Abstract: Most of the drugs used for pharmaceutical purposes
are poorly water-soluble drugs. About 40% of all newly discovered
drugs are lipophilic and the numbers of lipophilic drugs seem to
increase more and more. Drug delivery systems such as
nanoparticles, micelles or liposomes are applied to improve their
solubility and thus their bioavailability. Besides various techniques of
solubilization, oil-in-water emulsions are often used to incorporate
lipophilic drugs into the oil phase. To stabilize emulsions surface
active substances (surfactants) are generally used. An alternative
method to avoid the application of surfactants was of great interest.
One possibility is to develop O/W-emulsion without any addition of
surface active agents or the so called “surfactant-free emulsion or
SFE”. The aim of this study was to develop and characterize SFE as a
drug carrier by varying the production conditions. Lidocaine base
was used as a model drug. The injection method was developed.
Effects of ultrasound as well as of temperature on the properties of
the emulsion were studied. Particle sizes and release were
determined. The long-term stability up to 30 days was performed.
The results showed that the surfactant-free O/W emulsions with
pharmaceutical oil as drug carrier can be produced.
Abstract: Polyphenolics and sugar are the components of many
fruit juices. In this work, the performance of ultra-filtration (UF) for
separating phenolic compounds from apple juice was studied by
performing batch experiments in a membrane module with an area of
0.1 m2 and fitted with a regenerated cellulose membrane of 1 kDa
MWCO. The effects of various operating conditions: transmembrane
pressure (3, 4, 5 bar), temperature (30, 35, 40 ºC), pH (2, 3, 4, 5),
feed concentration (3, 5, 7, 10, 15 ºBrix for apple juice) and feed flow
rate (1, 1.5, 1.8 L/min) on the performance were determined.
The optimum operating conditions were: transmembrane pressure
4 bar, temperature 30 ºC, feed flow rate 1 – 1.8 L/min, pH 3 and 10
Brix (apple juice). After performing ultrafiltration under these
conditions, the concentration of polyphenolics in retentate was
increased by a factor of up to 2.7 with up to 70% recovered in the
permeate and with approx. 20% of the sugar in that stream..
Application of diafiltration (addition of water to the concentrate) can
regain the flux by a factor of 1.5, which has been decreased due to
fouling. The material balance performed on the process has shown
the amount of deposits on the membrane and the extent of fouling in
the system. In conclusion, ultrafiltration has been demonstrated as a
potential technology to separate the polyphenolics and sugars from
their mixtures and can be applied to remove sugars from fruit juice.
Abstract: Three service providers in competition, try to optimize
their quality of service / content level and their service access
price. But, they have to deal with uncertainty on the consumers-
preferences. To reduce their uncertainty, they have the opportunity
to buy information and to build alliances. We determine the Shapley
value which is a fair way to allocate the grand coalition-s revenue
between the service providers. Then, we identify the values of β
(consumers- sensitivity coefficient to the quality of service / contents)
for which allocating the grand coalition-s revenue using the Shapley
value guarantees the system stability. For other values of β, we prove
that it is possible for the regulator to impose a per-period interest rate
maximizing the market coverage under equal allocation rules.
Abstract: Water 2H NMR signal on the surface of nano-silica material, MCM-41, consists of two overlapping resonances. The 2H water spectrum shows a superposition of a Lorentzian line shape and the familiar NMR powder pattern line shape, indicating the existence of two spin components. Chemical exchange occurs between these two groups. Decomposition of the two signals is a crucial starting point for study the exchange process. In this article we have determined these spin component populations along with other important parameters for the 2H water NMR signal over a temperature range between 223 K and 343 K.
Abstract: This paper proposes a Fuzzy Expert System design to
determine the wearing properties of nitrided and non nitrided steel.
The proposed Fuzzy Expert System approach helps the user and the
manufacturer to forecast the wearing properties of nitrided and non
nitrided steel under specified laboratory conditions. Surfaces of the
engineering components are often nitrided for improving wear,
corosion, fatigue specifications. A major property of nitriding
process is reducing distortion and wearing of the metalic alloys. A
Fuzzy Expert System was developed for determining the wearing and
durability properties of nitrided and non nitrided steels that were
tested under different loads and different sliding speeds in the
laboratory conditions.
Abstract: The ever increasing product diversity and competition on the market of goods and services has dictated the pace of growth in the number of advertisements. Despite their admittedly diminished effectiveness over the recent years, advertisements remain the favored method of sales promotion. Consequently, the challenge for an advertiser is to explore every possible avenue of making an advertisement more noticeable, attractive and impellent for consumers. One way to achieve this is through invoking celebrity endorsements. On the one hand, the use of a celebrity to endorse a product involves substantial costs, however, on the other hand, it does not immediately guarantee the success of an advertisement. The question of how celebrities can be used in advertising to the best advantage is therefore of utmost importance. Celebrity endorsements have become commonplace: empirical evidence indicates that approximately 20 to 25 per cent of advertisements feature some famous person as a product endorser. The popularity of celebrity endorsements demonstrates the relevance of the topic, especially in the context of the current global economic downturn, when companies are forced to save in order to survive, yet simultaneously to heavily invest in advertising and sales promotion. The issue of the effective use of celebrity endorsements also figures prominently in the academic discourse. The study presented below is thus aimed at exploring what qualities (characteristics) of a celebrity endorser have an impact on the ffectiveness of the advertisement in which he/she appears and how.
Abstract: Drought is natural and climate phenomenon and in fact server as a part of climate in an area and also it has significant environmental, social ,and economic consequences .drought differs from the other natural disasters from this viewpoint that it s a creeping phenomenon meaning that it progresses little and its difficult to determine the time of its onset and termination .most of the drought definitions are on based on precipitation shortage and consequently ,the shortage of water some of the activities related to the water such as agriculture In this research ,drought condition in Fars province was evacuated using SPI method within a 37 year – statistical –period(1974-2010)and maps related to the drought were prepared for each of the statistical period years. According to the results obtained from this research, the years 1974, 1976, 1975, 1982 with SPI (-1.03, 0.39, -1.05, -1.49) respectively, were the doughiest years and 1996,1997,2000 with SPI (2.49, 1.49, 1.46, 1.04) respectively, the most humid within the studying time series and the rest are in more normal conditions in the term of drought.
Abstract: This study proposes a new recommender system based on the collaborative folksonomy. The purpose of the proposed system is to recommend Internet resources (such as books, articles, documents, pictures, audio and video) to users. The proposed method includes four steps: creating the user profile based on the tags, grouping the similar users into clusters using an agglomerative hierarchical clustering, finding similar resources based on the user-s past collections by using content-based filtering, and recommending similar items to the target user. This study examines the system-s performance for the dataset collected from “del.icio.us," which is a famous social bookmarking website. Experimental results show that the proposed tag-based collaborative and content-based filtering hybridized recommender system is promising and effectiveness in the folksonomy-based bookmarking website.
Abstract: An experiment was conducted to examine the effect of the level of performance stabilization on the human adaptability to perceptual-motor perturbation in a complex coincident timing task. Three levels of performance stabilization were established operationally: pre-stabilization, stabilization, and super-stabilization groups. Each group practiced the task until reached its level of stabilization in a constant sequence of movements and under a constant time constraint before exposure to perturbation. The results clearly showed that performance stabilization is a pre-condition for adaptation. Moreover, variability before reaching stabilization is harmful to adaptation and persistent variability after stabilization is beneficial. Moreover, the behavior of variability is specific to each measure.
Abstract: The article contains results of the flour and bread
quality assessment from the grains of spring spelt, also called as an
ancient wheat. Spelt was cultivated on heavy and medium soils
observing principles of organic farming. Based on flour and bread
laboratory studies, as well as laboratory baking, the technological
usefulness of studied flour has been determined. These results were
referred to the standard derived from common wheat cultivated in the
same conditions. Grain of spring spelt is a good raw material for
manufacturing bread flour, from which to get high-quality bakery
products, but this is strictly dependent on the variety of ancient
wheat.
Abstract: In this experimental study, performance of a counter
flow Ranque-Hilsch vortex tube (RHVT) with threads cut on its inner
surface was investigated experimentally (pitch is 1 and 2 mm). The
inner diameter of the vortex tube used was D=9 mm and the ratio of
the tube’s length to diameter was L/D=12. The experimental system
was a thermodynamic open system. Flow was controlled by a valve
on the hot outlet side, where the valve was changed from a nearly
closed position to its nearly open position. Fraction of cold flow (ξ) =
0.1-0.9, was determined under 300 and 350 kPa pressurized air. All
experimental data were compared with each other, the maximum
heating performance of the RHVT system was found to be 38.2 oC
and the maximum cooling performance of the RHVT in this study
was found to be -30.9 oC at pitch 1 mm.
Abstract: Tubular process equipment is often damaged in
industrial processes. The damage occurs both on devices working at
high temperatures and also on less exposed devices. In case of sudden
damage of key equipment a shutdown of the whole production unit
and resulting significant economic losses are imminent. This paper
presents a solution of several types of tubular process equipment. The
causes of damage and suggestions of correction actions are discussed
in all cases. Very important part is the analysis of operational
conditions, determination of unfavourable working states decreasing
lifetime of devices and suggestions of correction actions. Lately very
popular numerical methods are used for analysis of the equipment.
Abstract: This study examines the use of the persuasive strategy
of deixis and personalization in advertising slogans. This rhetorical/
stylistic and linguistic strategy has been found to be widely used in
advertising slogans for over a century. A total of five hundred
advertising slogans of multinational companies in both product and
service sectors were obtained. The analysis reveals the 3 main
components of this strategy as being deictic words, absolute
uniqueness and personal pronouns. The percentage and mean of the
use of the 3 components are tabulated. The findings show that
advertisers have used this persuasive strategy in creative ways to
persuade consumers to buy their products and services.
Abstract: The frontal area in the brain is known to be involved in
behavioral judgement. Because a Kanji character can be discriminated
visually and linguistically from other characters, in Kanji character
discrimination, we hypothesized that frontal event-related potential
(ERP) waveforms reflect two discrimination processes in separate
time periods: one based on visual analysis and the other based
on lexcical access. To examine this hypothesis, we recorded ERPs
while performing a Kanji lexical decision task. In this task, either a
known Kanji character, an unknown Kanji character or a symbol was
presented and the subject had to report if the presented character was
a known Kanji character for the subject or not. The same response
was required for unknown Kanji trials and symbol trials. As a preprocessing
of signals, we examined the performance of a method
using independent component analysis for artifact rejection and found
it was effective. Therefore we used it. In the ERP results, there
were two time periods in which the frontal ERP wavefoms were
significantly different betweeen the unknown Kanji trials and the
symbol trials: around 170ms and around 300ms after stimulus onset.
This result supported our hypothesis. In addition, the result suggests
that Kanji character lexical access may be fully completed by around
260ms after stimulus onset.
Abstract: This paper proposes a bi-objective model for the
facility location problem under a congestion system. The idea of the
model is motivated by applications of locating servers in bank
automated teller machines (ATMS), communication networks, and so
on. This model can be specifically considered for situations in which
fixed service facilities are congested by stochastic demand within
queueing framework. We formulate this model with two perspectives
simultaneously: (i) customers and (ii) service provider. The
objectives of the model are to minimize (i) the total expected
travelling and waiting time and (ii) the average facility idle-time.
This model represents a mixed-integer nonlinear programming
problem which belongs to the class of NP-hard problems. In addition,
to solve the model, two metaheuristic algorithms including nondominated
sorting genetic algorithms (NSGA-II) and non-dominated
ranking genetic algorithms (NRGA) are proposed. Besides, to
evaluate the performance of the two algorithms some numerical
examples are produced and analyzed with some metrics to determine
which algorithm works better.
Abstract: Precise frequency estimation methods for pulseshaped echoes are a prerequisite to determine the relative velocity between sensor and reflector. Signal frequencies are analysed using three different methods: Fourier Transform, Chirp ZTransform and the MUSIC algorithm. Simulations of echoes are performed varying both the noise level and the number of reflecting points. The superposition of echoes with a random initial phase is found to influence the precision of frequency estimation severely for FFT and MUSIC. The standard deviation of the frequency using FFT is larger than for MUSIC. However, MUSIC is more noise-sensitive. The distorting effect of superpositions is less pronounced in experimental data.
Abstract: Novel polystrene-bound Schiff bases and their Pt(IV)
complexes have been prepared from condensation reaction of
polystyrene-A-NH2 with 2-hydroxybenzaldehyde and 5-fluoro-3-
bromo-2-hydroxybenzaldehyde. The structures of Pt(IV) complexes
with polystyrene including Schiff bases have been determined by
elemental analyses, magnetic susceptibility, IR, 1H-NMR, UV-vis,
TG/DTA and AAS. The antibacterial and antifungal activities of the
synthesized compounds have been studied by the well-diffusion
method against some selected microorganisms: (Bacillus cereus spp.,
Listeria monocytogenes 4b, Micrococcus luteus, Staphylococcus
aureus, Staphylococcus epidermis, Brucella abortus, Escherichia
coli, Pseudomonas putida spp., Shigella dysenteria type 10,
Salmonella typhi H).
Abstract: Currently, many types of no-reversible compressed
sound source, represented by MP3 (MPEG Audio Layer-3) are
popular in the world and they are widely used to make the music file
size smaller. The sound data created in this way has less information as
compared to pre-compressed data. The objective of this study is by
analyzing EEG to determine if people can recognize such difference as
differences in sound. A measurement system that can measure and
analyze EEG when a subject listens to music were experimentally
developed. And ten subjects were studied with this system. In this
experiment, a WAVE formatted music data and a MP3 compressed
music data that is made from the WAVE formatted data were
prepared. Each subject was made to hear these music sources at the
same volume. From the results of this experiment, clear differences
were confirmed between two wound sources.
Abstract: Result of the study on knowledge management systems in businesses was shown that the most of these businesses provide internet accessibility for their employees in order to study new knowledge via internet, corporate website, electronic mail, and electronic learning system. These business organizations use information technology application for knowledge management because of convenience, time saving, ease of use, accuracy of information and knowledge usefulness. The result indicated prominent improvements for corporate knowledge management systems as the following; 1) administrations must support corporate knowledge management system 2) the goal of corporate knowledge management must be clear 3) corporate culture should facilitate the exchange and sharing of knowledge within the organization 4) cooperation of personnel of all levels must be obtained 5) information technology infrastructure must be provided 6) they must develop the system regularly and constantly.
Abstract: Kazakhstan attaches the great importance to
cooperation with European countries within the framework of
multilateral security organizations such as NATO. Cooperation of
Kazakhstan with the NATO is a prominent aspect of strengthening of
regional security of republic. It covers a wide spectrum of areas, such
as reform of sector of defense and security, military operative
compatibility of armed forces of NATO member-countries and
Kazakhstan, civil emergency planning and scientific cooperation. The
cooperation between Kazakhstan and NATO is based on the mutual
interests of neighboring republics in the region so that the existing
forms of cooperation between Kazakhstan and NATO will not be
negatively perceived both in Asia as well as among CIS countries.
Kazakhstan tailors its participation in the PfP programme through an
annual Individual Partnership Programme, selecting those activities
that will help achieve the goals it has set in the IPAP. Level of
cooperation within the limits of PfP essentially differs on each
republic. Cooperation with Kazakhstan progressed most of all since
has been signed IPAP from the NATO