Towards the Integration of a Micro Pump in μTAS

The objective of this study is to present a micro mechanical pump that was fabricated using SwIFT™ microfabrication surface micromachining process and to demonstrate the feasibility of integrating such micro pump into a micro analysis system. The micropump circulates the bio-sample and magnetic nanoparticles through different compartments to separate and purify the targeted bio-sample. This article reports the flow characteristics in the microchannels and in a crescent micro pump.


Authors:



References:
[1] Kilani, M., Development of a Surface Micromachined Spiral-Channel Viscous Pump, The Florida State University, 2002
[2] Sosnowchik, B. D., Galambos, P. C., Sharp, K.V., Jenkins, M.W., Horn, M.W., Hendrix, J.R., SPIE, 2003
[3] Kilani M., Glambos P., Haik Y., Chen C-J. Design and Analysis of Surface Micromachined Spiral Channel Viscous Pump, Journal of Fluid Engineering, 152(2), 339-344, 2003.
[4] Chen C-J, Galambos P, Haik Y, Kilani M, Surface Micromachined Mechanical Micropumps and Fluid Shear Mixing, Lysing and Separation Microsystem, US Patent Application 20040126254, 2004.
[5] Tsai, Jr-Hung, Lin, Liwei, Journal of Microelectromechanical Systems, Vol. 11, NO. 6, 2002.
[6] Manz, A., Effenhauser, C.S., Burggraf, N., Harrison, D. J. Seller,, K., and Fluri, K., Journal of Micromechanics and Micro Engineering, Vol. 4, 1994.
[7] Moroney, R.M., White, R.M., and Howe, R.T, IEEE 1990 Ultrasonics Symposium Proceedings, Honolulu, 1990
[8] Hsu T-R. MEMS and Microsystems Design and Manufacture. New York, New York: McGraw-Hill, 2002.
[9] Blanchard R.J.W., Grotenhuis I., LaFave J.W., Perry Jr. J.F. Proceedings of the Society for Experimental Biology and Medicine 1965 Vol. 118; pages 465-468.
[10] Gupta P.K., Hung C. T. Journal of Encapsulation 1989; 427-462.
[11] Okandan Murat, (SPIE) Micromachining and Microfabrication Symposium; San Francisco, CA. SPIE Publishing; 2001. p. 133-39.
[12] Kalyan K. Kuricheti, Volker Buschmann, Paul Brister and Kennith D. Weston. Velocity Imaging in Microfluidic Devices using Fluorescence Correlation Spectroscopy. Department of Chemistry, The Florida State University.