Abstract: Purpose of this work is the development of an
automatic classification system which could be useful for radiologists
in the investigation of breast cancer. The software has been designed
in the framework of the MAGIC-5 collaboration.
In the automatic classification system the suspicious regions with
high probability to include a lesion are extracted from the image as
regions of interest (ROIs). Each ROI is characterized by some
features based on morphological lesion differences.
Some classifiers as a Feed Forward Neural Network, a K-Nearest
Neighbours and a Support Vector Machine are used to distinguish the
pathological records from the healthy ones.
The results obtained in terms of sensitivity (percentage of
pathological ROIs correctly classified) and specificity (percentage of
non-pathological ROIs correctly classified) will be presented through
the Receive Operating Characteristic curve (ROC). In particular the
best performances are 88% ± 1 of area under ROC curve obtained
with the Feed Forward Neural Network.
Abstract: This paper presents an approach for early breast
cancer diagnostic by employing combination of artificial neural
networks (ANN) and multiwaveletpacket based subband image
decomposition. The microcalcifications correspond to high-frequency
components of the image spectrum, detection of microcalcifications
is achieved by decomposing the mammograms into different
frequency subbands,, reconstructing the mammograms from the
subbands containing only high frequencies. For this approach we
employed different types of multiwaveletpacket. We used the result
as an input of neural network for classification. The proposed
methodology is tested using the Nijmegen and the Mammographic
Image Analysis Society (MIAS) mammographic databases and
images collected from local hospitals. Results are presented as the
receiver operating characteristic (ROC) performance and are
quantified by the area under the ROC curve.
Abstract: In this paper, a second order autoregressive (AR)
model is proposed to discriminate alcoholics using single trial
gamma band Visual Evoked Potential (VEP) signals using 3 different
classifiers: Simplified Fuzzy ARTMAP (SFA) neural network (NN),
Multilayer-perceptron-backpropagation (MLP-BP) NN and Linear
Discriminant (LD). Electroencephalogram (EEG) signals were
recorded from alcoholic and control subjects during the presentation
of visuals from Snodgrass and Vanderwart picture set. Single trial
VEP signals were extracted from EEG signals using Elliptic filtering
in the gamma band spectral range. A second order AR model was
used as gamma band VEP exhibits pseudo-periodic behaviour and
second order AR is optimal to represent this behaviour. This
circumvents the requirement of having to use some criteria to choose
the correct order. The averaged discrimination errors of 2.6%, 2.8%
and 11.9% were given by LD, MLP-BP and SFA classifiers. The
high LD discrimination results show the validity of the proposed
method to discriminate between alcoholic subjects.
Abstract: Classification of electroencephalogram (EEG) signals
extracted during mental tasks is a technique that is actively pursued
for Brain Computer Interfaces (BCI) designs. In this paper, we
compared the classification performances of univariateautoregressive
(AR) and multivariate autoregressive (MAR) models
for representing EEG signals that were extracted during different
mental tasks. Multilayer Perceptron (MLP) neural network (NN)
trained by the backpropagation (BP) algorithm was used to classify
these features into the different categories representing the mental
tasks. Classification performances were also compared across
different mental task combinations and 2 sets of hidden units (HU): 2
to 10 HU in steps of 2 and 20 to 100 HU in steps of 20. Five different
mental tasks from 4 subjects were used in the experimental study and
combinations of 2 different mental tasks were studied for each
subject. Three different feature extraction methods with 6th order
were used to extract features from these EEG signals: AR
coefficients computed with Burg-s algorithm (ARBG), AR
coefficients computed with stepwise least square algorithm (ARLS)
and MAR coefficients computed with stepwise least square
algorithm. The best results were obtained with 20 to 100 HU using
ARBG. It is concluded that i) it is important to choose the suitable
mental tasks for different individuals for a successful BCI design, ii)
higher HU are more suitable and iii) ARBG is the most suitable
feature extraction method.
Abstract: Pattern recognition is the research area of Artificial
Intelligence that studies the operation and design of systems that
recognize patterns in the data. Important application areas are image
analysis, character recognition, fingerprint classification, speech
analysis, DNA sequence identification, man and machine
diagnostics, person identification and industrial inspection. The
interest in improving the classification systems of data analysis is
independent from the context of applications. In fact, in many
studies it is often the case to have to recognize and to distinguish
groups of various objects, which requires the need for valid
instruments capable to perform this task. The objective of this article
is to show several methodologies of Artificial Intelligence for data
classification applied to biomedical patterns. In particular, this work
deals with the realization of a Computer-Aided Detection system
(CADe) that is able to assist the radiologist in identifying types of
mammary tumor lesions. As an additional biomedical application of
the classification systems, we present a study conducted on blood
samples which shows how these methods may help to distinguish
between carriers of Thalassemia (or Mediterranean Anaemia) and
healthy subjects.
Abstract: This study investigated the climatic factors associated
with Influenza incidence in Nakhon Si Thammarat, Southern
Thailand. Climatic factors comprised of the amount of rainfall,
percent of rainy days, relative humidity, wind speed, maximum,
minimum temperatures and temperature difference. A multiple
stepwise regression technique was used to fit the statistical model.
The result showed that the temperature difference and percent of
rainy days were positively associated with Influenza incidence in
Nakhon Si Thammarat.
Abstract: PARADIGMA (PARticipative Approach to DIsease
Global Management) is a pilot project which aims to develop and
demonstrate an Internet based reference framework to share scientific
resources and findings in the treatment of major diseases.
PARADIGMA defines and disseminates a common methodology and
optimised protocols (Clinical Pathways) to support service functions
directed to patients and individuals on matters like prevention, posthospitalisation
support and awareness. PARADIGMA will provide a
platform of information services - user oriented and optimised
against social, cultural and technological constraints - supporting the
Health Care Global System of the Euro-Mediterranean Community
in a continuous improvement process.
Abstract: The development of aid's systems for the medical
diagnosis is not easy thing because of presence of inhomogeneities in
the MRI, the variability of the data from a sequence to the other as
well as of other different source distortions that accentuate this
difficulty. A new automatic, contextual, adaptive and robust
segmentation procedure by MRI brain tissue classification is
described in this article. A first phase consists in estimating the
density of probability of the data by the Parzen-Rozenblatt method.
The classification procedure is completely automatic and doesn't
make any assumptions nor on the clusters number nor on the
prototypes of these clusters since these last are detected in an
automatic manner by an operator of mathematical morphology called
skeleton by influence zones detection (SKIZ). The problem of
initialization of the prototypes as well as their number is transformed
in an optimization problem; in more the procedure is adaptive since it
takes in consideration the contextual information presents in every
voxel by an adaptive and robust non parametric model by the
Markov fields (MF). The number of bad classifications is reduced by
the use of the criteria of MPM minimization (Maximum Posterior
Marginal).
Abstract: The myocardial sintigraphy is an imaging modality which provides functional informations. Whereas, coronarography modality gives useful informations about coronary arteries anatomy. In case of coronary artery disease (CAD), the coronarography can not determine precisely which moderate lesions (artery reduction between 50% and 70%), known as the “gray zone", are haemodynamicaly significant. In this paper, we aim to define the relationship between the location and the degree of the stenosis in coronary arteries and the observed perfusion on the myocardial scintigraphy. This allows us to model the impact evolution of these stenoses in order to justify a coronarography or to avoid it for patients suspected being in the gray zone. Our approach is decomposed in two steps. The first step consists in modelling a coronary artery bed and stenoses of different location and degree. The second step consists in modelling the left ventricle at stress and at rest using the sphercical harmonics model and myocardial scintigraphic data. We use the spherical harmonics descriptors to analyse left ventricle model deformation between stress and rest which permits us to conclude if ever an ischemia exists and to quantify it.