Coupled Multifield Analysis of Piezoelectrically Actuated Microfluidic Device for Transdermal Drug Delivery Applications

In this paper, design, fabrication and coupled multifield analysis of hollow out-of-plane silicon microneedle array with piezoelectrically actuated microfluidic device for transdermal drug delivery (TDD) applications is presented. The fabrication process of silicon microneedle array is first done by series of combined isotropic and anisotropic etching processes using inductively coupled plasma (ICP) etching technology. Then coupled multifield analysis of MEMS based piezoelectrically actuated device with integrated 2×2 silicon microneedle array is presented. To predict the stress distribution and model fluid flow in coupled field analysis, finite element (FE) and computational fluid dynamic (CFD) analysis using ANSYS rather than analytical systems has been performed. Static analysis and transient CFD analysis were performed to predict the fluid flow through the microneedle array. The inlet pressure from 10 kPa to 150 kPa was considered for static CFD analysis. In the lumen region fluid flow rate 3.2946 μL/min is obtained at 150 V for 2×2 microneedle array. In the present study the authors have performed simulation of structural, piezoelectric and CFD analysis on three dimensional model of the piezoelectrically actuated mcirofluidic device integrated with 2×2 microneedle array.

Application of Java-based Pointcuts in Aspect Oriented Programming (AOP) for Data Race Detection

Wide applicability of concurrent programming practices in developing various software applications leads to different concurrency errors amongst which data race is the most important. Java provides greatest support for concurrent programming by introducing various concurrency packages. Aspect oriented programming (AOP) is modern programming paradigm facilitating the runtime interception of events of interest and can be effectively used to handle the concurrency problems. AspectJ being an aspect oriented extension to java facilitates the application of concepts of AOP for data race detection. Volatile variables are usually considered thread safe, but they can become the possible candidates of data races if non-atomic operations are performed concurrently upon them. Various data race detection algorithms have been proposed in the past but this issue of volatility and atomicity is still unaddressed. The aim of this research is to propose some suggestions for incorporating certain conditions for data race detection in java programs at the volatile fields by taking into account support for atomicity in java concurrency packages and making use of pointcuts. Two simple test programs will demonstrate the results of research. The results are verified on two different Java Development Kits (JDKs) for the purpose of comparison.

Grid Learning; Computer Grid Joins to e- Learning

According to development of communications and web-based technologies in recent years, e-Learning has became very important for everyone and is seen as one of most dynamic teaching methods. Grid computing is a pattern for increasing of computing power and storage capacity of a system and is based on hardware and software resources in a network with common purpose. In this article we study grid architecture and describe its different layers. In this way, we will analyze grid layered architecture. Then we will introduce a new suitable architecture for e-Learning which is based on grid network, and for this reason we call it Grid Learning Architecture. Various sections and layers of suggested architecture will be analyzed; especially grid middleware layer that has key role. This layer is heart of grid learning architecture and, in fact, regardless of this layer, e-Learning based on grid architecture will not be feasible.

Importance of Pastoral Human Factor Overloading in Land Desertification: Case Studies in Northeastern Libya

Grazing and pastoral overloading through human factors result in significant land desertification. Failure to take into account the phenomenon of desertification as a serious problem can lead to an environmental disaster because of the damages caused by land encroachment. Therefore, soil on residential and urban areas is affected because of the deterioration of vegetation. Overgrazing or grazing in open and irregular lands is practiced in these areas almost throughout the year, especially during the growth cycle of edible plants, thereby leading to their disappearance. In addition, the large number of livestock in these areas exceeds the capacity of these pastures because of pastoral land overloading, which results in deterioration and desertification in the region. In addition, rare plants, the extinction of some edible plants in the region, and the emergence of plants unsuitable for grazing, must be taken into consideration, as along with the emergence of dust and sand storms during the dry seasons (summer to autumn) due to the degradation of vegetation. These results show that strategic plans and regulations that protect the environment from desertification must be developed. Therefore, increased pastoral load is a key human factor in the deterioration of vegetation cover, leading to land desertification in this region.

Numerical Simulation of unsteady MHD Flow and Heat Transfer of a Second Grade Fluid with Viscous Dissipation and Joule Heating using Meshfree Approach

In the present study, a numerical analysis is carried out to investigate unsteady MHD (magneto-hydrodynamic) flow and heat transfer of a non-Newtonian second grade viscoelastic fluid over an oscillatory stretching sheet. The flow is induced due to an infinite elastic sheet which is stretched oscillatory (back and forth) in its own plane. Effect of viscous dissipation and joule heating are taken into account. The non-linear differential equations governing the problem are transformed into system of non-dimensional differential equations using similarity transformations. A newly developed meshfree numerical technique Element free Galerkin method (EFGM) is employed to solve the coupled non linear differential equations. The results illustrating the effect of various parameters like viscoelastic parameter, Hartman number, relative frequency amplitude of the oscillatory sheet to the stretching rate and Eckert number on velocity and temperature field are reported in terms of graphs and tables. The present model finds its application in polymer extrusion, drawing of plastic films and wires, glass, fiber and paper production etc.

The Key Role of the Steroidal Hormones in the Pattern Distribution of the Epiphyseal Structure in Rabbit

Steroidal hormones with the efficient changes on the epiphyseal growth plate may influence tissue structure properties. Presents paper to investigate the effects of gonadectomy in the pattern distribution of the epiphyseal structure. Fifteen adult female New Zealand white rabbits were separated into three groups. One group was intact and others groups were selected for surgical operation. From these two groups, one group carried out steroidal administration. The results obtained showed that there is no statistically difference in the mean diameter of the growth plate cells between all three groups. The maximum value of the cartilage cells were allocated to the gonadectomized group and the minimum number were observed in Hormonal induced group significantly. Growth plate height was significantly greater in gonadectomized group than in two other groups.

Vacuum Membrane Distillation for Desalination of Ground Water by using Flat Sheet Membrane

The possibility of producing drinking water from brackish ground water using Vacuum membrane distillation (VMD) process was studied. It is a rising technology for seawater or brine desalination process. The process simply consists of a flat sheet hydrophobic micro porous PTFE membrane and diaphragm vacuum pump without a condenser for the water recovery or trap. In this work, VMD performance was investigated for aqueous NaCl solution and natural ground water. The influence of operational parameters such as feed flow rate (30 to 55 l/h), feed temperature (313 to 333 K), feed salt concentration (5000 to 7000 mg/l) and permeate pressure (1.5 to 6 kPa) on the membrane distillation (MD) permeation flux have been investigated. The maximum flux reached to 28.34 kg/m2 h at feed temperature, 333 K; vacuum pressure, 1.5 kPa; feed flow rate, 55 l/h and feed salt concentration, 7000 mg/l. The negligible effects in the reduction of permeate flux found over 150 h experimental run for salt water. But for the natural ground water application over 75 h, scale deposits observed on the membrane surface and 29% reduction in the permeate flux over 75 h. This reduction can be eliminated by acidification of feed water. Hence, promote the research attention in apply of VMD for the ground water purification over today-s conventional RO operation.

A Comparison of Recent Methods for Solving a Model 1D Convection Diffusion Equation

In this paper we study some numerical methods to solve a model one-dimensional convection–diffusion equation. The semi-discretisation of the space variable results into a system of ordinary differential equations and the solution of the latter involves the evaluation of a matrix exponent. Since the calculation of this term is computationally expensive, we study some methods based on Krylov subspace and on Restrictive Taylor series approximation respectively. We also consider the Chebyshev Pseudospectral collocation method to do the spatial discretisation and we present the numerical solution obtained by these methods.

Locating Cultural Centers in Shiraz (Iran) Applying Geographic Information System (GIS)

Optimal cultural site selection is one of the ways that can lead to the promotion of citizenship culture in addition to ensuring the health and leisure of city residents. This study examines the social and cultural needs of the community and optimal cultural site allocation and after identifying the problems and shortcomings, provides a suitable model for finding the best location for these centers where there is the greatest impact on the promotion of citizenship culture. On the other hand, non-scientific methods cause irreversible impacts to the urban environment and citizens. But modern efficient methods can reduce these impacts. One of these methods is using geographical information systems (GIS). In this study, Analytical Hierarchy Process (AHP) method was used to locate the optimal cultural site. In AHP, three principles (decomposition), (comparative analysis), and (combining preferences) are used. The objectives of this research include providing optimal contexts for passing time and performing cultural activities by Shiraz residents and also proposing construction of some cultural sites in different areas of the city. The results of this study show the correct positioning of cultural sites based on social needs of citizens. Thus, considering the population parameters and radii access, GIS and AHP model for locating cultural centers can meet social needs of citizens.

Comparative Analysis of Diversity and Similarity Indices with Special Relevance to Vegetations around Sewage Drains

Indices summarizing community structure are used to evaluate fundamental community ecology, species interaction, biogeographical factors, and environmental stress. Some of these indices are insensitive to gross community changes induced by contaminants of pollution. Diversity indices and similarity indices are reviewed considering their ecological application, both theoretical and practical. For some useful indices, empirical equations are given to calculate the expected maximum value of the indices to which the observed values can be related at any combination of sample sizes at the experimental sites. This paper examines the effects of sample size and diversity on the expected values of diversity indices and similarity indices, using various formulae. It has been shown that all indices are strongly affected by sample size and diversity. In some indices, this influence is greater than the others and an attempt has been made to deal with these influences.

Performance Evaluation of Music and Minimum Norm Eigenvector Algorithms in Resolving Noisy Multiexponential Signals

Eigenvector methods are gaining increasing acceptance in the area of spectrum estimation. This paper presents a successful attempt at testing and evaluating the performance of two of the most popular types of subspace techniques in determining the parameters of multiexponential signals with real decay constants buried in noise. In particular, MUSIC (Multiple Signal Classification) and minimum-norm techniques are examined. It is shown that these methods perform almost equally well on multiexponential signals with MUSIC displaying better defined peaks.

Web Service Security Method To SOA Development

Web services provide significant new benefits for SOAbased applications, but they also expose significant new security risks. There are huge number of WS security standards and processes. At present, there is still a lack of a comprehensive approach which offers a methodical development in the construction of secure WS-based SOA. Thus, the main objective of this paper is to address this needs, presenting a comprehensive method for Web Services Security guaranty in SOA. The proposed method defines three stages, Initial Security Analysis, Architectural Security Guaranty and WS Security Standards Identification. These facilitate, respectively, the definition and analysis of WS-specific security requirements, the development of a WS-based security architecture and the identification of the related WS security standards that the security architecture must articulate in order to implement the security services.

QoS Management in the Future Internet

The talks about technological convergence had been around for almost twenty years. Today Internet made it possible. And this is not only technical evolution. The way it changed our lives reflected in variety of applications, services and technologies used in day-to-day life. Such benefits imposed even more requirements on heterogeneous and unreliable IP networks. Current paper outlines QoS management system developed in the NetQoS [1] project. It describes an overall architecture of management system for heterogeneous networks and proposes automated multi-layer QoS management. Paper focuses on the structure of the most crucial modules of the system that enable autonomous and multi-layer provisioning and dynamic adaptation.

The Quality Maintenance and Extending Storage Life of Mango Fruit after Postharvest Treatments

The quality attributes and storage life of 'Jinhwang' mango fruit can be effectively maintained with 1-methylcyclopropene (1-MCP) application and/or chitosan coating. 'Jinhwang' mango fruit was treated with 5 μl l-1 1-MCP for 12 h, dipped with 0.5 % chitosan, 5 μl l-1 1-MCP combine with 0.5 % chitosan and untreated (control) then stored at 10oC. Mango treated with 1-MCP maintained firmness, sucrose and starch content. Chitosan coating delayed firmness loss, sucrose content and the fruit decay when compare with control. Application of 1-MCP combine with chitosan also delayed firmness loss, sucrose content and starch content during storage. Furthermore, chitosan coating and combine treatment prolonged storage life of mango up to 29 days after storage while 1-MCP extended to 28 days after storage. Therefore, using all application of chitosan coating or 1-MCP combine with chitosan or 1-MCP in mango at 10oC is a feasible technology for maintains quality and prolongs storage life in order to expand marketability and export options.

Simulation of Thermal Storage Phase Change Material in Buildings

One of the potential and effective ways of storing thermal energy in buildings is the integration of brick with phase change materials (PCMs). This paper presents a two-dimensional model for simulating and analyzing of PCM in order to minimize energy consumption in the buildings. The numerical approach has been used with the real weather data of a selected city of Iran (Tehran). Two kinds of brick integrated PCM are investigated and compared base on outdoor weather conditions and the amount of energy consumption. The results show a significant reduction in maximum entering heat flux to building about 32.8% depending on PCM quantity. The results are analyzed by various temperature contour plots. The contour plots illustrated the time dependent mechanism of entering heat flux for a brick integrated with PCM. Further analysis is developed to investigate the effect of PCM location on the inlet heat flux. The results demonstrated that to achieve maximum performance of PCM it is better to locate PCM near the outdoor.

Algorithm for Bleeding Determination Based On Object Recognition and Local Color Features in Capsule Endoscopy

Automatic determination of blood in less bright or noisy capsule endoscopic images is difficult due to low S/N ratio. Especially it may not be accurate to analyze these images due to the influence of external disturbance. Therefore, we proposed detection methods that are not dependent only on color bands. In locating bleeding regions, the identification of object outlines in the frame and features of their local colors were taken into consideration. The results showed that the capability of detecting bleeding was much improved.

Collaborative E-Learning with Multiple Imaginary Co-Learner: Design, Issues and Implementation

Collaborative problem solving in e-learning can take in the form of discussion among learner, creating a highly social learning environment and characterized by participation and interactivity. This paper, designed a collaborative learning environment where agent act as co-learner, can play different roles during interaction. Since different roles have been assigned to the agent, learner will assume that multiple co-learner exists to help and guide him all throughout the collaborative problem solving process, but in fact, alone during the learning process. Specifically, it answers the questions what roles of the agent should be incorporated to contribute better learning outcomes, how agent will facilitate the communication process to provide social learning and interactivity and what are the specific instructional strategies that facilitate learner participation, increased skill acquisition and develop critical thinking.

Numerical Simulation of Conjugated Heat Transfer Characteristics of Laminar Air Flows in Parallel-Plate Dimpled Channels

This paper presents a numerical study on surface heat transfer characteristics of laminar air flows in parallel-plate dimpled channels. The two-dimensional numerical model is provided by commercial code FLUENT and the results are obtained for channels with symmetrically opposing hemi-cylindrical cavities onto both walls for Reynolds number ranging from 1000 to 2500. The influence of variations in relative depth of dimples (the ratio of cavity depth to the cavity curvature diameter), the number of them and the thermophysical properties of channel walls on heat transfer enhancement is studied. The results are evident for existence of an optimum value for the relative depth of dimples in which the largest wall heat flux and average Nusselt number can be achieved. In addition, the results of conjugation simulation indicate that the overall influence of the ratio of wall thermal conductivity to the one of the fluid on heat transfer rate is not much significant and can be ignored.

Modeling the Symptom-Disease Relationship by Using Rough Set Theory and Formal Concept Analysis

Medical Decision Support Systems (MDSSs) are sophisticated, intelligent systems that can provide inference due to lack of information and uncertainty. In such systems, to model the uncertainty various soft computing methods such as Bayesian networks, rough sets, artificial neural networks, fuzzy logic, inductive logic programming and genetic algorithms and hybrid methods that formed from the combination of the few mentioned methods are used. In this study, symptom-disease relationships are presented by a framework which is modeled with a formal concept analysis and theory, as diseases, objects and attributes of symptoms. After a concept lattice is formed, Bayes theorem can be used to determine the relationships between attributes and objects. A discernibility relation that forms the base of the rough sets can be applied to attribute data sets in order to reduce attributes and decrease the complexity of computation.

Effect of Buoyancy Ratio on Non-Darcy Mixed Convection in a Vertical Channel: A Thermal Non-equilibrium Approach

This article presents a numerical study of the doublediffusive mixed convection in a vertical channel filled with porous medium by using non-equilibrium model. The flow is assumed fully developed, uni-directional and steady state. The controlling parameters are thermal Rayleigh number (RaT ), Darcy number (Da), Forchheimer number (F), buoyancy ratio (N), inter phase heat transfer coefficient (H), and porosity scaled thermal conductivity ratio (γ). The Brinkman-extended non-Darcy model is considered. The governing equations are solved by spectral collocation method. The main emphasize is given on flow profiles as well as heat and solute transfer rates, when two diffusive components in terms of buoyancy ratio are in favor (against) of each other and solid matrix and fluid are thermally non-equilibrium. The results show that, for aiding flow (RaT = 1000), the heat transfer rate of fluid (Nuf ) increases upto a certain value of H, beyond that decreases smoothly and converges to a constant, whereas in case of opposing flow (RaT = -1000), the result is same for N = 0 and 1. The variation of Nuf in (N, Nuf )-plane shows sinusoidal pattern for RaT = -1000. For both cases (aiding and opposing) the flow destabilize on increasing N by inviting point of inflection or flow separation on the velocity profile. Overall, the buoyancy force have significant impact on the non-Darcy mixed convection under LTNE conditions.