Multifunctional Cell Processing with Plasmonic Nanobubbles
Cell processing techniques for gene and cell therapies use several separate procedures for gene transfer and cell separation or elimination, because no current technology can offer simultaneous multi-functional processing of specific cell sub-sets in heterogeneous cell systems. Using our novel on-demand nonstationary intracellular events instead of permanent materials, plasmonic nanobubbles, generated with a short laser pulse only in target cells, we achieved simultaneous multifunctional cell-specific processing with the rate up to 50 million cells per minute.
<p>[1] G. Tricot, et al. Collection, tumor contamination, and engraftment kinetics of highly purified hematopoietic progenitor cells to support high dose therapy in multiple myeloma, Blood 1998; 91: 4489-4495.
[2] A. Al-Mawali, D. Gillis, I. Lewis, The role of multiparameter flow cytometry for detection of minimal residual disease in acute myeloid leukemia, Am J Clin Pathology 2009; 131:16-26.
[3] S. Rutella, et al. Immune reconstitution after transplantation of autologous peripheral CD34+ cells: analysis of predictive factors and comparison with unselected progenitor transplants, Br J Haematol 2000; 108:105-115.
[4] A. Pfeifer, I.M. Verma, Gene therapy: promises and problems, Annu Rev Genomics Hum Genet 2001; 2:177-211.
[5] T.K. Kim, J.H. Eberwine, Mammalian cell transfection: the present and the future, Anal Bioanal Chem 2010; 397:3173-3178.
[6] M.-L. Rogers, R.A. Rush, Non-viral gene therapy for neurological diseases, with an emphasis on targeted gene delivery, J Controlled Release 2012; 157:183–189.
[7] V. Torchilin, Liposomes in drug delivery, In: Fundamentals and Applications of Controlled Release Drug Delivery, Advances in Delivery Science and Technology, Part 4, 2012; 289-328.
[8] C.X. He, Y. Tabata, J.Q. Gao, Non-viral gene delivery carrier and its three-dimensional transfection system, Int J Pharm 2010; 386:232-242.
[9] F. Scheibe, et al. Nonviral gene delivery of erythropoietin by mesenchymal stromal cells, Gene Ther 2012; 19:550-560.
[10] V.M. Gaspar, et al. Nanoparticle mediated delivery of pure P53 supercoiled plasmid DNA for gene therapy, J Controlled Release 2011;156:212-222.
[11] D. Pissuwan, T. Niidome, M.B. Cortie, The forthcoming applications of gold nanoparticles in drug and gene delivery systems, J Controlled Release 2011; 149:65-71.
[12] M. Bazan-Peregrino, C.D. Arvanitis, B. Rifai, L.W. Seymour, C.-C. Coussios, Ultrasound-induced cavitation enhances the delivery and therapeutic efficacy of an oncolytic virus in an in vitro model, J Controlled Release 2012; 157:235–242.
[13] Y. Choi, et al. A high throughput microelectroporation device to introduce a chimeric antigen receptor to redirect the specificity of human T cells, Biomed Microdevices 2010; 12:855-863.
[14] J.S. Soughayer, et al. Characterization of cellular optoporation with distance, Anal Chem 2000; 72:1342-1347.
[15] Y. Arita, et al. Spatially optimized gene transfection by laser-induced breakdown of optically trapped nanoparticles, Appl Phys Lett 2011; 98 093702.
[16] D. Stevenson, et al. Femtosecond optical transfection of cells: viability and efficiency, Opt Express 2006; 14:7125-7133.
[17] M. Schomaker, et al. Plasmonic perforation of living cells using ultrashort laser pulses and gold nanoparticles, SPIE Proc 2009; 7192: 71920U.
[18] R. Dijkink, et al. Controlled cavitation-cell interaction: trans-membrane transport and viability studies, Phys Med Biol 2008; 53:375-390.
[19] E. Lukianova-Hleb, et al. Plasmonic nanobubbles as transient vapor nanobubbles generated around plasmonic nanoparticles, ACS Nano 2010; 4:2109-2123.
[20] E. Lukianova-Hleb, et al. Selective gene transfection of individual cells in vitro with plasmonic nanobubbles, J Controlled Release 2011; 152:286-293.
[21] E. Lukianova-Hleb, D. Wagner, M. Brenner, D. Lapotko, Cell-specific transmembrane injection of molecular cargo with gold nanoparticle-generated transient plasmonic nanobubbles, Biomaterials 2012; 33:5441-5450.
[22] E.Y. Lukianova-Hleb, M. Mutonga, D.O. Lapotko, Cell-specific multifunctional processing of heterogeneous cell systems in a single laser pulse treatment, ACS Nano 2012; 6:10973-10981.
[23] E.Y. Lukianova-Hleb, X. Ren, J.A. Zasadzinski, X. Wu, D.O. Lapotko, Plasmonic nanobubbles enhance efficacy and selectivity of chemotherapy against drug-resistant cancer cells, Adv Mater 2012; 24:3831-3837.
[24] E. Lukianova-Hleb, et al. Improved cellular specificity of plasmonic nanobubbles versus nanoparticles in heterogeneous cell systems, PLoS One 2012; 7:e34537.
[25] D. Lapotko, E. Lukianova-Hleb, A. Oraevsky, Clusterization of nanoparticles during their interaction with living cells, Nanomedicine 2007; 2:241–253.</p>
<p> </p>
<p>[1] G. Tricot, et al. Collection, tumor contamination, and engraftment kinetics of highly purified hematopoietic progenitor cells to support high dose therapy in multiple myeloma, Blood 1998; 91: 4489-4495.
[2] A. Al-Mawali, D. Gillis, I. Lewis, The role of multiparameter flow cytometry for detection of minimal residual disease in acute myeloid leukemia, Am J Clin Pathology 2009; 131:16-26.
[3] S. Rutella, et al. Immune reconstitution after transplantation of autologous peripheral CD34+ cells: analysis of predictive factors and comparison with unselected progenitor transplants, Br J Haematol 2000; 108:105-115.
[4] A. Pfeifer, I.M. Verma, Gene therapy: promises and problems, Annu Rev Genomics Hum Genet 2001; 2:177-211.
[5] T.K. Kim, J.H. Eberwine, Mammalian cell transfection: the present and the future, Anal Bioanal Chem 2010; 397:3173-3178.
[6] M.-L. Rogers, R.A. Rush, Non-viral gene therapy for neurological diseases, with an emphasis on targeted gene delivery, J Controlled Release 2012; 157:183–189.
[7] V. Torchilin, Liposomes in drug delivery, In: Fundamentals and Applications of Controlled Release Drug Delivery, Advances in Delivery Science and Technology, Part 4, 2012; 289-328.
[8] C.X. He, Y. Tabata, J.Q. Gao, Non-viral gene delivery carrier and its three-dimensional transfection system, Int J Pharm 2010; 386:232-242.
[9] F. Scheibe, et al. Nonviral gene delivery of erythropoietin by mesenchymal stromal cells, Gene Ther 2012; 19:550-560.
[10] V.M. Gaspar, et al. Nanoparticle mediated delivery of pure P53 supercoiled plasmid DNA for gene therapy, J Controlled Release 2011;156:212-222.
[11] D. Pissuwan, T. Niidome, M.B. Cortie, The forthcoming applications of gold nanoparticles in drug and gene delivery systems, J Controlled Release 2011; 149:65-71.
[12] M. Bazan-Peregrino, C.D. Arvanitis, B. Rifai, L.W. Seymour, C.-C. Coussios, Ultrasound-induced cavitation enhances the delivery and therapeutic efficacy of an oncolytic virus in an in vitro model, J Controlled Release 2012; 157:235–242.
[13] Y. Choi, et al. A high throughput microelectroporation device to introduce a chimeric antigen receptor to redirect the specificity of human T cells, Biomed Microdevices 2010; 12:855-863.
[14] J.S. Soughayer, et al. Characterization of cellular optoporation with distance, Anal Chem 2000; 72:1342-1347.
[15] Y. Arita, et al. Spatially optimized gene transfection by laser-induced breakdown of optically trapped nanoparticles, Appl Phys Lett 2011; 98 093702.
[16] D. Stevenson, et al. Femtosecond optical transfection of cells: viability and efficiency, Opt Express 2006; 14:7125-7133.
[17] M. Schomaker, et al. Plasmonic perforation of living cells using ultrashort laser pulses and gold nanoparticles, SPIE Proc 2009; 7192: 71920U.
[18] R. Dijkink, et al. Controlled cavitation-cell interaction: trans-membrane transport and viability studies, Phys Med Biol 2008; 53:375-390.
[19] E. Lukianova-Hleb, et al. Plasmonic nanobubbles as transient vapor nanobubbles generated around plasmonic nanoparticles, ACS Nano 2010; 4:2109-2123.
[20] E. Lukianova-Hleb, et al. Selective gene transfection of individual cells in vitro with plasmonic nanobubbles, J Controlled Release 2011; 152:286-293.
[21] E. Lukianova-Hleb, D. Wagner, M. Brenner, D. Lapotko, Cell-specific transmembrane injection of molecular cargo with gold nanoparticle-generated transient plasmonic nanobubbles, Biomaterials 2012; 33:5441-5450.
[22] E.Y. Lukianova-Hleb, M. Mutonga, D.O. Lapotko, Cell-specific multifunctional processing of heterogeneous cell systems in a single laser pulse treatment, ACS Nano 2012; 6:10973-10981.
[23] E.Y. Lukianova-Hleb, X. Ren, J.A. Zasadzinski, X. Wu, D.O. Lapotko, Plasmonic nanobubbles enhance efficacy and selectivity of chemotherapy against drug-resistant cancer cells, Adv Mater 2012; 24:3831-3837.
[24] E. Lukianova-Hleb, et al. Improved cellular specificity of plasmonic nanobubbles versus nanoparticles in heterogeneous cell systems, PLoS One 2012; 7:e34537.
[25] D. Lapotko, E. Lukianova-Hleb, A. Oraevsky, Clusterization of nanoparticles during their interaction with living cells, Nanomedicine 2007; 2:241–253.</p>
<p> </p>
@article{"International Journal of Medical, Medicine and Health Sciences:65538", author = "Ekaterina Y. Lukianova-Hleb and Dmitri O. Lapotko", title = "Multifunctional Cell Processing with Plasmonic Nanobubbles", abstract = "Cell processing techniques for gene and cell therapies use several separate procedures for gene transfer and cell separation or elimination, because no current technology can offer simultaneous multi-functional processing of specific cell sub-sets in heterogeneous cell systems. Using our novel on-demand nonstationary intracellular events instead of permanent materials, plasmonic nanobubbles, generated with a short laser pulse only in target cells, we achieved simultaneous multifunctional cell-specific processing with the rate up to 50 million cells per minute.
", keywords = "Delivery, cell separation, graft, laser, plasmonic nanobubble, cell therapy, gold nanoparticle.", volume = "7", number = "11", pages = "692-5", }
