Abstract: A business case is a proposal for an investment
initiative to satisfy business and functional requirements. The
business case provides the foundation for tactical decision making
and technology risk management. It helps to clarify how the
organization will use its resources in the best way by providing
justification for investment of resources. This paper describes how
simulation was used for business case benefits and return on
investment for the procurement of 8 production machines. With
investment costs of about 4.7 million dollars and annual operating
costs of about 1.3 million, we needed to determine if the machines
would provide enough cost savings and cost avoidance. We
constructed a model of the existing factory environment consisting of
8 machines and subsequently, we conducted average day simulations
with light and heavy volumes to facilitate planning decisions
required to be documented and substantiated in the business case.
Abstract: The neurogenic potential of many herbal extracts used
in Indian medicine is hitherto unknown. Extracts derived from
Clitoria ternatea Linn have been used in Indian Ayurvedic system of
medicine as an ingredient of “Medhya rasayana", consumed for
improving memory and longevity in humans and also in treatment of
various neurological disorders. Our earlier experimental studies with
oral intubation of Clitoria ternatea aqueous root extract (CTR) had
shown significant enhancement of learning and memory in postnatal
and young adult Wistar rats. The present study was designed to
elucidate the in vitro effects of 200ng/ml of CTR on proliferation,
differentiation and growth of anterior subventricular zone neural
stem cells (aSVZ NSC-s) derived from prenatal and postnatal rat
pups. Results show significant increase in proliferation and growth of
neurospheres and increase in the yield of differentiated neurons of
aSVZ neural precursor cells (aSVZNPC-s) at 7 days in vitro when
treated with 200ng/ml of CTR as compared to age matched control.
Results indicate that CTR has growth promoting neurogenic effect on
aSVZ neural stem cells and their survival similar to neurotrophic
factors like Survivin, Neuregulin 1, FGF-2, BDNF possibly the basis
for enhanced learning and memory.
Abstract: The Post colonial society in India has witnessed the turmoil to come out from the widespread control and influence of colonialism. The socio-cultural life of a society with all its dynamics is reflected in realistic forms of literature. The social events and human experience are drawn into a new creative form and are given to the reader as a new understanding and perspective of life. It enables the reader to understand the essence of life and motivates him to prepare for a positive change. After India becoming free from the colonial rule in 1947, systematic efforts were made by central and state governments and institutions to limit the role of English and simultaneously enlarge the function of Indian languages by planning in a strategic manner. The eighteen languages recognized as national languages are having very rich literatures. Telugu language is one among the Dravidian language family and is widely spoken by a majority of people. The post colonial socio-cultural factors were very well reflected in Telugu literature. The anti-colonial, reform oriented, progressive, post modernistic trends in Telugu literature are nothing but creative reflections of the post colonial society. This paper examines the major socio-cultural reflections in Telugu literature of the post colonial period.
Abstract: In the present research, two nutraceuticals made from
red grape and walnut that showed previously to improve kidney
dysfunction were incorporated separately into functional foods' bread
made from barley and rice bran. The functional foods were evaluated
in rats in which chronic renal failure was induced through feeding
diet rich in adenine and phosphate (APD). The evaluation based on
assessing kidney function, oxidative stress, inflammatory biomarkers
and body weight gain. Results showed induction of chronic kidney
failure reflected in significant increase in plasma urea, creatinine,
malondialdehyde, tumor necrosis factor- α and low density
lipoprotein cholesterol along with significant reduction of plasma
albumin, and total antioxidant and creatinine clearance and body
weight gain on feeding APD compared to control healthy group.
Feeding the functional foods produced amelioration in the different
biochemical parameters and body weight gain indicating
improvement in kidney function.
Abstract: To compress, improve bit error performance and also enhance 2D images, a new scheme, called Iterative Cellular-Turbo System (IC-TS) is introduced. In IC-TS, the original image is partitioned into 2N quantization levels, where N is denoted as bit planes. Then each of the N-bit-plane is coded by Turbo encoder and transmitted over Additive White Gaussian Noise (AWGN) channel. At the receiver side, bit-planes are re-assembled taking into consideration of neighborhood relationship of pixels in 2-D images. Each of the noisy bit-plane values of the image is evaluated iteratively using IC-TS structure, which is composed of equalization block; Iterative Cellular Image Processing Algorithm (ICIPA) and Turbo decoder. In IC-TS, there is an iterative feedback link between ICIPA and Turbo decoder. ICIPA uses mean and standard deviation of estimated values of each pixel neighborhood. It has extra-ordinary satisfactory results of both Bit Error Rate (BER) and image enhancement performance for less than -1 dB Signal-to-Noise Ratio (SNR) values, compared to traditional turbo coding scheme and 2-D filtering, applied separately. Also, compression can be achieved by using IC-TS systems. In compression, less memory storage is used and data rate is increased up to N-1 times by simply choosing any number of bit slices, sacrificing resolution. Hence, it is concluded that IC-TS system will be a compromising approach in 2-D image transmission, recovery of noisy signals and image compression.
Abstract: Although automotive industry has brought different beneficiaries to human life, it is being pointed out as one of the major cause of global air pollution which resulted in climate change, smog, green house gases (GHGs), and human diseases by many reasons. Since auto industry is one of the largest consumers of fossil fuels, the realization of green innovations is becoming a crucial choice to meet the challenges towards sustainable development. Recently, many auto manufacturers have embarked on green technology initiatives to gain a competitive advantage in the global market; however, innovative manufacturing systems and technologies can enhance operational performance only if the human resource management is in place to elicit the motivation of the employees and develop their organizational expertise. No organization can perform at peak levels unless each employee is committed to the company goals and works as an effective team member. Strategic human resource practices are the primary means by which firms can shape the skills, attitudes, and behavior of individuals to align with the business strategic objectives. This study investigates on the comprehensive approach of multiple advanced technology innovations and human resource management at Toyota Motor Corporation as the market leader of full hybrid technology in the automotive industry. Then, HRM framework of the company is described and three sets of human resource practices that support the innovation-oriented HR system, presented. Finally, a conceptual framework for innovativeness in green technology in automotive industry by applying a deliberate strategic HR management system and knowledge management with the intervening factors of organizational culture, knowledge application and knowledge sharing is proposed.
Abstract: Multicarrier transmission system such as Orthogonal
Frequency Division Multiplexing (OFDM) is a promising technique
for high bit rate transmission in wireless communication system.
OFDM is a spectrally efficient modulation technique that can achieve
high speed data transmission over multipath fading channels without
the need for powerful equalization techniques. However the price
paid for this high spectral efficiency and less intensive equalization
is low power efficiency. OFDM signals are very sensitive to nonlinear
effects due to the high Peak-to-Average Power Ratio (PAPR),
which leads to the power inefficiency in the RF section of the
transmitter. This paper investigates the effect of PAPR reduction on
the performance parameter of multicarrier communication system.
Performance parameters considered are power consumption of Power
Amplifier (PA) and Digital-to-Analog Converter (DAC), power amplifier
efficiency, SNR of DAC and BER performance of the system.
From our analysis it is found that irrespective of PAPR reduction
technique being employed, the power consumption of PA and DAC
reduces and power amplifier efficiency increases due to reduction in
PAPR. Moreover, it has been shown that for a given BER performance
the requirement of Input-Backoff (IBO) reduces with reduction in
PAPR.
Abstract: The study of proteomics reached unexpected levels of
interest, as a direct consequence of its discovered influence over some
complex biological phenomena, such as problematic diseases like
cancer. This paper presents the latest authors- achievements regarding
the analysis of the networks of proteins (interactome networks), by
computing more efficiently the betweenness centrality measure. The
paper introduces the concept of betweenness centrality, and then
describes how betweenness computation can help the interactome net-
work analysis. Current sequential implementations for the between-
ness computation do not perform satisfactory in terms of execution
times. The paper-s main contribution is centered towards introducing
a speedup technique for the betweenness computation, based on
modified shortest path algorithms for sparse graphs. Three optimized
generic algorithms for betweenness computation are described and
implemented, and their performance tested against real biological
data, which is part of the IntAct dataset.
Abstract: The Emergency Department of a medical center in
Taiwan cooperated to conduct the research. A predictive model of
triage system is contracted from the contract procedure, selection of
parameters to sample screening. 2,000 pieces of data needed for the
patients is chosen randomly by the computer. After three
categorizations of data mining (Multi-group Discriminant Analysis,
Multinomial Logistic Regression, Back-propagation Neural
Networks), it is found that Back-propagation Neural Networks can
best distinguish the patients- extent of emergency, and the accuracy
rate can reach to as high as 95.1%. The Back-propagation Neural
Networks that has the highest accuracy rate is simulated into the triage
acuity expert system in this research. Data mining applied to the
predictive model of the triage acuity expert system can be updated
regularly for both the improvement of the system and for education
training, and will not be affected by subjective factors.
Abstract: Nowadays, without the awareness of consumer
behavior and correct understanding of it, it is not possible for organizations to take appropriate measures to meet the consumer
needs and demands. The aim of this paper is the identification and
prioritization of the factors affecting the consumer behavior based on
the product value. The population of the study includes all the
consumers of furniture producing firms in East Azarbaijan province,
Iran. The research sample includes 93 people selected by the sampling formula in unlimited population. The data collection
instrument was a questionnaire, the validity of which was confirmed
through face validity and the reliability of which was determined,
using Cronbach's alpha coefficient. The Kolmogorov-Smironov test
was used to test data normality, the t-test for identification of factors
affecting the product value, and Friedman test for prioritizing the
factors. The results show that quality, satisfaction, styling, price, finishing operation, performance, safety, worth, shape, use, and
excellence are placed from 1 to 11 priorities, respectively.
Abstract: The Yasuj city stream named the Beshar supply
water for different usages such as aquaculture farms , drinking,
agricultural and industrial usages. Fish processing plants
,Agricultural farms, waste water of industrial zones and hospitals
waste water which they are generate by human activity produce a
considerable volume of effluent and when they are released in to the
stream they can effect on the water quality and down stream aquatic
systems. This study was conducted to evaluate the effects of outflow
effluent from different human activity and point and non point
pollution sources on the water quality and health of the Beshar
river next to Yasuj. Yasuj is the biggest and most important city in
the Kohkiloye and Boyerahmad province . The Beshar River is one
of the most important aquatic ecosystems in the upstream of the
Karun watershed in south of Iran which is affected by point and non
point pollutant sources . This study was done in order to evaluate the
effects of human activities on the water quality and health of the
Beshar river. This river is approximately 190 km in length and
situated at the geographical positions of 51° 20' to 51° 48' E and 30°
18' to 30° 52' N it is one of the most important aquatic ecosystems of
Kohkiloye and Boyerahmad province in south-west Iran. In this
research project, five study stations were selected to examine water
pollution in the Beshar River systems. Human activity is now one of
the most important factors affecting on hydrology and water quality
of the Beshar river. Humans use large amounts of resources to sustain
various standards of living, although measures of sustainability are
highly variable depending on how sustainability is defined. The
Beshar river ecosystems are particularly sensitive and vulnerable to
human activities. The water samples were analyzed, then some
important water quality parameters such as pH, dissolve oxygen
(DO), Biochemical Oxygen Demand (BOD5), Chemical Oxygen
Demand (COD), Total Suspended Solids (TDS),Turbidity,
Temperature, Nitrates (NO3) and Phosphates (PO4) were estimated
at the two stations. The results show a downward trend in the water
quality at the down stream of the city. The amounts of
BOD5,COD,TSS,T,Turbidity, NO3 and PO4 in the down stream
stations were considerably more than the station 1. By contrast the
amounts of DO in the down stream stations were less than to the
station 1. However when effluent discharge consequence of human
activities are released into the Beshar river near the city, the quality
of river are decreases and the environmental problems of the river
during the next years are predicted to rise.
Abstract: WOLED is widely used as lighting for high efficacy and little power consumption. In this research, power factor testing between WOLED and fluorescent lamp to see which one is more efficient in consuming energy. Since both lamps use semiconductor components, so calculation of the power factor need to consider the effects of harmonics. Harmonic make bigger losses. The study is conducted by comparing the value of the power factor regardless of harmonics (DPF) and also by included the harmonics (TPF). The average value of DPF of fluorescent is 0.953 while WOLED is 0.972. The average value of TPF of fluorescent is 0.717 whereas WOLED is 0.933. So from the review of power factor WOLED is more energy efficient than fluorescent lamp.
Abstract: Abdominal aortic aneurysms rupture (AAAs) is one of the main causes of death in the world. This is a very complex phenomenon that usually occurs “without previous warning". Currently, criteria to assess the aneurysm rupture risk (peak diameter and growth rate) can not be considered as reliable indicators. In a first approach, the main geometric parameters of aneurysms have been linked into five biomechanical factors. These are combined to obtain a dimensionless rupture risk index, RI(t), which has been validated preliminarily with a clinical case and others from literature. This quantitative indicator is easy to understand, it allows estimating the aneurysms rupture risks and it is expected to be able to identify the one in aneurysm whose peak diameter is less than the threshold value. Based on initial results, a broader study has begun with twelve patients from the Clinic Hospital of Valladolid-Spain, which are submitted to periodic follow-up examinations.
Abstract: We prove detailed analysis of a waveguide-based Schottky barrier photodetector (SBPD) where a thin silicide film is put on the top of a silicon-on-insulator (SOI) channel waveguide to absorb light propagating along the waveguide. Taking both the confinement factor of light absorption and the wall scanning induced gain of the photoexcited carriers into account, an optimized silicide thickness is extracted to maximize the effective gain, thereby the responsivity. For typical lengths of the thin silicide film (10-20 Ðçm), the optimized thickness is estimated to be in the range of 1-2 nm, and only about 50-80% light power is absorbed to reach the maximum responsivity. Resonant waveguide-based SBPDs are proposed, which consist of a microloop, microdisc, or microring waveguide structure to allow light multiply propagating along the circular Si waveguide beneath the thin silicide film. Simulation results suggest that such resonant waveguide-based SBPDs have much higher repsonsivity at the resonant wavelengths as compared to the straight waveguidebased detectors. Some experimental results about Si waveguide-based SBPD are also reported.
Abstract: Concerning the measurement of friction properties of
textiles and fabrics using Kawabata Evaluation System (KES), whose
output is constrained to the surface friction factor of fabric, and no
other data would be generated; this research has been conducted to
gain information about surface roughness regarding its surface
friction factor. To assess roughness properties of light nonwovens, a
3-dimensional model of a surface has been simulated with regular
sinuous waves through it as an ideal surface. A new factor was
defined, namely Surface Roughness Factor, through comparing
roughness properties of simulated surface and real specimens. The
relation between the proposed factor and friction factor of specimens
has been analyzed by regression, and results showed a meaningful
correlation between them. It can be inferred that the new presented
factor can be used as an acceptable criterion for evaluating the
roughness properties of light nonwoven fabrics.
Abstract: Oxidative stress is considered to be the cause for onset
and the progression of type 2 diabetes mellitus (T2DM) and
complications including neuropathy. It is a deleterious process that
can be an important mediator of damage to cell structures: protein,
lipids and DNA. Data suggest that in patients with diabetes and
diabetic neuropathy DNA repair is impaired, which prevents effective
removal of lesions. Objective: The aim of our study was to evaluate
the association of the hOGG1 (326 Ser/Cys) and XRCC1 (194
Arg/Trp, 399 Arg/Gln) gene polymorphisms whose protein is
involved in the BER pathway with DNA repair efficiency in patients
with diabetes type 2 and diabetic neuropathy compared to the healthy
subjects. Genotypes were determined by PCR-RFLP analysis in 385
subjects, including 117 with type 2 diabetes, 56 with diabetic
neuropathy and 212 with normal glucose metabolism. The
polymorphisms studied include codon 326 of hOGG1 and 194, 399
of XRCC1 in the base excision repair (BER) genes. Comet assay was
carried out using peripheral blood lymphocytes from the patients and
controls. This test enabled the evaluation of DNA damage in cells
exposed to hydrogen peroxide alone and in the combination with the
endonuclease III (Nth). The results of the analysis of polymorphism
were statistically examination by calculating the odds ratio (OR) and
their 95% confidence intervals (95% CI) using the ¤ç2-tests. Our data
indicate that patients with diabetes mellitus type 2 (including those
with neuropathy) had higher frequencies of the XRCC1 399Arg/Gln
polymorphism in homozygote (GG) (OR: 1.85 [95% CI: 1.07-3.22],
P=0.3) and also increased frequency of 399Gln (G) allele (OR: 1.38
[95% CI: 1.03-1.83], P=0.3). No relation to other polymorphisms
with increased risk of diabetes or diabetic neuropathy. In T2DM
patients complicated by neuropathy, there was less efficient repair of
oxidative DNA damage induced by hydrogen peroxide in both the
presence and absence of the Nth enzyme. The results of our study
suggest that the XRCC1 399 Arg/Gln polymorphism is a significant
risk factor of T2DM in Polish population. Obtained data suggest a
decreased efficiency of DNA repair in cells from patients with
diabetes and neuropathy may be associated with oxidative stress.
Additionally, patients with neuropathy are characterized by even
greater sensitivity to oxidative damage than patients with diabetes,
which suggests participation of free radicals in the pathogenesis of
neuropathy.
Abstract: The risk sphere in business is fast changing and expanding. Almost anything has become a risk factor that will have potent, direct, and far reaching impacts on business. This paper examines the intensity of enterprise risk management (ERM) practices among the Malaysian public listed companies. The paper espouses a ERM framework comprising fourteen important implementation elements and processes. Results of the analysis indicate that the intensity of ERM implementation among the respondents is in the ‘good’ category of the semantic scale, which is deemed encouraging vis-à-vis the country’s regulatory regime.
Abstract: Yeast cells live in a constantly changing environment that requires the continuous adaptation of their genomic program in order to sustain their homeostasis, survive and proliferate. Due to the advancement of high throughput technologies, there is currently a large amount of data such as gene expression, gene deletion and protein-protein interactions for S. Cerevisiae under various environmental conditions. Mining these datasets requires efficient computational methods capable of integrating different types of data, identifying inter-relations between different components and inferring functional groups or 'modules' that shape intracellular processes. This study uses computational methods to delineate some of the mechanisms used by yeast cells to respond to environmental changes. The GRAM algorithm is first used to integrate gene expression data and ChIP-chip data in order to find modules of coexpressed and co-regulated genes as well as the transcription factors (TFs) that regulate these modules. Since transcription factors are themselves transcriptionally regulated, a three-layer regulatory cascade consisting of the TF-regulators, the TFs and the regulated modules is subsequently considered. This three-layer cascade is then modeled quantitatively using artificial neural networks (ANNs) where the input layer corresponds to the expression of the up-stream transcription factors (TF-regulators) and the output layer corresponds to the expression of genes within each module. This work shows that (a) the expression of at least 33 genes over time and for different stress conditions is well predicted by the expression of the top layer transcription factors, including cases in which the effect of up-stream regulators is shifted in time and (b) identifies at least 6 novel regulatory interactions that were not previously associated with stress-induced changes in gene expression. These findings suggest that the combination of gene expression and protein-DNA interaction data with artificial neural networks can successfully model biological pathways and capture quantitative dependencies between distant regulators and downstream genes.
Abstract: Starting from a biologically inspired framework, Gabor filters were built up from retinal filters via LMSE algorithms. Asubset of retinal filter kernels was chosen to form a particular Gabor filter by using a weighted sum. One-dimensional optimization approaches were shown to be inappropriate for the problem. All model parameters were fixed with biological or image processing constraints. Detailed analysis of the optimization procedure led to the introduction of a minimization constraint. Finally, quantization of weighting factors was investigated. This resulted in an optimized cascaded structure of a Gabor filter bank implementation with lower computational cost.
Abstract: There are many sources trough which the soil get
enriched and contaminated with REEs. The determination of REEs in
environmental samples has been limited because of the lack of
sensitive analytical techniques. Soil samples were collected from
four sites including open cast coal mine, natural coal burning, coal
washery and control in the coal field located in Dhanbad, India.
Total concentrations of rare earth elements (REEs) were determined
using the inductively coupled plasma atomic absorption spectrometry
in order to assess enrichment status in the coal field. Results showed
that the mean concentrations of La, Pr, Eu, Tb, Ho, and Tm in open
cast mine and natural coal burning sites were elevated compared to
the reference concentrations, while Ce, Nd, Sm, and Gd were
elevated in coal washery site. When compared to reference soil,
heavy REEs (HREEs) were enriched in open cast mines and natural
coal burning affected soils, however, the HREEs were depleted in the
coal washery sites. But, the Chondrite-normalization diagram showed
significant enrichment for light REEs (LREEs) in all the soils. High
concentration of Pr, Eu, Tb, Ho, Tm, and Lu in coal mining and coal
burning sites may pose human health risks. Factor analysis showed
that distribution and relative abundance of REEs of the coal washery
site is comparable with the control. Eventually washing or cleaning
of coal could significantly decrease the emission of REEs from coal
into the environment.