Richtmyer-Meshkov Instability and Gas-Particle Interaction of Contoured Shock-Tube Flows: A Numerical Study
In this paper, computational fluid dynamics (CFD) is utilized to characterize a prototype biolistic delivery system, the biomedical device based on the contoured-shock-tube design (CST), with the aim at investigating shocks induced flow instabilities within the contoured shock tube. The shock/interface interactions, the growth of perturbation at an interface between two fluids of different density are interrogated. The key features of the gas dynamics and gas-particle interaction are discussed
[1] B.J. Bellhouse, D.F. Sarphie and J.C. Greenford (1994)
Needless syringe using supersonic gas flow for micro-particle
delivery, Int. Patent WO94/24263
[2] B.J. Bellhouse, N.J. Quinlan and R.W. Ainsworth (1997)
Needle-less delivery of drugs, in dry powder form, using shock
waves and supersonic gas flow, Proc. 21st Int. Symp. on Shock
Waves, Queensland, Australia
[3] Y. Liu, and M.A.F. Kendall (2004) Numerical Simulation of
Heat Transfer from a Transonic Jet Impinging on Skin for
Needle-free Powdered Drug and Vaccine Delivery, Journal of
Mechanical Engineering Science, Proceedings of the Institution
of Mechanical Engineers Part C, 218(11): 1373-1383
[4] Y. Liu (2007) Impact studies of high speed micro-particles
following biolistic delivery. IEEE Transactions on Biomedical
Engineering 54(8): 1507-1513.
[5] D.L. Youngs (1994) Numerical simulation of mixing by
Rayleigh-Taylor and Richtmyer-Meshkov instability, Laser
Particle Beams 12(4): 725-750
[6] R.L. Holmes, G. Dimonte, B. Fryxell, M.L. Gittings, J.W.
Grove, M. Schneider, D.H. Sharp, A.L. Velikovich, R.P.
Weaver and Q. Zhang (1999) Richtmyer-Meshkov instability
growth: experiment, simulation and theory, Journal of Fluid
Mechanics 389: 55-79
[7] S. Kumar, P. Vorobieff, G. Orlicz, A. Palekar, C. Tomkins, C.
Goodenough, M. Marr-Lyon, K.P. Prestridge and R.F. Benjamin
(2007) Complex flow morphologies in shock-accelerated
gaseous flows, Physica D: Nonlinear Phenomena, 235(1-2): 21-
28
[8] N.K. Truong, Y. Liu, M.A.F. Kendall (2006) Gas and particle
dynamics of a contoured shock tube for pre-clinical
microparticle drug delivery, Shock Waves, 15(3-4): 149-164
[9] C.B. Henderson (1976) Drag coefficient of spheres in
continuum and rarefied flows, AIAA J. 14(6): 707-708.
[10] O. Igra, K. Takayama (1993) Shock tube study of the drag
coefficient of a sphere in a non-stationary flow, Proc R. Soc.
Lond. A, 442: 231-247.
[11] J. Kurian, H.K. Das (1997) Studies of shock Wave Propagation
in gas-particle mixtures, in: Proc. 21st Int. Symp. on Shock
Waves, Great Keppel Island, Australia.
[1] B.J. Bellhouse, D.F. Sarphie and J.C. Greenford (1994)
Needless syringe using supersonic gas flow for micro-particle
delivery, Int. Patent WO94/24263
[2] B.J. Bellhouse, N.J. Quinlan and R.W. Ainsworth (1997)
Needle-less delivery of drugs, in dry powder form, using shock
waves and supersonic gas flow, Proc. 21st Int. Symp. on Shock
Waves, Queensland, Australia
[3] Y. Liu, and M.A.F. Kendall (2004) Numerical Simulation of
Heat Transfer from a Transonic Jet Impinging on Skin for
Needle-free Powdered Drug and Vaccine Delivery, Journal of
Mechanical Engineering Science, Proceedings of the Institution
of Mechanical Engineers Part C, 218(11): 1373-1383
[4] Y. Liu (2007) Impact studies of high speed micro-particles
following biolistic delivery. IEEE Transactions on Biomedical
Engineering 54(8): 1507-1513.
[5] D.L. Youngs (1994) Numerical simulation of mixing by
Rayleigh-Taylor and Richtmyer-Meshkov instability, Laser
Particle Beams 12(4): 725-750
[6] R.L. Holmes, G. Dimonte, B. Fryxell, M.L. Gittings, J.W.
Grove, M. Schneider, D.H. Sharp, A.L. Velikovich, R.P.
Weaver and Q. Zhang (1999) Richtmyer-Meshkov instability
growth: experiment, simulation and theory, Journal of Fluid
Mechanics 389: 55-79
[7] S. Kumar, P. Vorobieff, G. Orlicz, A. Palekar, C. Tomkins, C.
Goodenough, M. Marr-Lyon, K.P. Prestridge and R.F. Benjamin
(2007) Complex flow morphologies in shock-accelerated
gaseous flows, Physica D: Nonlinear Phenomena, 235(1-2): 21-
28
[8] N.K. Truong, Y. Liu, M.A.F. Kendall (2006) Gas and particle
dynamics of a contoured shock tube for pre-clinical
microparticle drug delivery, Shock Waves, 15(3-4): 149-164
[9] C.B. Henderson (1976) Drag coefficient of spheres in
continuum and rarefied flows, AIAA J. 14(6): 707-708.
[10] O. Igra, K. Takayama (1993) Shock tube study of the drag
coefficient of a sphere in a non-stationary flow, Proc R. Soc.
Lond. A, 442: 231-247.
[11] J. Kurian, H.K. Das (1997) Studies of shock Wave Propagation
in gas-particle mixtures, in: Proc. 21st Int. Symp. on Shock
Waves, Great Keppel Island, Australia.
@article{"International Journal of Mechanical, Industrial and Aerospace Sciences:49354", author = "Yi Liu", title = "Richtmyer-Meshkov Instability and Gas-Particle Interaction of Contoured Shock-Tube Flows: A Numerical Study", abstract = "In this paper, computational fluid dynamics (CFD) is utilized to characterize a prototype biolistic delivery system, the biomedical device based on the contoured-shock-tube design (CST), with the aim at investigating shocks induced flow instabilities within the contoured shock tube. The shock/interface interactions, the growth of perturbation at an interface between two fluids of different density are interrogated. The key features of the gas dynamics and gas-particle interaction are discussed
", keywords = "Simulation, Shock wave, Particle, Interface, Supersonic, Richtmyer-Meshkov Instability", volume = "2", number = "10", pages = "1088-5", }
