electromagnetic and transient thermal field. It has been
solved using finite element method. The detailed maps of
electromagnetic and thermal field distribution have been obtained.
The good understanding of the processes in the considered system
ensures possibilities for control, management and increasing the
efficiency of the welding process.
Abstract: Cloud Computing is an approach that provides computation and storage services on-demand to clients over the network, independent of device and location. In the last few years, cloud computing became a trend in information technology with many companies that transfer their business processes and applications in the cloud. Cloud computing with service oriented architecture has contributed to rapid development of Geographic Information Systems. Open Geospatial Consortium with its standards provides the interfaces for hosted spatial data and GIS functionality to integrated GIS applications. Furthermore, with the enormous processing power, clouds provide efficient environment for data intensive applications that can be performed efficiently, with higher precision, and greater reliability. This paper presents our work on the geospatial data services within the cloud computing environment and its technology. A cloud computing environment with the strengths and weaknesses of the geographic information system will be introduced. The OGC standards that solve our application interoperability are highlighted. Finally, we outline our system architecture with utilities for requesting and invoking our developed data intensive applications as a web service.
Abstract: While service quality is acceptably most valued in the tourism industry, the issue of safety and security plays a key role in sustaining the industry success. Such an issue has been part of Thailand-s tourism development and promotion for several years. Evidently, the Tourist Police Department was set up for this purpose. Its main responsibility is to deal with international tourists- safety and confidence in travelling within Thai territory. However, to strengthen the tourism safety of the country, it is important to better understand international tourists- safety concerns about Thailand. This article seeks to compare international tourists- safety needs and Thai tourist polices- perception towards the tourists- safety concern to determine what measure should be taken to assure the tourist of Thailand-s secure environment. Through the employment of quantitative and qualitative methodological approaches, the tourism safety need of international tourists from Europe, North America and Asia was excavated, how Thai tourist polices and local polices perceived the international tourist-s safety concern was investigated, and opinion and experiences about how the police deal with international tourists- problems in eight touristic areas were also explored. A comparative result reveals a certain degrees of differences in international tourists- safety needs and Thai polices- perception towards their needs. The tourism safety prevention and protection measure and practice are also suggested.
Abstract: Hardness of the widely used structural steel is of vital
importance since it may help in the determination of many
mechanical properties of a material under loading situations. In order
to obtain reliable information for design, properties homogeneity
should be validated. In the current study the hardness variation over
the different diameters of the same AISI 4140 bar is investigated.
Measurements were taken on the two faces of the stock at equally
spaced eight sectors and fifteen layers. Statistical and graphical
analysis are performed to asses the distribution of hardness
measurements over the specified area. Hardness measurements
showed some degree of dispersion with about ± 10% of its nominal
value provided by manufacturer. Hardness value is found to have a
slight decrease trend as the diameter is reduced. However, an
opposite behavior is noticed regarding the sequence of the sector
indicating a nonuniform distribution over the same area either on the
same face or considering the corresponding sector on the other face
(cross section) of the same material bar.
Abstract: Developing techniques for mobile robot navigation constitutes one of the major trends in the current
research on mobile robotics. This paper develops a local
model network (LMN) for mobile robot navigation. The
LMN represents the mobile robot by a set of locally valid
submodels that are Multi-Layer Perceptrons (MLPs).
Training these submodels employs Back Propagation (BP) algorithm. The paper proposes the fuzzy C-means (FCM) in this scheme to divide the input space to sub regions, and then a submodel (MLP) is identified to represent a particular
region. The submodels then are combined in a unified
structure. In run time phase, Radial Basis Functions (RBFs) are employed as windows for the activated submodels. This
proposed structure overcomes the problem of changing operating regions of mobile robots. Read data are used in all experiments. Results for mobile robot navigation using the
proposed LMN reflect the soundness of the proposed
scheme.
Abstract: Censored Production Rule is an extension of standard
production rule, which is concerned with problems of reasoning with
incomplete information, subject to resource constraints and problem
of reasoning efficiently with exceptions. A CPR has a form: IF A
(Condition) THEN B (Action) UNLESS C (Censor), Where C is the
exception condition. Fuzzy CPR are obtained by augmenting
ordinary fuzzy production rule “If X is A then Y is B with an
exception condition and are written in the form “If X is A then Y is B
Unless Z is C. Such rules are employed in situation in which the
fuzzy conditional statement “If X is A then Y is B" holds frequently
and the exception condition “Z is C" holds rarely. Thus “If X is A
then Y is B" part of the fuzzy CPR express important information
while the unless part acts only as a switch that changes the polarity of
“Y is B" to “Y is not B" when the assertion “Z is C" holds. The
proposed approach is an attempt to discover fuzzy censored
production rules from set of discovered fuzzy if then rules in the
form:
A(X)  B(Y) || C(Z).
Abstract: The aim of this study was to compare the effects
of an altitude training camp on heart rate variability and
performance in elite triathletes. Ten athletes completed 20 days of live-high, train-low training at 1650m. Athletes
underwent pre and post 800-m swim time trials at sea-level, and two heart rate variability tests at 1650m on the first and
last day of the training camp. Based on their time trial results,
athletes were divided into responders and non-responders. Relative to the non-responders, the responders sympathetic-toparasympathetic
ratio decreased substantially after 20 days of altitude training (-0.68 ± 1.08 and -1.2 ± 0.96, mean ± 90%
confidence interval for supine and standing respectively). In
addition, sympathetic activity while standing was also
substantially lower post-altitude in the responders compared to the non-responders (-1869 ± 4764 ms2). Results indicate that
responders demonstrated a change to more vagal
predominance compared to non-responders.
Abstract: The purpose of this study is comparing and analysing
of the financial characteristics for development methods of the urban development project in the established area, focusing on the
multi-level replotting.
Analysis showed that the type of the lowest expenditure was
'combination type of group-land and multi-level replotting' and the type of the highest profitability was 'multi-level replotting type'. But
'multi-level replotting type' has still risk of amount of cost for the additional architecture. In addition, we subdivided standard amount
for liquidation of replotting and analysed income-expenditure flow.
Analysis showed that both of 'multi-level replotting type' and 'combination type of group-land and multi-level replotting' improved
profitability of project and property change ratio. However, when the
standard was under a certain amount, amount of original property for the replotting was increased exponentially, and profitability of project.
Abstract: The ionizing radiation of livestock wastewater for the
removal of nitrogen and phosphorus was studied in the presence of a
natural zeolite. The feasibility of a combined process of zeolite ion
exchange and electron beam irradiation of livestock wastewater was
also investigated. The removal efficiencies of NH4
+-N, T-N and T-P
were significantly enhanced by electron beam irradiation after zeolite
ion exchange as a pre-treatment. The presence of silica zeolite
accelerated the decomposition rate of livestock wastewater in the
electron beam irradiation process. These results indicate that the
combined process of zeolite ion exchange and electron beam
irradiation has the potential for the treatment of livestock wastewater
Abstract: Biclustering aims at identifying several biclusters that
reveal potential local patterns from a microarray matrix. A bicluster is
a sub-matrix of the microarray consisting of only a subset of genes
co-regulates in a subset of conditions. In this study, we extend the
motif of subspace clustering to present a K-biclusters clustering (KBC)
algorithm for the microarray biclustering issue. Besides minimizing
the dissimilarities between genes and bicluster centers within all
biclusters, the objective function of the KBC algorithm additionally
takes into account how to minimize the residues within all biclusters
based on the mean square residue model. In addition, the objective
function also maximizes the entropy of conditions to stimulate more
conditions to contribute the identification of biclusters. The KBC
algorithm adopts the K-means type clustering process to efficiently
make the partition of K biclusters be optimized. A set of experiments
on a practical microarray dataset are demonstrated to show the
performance of the proposed KBC algorithm.
Abstract: Battery storage system is emerging as an essential component of hybrid power system based on renewable energy resources such as solar and wind in order to make these sources dispatchable. Accurate modeling of battery storage system is ssential in order to ensure optimal planning of hybrid power systems incorporating battery storage. Majority of the system planning studies involving battery storage assume battery charging efficiency to be constant. However a strong correlation exists between battery charging efficiency and battery state of charge. In this work a Fuzzy logic based model has been presented for determining battery charging efficiency relative to a particular SOC. In order to demonstrate the efficacy of proposed approach, reliability evaluation studies are carried out for a hypothetical autonomous hybrid power system located in Jaisalmer, Rajasthan, India. The impact of considering battery charging efficiency as a function of state of charge is compared against the assumption of fixed battery charging efficiency for three different configurations comprising of wind-storage, solar-storage and wind-solar-storage.
Abstract: Heavy rainfall greatly affects the aerodynamic performance of the aircraft. There are many accidents of aircraft caused by aerodynamic efficiency degradation by heavy rain. In this Paper we have studied the heavy rain effects on the aerodynamic efficiency of NACA 64-210 & NACA 0012 airfoils. For our analysis, CFD method and preprocessing grid generator are used as our main analytical tools, and the simulation of rain is accomplished via two phase flow approach-s Discrete Phase Model (DPM). Raindrops are assumed to be non-interacting, non-deforming, non-evaporating and non-spinning spheres. Both airfoil sections exhibited significant reduction in lift and increase in drag for a given lift condition in simulated rain. The most significant difference between these two airfoils was the sensitivity of the NACA 64-210 to liquid water content (LWC), while NACA 0012 performance losses in the rain environment is not a function of LWC . It is expected that the quantitative information gained in this paper will be useful to the operational airline industry and greater effort such as small scale and full scale flight tests should put in this direction to further improve aviation safety.
Abstract: In this study, shaking table tests are performed to investigate the behavior of excess pore water pressure in different soft soil-foundations of soil-structure interaction (SSI) system. The variation of the behaviors under cycled minor shock is observed. Moreover, The generation and variation mechanism of excess pore water pressure under earthquake excitation in different soft soilfoundations are analyzed and discussed.
Abstract: Many digital signal processing, techniques have been used to automatically distinguish protein coding regions (exons) from non-coding regions (introns) in DNA sequences. In this work, we have characterized these sequences according to their nonlinear dynamical features such as moment invariants, correlation dimension, and largest Lyapunov exponent estimates. We have applied our model to a number of real sequences encoded into a time series using EIIP sequence indicators. In order to discriminate between coding and non coding DNA regions, the phase space trajectory was first reconstructed for coding and non-coding regions. Nonlinear dynamical features are extracted from those regions and used to investigate a difference between them. Our results indicate that the nonlinear dynamical characteristics have yielded significant differences between coding (CR) and non-coding regions (NCR) in DNA sequences. Finally, the classifier is tested on real genes where coding and non-coding regions are well known.
Abstract: Saturated two-phase fluid flows are often subject to
pressure induced oscillations. Due to compressibility the vapor
bubbles act as a spring with an asymmetric non-linear characteristic.
The volume of the vapor bubbles increases or decreases differently if
the pressure fluctuations are compressing or expanding;
consequently, compressing pressure fluctuations in a two-phase pipe
flow cause less displacement in the direction of the pipe flow than
expanding pressure fluctuations. The displacement depends on the
ratio of liquid to vapor, the ratio of pressure fluctuations over average
pressure and on the exciting frequency of the pressure fluctuations.
In addition, pressure fluctuations in saturated vapor bubbles cause
condensation and evaporation within the bubbles and change
periodically the ratio between liquid to vapor, and influence the
dynamical parameters for the oscillation. The oscillations are
conforming to an isenthalpic process at constant enthalpy with no
heat transfer and no exchange of work.
The paper describes the governing non-linear equation for twophase
fluid oscillations with condensation and evaporation, and
presents steady state approximate solutions for free and for pressure
induced oscillations. Resonance criteria and stability are discussed.
Abstract: Project selection problems on management
information system (MIS) are often considered a multi-criteria
decision-making (MCDM) for a solving method. These problems
contain two aspects, such as interdependencies among criteria and
candidate projects and qualitative and quantitative factors of projects.
However, most existing methods reported in literature consider these
aspects separately even though these two aspects are simultaneously
incorporated. For this reason, we proposed a hybrid method using
analytic network process (ANP) and fuzzy logic in order to represent
both aspects. We then propose a goal programming model to conduct
an optimization for the project selection problems interpreted by a
hybrid concept. Finally, a numerical example is conducted as
verification purposes.
Abstract: Technology of thin film deposition is of interest in
many engineering fields, from electronic manufacturing to corrosion
protective coating. A typical deposition process, like that developed
at the University of Eindhoven, considers the deposition of a thin,
amorphous film of C:H or of Si:H on the substrate, using the
Expanding Thermal arc Plasma technique. In this paper a computing
procedure is proposed to simulate the flow field in a deposition
chamber similar to that at the University of Eindhoven and a
sensitivity analysis is carried out in terms of: precursor mass flow
rate, electrical power, supplied to the torch and fluid-dynamic
characteristics of the plasma jet, using different nozzles. To this
purpose a deposition chamber similar in shape, dimensions and
operating parameters to the above mentioned chamber is considered.
Furthermore, a method is proposed for a very preliminary evaluation
of the film thickness distribution on the substrate. The computing
procedure relies on two codes working in tandem; the output from
the first code is the input to the second one. The first code simulates
the flow field in the torch, where Argon is ionized according to the
Saha-s equation, and in the nozzle. The second code simulates the
flow field in the chamber. Due to high rarefaction level, this is a
(commercial) Direct Simulation Monte Carlo code. Gas is a mixture
of 21 chemical species and 24 chemical reactions from Argon plasma
and Acetylene are implemented in both codes. The effects of the
above mentioned operating parameters are evaluated and discussed
by 2-D maps and profiles of some important thermo-fluid-dynamic
parameters, as per Mach number, velocity and temperature. Intensity,
position and extension of the shock wave are evaluated and the
influence of the above mentioned test conditions on the film
thickness and uniformity of distribution are also evaluated.
Abstract: This research focus on the intrusion detection system (IDS) development which using artificial immune system (AIS) with population based incremental learning (PBIL). AIS have powerful distinguished capability to extirpate antigen when the antigen intrude into human body. The PBIL is based on past learning experience to adjust new learning. Therefore we propose an intrusion detection system call PBIL-AIS which combine two approaches of PBIL and AIS to evolution computing. In AIS part we design three mechanisms such as clonal selection, negative selection and antibody level to intensify AIS performance. In experimental result, our PBIL-AIS IDS can capture high accuracy when an intrusion connection attacks.
Abstract: The purpose of this paper is to develop models that would enable predicting student success. These models could improve allocation of students among colleges and optimize the newly introduced model of government subsidies for higher education. For the purpose of collecting data, an anonymous survey was carried out in the last year of undergraduate degree student population using random sampling method. Decision trees were created of which two have been chosen that were most successful in predicting student success based on two criteria: Grade Point Average (GPA) and time that a student needs to finish the undergraduate program (time-to-degree). Decision trees have been shown as a good method of classification student success and they could be even more improved by increasing survey sample and developing specialized decision trees for each type of college. These types of methods have a big potential for use in decision support systems.