Abstract: This study was aimed to measure effective transverse
relaxation rates (R2*) in the liver and muscle of normal New Zealand
White (NZW) rabbits. R2* relaxation rate has been widely used in
various hepatic diseases for iron overload by quantifying iron contents
in liver. R2* relaxation rate is defined as the reciprocal of T2*
relaxation time and mainly depends on the constituents of tissue.
Different tissues would have different R2* relaxation rates. The signal
intensity decay in Magnetic resonance imaging (MRI) may be
characterized by R2* relaxation rates. In this study, a 1.5T GE Signa
HDxt whole body MR scanner equipped with an 8-channel high
resolution knee coil was used to observe R2* values in NZW rabbit’s
liver and muscle. Eight healthy NZW rabbits weighted 2 ~ 2.5 kg were
recruited. After anesthesia using Zoletil 50 and Rompun 2% mixture,
the abdomen of rabbit was landmarked at the center of knee coil to
perform 3-plane localizer scan using fast spoiled gradient echo
(FSPGR) pulse sequence. Afterwards, multi-planar fast gradient echo
(MFGR) scans were performed with 8 various echo times (TEs) to
acquire images for R2* measurements. Regions of interest (ROIs) at
liver and muscle were measured using Advantage workstation.
Finally, the R2* was obtained by a linear regression of ln(sı) on TE.
The results showed that the longer the echo time, the smaller the signal
intensity. The R2* values of liver and muscle were 44.8 ± 10.9 s-1 and
37.4 ± 9.5 s-1, respectively. It implies that the iron concentration of
liver is higher than that of muscle. In conclusion, the more the iron
contents in tissue, the higher the R2*. The correlations between R2*
and iron content in NZW rabbits might be valuable for further
exploration.
Abstract: Noninvasive diagnostics of diseases via breath
analysis has attracted considerable scientific and clinical interest for
many years and become more and more promising with the rapid
advancements in nanotechnology and biotechnology. The volatile
organic compounds (VOCs) in exhaled breath, which are mainly
blood borne, particularly provide highly valuable information about
individuals’ physiological and pathophysiological conditions.
Additionally, breath analysis is noninvasive, real-time, painless, and
agreeable to patients. We have developed a wireless sensor array
based on single-stranded DNA (ssDNA)-functionalized single-walled
carbon nanotubes (SWNT) for the detection of a number of
physiological indicators in breath. Seven DNA sequences were used
to functionalize SWNT sensors to detect trace amount of methanol,
benzene, dimethyl sulfide, hydrogen sulfide, acetone, and ethanol,
which are indicators of heavy smoking, excessive drinking, and
diseases such as lung cancer, breast cancer, and diabetes. Our test
results indicated that DNA functionalized SWNT sensors exhibit
great selectivity, sensitivity, and repeatability; and different
molecules can be distinguished through pattern recognition enabled
by this sensor array. Furthermore, the experimental sensing results
are consistent with the Molecular Dynamics simulated ssDNAmolecular
target interaction rankings. Thus, the DNA-SWNT sensor
array has great potential to be applied in chemical or biomolecular
detection for the noninvasive diagnostics of diseases and personal
health monitoring.
Abstract: The importance of agribusiness development is
proved in accordance with the trends in the agricultural sector of
Georgia. Agribusiness environment and the consequences of the
agricultural reforms are evaluated. The factors hindering the
development of agribusiness are revealed and the ways for
overcoming these problems are suggested. SWOT analysis is done in
order to identify the needs of agribusiness. The needs of agribusiness
development in Georgia are evaluated by priorities: prevention of
diseases and reduction of the harm caused by these diseases,
accessibility of long-term agricultural loans with low interest rates,
improving qualification of farmers, the level of education and usage
of modern technologies, changes in legislation, accessibility to high
quality agricultural machinery, and the development of infrastructure.
Based on the outcomes of the research, agribusiness development
strategies in Georgia are suggested and appropriate priorities of
economic policy are determined. Conclusions are made and based on
these conclusions, some recommendations are suggested.
Abstract: Introduction: The process to build a better safety
culture, methods of error analysis, and preventive measures, starts
with an understanding of the effects when human factors engineering
refer to remote microscopic diagnosis in surgery and specially in
organ transplantation for the remote evaluation of the grafts. It has
been estimated that even in well-organized transplant systems an
average of 8% to 14% of the grafts (G) that arrive at the recipient
hospitals may be considered as diseased, injured, damaged or
improper for transplantation. Digital microscopy adds information on
a microscopic level about the grafts in Organ Transplant (OT), and
may lead to a change in their management. Such a method will
reduce the possibility that a diseased G, will arrive at the recipient
hospital for implantation. Aim: Ergonomics of Digital Microscopy
(DM) based on virtual slides, on Telemedicine Systems (TS) for
Tele-Pathological (TPE) evaluation of the grafts (G) in organ
transplantation (OT). Material and Methods: By experimental
simulation, the ergonomics of DM for microscopic TPE of Renal
Graft (RG), Liver Graft (LG) and Pancreatic Graft (PG) tissues is
analyzed. In fact, this corresponded to the ergonomics of digital
microscopy for TPE in OT by applying Virtual Slide (VS) system for
graft tissue image capture, for remote diagnoses of possible
microscopic inflammatory and/or neoplastic lesions. Experimentation
included: a. Development of an OTE-TS similar Experimental
Telemedicine System (Exp.-TS), b. Simulation of the integration of
TS with the VS based microscopic TPE of RG, LG and PG applying
DM. Simulation of the DM based TPE was performed by 2
specialists on a total of 238 human Renal Graft (RG), 172 Liver Graft
(LG) and 108 Pancreatic Graft (PG) tissues digital microscopic
images for inflammatory and neoplastic lesions on four electronic
spaces of the four used TS. Results: Statistical analysis of specialist‘s
answers about the ability to diagnose accurately the diseased RG, LG
and PG tissues on the electronic space among four TS (A,B,C,D)
showed that DM on TS for TPE in OT is elaborated perfectly on the
ES of a Desktop, followed by the ES of the applied Exp.-TS. Tablet
and Mobile-Phone ES seem significantly risky for the application of
DM in OT (p
Abstract: Cancer is still one of the serious diseases threatening
the lives of human beings. How to have an early diagnosis and
effective treatment for tumors is a very important issue. The animal
carcinoma model can provide a simulation tool for the studies of
pathogenesis, biological characteristics, and therapeutic effects.
Recently, drug delivery systems have been rapidly developed to
effectively improve the therapeutic effects. Liposome plays an
increasingly important role in clinical diagnosis and therapy for
delivering a pharmaceutic or contrast agent to the targeted sites.
Liposome can be absorbed and excreted by the human body, and is
well known that no harm to the human body. This study aimed to
compare the therapeutic effects between encapsulated (doxorubicin
liposomal, Lipodox) and un-encapsulated (doxorubicin, Dox)
anti-tumor drugs using magnetic resonance imaging (MRI).
Twenty-four New Zealand rabbits implanted with VX2 carcinoma at
left thighs were classified into three groups: control group (untreated),
Dox-treated group, and LipoDox-treated group, 8 rabbits for each
group. MRI scans were performed three days after tumor implantation.
A 1.5T GE Signa HDxt whole body MRI scanner with a high
resolution knee coil was used in this study. After a 3-plane localizer
scan was performed, three-dimensional (3D) fast spin echo (FSE)
T2-weighted Images (T2WI) was used for tumor volumetric
quantification. Afterwards, two-dimensional (2D) spoiled gradient
recalled echo (SPGR) dynamic contrast-enhanced (DCE) MRI was
used for tumor perfusion evaluation. DCE-MRI was designed to
acquire four baseline images, followed by contrast agent Gd-DOTA
injection through the ear vein of rabbit. A series of 32 images were
acquired to observe the signals change over time in the tumor and
muscle. The MRI scanning was scheduled on a weekly basis for a
period of four weeks to observe the tumor progression longitudinally.
The Dox and LipoDox treatments were prescribed 3 times in the first
week immediately after the first MRI scan; i.e. 3 days after VX2 tumor
implantation. ImageJ was used to quantitate tumor volume and time
course signal enhancement on DCE images. The changes of tumor size
showed that the growth of VX2 tumors was effectively inhibited for
both LipoDox-treated and Dox-treated groups. Furthermore, the tumor
volume of LipoDox-treated group was significantly lower than that of
Dox-treated group, which implies that LipoDox has better therapeutic effect than Dox. The signal intensity of LipoDox-treated group is
significantly lower than that of the other two groups, which implies
that targeted therapeutic drug remained in the tumor tissue. This study
provides a radiation-free and non-invasive MRI method for
therapeutic monitoring of targeted liposome on an animal tumor
model.
Abstract: Scheduled waste management is very important in
environmental and health aspects. In delivering services, highway
industry has been indirectly involved in producing scheduled wastes.
This paper aims to define the scheduled waste, to provide a
conceptual framework of the scheduled waste management in
highway industry, to highlight the effect of improper management of
scheduled waste and to encourage future researchers to identify and
share the present practice of scheduled waste management in their
country. The understanding on effective management of scheduled
waste will help the operators of highway industry, the academicians,
future researchers, and encourage a friendly environment around the
world. The study on scheduled waste management in highway
industry is very crucial as highway transverse and run along
kilometers crossing the various type of environment, residential and
schools. Using Environmental Quality (Scheduled Waste)
Regulations 2005 as a guide, this conceptual paper highlight several
scheduled wastes produced by highway industry in Malaysia and
provide a conceptual framework of scheduled waste management that
focused on the highway industry. Understanding on scheduled waste
management is vital in order to preserve the environment. Besides
that, the waste substances are hazardous to human being. Many
diseases have been associated with the improper management of
schedule waste such as cancer, throat irritation and respiration
problem.
Abstract: Myocardial infarction is one of the leading causes of
death in the world. Some of these deaths occur even before the
patient reaches the hospital. Myocardial infarction occurs as a result
of impaired blood supply. Because the most of these deaths are due to
coronary artery disease, hence the awareness of the warning signs of
a heart attack is essential. Some heart attacks are sudden and intense,
but most of them start slowly, with mild pain or discomfort, then
early detection and successful treatment of these symptoms is vital to
save them. Therefore, importance and usefulness of a system
designing to assist physicians in early diagnosis of the acute heart
attacks is obvious. The main purpose of this study would be to enable patients to
become better informed about their condition and to encourage them
to seek professional care at an earlier stage in the appropriate
situations. For this purpose, the data were collected on 711 heart
patients in Iran hospitals. 28 attributes of clinical factors can be
reported by patients; were studied. Three logistic regression models
were made on the basis of the 28 features to predict the risk of heart
attacks. The best logistic regression model in terms of performance
had a C-index of 0.955 and with an accuracy of 94.9%. The variables,
severe chest pain, back pain, cold sweats, shortness of breath, nausea
and vomiting, were selected as the main features.
Abstract: Cholera is a disease that is predominately common in
developing countries due to poor sanitation and overcrowding
population. In this paper, a deterministic model for the dynamics of
cholera is developed and control measures such as health educational
message, therapeutic treatment, and vaccination are incorporated in
the model. The effective reproduction number is computed in terms
of the model parameters. The existence and stability of the
equilibrium states, disease free and endemic equilibrium states are
established and showed to be locally and globally asymptotically
stable when R0 < 1 and R0 > 1 respectively. The existence of
backward bifurcation of the model is investigated. Furthermore,
numerical simulation of the model developed is carried out to show
the impact of the control measures and the result indicates that
combined control measures will help to reduce the spread of cholera
in the population.
Abstract: The growing concerns for physical wellbeing and
health have been reflected in the way we choose food in our table.
Nowadays, we are all more informed consumers and choose healthier
foods. On the other hand, stroke, cancer and atherosclerosis may be
somehow minimized by the intake of some bioactive compounds
present in food, the so-called nutraceuticals and functional foods. The
aim of this work was to make a revision of the published studies
about the effects of some bioactive compounds, namely lycopene in
human health, in the prevention of diseases, thus playing the role of a
functional food. Free radical in human body can induce cell damage
and consequently can be responsible for the development of some
cancers and chronic diseases. Lycopene is one of the most powerful
antioxidants known, being the predominant carotenoid in tomato. The
respective chemistry, bioavailability, and its functional role in the
prevention of several diseases will be object of this work. On the
other hand, the inclusion of lycopene in some foods can also be made
by biotechnology and represents a way to recover the wastes in the
tomato industry with nutritional positive effects in health.
Abstract: This study was undertaken at four different sites
(north polluted, south polluted, south healthy and north healthy) in
Tehran, in order to examine whether there was a relationship between
publicly available air quality data and the public’s perception of air
quality and to suggest some guidelines for reducing air pollution. A
total of 200 people were accidentally filled out the research
questionnaires at mentioned sites and air quality data were obtained
simultaneously from the Air Quality Control Department. Data was
analyzed in Excel and SPSS software’s. Clean air and job security
were of great importance to people comparing to other pleasant
aspect of life. Also air pollution and serious diseases were the most
important of people concerns. Street monitors and news paper
services on air quality were little used by the public as a means of
obtaining information on air pollution. Using public transportation
and avoiding inevitable journeys are the most important ways for
reducing air pollution. The results reveal that the public’s perception
of air quality is not a reliable indicator of the actual levels of air
pollution.
Abstract: Measuring the Electrocardiogram (ECG) signal is an
essential process for the diagnosis of the heart diseases. The ECG
signal has the information of the degree of how much the heart
performs its functions. In medical diagnosis and treatment systems,
Decision Support Systems processing the ECG signal are being
developed for the use of clinicians while medical examination. In this
study, a modular wireless ECG (WECG) measuring and recording
system using a single board computer and e-Health sensor platform
is developed. In this designed modular system, after the ECG signal
is taken from the body surface by the electrodes first, it is filtered and
converted to digital form. Then, it is recorded to the health database
using Wi-Fi communication technology. The real time access of the
ECG data is provided through the internet utilizing the developed
web interface.
Abstract: Leishmaniasis is the collective name for a number of
diseases caused by protozoan flagellates of the genus Leishmania,
which is transmitted by Phlebotomine sandfly, the disease has diverse
clinical manifestations and found in many areas of the world,
particularly in Africa, Latin America, South and Central Asia, the
Mediterranean basin and the Middle East. This study was done to
assess primary health care physicians’ knowledge (PHP) and attitude
about leishmaniasis and to assess awareness of local inhabitants
about the disease and its vector in four areas in west Alexandria,
Egypt. It is a cross sectional survey that was conducted in four PHC
units in west Alexandria. All physicians currently working in these
units during the study period were invited to participate in the study;
only 20 PHP completed the questionnaire. 60 local inhabitants were
selected randomly from the four areas of the study, 15 from each
area; Data was collected through two different specially designed
questionnaires. Results showed that 11 (55%) percent of the
physicians had satisfactory knowledge; they answered more than 9
(60%) questions out of a total 14 questions about leishmaniasis and
sandfly. On the other hand when attitude of the primary health care
physicians about leishmaniasis was measured, results showed that 17
(85%) had good attitude and 3 (15%) had poor attitude. The second
questionnaire showed that the awareness of local inhabitants about
leishmaniasis and sandfly as a vector of the disease is poor and needs
to be corrected. (90%) of the interviewed inhabitants had not heard
about leishmaniasis, Only 3 (5%) of them said they know sandfly and
its role in transmission of leishmaniasis. Thus we conclude that
knowledge and attitudes of physicians are acceptable. However, there
is, room for improvement and could be done through formal training
courses and distribution of guidelines. In addition to raising the
awareness of primary health care physicians about the importance of
early detection and notification of cases of leishmaniasis, health
education for raising awareness of the public regarding the vector and
the disease is necessary because related studies have demonstrated
that for inhabitants to take enough protective measures against the
vector, they should perceive that it is responsible for causing a
disease.
Abstract: Numerous investigations suggest that Mesenchymal
Stem Cells (MSCs) in general represent a valuable tool for therapy of
symptoms related to chronic inflammatory diseases. Blue Horizon
Stem Cell Therapy Program is a leading provider of adult and
children’s stem cell therapies. Uniquely we have safely and
efficiently treated more than 600 patients with documenting each
procedure. The purpose of our study is primarily to monitor the
immune response in order to validate the safety of intravenous
infusion of human umbilical cord blood derived MSCs (UC-MSCs),
and secondly, to evaluate effects on biomarkers associated with
chronic inflammation. Nine patients were treated for conditions
associated with chronic inflammation and for the purpose of antiaging.
They have been given one intravenous infusion of UCMSCs.
Our study of blood test markers of 9 patients with chronic
inflammation before and within three months after MSCs treatment
demonstrates that there is no significant changes and MSCs treatment
was safe for the patients. Analysis of different indicators of chronic
inflammation and aging included in initial, 24-hours, two weeks and
three months protocols showed that stem cell treatment was safe for
the patients; there were no adverse reactions. Moreover data from
follow up protocols demonstrates significant improvement in energy
level, hair, nails growth and skin conditions. Intravenously
administered UC-MSCs were safe and effective in the improvement
of symptoms related to chronic inflammation. Further close
monitoring and inclusion of more patients are necessary to fully
characterize the advantages of UC-MSCs application in treatment of
symptoms related to chronic inflammation.
Abstract: The right to basic sanitation, was elevated to the
category of fundamental right by the Constitution of 1988 to protect
the ecologically balanced environment, ensuring social rights to
health and adequate housing and put the dignity of the human person
as the foundation of the Brazilian Democratic State. Before their
essentiality to humans, this article seeks to understand why universal
access to basic sanitation is a goal so difficult to achieve in Brazil.
Therefore, this research uses the deductive and analytical method.
Given the nature of the research literature, research techniques were
centered in specialized books on the subject, journals, theses and
dissertations, laws, relevant law case and raising social indicators
relating to the theme. The relevance of the topic stems, among other
things, the fact that sanitation services are essential for a dignified
life, i.e., everyone is entitled to the maintenance of the necessary
existence conditions are satisfied. However, the effectiveness of this
right is undermined in society, since Brazil has huge deficit in
sanitation services, denying thus a worthy life to most of the
population. Thus, it can be seen that the provision of water and
sewage services in Brazil is still characterized by a large imbalance,
since the municipalities with lower population index have greater
disability in the sanitation service. The truth is that the precariousness
of water and sewage services in Brazil is still very concentrated in the
North and Northeast regions, limiting the effective implementation of
the Law 11.445/2007 in the country. Therefore, there is urgent need
for a positive service by the State in the provision of sanitation
services in order to prevent and control disease, improve quality of
life and productivity of individuals, besides preventing contamination
of water resources. More than just social and economic necessity,
there is a government duty to implement such services. In this sense,
given the current scenario, to achieve universal access to basic
sanitation imposes many hurdles. These are mainly in the field of
properly formulated and implemented public policies, i.e., it requires
an excellent institutional organization, management services,
strategic planning, social control, in order to provide answers to
complex challenges.
Abstract: In this paper, we report the development of the device
for diagnostics of cardiovascular system state and associated
automated workstation for large-scale medical measurement data
collection and analysis. It was shown that optimal design for the
monitoring device is wristband as it represents engineering trade-off
between accuracy and usability. Monitoring device is based on the
infrared reflective photoplethysmographic sensor, which allows
collecting multiple physiological parameters, such as heart rate and
pulsing wave characteristics. Developed device uses BLE interface
for medical and supplementary data transmission to the coupled
mobile phone, which processes it and send it to the doctor's
automated workstation. Results of this experimental model
approbation confirmed the applicability of the proposed approach.
Abstract: Grains, including oats (Avena sativa L.), have been
recognized functional foods, because provide beneficial effect on the
health of the consumer and decrease the risk of various diseases. Oats
are good source of soluble fibre, essential amino acids, unsaturated
fatty acids, vitamins and minerals. Oat breeders have developed oat
varieties and improved yielding ability potential of oat varieties.
Therefore, the aim of investigation was to analyze the composition of
perspective oat varieties and breeding lines grains grown in different
conditions and evaluate functional properties. In the studied samples
content of protein, starch, β-glucans, total dietetic fibre, composition
of amino acids and vitamin E were determined. The results of
analysis showed that protein content depending of varieties ranged
9.70% to 17.30% total dietary fibre 13.66 g100g-1 to 30.17 g100g-1,
content of β-glucans 2.7 g100g-1 to 3.5 g100g-1, amount of
vitamin E (α-tocopherol) determined from 4 mgkg-1 to 9.9 mgkg-1.
The sums of essential amino acids in oat grain samples were
determined from 31.63 gkg-1 to 54.90 gkg-1. It is concluded that
amino acids composition of husked and naked oats grown in organic
or conventional conditions is close to optimal for human health.
Abstract: Phonocardiography is important in appraisal of
congenital heart disease and pulmonary hypertension as it reflects the
duration of right ventricular systoles. The systolic murmur in patients
with intra-cardiac shunt decreases as pulmonary hypertension
develops and may eventually disappear completely as the pulmonary
pressure reaches systemic level. Phonocardiography and auscultation
are non-invasive, low-cost, and accurate methods to assess heart
disease. In this work an objective signal processing tool to extract
information from phonocardiography signal using Wavelet is
proposed to classify the murmur as normal or abnormal. Since the
feature vector is large, a Binary Particle Swarm Optimization (PSO)
with mutation for feature selection is proposed. The extracted
features improve the classification accuracy and were tested across
various classifiers including Naïve Bayes, kNN, C4.5, and SVM.
Abstract: Crops diversity and maintaining and enhancing the
fertility of agricultural lands are basic principles of organic farming.
With a wider range of crops in agroecosystem can improve the ability
to control weeds, pests and diseases, and the performance of crops
rotation and food safety. In this sense, the main objective of the
research was to study the productivity and chemical composition of
some alternative crops and their adaptability to soil and climatic
conditions of the agricultural area in Southern Romania and to
cultivation in the organic farming system. The alternative crops were:
lentil (7 genotypes); five species of grain legumes (5 genotypes); four
species of oil crops (5 genotypes). The seed production was, on
average: 1343 kg/ha of lentil; 2500 kg/ha of field beans; 2400 kg/ha
of chick peas and blackeyed peas; more than 2000 kg/ha of atzuki
beans, over 1250 kg/ha of fenugreek; 2200 kg/ha of safflower; 570
kg/ha of oil pumpkin; 2150 kg/ha of oil flax; 1518 kg/ha of camelina.
Regarding chemical composition, lentil seeds contained: 22.18%
proteins, 3.03% lipids, 33.29% glucides, 4.00% minerals, and 259.97
kcal energy values. For field beans: 21.50% proteins, 4.40% lipids,
63.90% glucides, 5.85% minerals, 395.36 kcal energetic value. For
chick peas: 21.23% proteins, 4.55% lipids, 53.00% glucides, 3.67%
minerals, 348.22 kcal energetic value. For blackeyed peas: 23.30%
proteins, 2.10% lipids, 68.10% glucides, 3.93% minerals, 350.14 kcal
energetic value. For adzuki beans: 21.90% proteins, 2.60% lipids,
69.30% glucides, 4.10% minerals, 402.48 kcal energetic value. For
fenugreek: 21.30% proteins, 4.65% lipids, 63.83% glucides, 5.69%
minerals, 396.54 kcal energetic value. For safflower: 12.60%
proteins, 28.37% lipids, 46.41% glucides, 3.60% minerals, 505.78
kcal energetic value. For camelina: 20.29% proteins, 31.68% lipids,
36.28% glucides, 4.29% minerals, 526.63 kcal energetic value. For
oil pumpkin: 29.50% proteins, 36.92% lipids, 18.50% glucides,
5.41% minerals, 540.15 kcal energetic value. For oil flax: 22.56%
proteins, 34.10% lipids, 27.73% glucides, 5.25% minerals, 558.45
kcal energetic value.
Abstract: The use of engineered nanomaterials has increased as
a result of their positive impact on many sectors of the economy,
including agriculture. Silver nanoparticles (AgNPs) are now used to
enhance seed germination, plant growth, and photosynthetic quantum
efficiency and as antimicrobial agents to control plant diseases. In
this study, we examined the effect of AgNP dosage on the seed
germination of three plant species: corn (Zea mays L.), watermelon
(Citrullus lanatus [Thunb.] Matsum. & Nakai) and zucchini
(Cucurbita pepo L.). This experiment was designed to study the
effect of AgNPs on germination percentage, germination rate, mean
germination time, root length and fresh and dry weight of seedlings
for the three species. Seven concentrations (0.05, 0.1, 0.5, 1, 1.5, 2
and 2.5 mg/ml) of AgNPs were examined at the seed germination
stage. The three species had different dose responses to AgNPs in
terms of germination parameters and the measured growth
characteristics. The germination rates of the three plants were
enhanced in response to AgNPs. Significant enhancement of the
germination percentage values was observed after treatment of the
watermelon and zucchini plants with AgNPs in comparison with
untreated seeds. AgNPs showed a toxic effect on corn root
elongation, whereas watermelon and zucchini seedling growth were
positively affected by certain concentrations of AgNPs. This study
showed that exposure to AgNPs caused both positive and negative
effects on plant growth and germination.
Abstract: The goal of this paper is to present the diagnostic
contribution that the screening instrument, Mini-Mental State
Examination-2: Expanded Version (MMSE-2:EV), brings in
detecting the cognitive impairment or in monitoring the progress of
degenerative disorders. The diagnostic signification is underlined by
the interpretation of the MMSE-2:EV scores, resulted from the test
application to patients with mild and major neurocognitive disorders.
The cases were selected from current practice, in order to cover vast
and significant neurocognitive pathology: mild cognitive impairment,
Alzheimer’s disease, vascular dementia, mixed dementia, Parkinson’s
disease, conversion of the mild cognitive impairment into
Alzheimer’s disease. The MMSE-2:EV version was used: it was
applied one month after the initial assessment, three months after the
first reevaluation and then every six months, alternating the blue and
red forms. Correlated with age and educational level, the raw scores
were converted in T scores and then, with the mean and the standard
deviation, the z scores were calculated. The differences of raw scores
between the evaluations were analyzed from the point of view of
statistic signification, in order to establish the progression in time of
the disease. The results indicated that the psycho-diagnostic approach
for the evaluation of the cognitive impairment with MMSE-2:EV is
safe and the application interval is optimal. In clinical settings with a
large flux of patients, the application of the MMSE-2:EV is a safe
and fast psychodiagnostic solution. The clinicians can draw objective
decisions and for the patients: it does not take too much time and
energy, it does not bother them and it doesn’t force them to travel
frequently.