Abstract: COPD is characterized by loss of elastic fibers from
small airways and alveolar walls, with the decrease in elastin
increasing with disease severity. It is unclear why there is a lack of
repair of elastic fibers. We have examined fibroblasts cultured from
lung tissue from normal and COPD subjects to determine if the
secretory profile explains lack of tissue repair. In this study,
fibroblasts were cultured from lung parenchyma of bronchial
carcinoma patients with varying degrees of COPD; controls
(non-COPD, n=5), mild COPD (GOLD 1, n=5) and moderate-severe
COPD (GOLD 2-3, n=12). Measurements were made of proliferation,
senescence-associated beta-galactosidase-1, mRNA expression of
IL-6, IL-8, MMP-1, tropoelastin and versican, and protein levels for
IL-6, IL-8, PGE2, tropoelastin, insoluble elastin, and versican. It was
found that GOLD 2-3 fibroblasts proliferated more slowly (p
Abstract: This study applied the Theory of Planned Behavior
model in predicting dietary behavior among Type 2 diabetics in a
Kenyan environment. The study was conducted for three months
within the diabetic clinic at Kisii Hospital in Nyanza Province in
Kenya and adopted sequential mixed methods design combing both
qualitative and quantitative phases. Qualitative data was analyzed
using grounded theory analysis method. Structural equation modeling
using maximum likelihood was used to analyze quantitative data.
The results based on the common fit indices revealed that the theory
of planned behavior fitted the data acceptably well among the Type 2
diabetes and within dietary behavior {χ2 = 223.3, df = 77, p = .02,
χ2/df = 2.9, n=237; TLI = .93; CFI =.91; RMSEA (90CI) = .090(.039,
.146)}. This implies that the Theory of Planned Behavior holds and
forms a framework for promoting dietary practice among Type 2
diabetics.
Abstract: In this paper, a mathematical model of human immunodeficiency
virus (HIV) is utilized and an optimization problem is
proposed, with the final goal of implementing an optimal 900-day
structured treatment interruption (STI) protocol. Two type of commonly
used drugs in highly active antiretroviral therapy (HAART),
reverse transcriptase inhibitors (RTI) and protease inhibitors (PI), are
considered. In order to solving the proposed optimization problem an
adaptive memetic algorithm with population management (AMAPM)
is proposed. The AMAPM uses a distance measure to control the
diversity of population in genotype space and thus preventing the
stagnation and premature convergence. Moreover, the AMAPM uses
diversity parameter in phenotype space to dynamically set the population
size and the number of crossovers during the search process.
Three crossover operators diversify the population, simultaneously.
The progresses of crossover operators are utilized to set the number
of each crossover per generation. In order to escaping the local optima
and introducing the new search directions toward the global optima,
two local searchers assist the evolutionary process. In contrast to
traditional memetic algorithms, the activation of these local searchers
is not random and depends on both the diversity parameters in
genotype space and phenotype space. The capability of AMAPM in
finding optimal solutions compared with three popular metaheurestics
is introduced.
Abstract: Automatic segmentation of skin lesions is the first step
towards development of a computer-aided diagnosis of melanoma.
Although numerous segmentation methods have been developed,
few studies have focused on determining the most discriminative
and effective color space for melanoma application. This paper
proposes a novel automatic segmentation algorithm using color space
analysis and clustering-based histogram thresholding, which is able to
determine the optimal color channel for segmentation of skin lesions.
To demonstrate the validity of the algorithm, it is tested on a set of 30
high resolution dermoscopy images and a comprehensive evaluation
of the results is provided, where borders manually drawn by four
dermatologists, are compared to automated borders detected by the
proposed algorithm. The evaluation is carried out by applying three
previously used metrics of accuracy, sensitivity, and specificity and
a new metric of similarity. Through ROC analysis and ranking the
metrics, it is shown that the best results are obtained with the X and
XoYoR color channels which results in an accuracy of approximately
97%. The proposed method is also compared with two state-ofthe-
art skin lesion segmentation methods, which demonstrates the
effectiveness and superiority of the proposed segmentation method.