Abstract: Sense-antisense gene pair (SAGP) is a pair of two oppositely transcribed genes sharing a common region on a chromosome. In the mammalian genomes, SAGPs can be organized in more complex sense-antisense gene architectures (CSAGA) in which at least one gene could share loci with two or more antisense partners. Many dozens of CSAGAs can be found in the human genome. However, CSAGAs have not been systematically identified and characterized in context of their role in human diseases including cancers. In this work we characterize the structural-functional properties of a cluster of 5 genes –TMEM97, IFT20, TNFAIP1, POLDIP2 and TMEM199, termed TNFAIP1 / POLDIP2 module. This cluster is organized as CSAGA in cytoband 17q11.2. Affymetrix U133A&B expression data of two large cohorts (410 atients, in total) of breast cancer patients and patient survival data were used. For the both studied cohorts, we demonstrate (i) strong and reproducible transcriptional co-regulatory patterns of genes of TNFAIP1/POLDIP2 module in breast cancer cell subtypes and (ii) significant associations of TNFAIP1/POLDIP2 CSAGA with amplification of the CSAGA region in breast cancer, (ii) cancer aggressiveness (e.g. genetic grades) and (iv) disease free patient-s survival. Moreover, gene pairs of this module demonstrate strong synergetic effect in the prognosis of time of breast cancer relapse. We suggest that TNFAIP1/ POLDIP2 cluster can be considered as a novel type of structural-functional gene modules in the human genome.
Abstract: In this study the mixed mode fracture mechanics
parameters were investigated for high tensile steel butt welded joint
based on modified Arcan test and finite element analysis was used to
evaluate the effect of crack length on fracture criterion. The nondimensional
stress intensity factors, strain energy release rates and Jintegral
energy on crack tip were obtained for various in-plane
loading combinations on Arcan specimen starting from pure mode-I
to pure mode-II loading conditions. The specimen and apparatus were
modeled by finite element method and analyzed under various
loading angles (between 0 to 90 degrees with 15 degree interval) to
simulate the pure mode-I, II and mixed mode fracture. Since the
analytical results are independent from elasticity modules for
isotropic materials, therefore the results in elastic fields can be used
for Arcan specimens. The main objective of this study was to
evaluate the geometric calibration factors for modified Arcan test
specimen in order to obtain fracture toughness under mixed mode
loading conditions.
Abstract: In this paper, the requirement for Coke quality
prediction, its role in Blast furnaces, and the model output is
explained. By applying method of Artificial Neural Networking
(ANN) using back propagation (BP) algorithm, prediction model has
been developed to predict CSR. Important blast furnace functions
such as permeability, heat exchanging, melting, and reducing
capacity are mostly connected to coke quality. Coke quality is further
dependent upon coal characterization and coke making process
parameters. The ANN model developed is a useful tool for process
experts to adjust the control parameters in case of coke quality
deviations. The model also makes it possible to predict CSR for new
coal blends which are yet to be used in Coke Plant. Input data to the
model was structured into 3 modules, for tenure of past 2 years and
the incremental models thus developed assists in identifying the
group causing the deviation of CSR.
Abstract: The paper proposes an approach for design of modular
systems based on original technique for modeling and formulation of
combinatorial optimization problems. The proposed approach is
described on the example of personal computer configuration design.
It takes into account the existing compatibility restrictions between
the modules and can be extended and modified to reflect different
functional and users- requirements. The developed design modeling
technique is used to formulate single objective nonlinear mixedinteger
optimization tasks. The practical applicability of the
developed approach is numerically tested on the basis of real modules
data. Solutions of the formulated optimization tasks define the
optimal configuration of the system that satisfies all compatibility
restrictions and user requirements.
Abstract: This paper addresses the problems encountered by conventional distance relays when protecting double-circuit transmission lines. The problems arise principally as a result of the mutual coupling between the two circuits under different fault conditions; this mutual coupling is highly nonlinear in nature. An adaptive protection scheme is proposed for such lines based on application of artificial neural network (ANN). ANN has the ability to classify the nonlinear relationship between measured signals by identifying different patterns of the associated signals. One of the key points of the present work is that only current signals measured at local end have been used to detect and classify the faults in the double circuit transmission line with double end infeed. The adaptive protection scheme is tested under a specific fault type, but varying fault location, fault resistance, fault inception angle and with remote end infeed. An improved performance is experienced once the neural network is trained adequately, which performs precisely when faced with different system parameters and conditions. The entire test results clearly show that the fault is detected and classified within a quarter cycle; thus the proposed adaptive protection technique is well suited for double circuit transmission line fault detection & classification. Results of performance studies show that the proposed neural network-based module can improve the performance of conventional fault selection algorithms.
Abstract: Mechanical design of the thin-film solar framed
module and mounting system is important to enhance module
reliability and to increase areas of applications. The stress induced by
different mounting positions played a main role controlling the
stability of the whole mechanical structure. From the finite element
method, under the pressure from the back of module, the stress at Lc
(center point of the Long frame) increased and the stresses at Center,
Corner and Sc (center point of the Short frame) decreased while the
mounting position was away from the center of the module. In addition,
not only the stress of the glass but also the stress of the frame
decreased. Accordingly it was safer to mount in the position away
from the center of the module. The emphasis of designing frame
system of the module was on the upper support of the Short frame.
Strength of the overall structure and design of the corner were also
important due to the complexity of the stress in the Long frame.
Abstract: In this paper we present an efficient method for inverting an ideal in the ideal class group of a Cab curve by extending the method which is presented in [3]. More precisely we introduce a useful generator for the inverse ideal as a K[X]-module.
Abstract: MATCH project [1] entitle the development of an
automatic diagnosis system that aims to support treatment of colon
cancer diseases by discovering mutations that occurs to tumour
suppressor genes (TSGs) and contributes to the development of
cancerous tumours. The constitution of the system is based on a)
colon cancer clinical data and b) biological information that will be
derived by data mining techniques from genomic and proteomic
sources The core mining module will consist of the popular, well
tested hybrid feature extraction methods, and new combined
algorithms, designed especially for the project. Elements of rough
sets, evolutionary computing, cluster analysis, self-organization maps
and association rules will be used to discover the annotations
between genes, and their influence on tumours [2]-[11].
The methods used to process the data have to address their high
complexity, potential inconsistency and problems of dealing with the
missing values. They must integrate all the useful information
necessary to solve the expert's question. For this purpose, the system
has to learn from data, or be able to interactively specify by a domain
specialist, the part of the knowledge structure it needs to answer a
given query. The program should also take into account the
importance/rank of the particular parts of data it analyses, and adjusts
the used algorithms accordingly.
Abstract: Let R be a ring and n a fixed positive integer, we
investigate the properties of n-strongly Gorenstein projective, injective
and flat modules. Using the homological theory , we prove that
the tensor product of an n-strongly Gorenstein projective (flat) right
R -module and projective (flat) left R-module is also n-strongly
Gorenstein projective (flat). Let R be a coherent ring ,we prove that
the character module of an n -strongly Gorenstein flat left R -module
is an n-strongly Gorenstein injective right R -module . At last, let
R be a commutative ring and S a multiplicatively closed set of R ,
we establish the relation between n -strongly Gorenstein projective
(injective , flat ) R -modules and n-strongly Gorenstein projective
(injective , flat ) S−1R-modules. All conclusions in this paper is
helpful for the research of Gorenstein dimensions in future.
Abstract: In the past few years there is a change in the view of high performance applications and parallel computing. Initially such applications were targeted towards dedicated parallel machines. Recently trend is changing towards building meta-applications composed of several modules that exploit heterogeneous platforms and employ hybrid forms of parallelism. The aim of this paper is to propose a model of virtual parallel computing. Virtual parallel computing system provides a flexible object oriented software framework that makes it easy for programmers to write various parallel applications.
Abstract: We present a new approach to evaluation of Cyber Security in Power Systems using the method of modeling the power systems Infrastructure using software agents. Interfaces between module and the home smart meter are recognized as the primary points of intrusion.
Abstract: Many environment specific methods and systems for Robot Navigation exist. However vast strides in the evolution of navigation technologies and system techniques create the need for a general unified framework that is scalable, modular and dynamic. In this paper a Unified Framework for a Robust Conflict-free Robot Navigation System that can be used for either a structured or unstructured and indoor or outdoor environments has been proposed. The fundamental design aspects and implementation issues encountered during the development of the module are discussed. The results of the deployment of three major peripheral modules of the framework namely the GSM based communication module, GIS Module and GPS module are reported in this paper.
Abstract: The current education system in India is adept in
equipping and assessing the scholastic development of children.
However, there is an immediate need to strengthen co-scholastic
areas like life-skills, values and attitudes to equip students to face real
life challenges. Audio-visual technology and their respective media
can make a significant contribution to a value based learning
curriculum. Thus, co-scholastic skills need to be effectively nurtured
by a medium that is entertaining and impactful. Films in general have
a tremendous impact in our society. Films with a positive message
make a formidable learning experience that can influence and inspire
generations of learners. Leveraging on this powerful medium,
EduMedia India Pvt. Ltd. has introduced School Cinema a well
researched film-based learning module supported by a fun and
exciting workbook, designed to introduce and reaffirm life-skills and
values to children, thereby having a positive influence on their
attitudes.
Abstract: In this paper a low cost knowledge base system (KBS)
framework is proposed for design of deep drawing die and procedure
for developing system modules. The task of building the system is
structured into different modules for major activities of design of
deep drawing die. A manufacturability assessment module of the
proposed framework is developed to check the manufacturability of
deep drawn parts. The technological knowledge is represented by
using IF- THEN rules and it is coded in AutoLISP language. The
module is designed to be loaded into the prompt area of AutoCAD.
The cost of implementation of proposed system makes it affordable
for small and medium scale sheet metal industries.
Abstract: The article presents a new method for detection of
artificial objects and materials from images of the environmental
(non-urban) terrain. Our approach uses the hue and saturation (or Cb
and Cr) components of the image as the input to the segmentation
module that uses the mean shift method. The clusters obtained as the
output of this stage have been processed by the decision-making
module in order to find the regions of the image with the significant
possibility of representing human. Although this method will detect
various non-natural objects, it is primarily intended and optimized for
detection of humans; i.e. for search and rescue purposes in non-urban
terrain where, in normal circumstances, non-natural objects shouldn-t
be present. Real world images are used for the evaluation of the
method.
Abstract: Data Structures and Algorithms is a module in most
Computer Science or Information Technology curricula. It is one of
the modules most students identify as being difficult. This paper
demonstrates how programming a solution for Sudoku can make
abstract concepts more concrete. The paper relates concepts of a
typical Data Structures and Algorithms module to a step by step
solution for Sudoku in a human type as opposed to a computer
oriented solution.
Abstract: This paper presents one of the best applications of wireless sensor network for campus Monitoring. With the help of PIR sensor, temperature sensor and humidity sensor, effective utilization of energy resources has been implemented in one of rooms of Sharda University, Greater Noida, India. The RISC microcontroller is used here for analysis of output of sensors and providing proper control using ZigBee protocol. This wireless sensor module presents a tremendous power saving method for any campus
Abstract: In contrast to existing methods which do not take into account multiconnectivity in a broad sense of this term, we develop mathematical models and highly effective combination (BIEM and FDM) numerical methods of calculation of stationary and quasistationary temperature field of a profile part of a blade with convective cooling (from the point of view of realization on PC). The theoretical substantiation of these methods is proved by appropriate theorems. For it, converging quadrature processes have been developed and the estimations of errors in the terms of A.Ziqmound continuity modules have been received. For visualization of profiles are used: the method of the least squares with automatic conjecture, device spline, smooth replenishment and neural nets. Boundary conditions of heat exchange are determined from the solution of the corresponding integral equations and empirical relationships. The reliability of designed methods is proved by calculation and experimental investigations heat and hydraulic characteristics of the gas turbine first stage nozzle blade.
Abstract: In this paper, we present the recently implemented approach allowing dynamics systems to plan its actions, taking into account the environment perception changes, and to control their execution when uncertainty and incomplete knowledge are the major characteristics of the situated environment [1],[2],[3],[4]. The control distributed architecture has three modules and the approach is related to hierarchical planning: the plan produced by the planner is further refined at the control layer that in turn supervises its execution by a functional level. We propose a new intelligent distributed architecture constituted by: Multi-Agent subsystem of the sensor, of the interpretation and representation of environment [9], of the dynamic localization and of the action. We tested this distributed architecture with dynamic system in the known environment. The autonomous for Rotor Mini Rotorcraft task is described by the primitive actions. The distributed controlbased on multi-agent system is in charge of achieving each task in the best possible way taking into account the context and sensory feedback.
Abstract: This study is about an application of King Bhumibol
Adulyadej’s “Learn Wisely” (LW) concept in instructional design
and management process at the Faculty of Education, Suan Sunahdha
Rajabhat University. The concept suggests four strategies for true
learning. Related literature and significant LW methods in teaching
and learning are also reviewed and then applied in designing a
pedagogy learning module. The design has been implemented in
three classrooms with a total of 115 sophomore student teachers.
After one consecutive semester of managing and adjusting the
process by instructors and experts using collected data from minutes,
assessment of learning management, satisfaction and learning
achievement of the students, it is found that the effective SSRU
model of LW instructional method comprises of five steps.