Optimizing Voltage Parameter of Deep Brain Stimulation for Parkinsonian Patients by Modeling
Deep Brain Stimulation or DBS is the second solution
for Parkinson's Disease. Its three parameters are: frequency, pulse
width and voltage. They must be optimized to achieve successful
treatment. Nowadays it is done clinically by neurologists and there is
not certain numerical method to detect them. The aim of this research
is to introduce simulation and modeling of Parkinson's Disease
treatment as a computational procedure to select optimum voltage.
We recorded finger tremor signals of some Parkinsonian patients
under DBS treatment at constant frequency and pulse width but
variable voltages; then, we adapted a new model to fit these data. The
optimum voltages obtained by data fitting results were the same as
neurologists- commented voltages, which means modeling can be
used as an engineering method to select optimum stimulation
voltages.
[1] H. Yu, J. S. Neimat, "The Treatment of Movement Disorders by Deep
Brain Stimulation", Vol. 5, 26-36, January 2008 ┬® The American
Society for Experimental NeuroTherapeutics, Inc.
[2] D. S. Kern, R. Kumar, "Deep Brain Stimulation", The Neurologist ÔÇó
Volume 13, Number 5, September 2007.
[3] R. Edwards, A. Beuter, "Parkinsonian Tremor and Simplification in
Network Dynamics" Bulletin of Mathematical Biology (1999)51,
157_177 Article No. bulm 1998.0086
[4] A. H. V. Schapira, E. Bezard, J. Brotchie, F. Calon, G. L. Collingridge,
B. Ferger, B. Hengerer, E. Hirsch, P. Jenner, N. Le Novere, J. A.
Obeso, M. A. Schwarzschild, U. Spampinate and G. Davidai."Novel
Pharmacological Targets the Treatment of Parkinson-s Disease"
NATURE REVIEWS DRUG DISCOVERY, VOLUME 5, Oct 2006,
845
[5] J. L. Alberts, M.S. Vitek, " The Persistent Effects of Unilateral Pallidal
and Subthalamic Deep Brain Stimulation on Force Control in
Advanced Parkinson-s Patients"
[6] M. Haeri, Y. Sarbaz, Sh. Gharibzadeh, "Modeling the Parkinson-s
tremor and its treatments", Journal of Theoretical Biology 236, 311-
322, 2005.
[7] P. Limousin, I. Martinez-Torres, "Deep Brain Stimulation for
Parkinson-s Disease" Vol. 5, 309-319, April 2008, the American
Society for Experimental NeuroTherapeutics,Inc.
[8] A. Antonini, "New Strategies in Motor Parkinsonism" 2007 Elsevier
[9] X. J. Feng, B. Greenwald, H. Rabitz, E. S. Brrown and R. Kosut. "
ToWard Closed-Loop Optimization of Deep Brain Stimulation for
Parkinson-s Disease: Concepts and Lessons from a Computational
Modeling" Appears in J. Neuroengineering 4 (2007) L14-L21
[10] T. Fiegele, G. Feuchtner, F. Sohm, R. Bauer, J. V. Anton, T. Gotwald
and et al "Accuracy of stereotactic electrode placement in deep brain
stimulation by intraoperative computed tomography"., Department of
Neurosurgery, Innsbruck Medical University, Anichstrasse 35, 6020
Innsbruck, Austria b Department of Radiology II, Innsbruck Medical
University, Innsbruck, Austria Received 16 August 2007; received in
revised form 13 November 2007; accepted 3 January 2008
[11] A. M. Kuncel, W. M. Grill, "Selection of stimulus parameters for deep
brain stimulation", Clinical Neurophysiology 115 (2004) 2431-2441
[12] Erwin B. Montgomery Jra,_, John T. Galeb "Mechanisms of action of
deep brain stimulation (DBS)" Department of Neurology, National
Primate Research Center, University of Wisconsin-Madison, H6/538
CSC, 600 Highland Ave., Madison, WI 53792, USA Department of
Neurosurgery, Massachusetts General Hospital/Harvard Medical
School, Edwards Research Building, EDR 410, 50 Blossom St.,
Boston, MA 02114, USA
[13] M.S. Titcombe, L. Glass, A. Beuter , "Dynamics of Parkinsonian
tremor during deep brain stimulation", American Institute of Physics,
DECEMBER 2001.
[14] T. O. Videen, M. C. Campbell , S. D. Tabbal, M. Karimi, T. Hershey,
J. S. Perlmutter, "Validation of a fiducial-based atlas localization
method for deep brain stimulation contacts in the area of the
subthalamic nucleus", Department of Neurology, Washington
University School of Medicine, St. Louis, MO 63110, USA
Mallinckrodt Institute of Radiology, Washington University School of
Medicine, St. Louis, MO 63110, USA Department of Psychiatry,
Washington University School of Medicine, St. Louis, MO 63110,
USA Department of Anatomy & Neurobiology, Washington University
School of Medicine, St. Louis, MO 63110, USA Program in Physical
Therapy, Washington University School of Medicine, St. Louis, MO
63110, USA Received 7 June 2007; received in revised form 11
October 2007; accepted 11 October 2007
[15] B. Blad, L. Bertenstam, S. Rehncrona, H. Bjartmarz, A.-L. Törnqvist,
"Measurement of contact impedance of electrodes used for deep brain
stimulation", ITBM-RBM 26 (2005) 344-346.
[1] H. Yu, J. S. Neimat, "The Treatment of Movement Disorders by Deep
Brain Stimulation", Vol. 5, 26-36, January 2008 ┬® The American
Society for Experimental NeuroTherapeutics, Inc.
[2] D. S. Kern, R. Kumar, "Deep Brain Stimulation", The Neurologist ÔÇó
Volume 13, Number 5, September 2007.
[3] R. Edwards, A. Beuter, "Parkinsonian Tremor and Simplification in
Network Dynamics" Bulletin of Mathematical Biology (1999)51,
157_177 Article No. bulm 1998.0086
[4] A. H. V. Schapira, E. Bezard, J. Brotchie, F. Calon, G. L. Collingridge,
B. Ferger, B. Hengerer, E. Hirsch, P. Jenner, N. Le Novere, J. A.
Obeso, M. A. Schwarzschild, U. Spampinate and G. Davidai."Novel
Pharmacological Targets the Treatment of Parkinson-s Disease"
NATURE REVIEWS DRUG DISCOVERY, VOLUME 5, Oct 2006,
845
[5] J. L. Alberts, M.S. Vitek, " The Persistent Effects of Unilateral Pallidal
and Subthalamic Deep Brain Stimulation on Force Control in
Advanced Parkinson-s Patients"
[6] M. Haeri, Y. Sarbaz, Sh. Gharibzadeh, "Modeling the Parkinson-s
tremor and its treatments", Journal of Theoretical Biology 236, 311-
322, 2005.
[7] P. Limousin, I. Martinez-Torres, "Deep Brain Stimulation for
Parkinson-s Disease" Vol. 5, 309-319, April 2008, the American
Society for Experimental NeuroTherapeutics,Inc.
[8] A. Antonini, "New Strategies in Motor Parkinsonism" 2007 Elsevier
[9] X. J. Feng, B. Greenwald, H. Rabitz, E. S. Brrown and R. Kosut. "
ToWard Closed-Loop Optimization of Deep Brain Stimulation for
Parkinson-s Disease: Concepts and Lessons from a Computational
Modeling" Appears in J. Neuroengineering 4 (2007) L14-L21
[10] T. Fiegele, G. Feuchtner, F. Sohm, R. Bauer, J. V. Anton, T. Gotwald
and et al "Accuracy of stereotactic electrode placement in deep brain
stimulation by intraoperative computed tomography"., Department of
Neurosurgery, Innsbruck Medical University, Anichstrasse 35, 6020
Innsbruck, Austria b Department of Radiology II, Innsbruck Medical
University, Innsbruck, Austria Received 16 August 2007; received in
revised form 13 November 2007; accepted 3 January 2008
[11] A. M. Kuncel, W. M. Grill, "Selection of stimulus parameters for deep
brain stimulation", Clinical Neurophysiology 115 (2004) 2431-2441
[12] Erwin B. Montgomery Jra,_, John T. Galeb "Mechanisms of action of
deep brain stimulation (DBS)" Department of Neurology, National
Primate Research Center, University of Wisconsin-Madison, H6/538
CSC, 600 Highland Ave., Madison, WI 53792, USA Department of
Neurosurgery, Massachusetts General Hospital/Harvard Medical
School, Edwards Research Building, EDR 410, 50 Blossom St.,
Boston, MA 02114, USA
[13] M.S. Titcombe, L. Glass, A. Beuter , "Dynamics of Parkinsonian
tremor during deep brain stimulation", American Institute of Physics,
DECEMBER 2001.
[14] T. O. Videen, M. C. Campbell , S. D. Tabbal, M. Karimi, T. Hershey,
J. S. Perlmutter, "Validation of a fiducial-based atlas localization
method for deep brain stimulation contacts in the area of the
subthalamic nucleus", Department of Neurology, Washington
University School of Medicine, St. Louis, MO 63110, USA
Mallinckrodt Institute of Radiology, Washington University School of
Medicine, St. Louis, MO 63110, USA Department of Psychiatry,
Washington University School of Medicine, St. Louis, MO 63110,
USA Department of Anatomy & Neurobiology, Washington University
School of Medicine, St. Louis, MO 63110, USA Program in Physical
Therapy, Washington University School of Medicine, St. Louis, MO
63110, USA Received 7 June 2007; received in revised form 11
October 2007; accepted 11 October 2007
[15] B. Blad, L. Bertenstam, S. Rehncrona, H. Bjartmarz, A.-L. Törnqvist,
"Measurement of contact impedance of electrodes used for deep brain
stimulation", ITBM-RBM 26 (2005) 344-346.
@article{"International Journal of Medical, Medicine and Health Sciences:62597", author = "M. Sadeghi and A.H. Jafari and S.M.P. Firoozabadi", title = "Optimizing Voltage Parameter of Deep Brain Stimulation for Parkinsonian Patients by Modeling", abstract = "Deep Brain Stimulation or DBS is the second solution
for Parkinson's Disease. Its three parameters are: frequency, pulse
width and voltage. They must be optimized to achieve successful
treatment. Nowadays it is done clinically by neurologists and there is
not certain numerical method to detect them. The aim of this research
is to introduce simulation and modeling of Parkinson's Disease
treatment as a computational procedure to select optimum voltage.
We recorded finger tremor signals of some Parkinsonian patients
under DBS treatment at constant frequency and pulse width but
variable voltages; then, we adapted a new model to fit these data. The
optimum voltages obtained by data fitting results were the same as
neurologists- commented voltages, which means modeling can be
used as an engineering method to select optimum stimulation
voltages.", keywords = "modeling, Deep Brain Stimulation, Parkinson'sdisease, tremor.", volume = "5", number = "2", pages = "64-6", }
