Identification of Regulatory Mechanism of Orthostatic Response
En bloc assumes modeling all phases of the orthostatic test with the only one mathematical model, which allows the complex parametric view of orthostatic response. The work presents the implementation of a mathematical model for processing of the measurements of systolic, diastolic blood pressure and heart rate performed on volunteers during orthostatic test. The original assumption of model hypothesis that every postural change means only one Stressor, did not complying with the measurements of physiological circulation factor-time profiles. Results of the identification support the hypothesis that second postural change of orthostatic test causes induced Stressors, with the observation of a physiological regulation mechanism. Maximal demonstrations are on the heart rate and diastolic blood pressure-time profile, minimal are for the measurements of the systolic blood pressure. Presented study gives a new view on orthostatic test with impact on clinical practice.
[1] Z. Placheta, J. Siegelova, M. Stejfa, P. Homolka, T. Kara, and J. Novotny, "The orthostatic tests,” in Stress-type diagnostics in outpatient and clinical practice (Zatezova diagnostika v amblulantni a klinicke praxi), Praha: Grada Publishing, 1999, pp. 160–166. [2] Z. Ambler, The basics of Neurology (Zaklady neurologie), 6th ed., L. Houdek, Ed. Praha: Galen, 2006, pp. 90. [3] P. Mitro, "Diagnostics and therapy of hypotension in general practitioner’s office (Diagnostika a terapia hypotenznych stavov v ambulancii praktickeho lekara),” Via practica, vol. 3, pp. 518–522, Nov. 2006.
[4] K. Ondrusova, "Rehabilitation of patients after ischemic stroke: Evaluation of heart rate variability (Rehabilitacia pacientov po cievnej
mozgovej prihode: Hodnotenie variability srdecnej frekvencie),”
Diploma thesis, Dept. Phys. Rehab., Fac. Medic., Masaryk Univ., Brno,
2010. [5] F. Schellong, B. Lüderitz, Regulationsprüfung des Kreislaufs,
Darmstadt: Steinkopff, 1954. [6] W. Hollmann, H.K. Strüder, H. Predel, and Ch.V.M. Tagarakis,
Spiroergometrie: Kardiopulmonale Leistungsdiagnostik des Gesunden
und Kranken, Stuttgart: Schattauer, 2006, pp. 5–6. [7] H. Selye, The stress of life, New York, Toronto, London: McGraw-Hill,
1965. [8] M. Vigas, Neuroendocrine reaction of man in stress (Neuroendokrinna
reakcia v strese u cloveka), L. Macho, Ed. Bratislava: Veda, Publishing
House of the Slovak Academy of Sciences, 1985, pp. 15-40. [9] R. Kvetnansky, E. L. Sabban, and M. Palkovits, "Catecholaminergic
systems in stress: Structural and molecular genetic approaches,” Physiol.
Rev., vol. 89, pp. 535–606, Apr. 2009. [10] J. Koska, L. Ksinantová, R. Kvetnanský, M. Marko, D. Hamar, M.
Vigas, and R. Hatala, "Effect of head-down bed rest on the
neuroendocrine response to orthostatic stress in physically fit men,"
Physiol. Res., vol. 52, no. 3, pp. 333-339, 2003. [11] Z. Radikova, A. Penesova, J. Koska, R. Kvetnansky, D. Jezova, M.
Huckova, M. Vigas, and L. Macho, "Does orthostatic stress influence
the neuroendocrine response to subsequent hypoglycemia in humans?,”
Ann. N. Y. Acad. Sci., vol. 1018, pp. 576-581, Jun. 2004. [12] A. Penesova, E. Cizmarova, V. Belan, P. Blazicek, R. Imrich, M. Vlcek,
M. Vigas, D. Selko, J. Koska, and Z. Radikova, "Insulin resistance in
young, lean male subjects with essential hypertension,” J. Hum.
Hypertens., vol. 25, no. 6, pp. 391-400, Jun. 2011. [13] L. Dedík, M. Durisova, System approach in technical, environmental,
and bio-medical studies, Bratislava: Publishing House of Slovak
University of Technology; 1999. 168 pp., Available:
http://www.uef.sav.sk/advanced.htm.[14] T. Trnovec, L. Dedik, T.A. Jusko, K. Lancz, L. Palkovicova, A. Kocan,
E. Sovcikova, S. Wimmerova, J. Tihanyi, H. Patayova, and I. Hertz-
Picciotto, "Assessment of exposure to PCB 153 from breast feeding and normal food intake in individual children using a system approach
model,” Chemosphere, vol. 85, no. 11, pp. 1687-1693, Dec. 2011. [15] I. Nozawa, S. Imamura, K. Hisamatsu, and Y. Murakami, "The
relationship between orthostatic dysregulation and the orthostatic test in
dizzy patients," Eur. Arch. Otorhinolaryngol., vol. 253, no.4-5, pp. 268-
272, May 1996. [16] R. Winker, W. Prager, A. Haider, B. Salameh, and HW. Rüdiger,
"Schellong test in orthostatic dysregulation: a comparison with tilt-table
testing," Wien. Klin. Wochenschr., vol. 117, no. 1-2, pp. 36-41, Jan.
2005. [17] N. Ohashi, H. Nakagawa, K. Kanda, and K. Mizukoshi,
"Otoneurological manifestations of the Shy-Drager syndrome," Eur.
Arch. Otorhinolaryngol, vol. 248, no. 3, pp. 150-152, Feb. 1991. [18] M. Rada, R. Zivna, "An evaluation of the effectiveness of hypertension
treatment in aviation personnel: Perspectives and the present situation,”
Miletary Medical Science Letters, no. 2, pp. 63-67, 2003.
[1] Z. Placheta, J. Siegelova, M. Stejfa, P. Homolka, T. Kara, and J. Novotny, "The orthostatic tests,” in Stress-type diagnostics in outpatient and clinical practice (Zatezova diagnostika v amblulantni a klinicke praxi), Praha: Grada Publishing, 1999, pp. 160–166. [2] Z. Ambler, The basics of Neurology (Zaklady neurologie), 6th ed., L. Houdek, Ed. Praha: Galen, 2006, pp. 90. [3] P. Mitro, "Diagnostics and therapy of hypotension in general practitioner’s office (Diagnostika a terapia hypotenznych stavov v ambulancii praktickeho lekara),” Via practica, vol. 3, pp. 518–522, Nov. 2006.
[4] K. Ondrusova, "Rehabilitation of patients after ischemic stroke: Evaluation of heart rate variability (Rehabilitacia pacientov po cievnej
mozgovej prihode: Hodnotenie variability srdecnej frekvencie),”
Diploma thesis, Dept. Phys. Rehab., Fac. Medic., Masaryk Univ., Brno,
2010. [5] F. Schellong, B. Lüderitz, Regulationsprüfung des Kreislaufs,
Darmstadt: Steinkopff, 1954. [6] W. Hollmann, H.K. Strüder, H. Predel, and Ch.V.M. Tagarakis,
Spiroergometrie: Kardiopulmonale Leistungsdiagnostik des Gesunden
und Kranken, Stuttgart: Schattauer, 2006, pp. 5–6. [7] H. Selye, The stress of life, New York, Toronto, London: McGraw-Hill,
1965. [8] M. Vigas, Neuroendocrine reaction of man in stress (Neuroendokrinna
reakcia v strese u cloveka), L. Macho, Ed. Bratislava: Veda, Publishing
House of the Slovak Academy of Sciences, 1985, pp. 15-40. [9] R. Kvetnansky, E. L. Sabban, and M. Palkovits, "Catecholaminergic
systems in stress: Structural and molecular genetic approaches,” Physiol.
Rev., vol. 89, pp. 535–606, Apr. 2009. [10] J. Koska, L. Ksinantová, R. Kvetnanský, M. Marko, D. Hamar, M.
Vigas, and R. Hatala, "Effect of head-down bed rest on the
neuroendocrine response to orthostatic stress in physically fit men,"
Physiol. Res., vol. 52, no. 3, pp. 333-339, 2003. [11] Z. Radikova, A. Penesova, J. Koska, R. Kvetnansky, D. Jezova, M.
Huckova, M. Vigas, and L. Macho, "Does orthostatic stress influence
the neuroendocrine response to subsequent hypoglycemia in humans?,”
Ann. N. Y. Acad. Sci., vol. 1018, pp. 576-581, Jun. 2004. [12] A. Penesova, E. Cizmarova, V. Belan, P. Blazicek, R. Imrich, M. Vlcek,
M. Vigas, D. Selko, J. Koska, and Z. Radikova, "Insulin resistance in
young, lean male subjects with essential hypertension,” J. Hum.
Hypertens., vol. 25, no. 6, pp. 391-400, Jun. 2011. [13] L. Dedík, M. Durisova, System approach in technical, environmental,
and bio-medical studies, Bratislava: Publishing House of Slovak
University of Technology; 1999. 168 pp., Available:
http://www.uef.sav.sk/advanced.htm.[14] T. Trnovec, L. Dedik, T.A. Jusko, K. Lancz, L. Palkovicova, A. Kocan,
E. Sovcikova, S. Wimmerova, J. Tihanyi, H. Patayova, and I. Hertz-
Picciotto, "Assessment of exposure to PCB 153 from breast feeding and normal food intake in individual children using a system approach
model,” Chemosphere, vol. 85, no. 11, pp. 1687-1693, Dec. 2011. [15] I. Nozawa, S. Imamura, K. Hisamatsu, and Y. Murakami, "The
relationship between orthostatic dysregulation and the orthostatic test in
dizzy patients," Eur. Arch. Otorhinolaryngol., vol. 253, no.4-5, pp. 268-
272, May 1996. [16] R. Winker, W. Prager, A. Haider, B. Salameh, and HW. Rüdiger,
"Schellong test in orthostatic dysregulation: a comparison with tilt-table
testing," Wien. Klin. Wochenschr., vol. 117, no. 1-2, pp. 36-41, Jan.
2005. [17] N. Ohashi, H. Nakagawa, K. Kanda, and K. Mizukoshi,
"Otoneurological manifestations of the Shy-Drager syndrome," Eur.
Arch. Otorhinolaryngol, vol. 248, no. 3, pp. 150-152, Feb. 1991. [18] M. Rada, R. Zivna, "An evaluation of the effectiveness of hypertension
treatment in aviation personnel: Perspectives and the present situation,”
Miletary Medical Science Letters, no. 2, pp. 63-67, 2003.
@article{"International Journal of Medical, Medicine and Health Sciences:58878", author = "E. Hlavacova and J. Chrenova and Z. Rausova and M. Vlcek and A. Penesova and L. Dedik", title = "Identification of Regulatory Mechanism of Orthostatic Response", abstract = "En bloc assumes modeling all phases of the orthostatic test with the only one mathematical model, which allows the complex parametric view of orthostatic response. The work presents the implementation of a mathematical model for processing of the measurements of systolic, diastolic blood pressure and heart rate performed on volunteers during orthostatic test. The original assumption of model hypothesis that every postural change means only one Stressor, did not complying with the measurements of physiological circulation factor-time profiles. Results of the identification support the hypothesis that second postural change of orthostatic test causes induced Stressors, with the observation of a physiological regulation mechanism. Maximal demonstrations are on the heart rate and diastolic blood pressure-time profile, minimal are for the measurements of the systolic blood pressure. Presented study gives a new view on orthostatic test with impact on clinical practice.
", keywords = "En bloc modeling, physiological circulatory factor, postural change, stressor", volume = "7", number = "5", pages = "191-6", }
