Region Based Hidden Markov Random Field Model for Brain MR Image Segmentation

In this paper, we present the region based hidden Markov random field model (RBHMRF), which encodes the characteristics of different brain regions into a probabilistic framework for brain MR image segmentation. The recently proposed TV+L1 model is used for region extraction. By utilizing different spatial characteristics in different brain regions, the RMHMRF model performs beyond the current state-of-the-art method, the hidden Markov random field model (HMRF), which uses identical spatial information throughout the whole brain. Experiments on both real and synthetic 3D MR images show that the segmentation result of the proposed method has higher accuracy compared to existing algorithms.




References:
[1] J. Besag, Spatial interaction and the statistical analysis of lattice system
(with discussion), J. of Royal Statist. Soc., series B, 36(2):192-326, 1974.
[2] T. F. Chan, and S. Esedoglu, Aspects of Total Variation Regularized L1
Function Approximation'' to appear in USIAMJ. Appl. Math. 2005.
[3] L. P. Clarke, R. P. Velthuizen, M. A. Camacho, J. J. Heine, M.
Vaidyanathan, L. O. Hall, R. W. Hatcher, and M. L. Silbiger, MRI
Segmentation: methods and applications, Megnetic Resonance Imaging,
13(3):343-368, 1995.
[4] M. B. Cuadra, B. Platel, E. Solanas, T. Butz, and J. -Ph. Thiran, Validation
of tissue modelization and classification techniques in T1-weighted MR
brain images, MICCAI, pp. 290-297, 2002.
[5] R. Guillemaud, and J. M. Brady, Estimating the bias field of MR images,
IEEE Transactions on Medical. Imaging, 16(3):238-251, 1997.
[6] R. K. -S. Kwan, A. C. Evans, and G. B. Pike, MRI simulation-based
evaluation of image-processing and classification methods, IEEE
Transactions on Medical. Imaging, 18(11):1085-1097, Nov, 1999.
[7] E. Solanas, V. Duay, O. Cuisenaire, and J. -P.Thiran, Relative anatomical
location for statistical non-parameter brain tissue classification in MR
images, Int-l conference on image processing (ICIP), 2001.
[8] W. M. Wells, E. L. Grimson, R. Kikinis, and F. A. Jolesz, Adaptive
segmentation of MRI data, IEEE Transactions on Medical. Imaging ,
15(4):429-442, 1996.
[9] Y. Zhang, M. Brady, and S. Smith, Segmentation of brain MR images
through a hidden Markov random field model and the
expectationmaximization algorithm, IEEE Transactions on Medical.
Imaging, 20(1):45-57, 2001.
[10] S. C. Zhu, and A. Yuille, Region Competition: Unifying snakes, region
growing, and Bayes/MDL for multiband image segmentation, IEEE
Transactions on Pattern Analysis and Machine Intelligence,
18(9):884-900, 1996.