Abstract: Kidney cancer is the most lethal urological cancer
accounting for 3% of adult malignancies. VHL, a tumor-suppressor
gene, is best known to be associated with renal cell carcinoma
(RCC). The VHL functions as negative regulator of hypoxia inducible
factors. Recent sequencing efforts have identified several novel
frequent mutations of histone modifying and chromatin remodeling
genes in ccRCC (clear cell RCC) including PBRM1 and SETD2. The
PBRM1 gene encodes the BAF180 protein, which involved in
transcriptional activation and repression of selected genes. SETD2
encodes a histone methyltransferase, which may play a role in
suppressing tumor development. In this study, RNAs of 30 paired
tumor and normal samples that were grouped according to the types
of kidney cancer and clinical characteristics of patients, including
gender and average age were examined by RT-PCR, SSCP and
sequencing techniques. VHL, PBRM1 and SETD2 expressions were
relatively down-regulated. However, statistically no significance was
found (Wilcoxon signed rank test, p>0.05). Interestingly, no mutation
was observed on the contrary of previous studies. Understanding the
molecular mechanisms involved in the pathogenesis of RCC has
aided the development of molecular-targeted drugs for kidney cancer.
Further analysis is required to identify the responsible genes rather
than VHL, PBRM1 and SETD2 in kidney cancer.
Abstract: This study investigated the behavior of improved soft soils through the vibro replacement technique by considering their settlements and consolidation rates and the applicability of this technique in various types of soils and settlement and bearing capacity calculations.
Abstract: In our research we aimed to test a managerial
approach for the fuzzy front end (FFE) of innovation by creating
controlled experiment/ business case in a breakthrough innovation
development. The experiment was in the sport industry and covered
all aspects of the customer discovery stage from ideation to
prototyping followed by patent application. In the paper we describe
and analyze mile stones, tasks, management challenges, decisions
made to create the break through innovation, evaluate overall
managerial efficiency that was at the considered FFE stage.
We set managerial outcome of the FFE stage as a valid product
concept in hand. In our paper we introduce hypothetical construct
“Q-factor” that helps us in the experiment to distinguish quality of
FFE outcomes.
The experiment simulated for entrepreneur the FFE of innovation
and put on his shoulders responsibility for the outcome of valid
product concept. While developing managerial approach to reach the
outcome there was a decision to look on product concept from the
cognitive psychology and cognitive science point of view. This view
helped us to develop the profile of a person whose projection (mental
representation) of a new product could optimize for a manager or
entrepreneur FFE activities. In the experiment this profile was tested
to develop breakthrough innovation for swimmers. Following the
managerial approach the product concept was created to help
swimmers to feel/sense water. The working prototype was developed
to estimate the product concept validity and value added effect for
customers.
Based on feedback from coachers and swimmers there were strong
positive effect that gave high value for customers, and for the
experiment – the valid product concept being developed by proposed
managerial approach for the FFE.
In conclusions there is a suggestion of managerial approach that
was derived from experiment.
Abstract: In this paper, the effect of grades 32.4 and 42.5
Portland-limestone cements generally used for concrete production in
Nigeria on concrete compressive strength is investigated.
Investigation revealed that the compressive strength of concrete
produced with Portland-limestone cement grade 42.5 is generally
higher than that produced with cement grade 32.5. The percentage
difference between the compressive strengths of the concrete cubes
produced with Portland-limestone cement grades 42.5 and 32.5 is
inversely proportional to the richness of the concrete with the highest
and the least percentage difference associated with the 1:2:4 and
1:1:2 mix ratios respectively. It is recommended that cement grade
42.5 be preferred for construction in Nigeria as this will lead to the
construction of stronger concrete structures, which will reduce the
incidence of failure of building and other concrete structures at no
additional cost since the cost of both cement grades are the same.
Abstract: Karst term is the determiner of a variety of areas or
landforms and unique perspectives that have been formed in result of
the of the ingredients dissolution of rocks constituter by natural
waters. Shiraz area with an area of 5322km2 is located in the simple
folded belt in the southern part of Zagros Mountain of Fars, and is
surrounded with Limestone Mountains (Asmari formation). Shiraz
area is located in Calcareous areas. The infrastructure of this city is
lime and absorbing wells that the city can influence the Limestone
dissolution and those accelerate its rate and increase the cavitation
below the surface. Dasht-e Arjan is a graben, which has been created
as the result of activity of two normal faults in its east and west sides.
It is a complete sample of Karst plains (Polje) which has been created
with the help of tectonic forces (fault) and dissolution process of
water in Asmari limestone formation. It is located 60km. off south
west of Shiraz (on Kazeroon-Shiraz road). In 1971, UNESCO has
recognized this plain as a reserve of biosphere. It is considered as one
of the world’s most beautiful geological phenomena, so that most of
the world’s geologists are interested in visiting this place. The
purpose of this paper is to identify and introduce landscapes of Karst
features shiraz city and Dasht-e Arjan including Karst dissolution
features (Lapiez, Karst springs, dolines, caves, underground caves,
ponors, and Karst valleys), anticlines and synclines, and Arjan Lake.
Abstract: Since large part of electricity is generated by using
fossil based resources, energy is an important agenda for countries. In
this context, renewable energy sources are alternative to conventional
sources due to the depletion of fossil resources, increasing awareness
of climate change and global warming concerns. Solar, wind and
hydropower energy are the main renewable energy sources. Among
of them, since installed capacity of wind power has increased
approximately eight times between 2008 - November of 2014, wind
energy is a promising source for Turkey. Furthermore, signing of
Kyoto Protocol can be accepted as a milestone for Turkey's energy
policy. Turkish Government has announced Vision 2023 (energy
targets by 2023) in 2010-2014 Strategic Plan prepared by Ministry of
Energy and Natural Resources (MENR). Energy targets in this plan
can be summarized as follows: Share of renewable energy sources in
electricity generation is 30% of total electricity generation by 2023.
Installed capacity of wind energy will be 20 GW by 2023. Other
renewable energy sources such as solar, hydropower and geothermal
are encouraged with new incentive mechanisms. Dependence on
foreign energy is reduced for sustainability and energy security. On
the other hand, since Turkey is surrounded by three coastal areas,
wind energy potential is convenient for wind power application. As
of November of 2014, total installed capacity of wind power plants is
3.51 GW and a lot of wind power plants are under construction with
capacity 1.16 GW. Turkish government also encourages the locally
manufactured equipments. In this context, one of the projects funded
by private sector, universities and TUBİTAK names as MILRES is
an important project aimed to promote the use wind energy in
electricity generation. Within this project, wind turbine with 500 kW
power has been produced and will be installed at the beginning of the
2015. After that, by using the experience obtained from the first
phase of the project, a wind turbine with 2.5 MW power will be
manufactured in an industrial scale.
Abstract: Periventricular Leukomalacia (PVL) is a White Matter
Injury (WMI) of preterm neonatal brain. Objectives of the study were
to assess the neuro-developmental outcome at one year of age and to
determine a good protocol of cranial ultrasonography to detect PVL.
Two hundred and sixty four preterm neonates were included in the
study. Series of cranial ultrasound scans were done by using a
dedicated neonatal head probe 4-10 MHz of Logic e portable
ultrasound scanner. Clinical history of seizures, abnormal head
growth (hydrocephalus or microcephaly) and developmental
milestones were assessed and neurological examinations were done
until one year of age. Among live neonates, 57% who had cystic PVL
(Grades 2 and 3) manifested as cerebral palsy. In conclusion cystic
PVL has permanent neurological disabilities like cerebral palsy.
Good protocol of real time cranial ultrasonography to detect PVL is
to perform scans at least once a week until one month and at term (40
weeks of gestation).
Abstract: Femtocells are regarded as a milestone for next
generation cellular networks. As femtocells are deployed in an
unplanned manner, there is a chance of assigning same resource to
neighboring femtocells. This scenario may induce co-channel
interference and may seriously affect the service quality of
neighboring femtocells. In addition, the dominant transmit power of a
femtocell will induce co-tier interference to neighboring femtocells.
Thus to jointly handle co-tier and co-channel interference, we
propose an interference-free power and resource block allocation
(IFPRBA) algorithm for closely located, closed access femtocells.
Based on neighboring list, inter-femto-base station distance and
uplink noise power, the IFPRBA algorithm assigns non-interfering
power and resource to femtocells. The IFPRBA algorithm also
guarantees the quality of service to femtouser based on the
knowledge of resource requirement, connection type, and the
tolerable delay budget. Simulation result shows that the interference
power experienced in IFPRBA algorithm is below the tolerable
interference power and hence the overall service success ratio, PRB
efficiency and network throughput are maximum when compared to
conventional resource allocation framework for femtocell (RAFF)
algorithm.
Abstract: Using cold EGR method with variable venturi and
turbocharger has a very significant effect on reduction of NOX and
grime simultaneously. EGR cooler is one of the most important parts
in the cold EGR circuit. In this paper optimum design of cooler for
working in different percentages of EGR and for determining
optimum temperature of exhausted gases, growth of efficiency,
reduction of weight, dimension, expenditures, sediment and also
optimum performance by using gasoil which has significant amounts
of brimstone are investigated and optimized.
Abstract: The present study was conducted to evaluate the
potential applicability of biological trickling filter system for the
treatment of simulated textile wastewater containing reactive azo
dyes with bacterial consortium under non-sterile conditions. The
percentage decolorization for the treatment of wastewater containing
structurally different dyes was found to be higher than 95% in all
trials. The stable bacterial count of the biofilm on stone media of the
trickling filter during the treatment confirmed the presence,
proliferation, dominance and involvement of the added microbial
consortium in the treatment of textile wastewater. Results of
physicochemical parameters revealed the reduction in chemical
oxygen demand (58.5-75.1%), sulphates (18.9-36.5%), and
phosphates (63.6-73.0%). UV-Visible and FTIR spectroscopy
confirmed decolorization of dye containing wastewater was ultimate
consequence of biodegradation. Toxicological studies revealed the
nontoxic nature of degradative metabolites.
Abstract: Asphaltic concrete for pavement construction in India
are produced by using crushed stone, gravels etc. as aggregate. In
north-Eastern region of India, there is a scarcity of stone aggregate.
Therefore the road engineers are always in search of an optional
material as aggregate which can replace the regularly used material.
The purpose of this work was to evaluate the utilization of
substandard or marginal aggregates in flexible pavement
construction. The investigation was undertaken to evaluate the effects
of using lower quality aggregates such as over burnt brick aggregate
on the preparation of asphalt concrete for flexible pavements. The
scope of this work included a review of available literature and
existing data, a laboratory evaluation organized to determine the
effects of marginal aggregates and potential techniques to upgrade
these substandard materials, and a laboratory evaluation of these
upgraded marginal aggregate asphalt mixtures. Over burnt brick
aggregates are water susceptible and can leads to moisture damage.
Moisture damage is the progressive loss of functionality of the
material owing to loss of the adhesion bond between the asphalt
binder and the aggregate surface. Hence zycosoil as an anti striping
additive were evaluated in this study. This study summarizes the
results of the laboratory evaluation carried out to investigate the
properties of asphalt concrete prepared with zycosoil modified over
burnt brick aggregate. Marshall specimen were prepared with stone
aggregate, zycosoil modified stone aggregate, over burnt brick
aggregate and zycosoil modified over burnt brick aggregate. Results
show that addition of zycosoil with stone aggregate increased
stability by 6% and addition of zycosoil with over burnt brick
aggregate increased stability by 30%.
Abstract: This paper involved the performance of a hightemperature
X-Ray powder diffraction analysis (XRD) of a sample of
chemical gypsum generated in the production of titanium white; this
gypsum originates by neutralizing highly acidic water with limestone
suspension. Specifically, it was gypsum formed in the first stage of
neutralization when the resulting material contains, apart from
gypsum, a number of waste products resulting from the
decomposition of ilmenite by sulphuric acid. So it can be described as
red titanogypsum. By conducting the experiment using XRD
apparatus Bruker D8 Advance with a Cu anode (λkα=1.54184 Å)
equipped with high-temperature chamber Anton Paar HTK 16, it was
possible to identify clearly in the sample each phase transition in the
system of CaSO4·xH2O.
Abstract: Advances technology in the field of photogrammetry
replaces analog cameras with reflection on aircraft GPS/IMU system
with a digital aerial camera. In this system, when determining the
position of the camera with the GPS, camera rotations are also
determined by the IMU systems. All around the world, digital aerial
cameras have been used for the photogrammetry applications in the
last ten years. In this way, in terms of the work done in
photogrammetry it is possible to use time effectively, costs to be
reduced to a minimum level, the opportunity to make fast and
accurate.
Geo-referencing techniques that are the cornerstone of the GPS /
INS systems, photogrammetric triangulation of images required for
balancing (interior and exterior orientation) brings flexibility to the
process. Also geo-referencing process; needed in the application of
photogrammetry targets to help to reduce the number of ground
control points. In this study, the use of direct and indirect georeferencing
techniques on the accuracy of the points was investigated
in the production of photogrammetric mapping.
Abstract: Web search engines are designed to retrieve and
extract the information in the web databases and to return dynamic
web pages. The Semantic Web is an extension of the current web in
which it includes semantic content in web pages. The main goal of
semantic web is to promote the quality of the current web by
changing its contents into machine understandable form. Therefore,
the milestone of semantic web is to have semantic level information
in the web. Nowadays, people use different keyword- based search
engines to find the relevant information they need from the web.
But many of the words are polysemous. When these words are
used to query a search engine, it displays the Search Result Records
(SRRs) with different meanings. The SRRs with similar meanings are
grouped together based on Word Sense Disambiguation (WSD). In
addition to that semantic annotation is also performed to improve the
efficiency of search result records. Semantic Annotation is the
process of adding the semantic metadata to web resources. Thus the
grouped SRRs are annotated and generate a summary which
describes the information in SRRs. But the automatic semantic
annotation is a significant challenge in the semantic web. Here
ontology and knowledge based representation are used to annotate
the web pages.
Abstract: The construction of a new airport or the extension of
an existing one requires massive investments and many times public
private partnerships were considered in order to make feasible such
projects. One characteristic of these projects is uncertainty with
respect to financial and environmental impacts on the medium to long
term. Another one is the multistage nature of these types of projects.
While many airport development projects have been a success, some
others have turned into a nightmare for their promoters.
This communication puts forward a new approach for airport
investment risk assessment. The approach takes explicitly into
account the degree of uncertainty in activity levels prediction and
proposes milestones for the different stages of the project for
minimizing risk. Uncertainty is represented through fuzzy dual theory
and risk management is performed using dynamic programming. An
illustration of the proposed approach is provided.
Abstract: Turbulent flow in complex geometries receives considerable attention due to its importance in many engineering applications. It has been the subject of interest for many researchers. Some of these interests include the design of storm water channels. The design of these channels requires testing through physical models. The main practical limitation of physical models is the so called “scale effect”, that is, the fact that in many cases only primary physical mechanisms can be correctly represented, while secondary mechanisms are often distorted. These observations form the basis of our study, which centered on problems associated with the design of storm water channels near the Dead Sea, in Israel. To help reach a final design decision we used different physical models. Our research showed good coincidence with the results of laboratory tests and theoretical calculations, and allowed us to study different effects of fluid flow in an open channel. We determined that problems of this nature cannot be solved only by means of theoretical calculation and computer simulation. This study demonstrates the use of physical models to help resolve very complicated problems of fluid flow through baffles and similar structures. The study applies these models and observations to different construction and multiphase water flows, among them, those that include sand and stone particles, a significant attempt to bring to the testing laboratory a closer association with reality.
Abstract: The use of low quality concrete has been identified as one of the main causes of the incessant collapse of buildings in Nigeria. Emphasis has been on the use of poor quality aggregates, poor workmanship and the use of lean concrete mix with low cement quantity as the reasons for the low quality of concrete used for building construction in Nigeria. Surveys conducted revealed that in the construction of most privately owned buildings where concrete trial mixes and concrete compressive strength quality assurance tests are not conducted, concretes used for building constructions are produced using the 1:2:4 mix ratio irrespective of the cement grade/strength class. In this paper, the possible role of the use of inappropriate cement grade/strength class as a cause of the incessant collapse of building in Nigeria is investigated. Investigation revealed that the compressive strengths of concrete cubes produced with Portland-limestone cement grade 32.5 using 1:2:4 and 1:1.5:3 mix ratios are less than the 25MPa and 30MPa cube strengths generally recommended for building superstructures and foundations respectively. Conversely, the compressive strengths of concrete cubes produced with Portland-limestone cement grade 42.5 using 1:2:4 and 1:1.5:3 mix ratios exceed the 25MPa and 30MPa generally recommended for building superstructures and foundations respectively. Thus, it can be concluded that the use of inappropriate cement grade (Portland-limestone cement grade 32.5), particularly for the construction of building foundations is a potential cause of the incessant collapse of buildings in Nigeria. It is recommended that the Standards Organisation of Nigeria should embark on creating awareness for Nigerians, particularly, the home owners and the roadside craftsmen that Portland-limestone cement grade 32.5 should not be used for the construction of building load-carrying members, particularly, building foundations in order to reduce the incessant incidence of collapsed building.
Abstract: The commercial sandcrete block makers in Nigeria use the same cement-sand mix ratio for sandcrete blocks production irrespective of the cement grade. Investigation revealed that the compressive strengths of hollow sandcrete blocks produced with Portland-limestone cement grade 42.5 are higher than the sandcrete blocks produced with cement grade 32.5. The use of stronger sandcrete blocks produced with cement grade 42.5 will ensure the construction of stronger buildings and other sandcrete blocks-based infrastructures and reduce the incessant failure of building and other sandcrete blocks-based infrastructures in Nigeria at no additional cost as both cement grades cost the same amount in Nigeria. It is recommended that the Standards Organisation of Nigeria should create grassroots awareness on the different cement grades in Nigeria and specify that Portland-limestone cement grade 42.5 be used for sandcrete blocks production.
Abstract: Utilizing solar energy in producing electricity can minimize environmental pollution generated by fossil fuel in producing electricity. Our research was base on the extraction of dye from Roystonea regia fruit by using methanol as solvent. The dye extracts were used as sensitizers in Dye-sensitized solar cell (DSSCs). Study was done on the electrical properties from the extracts of Roystonea regia fruit as Dye-sensitized solar cell (DSSCs). The absorptions of the extracts and extracts with dye were determined at different wavelengths (350-1000nm). Absorption peak was observed at 1.339 at wavelength 400nm. The obtained values for methanol extract Roystonea regia extract are, Imp = 0.015mA, Vmp = 12.0mV, fill factor = 0.763, Isc= 0.018 mA and Voc = 13.1 mV and efficiency of 0.32%. .The phytochemical screening was taken and it was observed that Roystonea regia extract contained less of anthocyanin compared to flavonoids. The nanostructured dye sensitized solar cell (DSSC) will provide economically credible alternative to present day silicon p–n junction photovoltaic.
Abstract: Stoneware clay, fired clay (as a grog), calcite waste and class C fly ash in various mixing rations were the basic raw materials for the mixture for production of dry pressed ceramic tiles. Mechanical properties (water absorption, bulk density, apparent porosity, flexural strength) as well as mineralogical composition were studied on samples with different source of calcium oxide after firing at 900, 1000, 1100 and 1200°C. It was found that samples with addition of calcite waste contain dmisteinbergit and anorthite. This minerals help to improve the strength of the body and reduce porosity fired at lower temperatures. Class C fly ash has not significantly influence on properties of the fired body as calcite waste.