Abstract: Purpose of this work is the development of an
automatic classification system which could be useful for radiologists
in the investigation of breast cancer. The software has been designed
in the framework of the MAGIC-5 collaboration.
In the automatic classification system the suspicious regions with
high probability to include a lesion are extracted from the image as
regions of interest (ROIs). Each ROI is characterized by some
features based on morphological lesion differences.
Some classifiers as a Feed Forward Neural Network, a K-Nearest
Neighbours and a Support Vector Machine are used to distinguish the
pathological records from the healthy ones.
The results obtained in terms of sensitivity (percentage of
pathological ROIs correctly classified) and specificity (percentage of
non-pathological ROIs correctly classified) will be presented through
the Receive Operating Characteristic curve (ROC). In particular the
best performances are 88% ± 1 of area under ROC curve obtained
with the Feed Forward Neural Network.
Abstract: We have proposed an information filtering system
using index word selection from a document set based on the
topics included in a set of documents. This method narrows
down the particularly characteristic words in a document set
and the topics are obtained by Sparse Non-negative Matrix
Factorization. In information filtering, a document is often
represented with the vector in which the elements correspond
to the weight of the index words, and the dimension of the
vector becomes larger as the number of documents is
increased. Therefore, it is possible that useless words as index
words for the information filtering are included. In order to
address the problem, the dimension needs to be reduced. Our
proposal reduces the dimension by selecting index words
based on the topics included in a document set. We have
applied the Sparse Non-negative Matrix Factorization to the
document set to obtain these topics. The filtering is carried out
based on a centroid of the learning document set. The centroid
is regarded as the user-s interest. In addition, the centroid is
represented with a document vector whose elements consist of
the weight of the selected index words. Using the English test
collection MEDLINE, thus, we confirm the effectiveness of
our proposal. Hence, our proposed selection can confirm the
improvement of the recommendation accuracy from the other
previous methods when selecting the appropriate number of
index words. In addition, we discussed the selected index
words by our proposal and we found our proposal was able to
select the index words covered some minor topics included in
the document set.
Abstract: The authors present an algorithm for order reduction of linear time invariant dynamic systems using the combined advantages of the eigen spectrum analysis and the error minimization by particle swarm optimization technique. Pole centroid and system stiffness of both original and reduced order systems remain same in this method to determine the poles, whereas zeros are synthesized by minimizing the integral square error in between the transient responses of original and reduced order models using particle swarm optimization technique, pertaining to a unit step input. It is shown that the algorithm has several advantages, e.g. the reduced order models retain the steady-state value and stability of the original system. The algorithm is illustrated with the help of two numerical examples and the results are compared with the other existing techniques.
Abstract: Inflammatory bowel disease (IBD) is a chronic
relapsing-remitting condition that afflicts millions of people
throughout the world and impairs their daily functions and quality of
life. Treatment of IBD depends largely on 5-aminosalicylic acid (5-
ASA) and corticosteroids. The present study aimed to clarify the
effects of 5-aminosalicylic acid, budesonide and currcumin on 90
male albino rats against trinitrobenzene sulfonic acid (TNB) induced
colitis. TNB was injected intrarectally to 50 rats. The other 40 rats
served as control groups. Both 5-ASA (in a dose of 120 mg/kg) and
budesonide (in a dose of 0.1 mg/kg) were administered daily for one
week whereas currcumin was injected intraperitonially (in a dose of
30 mg/kg daily) for 14 days after injection of either TNB in the
colitis rats (group B) or saline in control groups (group A). The study
included estimation of macroscopic score index, histological
examination of H&E stained sections of the colonic tissue,
biochemical estimation of myeloperoxidase (MPO), nitric oxide
(NO), and caspase-3 levels, in addition to studying the effect of tested
drugs on colonic motility. It was found that budesonide and curcumin
improved mucosal healing, reduced both NO production and caspase-
3 level. They had the best impact on the disturbed colonic motility in
TNBS-model of colitis.
Abstract: Pearson-s correlation coefficient and sequential path
analysis has been used for determining the interrelationship among
yield, yield components, soil minerals and aroma of Khao Dawk Mali
(KDML) 105 rice grown in the area of Tungkularonghai in Roi-Et
province, located in the northeast of Thailand. Pearson-s correlation
coefficient in this study showed that the number of panicles was the
only factor that had positive significant (0.790**) effect on grain
yield. Sequential path analysis revealed that the number of panicles
followed by the number of fertile spikelets and 100-grain weight
were the first-order factors which had positive direct effects on grain
yield. Whereas, other factors analyzed had indirect effects
influencing grain yield. This study also indicated that no significant
relationship was found between the aroma level and any of the
factors analyzed.
Abstract: In this paper a three dimensional thermal model of a
power toroidal transformer is proposed for both steady-state or
transient conditions. The influence of electric current and ambient
temperature on the temperature distribution, has been investigated.
To validate the three dimensional thermal model, some experimental
tests have been done. There is a good correlation between
experimental and simulation results.
Abstract: Commercially available lipases (Candida antarctica lipase B, Novozyme 435, Thermomyces lanuginosus lipase, and Lipozyme TL IM), as well as sol-gel immobilized lipases, have been screened for their ability to acylate regioselectively xylitol, sorbitol, and mannitol with a phenolic ester in a binary mixture of t-butanol and dimethylsulfoxide. HPLC and MALDI-TOF MS analysis revealed the exclusive formation of monoesters for all studied sugar alcohols. The lipases immobilized by the sol-gel entrapment method proved to be efficient catalysts, leading to high conversions (up to 60%) in the investigated acylation reactions. From a sequence of silane precursors with different nonhydrolyzable groups in their structure, the presence of octyl and i-butyl group was most beneficial for the catalytic activity of sol-gel entrapped lipases in the studied process.
Abstract: Text Mining is around applying knowledge discovery
techniques to unstructured text is termed knowledge discovery in text
(KDT), or Text data mining or Text Mining. In decision tree
approach is most useful in classification problem. With this
technique, tree is constructed to model the classification process.
There are two basic steps in the technique: building the tree and
applying the tree to the database. This paper describes a proposed
C5.0 classifier that performs rulesets, cross validation and boosting
for original C5.0 in order to reduce the optimization of error ratio.
The feasibility and the benefits of the proposed approach are
demonstrated by means of medial data set like hypothyroid. It is
shown that, the performance of a classifier on the training cases from
which it was constructed gives a poor estimate by sampling or using a
separate test file, either way, the classifier is evaluated on cases that
were not used to build and evaluate the classifier are both are large. If
the cases in hypothyroid.data and hypothyroid.test were to be
shuffled and divided into a new 2772 case training set and a 1000
case test set, C5.0 might construct a different classifier with a lower
or higher error rate on the test cases. An important feature of see5 is
its ability to classifiers called rulesets. The ruleset has an error rate
0.5 % on the test cases. The standard errors of the means provide an
estimate of the variability of results. One way to get a more reliable
estimate of predictive is by f-fold –cross- validation. The error rate of
a classifier produced from all the cases is estimated as the ratio of the
total number of errors on the hold-out cases to the total number of
cases. The Boost option with x trials instructs See5 to construct up to
x classifiers in this manner. Trials over numerous datasets, large and
small, show that on average 10-classifier boosting reduces the error
rate for test cases by about 25%.
Abstract: Physiological activity of the pineal gland with specific
responses in the reproductive territory may be interpreted by
monitoring the process parameters used in poultry practice in
different age batches of laying hens. As biological material were
used 105 laying hens, clinically healthy, belonging to ALBO SL-
2000 hybrid, raised on ground, from which blood samples were taken
at the age of 12 and 28 weeks. The haematological examinations
were concerned to obtain the total number of erythrocytes and
leukocytes and the main erythrocyte constant (RBC, PCV, MCV,
MCH, MCHC and WBC). The results allow the interpretation of the
reproductive status through the dynamics of the presented values.
Abstract: Switched-mode converters play now a significant role in
modern society. Their operation are often crucial in various electrical
applications affecting the every day life. Therefore, the quality of
the converters needs to be reliably verified. Recent studies have
shown that the converters can be fully characterized by a set of
frequency responses which can be efficiently used to validate the
proper operation of the converters. Consequently, several methods
have been proposed to measure the frequency responses fast and
accurately. Most often correlation-based techniques have been applied.
The presented measurement methods are highly sensitive to
external errors and system nonlinearities. This fact has been often
forgotten and the necessary uncertainty analysis of the measured
responses has been neglected. This paper presents a simple approach
to analyze the noise and nonlinearities in the frequency-response
measurements of switched-mode converters. Coherence analysis is
applied to form a confidence interval characterizing the noise and
nonlinearities involved in the measurements. The presented method is
verified by practical measurements from a high-frequency switchedmode
converter.
Abstract: Brain Computer Interface (BCI) has been recently
increased in research. Functional Near Infrared Spectroscope (fNIRs)
is one the latest technologies which utilize light in the near-infrared
range to determine brain activities. Because near infrared technology
allows design of safe, portable, wearable, non-invasive and wireless
qualities monitoring systems, fNIRs monitoring of brain
hemodynamics can be value in helping to understand brain tasks. In
this paper, we present results of fNIRs signal analysis indicating that
there exist distinct patterns of hemodynamic responses which
recognize brain tasks toward developing a BCI. We applied two
different mathematics tools separately, Wavelets analysis for
preprocessing as signal filters and feature extractions and Neural
networks for cognition brain tasks as a classification module. We
also discuss and compare with other methods while our proposals
perform better with an average accuracy of 99.9% for classification.
Abstract: Recent research has shown that milk proteins can
yield bioactive peptides with opioid, mineral binding,
cytomodulatory, antihypertensive, immunostimulating, antimicrobial
and antioxidative activity in the human body. Bioactive peptides are
encrypted in milk proteins and are only released by enzymatic
hydrolysis in vivo during gastrointestinal digestion, food processing
or by microbial enzymes in fermented products. At present
significant research is being undertaken on the health effects of
bioactive peptides. A variety of naturally formed bioactive peptides
have been found in fermented dairy products, such as yoghurt, sour
milk and cheese. In particular, antihypertensive peptides have been
identified in fermented milks, whey and ripened cheese. Some of
these peptides have been commercialized in the form of fermented
milks. Bioactive peptides have the potential to be used in the
formulation of health-enhancing nutraceuticals, and as potent drugs
with well defined pharmacological effects.
Abstract: In this paper three basic approaches and different
methods under each of them for extracting region of interest (ROI)
from stationary images are explored. The results obtained for each of
the proposed methods are shown, and it is demonstrated where each
method outperforms the other. Two main problems in ROI
extraction: the channel selection problem and the saliency reversal
problem are discussed and how best these two are addressed by
various methods is also seen. The basic approaches are 1) Saliency
based approach 2) Wavelet based approach 3) Clustering based
approach. The saliency approach performs well on images containing
objects of high saturation and brightness. The wavelet based
approach performs well on natural scene images that contain regions
of distinct textures. The mean shift clustering approach partitions the
image into regions according to the density distribution of pixel
intensities. The experimental results of various methodologies show
that each technique performs at different acceptable levels for
various types of images.
Abstract: The electrical interaction between two axisymmetric
spheroidal particles in an electrolyte solution is examined numerically.
A Galerkin finite element method combined with a Newton-Raphson
iteration scheme is proposed to evaluate the spatial variation in the
electrical potential, and the result obtained used to estimate the
interaction energy between two particles. We show that if the surface
charge density is fixed, the potential gradient is larger at a point, which
has a larger curvature, and if surface potential is fixed, surface charge
density is proportional to the curvature. Also, if the total interaction
energy against closest surface-to-surface curve exhibits a primary
maximum, the maximum follows the order (oblate-oblate) >
(sphere-sphere)>(oblate-prolate)>(prolate-prolate), and if the curve
has a secondary minimum, the absolute value of the minimum follows
the same order.
Abstract: Functional gastrointestinal disorders affect millions of people spread all age regardless of race and sex. There are, however, rare diagnostic methods for the functional gastrointestinal disorders because functional disorders show no evidence of organic and physical causes. Our research group identified recently that the gastrointestinal tract well in the patients with the functional gastrointestinal disorders becomes more rigid than healthy people when palpating the abdominal regions overlaying the gastrointestinal tract. Aim of this study is, therefore, to develop a diagnostic system for the functional gastrointestinal disorders based on ultrasound technique, which can quantify the characteristic above related to the rigidity of the gastrointestinal tract well. Ultrasound system was designed. The system consisted of transmitter, ultrasonic transducer, receiver, TGC, and CPLD, and verified via a phantom test. For the phantom test, ten soft-tissue specimens were harvested from porcine. Five of them were then treated chemically to mimic a rigid condition of gastrointestinal tract well, which was induced by functional gastrointestinal disorders. Additionally, the specimens were tested mechanically to identify if the mimic was reasonable. The customized ultrasound system was finally verified through application to human subjects with/without functional gastrointestinal disorders (Normal and Patient Groups). It was identified from the mechanical test that the chemically treated specimens were more rigid than normal specimen. This finding was favorably compared with the result obtained from the phantom test. The phantom test also showed that ultrasound system well described the specimen geometric characteristics and detected an alteration in the specimens. The maximum amplitude of the ultrasonic reflective signal in the rigid specimens (0.2±0.1Vp-p) at the interface between the fat and muscle layers was explicitly higher than that in the normal specimens (0.1±0.0Vp-p). Clinical tests using our customized ultrasound system for human subject showed that the maximum amplitudes of the ultrasonic reflective signals near to the gastrointestinal tract well for the patient group (2.6±0.3Vp-p) were generally higher than those in normal group (0.1±0.2Vp-p). Here, maximum reflective signals was appeared at 20mm depth approximately from abdominal skin for all human subjects, corresponding to the location of the boundary layer close to gastrointestinal tract well. These results suggest that newly designed diagnostic system based on ultrasound technique may diagnose enough the functional gastrointestinal disorders.
Abstract: An accident is an unexpected and unplanned situation
that happens and affects human in a negative outcome. The accident
can cause an injury to a human biological organism. Thus, the
provision of initial care for an illness or injury is very important
move to prepare the patients/victims before sending to the doctor. In
this paper, a First Aid Application is developed to give some
directions for preliminary taking care of patient/victim via Android
mobile device. Also, the navigation function using Google Maps API
is implemented in this paper for searching a suitable path to the
nearest hospital. Therefore, in the emergency case, this function can
be activated and navigate patients/victims to the hospital with the
shortest path.
Abstract: In this paper, we deal with the Steiner tree problem
(STP) on a graph in which a fuzzy number, instead of a real number,
is assigned to each edge. We propose a modification of the shortest
paths approximation based on the fuzzy shortest paths (FSP)
evaluations. Since a fuzzy min operation using the extension
principle leads to nondominated solutions, we propose another
approach to solving the FSP using Cheng's centroid point fuzzy
ranking method.
Abstract: The counting process of cell colonies is always a long
and laborious process that is dependent on the judgment and ability
of the operator. The judgment of the operator in counting can vary in
relation to fatigue. Moreover, since this activity is time consuming it
can limit the usable number of dishes for each experiment. For these
purposes, it is necessary that an automatic system of cell colony
counting is used. This article introduces a new automatic system of
counting based on the elaboration of the digital images of cellular
colonies grown on petri dishes. This system is mainly based on the
algorithms of region-growing for the recognition of the regions of
interest (ROI) in the image and a Sanger neural net for the
characterization of such regions. The better final classification is
supplied from a Feed-Forward Neural Net (FF-NN) and confronted
with the K-Nearest Neighbour (K-NN) and a Linear Discriminative
Function (LDF). The preliminary results are shown.
Abstract: Nejad and Mashinchi (2011) proposed a revision for ranking fuzzy numbers based on the areas of the left and the right sides of a fuzzy number. However, this method still has some shortcomings such as lack of discriminative power to rank similar fuzzy numbers and no guarantee the consistency between the ranking of fuzzy numbers and the ranking of their images. To overcome these drawbacks, we propose an epsilon-deviation degree method based on the left area and the right area of a fuzzy number, and the concept of the centroid point. The main advantage of the new approach is the development of an innovative index value which can be used to consistently evaluate and rank fuzzy numbers. Numerical examples are presented to illustrate the efficiency and superiority of the proposed method.
Abstract: Thyroid dysfunction is one of the most frequently
reported complications of chronic blood transfusion therapy in patients with beta-thalassemia major (BTM). However, the occurrence of thyroid dysfunction and its possible association with
iron overload in BTM patients is still under debate. Therefore, this
study aimed to investigate the status of thyroid functions and iron overload in adolescent and young adult patients with BTM in Jordan population. Thirty six BTM patients aged 12-28 years and matched controls were included in this study. All patients have been receiving frequent blood transfusion to maintain pretransfusion hemoglobin
concentration above 10 g dl-1 and deferoxamine at a dose of 45 mg kg-1 day-1 (8 h, 5-7 days/week) by subcutaneous infusion. Blood
samples were drawn from patients and controls. The status of thyroid functions and iron overload was evaluated by measurements of serum
free thyroxine (FT4), triiodothyronine (FT3), thyrotropin (TSH) and
serum ferritin level. A number of some hematological and
biochemical parameters were also measured. It was found that hematocrit, serum ferritin, hemoglobin, FT3 and zinc, copper mean values were significantly higher in the patients than in the controls (P< 0.05). On other hand, leukocyte, FT4 and TSH mean values were
similar to that of the controls. In addition, our data also indicated that
all of the above examined parameters were not significantly affected
by the patient-s age and gender. Deferoxamine approach for removing excess iron from our BTM patient did not normalize the
values of serum ferritin, copper and zinc, suggesting poor compliance
with deferoxamine chelation therapy. Thus, we recommend the use
of a combination of deferoxamine and deferiprone to reduce the risk
of excess of iron in our patients. Furthermore, thyroid dysfunction
appears to be a rare complication, because our patients showed
normal mean levels for serum TSH and FT4. However, high mean
levels of serum ferritin, zinc, copper might be seen as potential risk
factors for initiation and development of thyroid dysfunctions and
other diseases. Therefore, further studies must be carried out at
yearly intervals with large sample number, to detect subclinical
thyroid dysfunction cases.