Bone Mineral Density and Trabecular Bone Score in Ukrainian Women with Obesity
Obesity and osteoporosis are the two diseases whose
increasing prevalence and high impact on the global morbidity and
mortality, during the two recent decades, have gained a status of
major health threats worldwide. Obesity purports to affect the bone
metabolism through complex mechanisms. Debated data on the
connection between the bone mineral density and fracture prevalence
in the obese patients are widely presented in literature. There is
evidence that the correlation of weight and fracture risk is sitespecific.
This study is aimed at determining the connection between
the bone mineral density (BMD) and trabecular bone score (TBS)
parameters in Ukrainian women suffering from obesity. We
examined 1025 40-89-year-old women, divided them into the groups
according to their body mass index: Group A included 360 women
with obesity whose BMI was ≥30 kg/m2, and Group B – 665 women
with no obesity and BMI of <30 kg/m2. The BMD of total body,
lumbar spine at the site L1-L4, femur and forearm were measured by
DXA (Prodigy, GEHC Lunar, Madison, WI, USA). The TBS of L1-
L4 was assessed by means of TBS iNsight® software installed on our
DXA machine (product of Med-Imaps, Pessac, France). In general,
obese women had a significantly higher BMD of lumbar spine,
femoral neck, proximal femur, total body and ultradistal forearm
(p<0.001) in comparison with women without obesity. The TBS of
L1-L4 was significantly lower in obese women compared to nonobese
women (p<0.001). The BMD of lumbar spine, femoral neck
and total body differed to a significant extent in women of 40-49, 50-
59, 60-69 and 70-79 years (p<0.05). At same time, in women aged
80-89 years the BMD of lumbar spine (p=0.09), femoral neck
(p=0.22) and total body (p=0.06) barely differed. The BMD of
ultradistal forearm was significantly higher in women of all age
groups (p<0.05). The TBS of L1-L4 in all the age groups tended to
reveal the lower parameters in obese women compared with the nonobese;
however, those data were not statistically significant. By
contrast, a significant positive correlation was observed between the
fat mass and the BMD at different sites. The correlation between the
fat mass and TBS of L1-L4 was also significant, although negative.
Women with vertebral fractures had a significantly lower body
weight, body mass index and total body fat mass in comparison with
women without vertebral fractures in their anamnesis. In obese
women the frequency of vertebral fractures was 27%, while in
women without obesity – 57%.
[1] S. Bermeo, K. Gunaratnam, G. Duque, “Fat and bone interactions,”
Curr. Osteoporos. Rep., vol. 12, no. 2, pp. 235-42, 2014.
[2] J.J. Cao “Effects of obesity on bone metabolism,” J. Orthop. Surg. Res.,
vol. 15, no. 6, p. 30, 2011.
[3] J. Compston “Obesity and bone,” Curr. Osteoporos. Rep., vol. 11, no. 1,
pp. 30-5, 2013.
[4] A. Faje, A. Klibanski “Body composition and skeletal health: too heavy?
Too thin? ,” Curr. Osteoporos. Rep., vol. 10, no. 3, pp. 208-16, 2012.
[5] M.J. Gonçalves, A.M. Rodrigues, H. Canhão, J.E. Fonseca
“Osteoporosis: from bone biology to individual treatment decision,”
Acta Med. Port., vol. 26, no. 4, pp. 445-55, 2013.
[6] S. Gonnelli, C. Caffarelli, R. Nuti “Obesity and fracture risk,” Clin.
Cases Miner. Bone Metab., vol. 11, no. 1, pp. 9-14, 2014.
[7] B.A. Gower, K. Casazza “Divergent effects of obesity on bone health,”
J. Clin. Densitom., vol. 16, no. 4, pp. 450-4, 2013.
[8] M.B. Leonard, B.S. Zemel, B.H. Wrotniak et al. “Tibia and radius bone
geometry and volumetric density in obese compared to non-obese
adolescents,” Bone, vol. 73, pp. 69-76, 2015.
[9] D. Naot, J. Cornish “Cytokines and Hormones That Contribute to the
Positive Association between Fat and Bone,” Front Endocrinol
(Lausanne), vol. 9, no. 5, p. 70, 2014.
[10] C.M. Nielson, P. Srikanth, E.S. Orwoll “Obesity and fracture in men and
women: an epidemiologic perspective,” J. Bone Miner. Res., vol. 27, no.
1, pp. 1-10, 2012.
[11] C.J. Rosen, M.L. Bouxsein “Mechanisms of disease: is osteoporosis the
obesity of bone?,” Nature clinical practice, vol. 2 no. 1, pp. 35-43, 2006.
[12] S. Sharma, T.V. Randon, S. Mahajan et al. “Obesity: Friend or foe for
osteoporosis,” J. Midlife Health, vol. 5, no. 1, pp. 6-9, 2014.
[1] S. Bermeo, K. Gunaratnam, G. Duque, “Fat and bone interactions,”
Curr. Osteoporos. Rep., vol. 12, no. 2, pp. 235-42, 2014.
[2] J.J. Cao “Effects of obesity on bone metabolism,” J. Orthop. Surg. Res.,
vol. 15, no. 6, p. 30, 2011.
[3] J. Compston “Obesity and bone,” Curr. Osteoporos. Rep., vol. 11, no. 1,
pp. 30-5, 2013.
[4] A. Faje, A. Klibanski “Body composition and skeletal health: too heavy?
Too thin? ,” Curr. Osteoporos. Rep., vol. 10, no. 3, pp. 208-16, 2012.
[5] M.J. Gonçalves, A.M. Rodrigues, H. Canhão, J.E. Fonseca
“Osteoporosis: from bone biology to individual treatment decision,”
Acta Med. Port., vol. 26, no. 4, pp. 445-55, 2013.
[6] S. Gonnelli, C. Caffarelli, R. Nuti “Obesity and fracture risk,” Clin.
Cases Miner. Bone Metab., vol. 11, no. 1, pp. 9-14, 2014.
[7] B.A. Gower, K. Casazza “Divergent effects of obesity on bone health,”
J. Clin. Densitom., vol. 16, no. 4, pp. 450-4, 2013.
[8] M.B. Leonard, B.S. Zemel, B.H. Wrotniak et al. “Tibia and radius bone
geometry and volumetric density in obese compared to non-obese
adolescents,” Bone, vol. 73, pp. 69-76, 2015.
[9] D. Naot, J. Cornish “Cytokines and Hormones That Contribute to the
Positive Association between Fat and Bone,” Front Endocrinol
(Lausanne), vol. 9, no. 5, p. 70, 2014.
[10] C.M. Nielson, P. Srikanth, E.S. Orwoll “Obesity and fracture in men and
women: an epidemiologic perspective,” J. Bone Miner. Res., vol. 27, no.
1, pp. 1-10, 2012.
[11] C.J. Rosen, M.L. Bouxsein “Mechanisms of disease: is osteoporosis the
obesity of bone?,” Nature clinical practice, vol. 2 no. 1, pp. 35-43, 2006.
[12] S. Sharma, T.V. Randon, S. Mahajan et al. “Obesity: Friend or foe for
osteoporosis,” J. Midlife Health, vol. 5, no. 1, pp. 6-9, 2014.
@article{"International Journal of Medical, Medicine and Health Sciences:70310", author = "Vladyslav Povoroznyuk and Nataliia Dzerovych and Larysa Martynyuk and Tetiana Kovtun", title = "Bone Mineral Density and Trabecular Bone Score in Ukrainian Women with Obesity", abstract = "Obesity and osteoporosis are the two diseases whose
increasing prevalence and high impact on the global morbidity and
mortality, during the two recent decades, have gained a status of
major health threats worldwide. Obesity purports to affect the bone
metabolism through complex mechanisms. Debated data on the
connection between the bone mineral density and fracture prevalence
in the obese patients are widely presented in literature. There is
evidence that the correlation of weight and fracture risk is sitespecific.
This study is aimed at determining the connection between
the bone mineral density (BMD) and trabecular bone score (TBS)
parameters in Ukrainian women suffering from obesity. We
examined 1025 40-89-year-old women, divided them into the groups
according to their body mass index: Group A included 360 women
with obesity whose BMI was ≥30 kg/m2, and Group B – 665 women
with no obesity and BMI of ", keywords = "Bone mineral density, trabecular bone score, obesity,
women.", volume = "9", number = "5", pages = "452-4", }