Abstract: Aurein 1.2 is a 13-residue amphipathic peptide with antibacterial and anticancer activity. Aurein1.2 and its retro analog were synthesized to study the activity of the peptides in relation to their structure. The antibacterial test result showed the retro-analog is inactive. The secondary structural analysis by CD spectra indicated that both of the peptides at TFE/Water adopt alpha-helical conformation. MD simulation was performed on aurein 1.2 and retro-analog in water and TFE in order to analyse the factors that are involved in the activity difference between retro and the native peptide. The simulation results are discussed and validated in the light of experimental data from the CD experiment. Both of the peptides showed a relatively similar pattern for their hydrophobicity, hydrophilicity, solvent accessible surfaces, and solvent accessible hydrophobic surfaces. However, they showed different in directions of dipole moment of peptides. Also, Our results further indicate that the reversion of the amino acid sequence affects flexibility .The data also showed that factors causing structural rigidity may decrease the activity. Consequently, our finding suggests that in the case of sequence-reversed peptide strategy, one has to pay attention to the role of amino acid sequence order in making flexibility and role of dipole moment direction in peptide activity. KeywordsAntimicrobial peptides, retro, molecular dynamic, circular dichroism.
Abstract: A new deployment of the multiple criteria decision
making (MCDM) techniques: the Simple Additive Weighting
(SAW), and the Technique for Order Preference by Similarity to
Ideal Solution (TOPSIS) for portfolio allocation, is demonstrated in
this paper. Rather than exclusive reference to mean and variance as in
the traditional mean-variance method, the criteria used in this
demonstration are the first four moments of the portfolio distribution.
Each asset is evaluated based on its marginal impacts to portfolio
higher moments that are characterized by trapezoidal fuzzy numbers.
Then centroid-based defuzzification is applied to convert fuzzy
numbers to the crisp numbers by which SAW and TOPSIS can be
deployed. Experimental results suggest the similar efficiency of these
MCDM approaches to selecting dominant assets for an optimal
portfolio under higher moments. The proposed approaches allow
investors flexibly adjust their risk preferences regarding higher
moments via different schemes adapting to various (from
conservative to risky) kinds of investors. The other significant
advantage is that, compared to the mean-variance analysis, the
portfolio weights obtained by SAW and TOPSIS are consistently
well-diversified.
Abstract: In this paper, at first we explain about negative
hypergeometric distribution and its properties. Then we use the w-function
and the Stein identity to give a result on the poisson
approximation to the negative hypergeometric distribution in terms of the total variation distance between the negative hypergeometric and
poisson distributions and its upper bound.
Abstract: A person-to-person information sharing is easily realized
by P2P networks in which servers are not essential. Leakage
of information, which are caused by malicious accesses for P2P
networks, has become a new social issues. To prevent information
leakage, it is necessary to detect and block traffics of P2P software.
Since some P2P softwares can spoof port numbers, it is difficult to
detect the traffics sent from P2P softwares by using port numbers.
It is more difficult to devise effective countermeasures for detecting
the software because their protocol are not public.
In this paper, a discriminating method of network applications
based on communication characteristics of application messages
without port numbers is proposed. The proposed method is based
on an assumption that there can be some rules about time intervals
to transmit messages in application layer and the number of necessary
packets to send one message. By extracting the rule from network
traffic, the proposed method can discriminate applications without
port numbers.
Abstract: This research was conducted in the Pua Watershed whereas located in the Upper Nan River Basin in Nan province, Thailand. Nan River basin originated in Nan province that comprises of many tributary streams to produce as inflow to the Sirikit dam provided huge reservoir with the storage capacity of 9510 million cubic meters. The common problems of most watersheds were found i.e. shortage water supply for consumption and agriculture utilizations, deteriorate of water quality, flood and landslide including debris flow, and unstable of riverbank. The Pua Watershed is one of several small river basins that flow through the Nan River Basin. The watershed includes 404 km2 representing the Pua District, the Upper Nan Basin, or the whole Nan River Basin, of 61.5%, 18.2% or 1.2% respectively. The Pua River is a main stream producing all year streamflow supplying the Pua District and an inflow to the Upper Nan Basin. Its length approximately 56.3 kilometers with an average slope of the channel by 1.9% measured. A diversion weir namely Pua weir bound the plain and mountainous areas with a very steep slope of the riverbed to 2.9% and drainage area of 149 km2 as upstream watershed while a mild slope of the riverbed to 0.2% found in a river reach of 20.3 km downstream of this weir, which considered as a gauged basin. However, the major branch streams of the Pua River are ungauged catchments namely: Nam Kwang and Nam Koon with the drainage area of 86 and 35 km2 respectively. These upstream watersheds produce runoff through the 3-streams downstream of Pua weir, Jao weir, and Kang weir, with an averaged annual runoff of 578 million cubic meters. They were analyzed using both statistical data at Pua weir and simulated data resulted from the hydrologic modeling system (HEC–HMS) which applied for the remaining ungauged basins. Since the Kwang and Koon catchments were limited with lack of hydrological data included streamflow and rainfall. Therefore, the mathematical modeling: HEC-HMS with the Snyder-s hydrograph synthesized and transposed methods were applied for those areas using calibrated hydrological parameters from the upstream of Pua weir with continuously daily recorded of streamflow and rainfall data during 2008-2011. The results showed that the simulated daily streamflow and sum up as annual runoff in 2008, 2010, and 2011 were fitted with observed annual runoff at Pua weir using the simple linear regression with the satisfied correlation R2 of 0.64, 062, and 0.59, respectively. The sensitivity of simulation results were come from difficulty using calibrated parameters i.e. lag-time, coefficient of peak flow, initial losses, uniform loss rates, and missing some daily observed data. These calibrated parameters were used to apply for the other 2-ungauged catchments and downstream catchments simulated.
Abstract: The purpose of the research was to determine
effectiveness of habilitation of preschool children with cerebral palsy
in the process of pedagogical support of their families. The author
presents the study of psychology-pedagogical problems of families
with preschool children with cerebral palsy and the universal
program of pedagogical support of families. In the conclusion, the
author determines effectiveness of social adaptation of children with
cerebral palsy and their families.
Abstract: This paper presents a finite point method based on
directional derivatives for diffusion equation on 2D scattered points.
To discretize the diffusion operator at a given point, a six-point stencil
is derived by employing explicit numerical formulae of directional
derivatives, namely, for the point under consideration, only five
neighbor points are involved, the number of which is the smallest for
discretizing diffusion operator with first-order accuracy. A method for
selecting neighbor point set is proposed, which satisfies the solvability
condition of numerical derivatives. Some numerical examples are
performed to show the good performance of the proposed method.
Abstract: Multi-user interference (MUI) is the main reason of system deterioration in the Spectral Amplitude Coding Optical Code Division Multiple Access (SAC-OCDMA) system. MUI increases with the number of simultaneous users, resulting into higher probability bit rate and limits the maximum number of simultaneous users. On the other hand, Phase induced intensity noise (PIIN) problem which is originated from spontaneous emission of broad band source from MUI severely limits the system performance should be addressed as well. Since the MUI is caused by the interference of simultaneous users, reducing the MUI value as small as possible is desirable. In this paper, an extensive study for the system performance specified by MUI and PIIN reducing is examined. Vectors Combinatorial (VC) codes families are adopted as a signature sequence for the performance analysis and a comparison with reported codes is performed. The results show that, when the received power increases, the PIIN noise for all the codes increases linearly. The results also show that the effect of PIIN can be minimized by increasing the code weight leads to preserve adequate signal to noise ratio over bit error probability. A comparison study between the proposed code and the existing codes such as Modified frequency hopping (MFH), Modified Quadratic- Congruence (MQC) has been carried out.
Abstract: The self-organizing map (SOM) model is a well-known neural network model with wide spread of applications. The main characteristics of SOM are two-fold, namely dimension reduction and topology preservation. Using SOM, a high-dimensional data space will be mapped to some low-dimensional space. Meanwhile, the topological relations among data will be preserved. With such characteristics, the SOM was usually applied on data clustering and visualization tasks. However, the SOM has main disadvantage of the need to know the number and structure of neurons prior to training, which are difficult to be determined. Several schemes have been proposed to tackle such deficiency. Examples are growing/expandable SOM, hierarchical SOM, and growing hierarchical SOM. These schemes could dynamically expand the map, even generate hierarchical maps, during training. Encouraging results were reported. Basically, these schemes adapt the size and structure of the map according to the distribution of training data. That is, they are data-driven or dataoriented SOM schemes. In this work, a topic-oriented SOM scheme which is suitable for document clustering and organization will be developed. The proposed SOM will automatically adapt the number as well as the structure of the map according to identified topics. Unlike other data-oriented SOMs, our approach expands the map and generates the hierarchies both according to the topics and their characteristics of the neurons. The preliminary experiments give promising result and demonstrate the plausibility of the method.
Abstract: A new code for spectral-amplitude coding optical
code-division multiple-access system is proposed called Random
diagonal (RD) code. This code is constructed using code segment and
data segment. One of the important properties of this code is that the
cross correlation at data segment is always zero, which means that
Phase Intensity Induced Noise (PIIN) is reduced. For the performance
analysis, the effects of phase-induced intensity noise, shot noise, and
thermal noise are considered simultaneously. Bit-error rate (BER)
performance is compared with Hadamard and Modified Frequency
Hopping (MFH) codes. It is shown that the system using this new
code matrices not only suppress PIIN, but also allows larger number
of active users compare with other codes. Simulation results shown
that using point to point transmission with three encoded channels,
RD code has better BER performance than other codes, also its found
that at 0 dbm PIIN noise are 10-10 and 10-11 for RD and MFH
respectively.
Abstract: An adaptive spatial Gaussian mixture model is proposed for clustering based color image segmentation. A new clustering objective function which incorporates the spatial information is introduced in the Bayesian framework. The weighting parameter for controlling the importance of spatial information is made adaptive to the image content to augment the smoothness towards piecewisehomogeneous region and diminish the edge-blurring effect and hence the name adaptive spatial finite mixture model. The proposed approach is compared with the spatially variant finite mixture model for pixel labeling. The experimental results with synthetic and Berkeley dataset demonstrate that the proposed method is effective in improving the segmentation and it can be employed in different practical image content understanding applications.
Abstract: A way of achieving nanodimentional structural elements in high carbon steel by special kind of heat treatment and cold plastic deformation is being explored. This leads to increasing interlamellar spacing of ferrite-carbide mixture. Decreasing the interlamellar spacing with cooling temperature increasing is determined. Experiments confirm such interlamellar spacing with which high carbon steel demonstrates the highest treatment and hardening capability. Total deformation degree effect on interlamellar spacing value in a ferrite-carbide mixture is obtained. Mechanical experiments results show that high carbon steel after heat treatment and repetitive cold plastic deformation possesses high tensile strength and yield strength keeping good percentage elongation.
Abstract: Transcription factor p53 has a powerful tumor
suppressing function that is associated with many cancers. However,
p53 of the molecular weight was higher make the limitation across to
skin or cell membrane. Thymidine dinucleotide (pTT), an
oligonucleotide, can activate the p53 transcription factor. pTT is a
hydrophilic and negative charge oligonucleotide, which delivery in to
cell membrane need an appropriate carrier. The aim of this study was
to improve the bioavailability of the nucleotide fragment, thymidine
dinucleotide (pTT), using elasic liposome carriers to deliver the drug
into the skin. The study demonstrate that dioleoylphosphocholine
(DOPC) incorporated with sodium cholate at molar ratio 1:1 can
archived the particle size about 220 nm. This elastic liposome could
penetration through skin from stratum corneum to whole epidermis by
confocal laser scanning microscopy (CLSM). Moreover, we observed
the the slight increase in generation of p53 by western blot.
Abstract: In this paper, we have focused on study of swelling kinetics and salt-sensitivity behavior of a superabsorbing hydrogel based on carboxymethylcellulose (CMC) and acrylic acid and 2- Buthyl methacrylate. The swelling kinetics of the hydrogels with various particle sizes was preliminary investigated as well. The swelling of the hydrogel showed a second order kinetics of swelling in water. In addition, swelling measurements of the synthesized hydrogels in various chloride salt solutions was measured. Results indicated that a swelling-loss with an increase in the ionic strength of the salt solutions.
Abstract: Groundwater is one of the most important water
resources in Fars province. Based on this study, 95 percent of the
total annual water consumption in Fars is used for agriculture,
whereas the percentages for domestic and industrial uses are 4 and 1
percent, respectively. Population growth, urban and industrial
growth, and agricultural development in Fars have created a
condition of water stress. In this province, farmers and other users are
pumping groundwater faster than its natural replenishment rate,
causing a continuous drop in groundwater tables and depletion of this
resource. In this research variation of groundwater level, their effects
and ways to help control groundwater levels in aquifer of the Kavar-
Maharloo plains in Fars plain were evaluated .Excessive
exploitation of groundwater in this aquifer caused the groundwater
levels fall too fast or to unacceptable levels. The average drawdown
of the groundwater level in this plain were 17 meters during
1995 to 2006. The purpose of this study is to evaluate water level
changes in the Kavar-Maharloo Aquifer in the Fars province in order
to determine the areas of greatest depletion, the cause of depletion,
and predict the remaining life of the aquifer.
Abstract: Vibration of thin cylindrical shells made of a
functionally gradient material composed of stainless steel and nickel
is presented. The effects of the FGM configuration are studied by
studying the frequencies of FG cylindrical shells. In this case FG
cylindrical shell has Nickel on its outer surface and stainless steel on
its inner surface. The study is carried out based on third order shear
deformation shell theory. The objective is to study the natural
frequencies, the influence of constituent volume fractions and the
effects of configurations of the constituent materials on the
frequencies. The properties are graded in the thickness direction
according to the volume fraction power-law distribution. Results are
presented on the frequency characteristics, the influence of the
constituent various volume fractions on the frequencies.
Abstract: A parallel block method based on Backward
Differentiation Formulas (BDF) is developed for the parallel solution
of stiff Ordinary Differential Equations (ODEs). Most common
methods for solving stiff systems of ODEs are based on implicit
formulae and solved using Newton iteration which requires repeated
solution of systems of linear equations with coefficient matrix, I -
hβJ . Here, J is the Jacobian matrix of the problem. In this paper,
the matrix operations is paralleled in order to reduce the cost of the
iterations. Numerical results are given to compare the speedup and
efficiency of parallel algorithm and that of sequential algorithm.
Abstract: This paper deals with e-government issues at several
levels. Initially we look at the concept of e-government itself in order
to give it a sound framework. Than we look at the e-government
issues at three levels, first we analyse it at the global level, second we
analyse it at the level of transition economies, and finally we take a
closer look on developments in Croatia. The analysis includes actual
progress being made in selected transition economies given the Euro
area averages, along with e-government potential in future
demanding period.
Abstract: Explosive forming is one of the unconventional
techniques in which, most commonly, the water is used as the
pressure transmission medium. One of the newest methods in
explosive forming is gas detonation forming which uses a normal
shock wave derived of gas detonation, to form sheet metals. For this
purpose a detonation is developed from the reaction of H2+O2
mixture in a long cylindrical detonation tube. The detonation wave
goes through the detonation tube and acts as a blast load on the steel
blank and forms it. Experimental results are compared with a finite
element model; and the comparison of the experimental and
numerical results obtained from strain, thickness variation and
deformed geometry is carried out. Numerical and experimental
results showed approximately 75 – 90 % similarity in formability of
desired shape. Also optimum percent of gas mixture obtained when
we mix 68% H2 with 32% O2.
Abstract: This paper presents preliminary results on modeling
and control of a quadrotor UAV. With aerodynamic concepts, a
mathematical model is firstly proposed to describe the dynamics
of the quadrotor UAV. Parameters of this model are identified by
experiments with Matlab Identify Toolbox. A group of PID controllers
are then designed based on the developed model. To verify
the developed model and controllers, simulations and experiments for
altitude control, position control and trajectory tracking are carried
out. The results show that the quadrotor UAV well follows the
referenced commands, which clearly demonstrates the effectiveness
of the proposed approach.