Impact of Obesity on Fertility in a Population of Women in the Wilaya of Batna
Our study was designed to highlight changes in
certain biochemical parameters (CH, TG, HDL, GOT, GPT, LDL and
CRP), obese women infertile fertile witnesses and research potential
pathophysiological link between obesity and infertility in this
population of women. This practical work was focused on a
population of 24 obese women infertile, compared to controls,
subjects without any pathology causing disruption of parameters to
be studied to determine the contribution of obesity in the etiology of
infertility. The assay results revealed a highly significant difference
between the two groups in serum CH, TG, HDL, TGO and TGP (P
<0.0001) and in the rate of LDL (p = 0.0017) and CRP (p = 0.02).
The present study indicates that obesity is associated with infertility,
but no direct pathophysiological link between obesity and infertility
has been determined. Further in-depth studies are needed to
determine the exact mechanism by which overweight leads to female
infertility.
[1] J. W. Rich-Edwards, D. Spiegelman, M. Garland, E. Hertzmark, D. J.
Hunter, G. A. Colditz, W. C. Willett, J. E. W and H Manson, "Physical
Activity, Body Mass Index and Ovulatory Disorder Infertility”,
Epidemiology, 2002, pp. 13,184-190.
[2] R. Pasquali, L. Patton and A. Gambineri, "Obesity and Infertility”. Curr
Opin Endocrinol Diabetes Obes, 2006, pp. 14, 482-7.
[3] J. F. Strauss, "The Synthesis and Metabolism of Steroid Hormones”. In:
J. F. Strauss, R. L. Barbieri (eds). Yen and Jaffe’s Reproductive
Endocrinology: Physiology, Pathophysiology, and Clinical
Management, 5th edn, Philadelphia, PA: Elsevier, 2004, pp. 12, 51-54.
[4] D. R. Illingworth, D. K. Corbin, E. D. Kemp, E. J. Keenan, "Hormone
Changes during the Menstrual Cycles in Abeta-Lipoproteinemia:
Reduced Luteal Phase Progesterone in a Patient with Homozygous
Hypobeta-Lipoproteinemia”. Proc Natl Acad Sci, 1982, pp. 79, 6685-
6687.
[5] L. Speroff, R. H. Glass, N. G. Kase, "Progesterone in Human Pregnancy
and Parturition” Clinical Gynecologic Endocrinology and Infertility,
ED-5. Baltimore: Williams and Wilkins, USA, 1994, pp. 687-806.
[6] G. Hu, Q. Qiao, J. Tuomilehto et al, "Plasma Insulin and Cardiovascular
Mortality in Non-Diabetic European Men and Women: A Meta-Analysis
of Data from Eleven Prospective Studies”. The DECODE Insulin Study
Group. Diabetologia, 2004, pp. 47, 1245–56.
[7] R. L. Barbieri, A. Makris, R. W. Randall, G. Daniels, R. W. Kistner, K.
J. Ryan, "Insulin Stimulates Androgen Accumulation in Incubations of
Ovarian Stroma Obtained from Women with Hyperandrogenism” . J
Clin Endocrinol Metab, 1986, pp. 62,904 –10.
[8] S. Handwerger, et al, "Pre-beta-HDL Stimulates Placental Lactogen
Release from Human Trophoblast Cells”. Am. J. Physiol, 1999, pp. 276,
E384–E389.
[9] G.H. Rothblat et al, "Cell Cholesterol Efflux: Integration of Old and
New Observations Provides New Insights”. J Lipid Res, 1999, pp.
40,781–796.
[10] M. Krieger, "Charting the Fate of the "Good Cholesterol: Identification
and Characterization of the HDL Receptor SR-BI”. Ann. Rev.Biochem,
1999, pp. 68, 523–588.
[11] B. Trigatti et al, "Influence of the High Density Lipoprotein Receptor
SR-BI on Reproductive and Cardiovascular Pathophysiology”. Proc.
Natl. Acad. Sci. USA, 1999, pp. 96, 9322–9327.
[12] J. M. Clark, "The Epidemiology of Nonalcoholic Fatty Liver Disease in
Adults”. J Clin Gastroenterol, 2006, pp. 40(3):S5–S10.
[13] J. Ludwig, R. T. Viggiano, D. B. McGill, "Nonalcoholic Steatohepatitis:
Mayo Clinic Experience with a Hitherto Unnamed Disease”. Mayo Clin
Proc, 1980, pp. 55,342–8.
[14] N. A. Khan, "Inflammation et Immunité: Implications Dans L’obésité et
le Diabète de Type 2”. Oléagineux, Corps Gras, Lipides, 2006, pp.
13(5): 343-51.
[15] C.C. Kelly, H. Lyall, J.R Petrie, G.W Gould, J.M Connell, N. Sattar,
"Low Grade Chronic Inflammation in Women with Polycystic Ovarian
Syndrome”. J Clin Endocrinol Metab, 2001, pp. 86, 2453 –2455.
[1] J. W. Rich-Edwards, D. Spiegelman, M. Garland, E. Hertzmark, D. J.
Hunter, G. A. Colditz, W. C. Willett, J. E. W and H Manson, "Physical
Activity, Body Mass Index and Ovulatory Disorder Infertility”,
Epidemiology, 2002, pp. 13,184-190.
[2] R. Pasquali, L. Patton and A. Gambineri, "Obesity and Infertility”. Curr
Opin Endocrinol Diabetes Obes, 2006, pp. 14, 482-7.
[3] J. F. Strauss, "The Synthesis and Metabolism of Steroid Hormones”. In:
J. F. Strauss, R. L. Barbieri (eds). Yen and Jaffe’s Reproductive
Endocrinology: Physiology, Pathophysiology, and Clinical
Management, 5th edn, Philadelphia, PA: Elsevier, 2004, pp. 12, 51-54.
[4] D. R. Illingworth, D. K. Corbin, E. D. Kemp, E. J. Keenan, "Hormone
Changes during the Menstrual Cycles in Abeta-Lipoproteinemia:
Reduced Luteal Phase Progesterone in a Patient with Homozygous
Hypobeta-Lipoproteinemia”. Proc Natl Acad Sci, 1982, pp. 79, 6685-
6687.
[5] L. Speroff, R. H. Glass, N. G. Kase, "Progesterone in Human Pregnancy
and Parturition” Clinical Gynecologic Endocrinology and Infertility,
ED-5. Baltimore: Williams and Wilkins, USA, 1994, pp. 687-806.
[6] G. Hu, Q. Qiao, J. Tuomilehto et al, "Plasma Insulin and Cardiovascular
Mortality in Non-Diabetic European Men and Women: A Meta-Analysis
of Data from Eleven Prospective Studies”. The DECODE Insulin Study
Group. Diabetologia, 2004, pp. 47, 1245–56.
[7] R. L. Barbieri, A. Makris, R. W. Randall, G. Daniels, R. W. Kistner, K.
J. Ryan, "Insulin Stimulates Androgen Accumulation in Incubations of
Ovarian Stroma Obtained from Women with Hyperandrogenism” . J
Clin Endocrinol Metab, 1986, pp. 62,904 –10.
[8] S. Handwerger, et al, "Pre-beta-HDL Stimulates Placental Lactogen
Release from Human Trophoblast Cells”. Am. J. Physiol, 1999, pp. 276,
E384–E389.
[9] G.H. Rothblat et al, "Cell Cholesterol Efflux: Integration of Old and
New Observations Provides New Insights”. J Lipid Res, 1999, pp.
40,781–796.
[10] M. Krieger, "Charting the Fate of the "Good Cholesterol: Identification
and Characterization of the HDL Receptor SR-BI”. Ann. Rev.Biochem,
1999, pp. 68, 523–588.
[11] B. Trigatti et al, "Influence of the High Density Lipoprotein Receptor
SR-BI on Reproductive and Cardiovascular Pathophysiology”. Proc.
Natl. Acad. Sci. USA, 1999, pp. 96, 9322–9327.
[12] J. M. Clark, "The Epidemiology of Nonalcoholic Fatty Liver Disease in
Adults”. J Clin Gastroenterol, 2006, pp. 40(3):S5–S10.
[13] J. Ludwig, R. T. Viggiano, D. B. McGill, "Nonalcoholic Steatohepatitis:
Mayo Clinic Experience with a Hitherto Unnamed Disease”. Mayo Clin
Proc, 1980, pp. 55,342–8.
[14] N. A. Khan, "Inflammation et Immunité: Implications Dans L’obésité et
le Diabète de Type 2”. Oléagineux, Corps Gras, Lipides, 2006, pp.
13(5): 343-51.
[15] C.C. Kelly, H. Lyall, J.R Petrie, G.W Gould, J.M Connell, N. Sattar,
"Low Grade Chronic Inflammation in Women with Polycystic Ovarian
Syndrome”. J Clin Endocrinol Metab, 2001, pp. 86, 2453 –2455.
@article{"International Journal of Medical, Medicine and Health Sciences:66571", author = "A. Chennaf and M. Yahia and W. Bouafia and S. Benbia and D. Khellaf", title = "Impact of Obesity on Fertility in a Population of Women in the Wilaya of Batna", abstract = "Our study was designed to highlight changes in
certain biochemical parameters (CH, TG, HDL, GOT, GPT, LDL and
CRP), obese women infertile fertile witnesses and research potential
pathophysiological link between obesity and infertility in this
population of women. This practical work was focused on a
population of 24 obese women infertile, compared to controls,
subjects without any pathology causing disruption of parameters to
be studied to determine the contribution of obesity in the etiology of
infertility. The assay results revealed a highly significant difference
between the two groups in serum CH, TG, HDL, TGO and TGP (P
", keywords = "Obesity, fertility, infertility, biochemical, women.", volume = "8", number = "2", pages = "105-4", }
