Antibacterial activity of Plumeria alba (Frangipani)
petals methanolic extracts were evaluated against Escherichia coli,
Proteus vulgaris,Staphylococcus aureus, Klebsiella pneumoniae,
Pseudomonas aeruginosa, Staphylococcus saprophyticus,
Enterococcus faecalis and Serratia marcescens by using disk
diffusion method. Concentration extracts (80 %) showed the highest
inhibition zone towards Escherichia coli (14.3 mm). Frangipani
extract also showed high antibacterial activity against
Staphylococcus saprophyticus, Proteus vulgaris and Serratia
marcescens, but not more than the zones of the positive control used.
Comparison between two broad specrum antibiotics to frangipani
extracts showed that the 80 % concentration extracts produce the
same zone of inhibition as Streptomycin. Frangipani extracts showed
no bacterial activity towards Klebsiella pneumoniae, Pseudomonas
aeruginosa and Enterococcus faecalis. There are differences in the
sensitivity of different bacteria to frangipani extracts, suggesting that
frangipani-s potency varies between these bacteria. The present
results indicate that frangipani showed significant antibacterial
activity especially to Escherichia coli.
[1] Asolkar LV, Kakkar KK, Chakre OJ.(1992) Second Supplement to
Glossary of Indian medicinal plants with active principles; pp.173
[2] Amani S, Isla MI, Vattuone M, Poch M, Cudmani N, Sampietro A
(1998). Antimicrobial activities in some Argentine Medicinal Plants.
Acta Horticulture. 501:115-122.
[3] Arias ME, Gomez JD, Cudmani N, Vattuone MA, Isla MI (2004).
Antibacterial activity of ethanolic and aqueous extract of Acacia aroma
Gill ex Hook et. Life Science.
[4] Baron, Samuel 1996. Medical Microbiology, 4th ed., The University of
Texas Medical Branch at Galveston.75:191-202.
[5] Barrett, S.P., M.A. Savage, M.P. Rebec, N. Guyot A Andrews and S.B.
Shrimpton, 2000. Antibiotic sensitivity of bacteria associated with
communityacquired urinary tract infection in Britain. J. Antimicrob.
Chemother, 44: 359-365
[6] Barton, M.D., 1998. Does the use of antibiotics in animals affect human
health? Aust. Vet. J., 76: 177- 180.
[7] Bonten, M., E. Stobberingh, J. Philips and A. Houben, 1992. Antibiotic
resistance of Escherichia coli in fecal samples of healthy people in two
different areas in an industrialized country. Infection, 20: 258- 262.
[8] Cushnie TP, Lamb AJ (2005). Anti microbial activities of flavonoids.
Int. J. Antimicrob. Agents 26:343.
[9] Edward F. Gilman and Dennis G. Watson (October 1994). Plumeria alba
White Frangipani.
[10] Essawi T, Srour M (2000). Screening of some Palestinian medicinal
plants for antibacterial activity. J. Ethnopharmacol. 70:343-349.
[11] Fluit, A.C., M.E. Jones, F.J. Schmitz, J. Acar, R. Gupta and J. Verhoef,
2000. Antimicrobial susceptibility and frequency of occurrence of
clinical blood isolates in Europe from the SENTRY antimicrobial
surveillance program, 1997 and 1998. Clin. Infect. Dis., 30: 454- 460.
[12] George M Beringer, 1895. AMERICAN JOURNAL OF PHARMACY.
The APOCYNACEAE in materia medica - Volume 67, #3, March, 1895
- Page 18
[13] Hamil FA, Apio S, Mubiru NK, Bukenya-Ziraba R, Mosango M,
Maganyi OW, Soejarto DD (2003). Traditional herbal drugs of southern
uganda, II : Literature análysis and antimicrobial assays. J.
Ethnopharmacol. 84:57-78.
[14] Hartwell JL. Plants used against cancer (A survey) Quarterman
Publications, Inc. Lawrence, Massachu setts. 1982; pp.408.
[15] Henry AN, Kumeri GR, Chitra V. Flora of Tamil Nadu, India. 1987;
pp.78.
[16] Hooton, T. M., and W. E. Stamm. 1997. Diagnosis and treatment of
uncomplicated urinary tract infection. Infect. Dis. Clin. N. Am. 11:551-
581
[17] Huouinen P.2001.Bacteriotherapy: The time has come.BMJ.323:353-
354.
[18] Ika¨heimo, R., A. Siitonen, T. Heiskanen, U. Karkkainen, P.
Kuosmanen, P. Lipponen, and P. H. Makela. 1996. Recurrence of
urinary tract infection in a primary care setting: analysis of a 1-year
follow-up of 179 women. Clin.Infect. Dis. 22:91-99.
[19] Izzo AA (2004). Drug interactions with St. John-s wort (Hypericum
perforation): A review of the clinical evidence. Int. J. Clin. Pharmacol.
Thera 42:139-148.
[20] Machado T B, Pinto A V, Pinto M C F R, Leal I C R, Silva M G, Amaral
A C F, Kuster R M, Netto - dosSantos K R (2003). Invitro activity of
Brazilian medicinal plants, naturally occurring naphthoqinones and their
analogues, against methicillin-resistant staphylococcus aureus. Int. J. of
Antimicrobial Agents 21:279-284.
[21] Kodera, Y.1997.Ch.11.In: Nutraceuticals: Designer Foods III Garlic,
Soy and Licorice, Trumbell, Ct: Food & Nutrition Press), Paul
Lanchance; ed.,pp.95-105
[22] Julia F. Morton, Director, Morton. Collectanea University of Miami
Coral Gables, Ornamental flowers with toxic and/or irritant
properties,1962
[23] McKeon, D.M., J.P. Calabrese and G.K. Bissonnette, 1995. Antibiotic
resistant gram-negative bacteria in rural ground water supplies. Water
Res., 29: 1902- 1908.
[24] Meng JC, Zhu QX, Tan RX (2000). New antimicrobial mono- and
sesquiterpenes from soroseris hookeriana Subsp.erysimoides. Planta
Medica 66: 541-544.
[25] M.P Darokar , A.Mathur, S. Dwivedi, R. Bhalla, S.P.S Khanuja, Sushil
Kumar, Currents Science Volume, 75, No 3, 1998
[26] Neu, H.C., 1992. The crisis in antibiotic resistance. Sci., 257: 1064-
1073.
[27] New Directions Laboratory of Australia, Certificate of Analysis and
Material Safety Data Sheet, Frangipani Absolute - Batch R1742 -
BCRO1 (2006)
[28] Olaleye, Mary Tolulope (2007). Cytotoxocity and antibacterial activity
of Methanolic extract of Hibiscuss sabdariffa. Journal of Medicinal
Plants Research.1: 009 - 013
[29] Ordonez AA, Cudmani NM, Gomez D, Vattuone MA, Isla MI (2003).
Antimicrobial activity of nine extracts of sechium edule (Jacq) Swartz.
Microbiology Ecology in Health and Disease 15:33-39.
[30] ├ûsterberg E, Hallander HO, Kallner A, Lundin A, Svensson SB, Åberg
H. Female urinary tract infection in primary health care: bacteriological
and clinical characteristics. Scand J Infect Dis 1990; 22: 477-484.
[31] Poyart-Salmeron C, Carlier C, Trieu-cuot P, Courtieu A L, Courvalin P
(1990). Transferable plasmid - mediated antibiotic resistance in Listeria
monocytogenes. The Lancet 335:1422-1426.
[32] Rasool S.N, Jaheerunnisa S, Kumar Chitta and Jayaveera K.N (2008),
Antimicrobial activities of Plmeria acutfolia. Journal of Medicinal Plants
Research; 2: 077 - M. Young, The Techincal Writers Handbook. Mill
Valley, CA: University Science, 1989.
[33] Reid G; Bruce. 2003. Urogenital infection in women: can probiotics
help? Post graduate medical journal.79:428-432.
[34] Salvat A, Antonnacci L, Fartunato RH, Suarez EY, Godoy HM (2001).
Screening of some plants from Northern Argentina for their
antimicrobial activity. Letters in Applied Microbiology 32: 293-297
[35] W. Rizvi, A. Kumar, R. Kumar, N. Haider. 2010. Evaluation of Anti
filarial activity in roots of Plumeria alba.Proceedings of the 6th
Conference of Medicinal and Aromatic Plants of Southeast European
countries. pp 132
[1] Asolkar LV, Kakkar KK, Chakre OJ.(1992) Second Supplement to
Glossary of Indian medicinal plants with active principles; pp.173
[2] Amani S, Isla MI, Vattuone M, Poch M, Cudmani N, Sampietro A
(1998). Antimicrobial activities in some Argentine Medicinal Plants.
Acta Horticulture. 501:115-122.
[3] Arias ME, Gomez JD, Cudmani N, Vattuone MA, Isla MI (2004).
Antibacterial activity of ethanolic and aqueous extract of Acacia aroma
Gill ex Hook et. Life Science.
[4] Baron, Samuel 1996. Medical Microbiology, 4th ed., The University of
Texas Medical Branch at Galveston.75:191-202.
[5] Barrett, S.P., M.A. Savage, M.P. Rebec, N. Guyot A Andrews and S.B.
Shrimpton, 2000. Antibiotic sensitivity of bacteria associated with
communityacquired urinary tract infection in Britain. J. Antimicrob.
Chemother, 44: 359-365
[6] Barton, M.D., 1998. Does the use of antibiotics in animals affect human
health? Aust. Vet. J., 76: 177- 180.
[7] Bonten, M., E. Stobberingh, J. Philips and A. Houben, 1992. Antibiotic
resistance of Escherichia coli in fecal samples of healthy people in two
different areas in an industrialized country. Infection, 20: 258- 262.
[8] Cushnie TP, Lamb AJ (2005). Anti microbial activities of flavonoids.
Int. J. Antimicrob. Agents 26:343.
[9] Edward F. Gilman and Dennis G. Watson (October 1994). Plumeria alba
White Frangipani.
[10] Essawi T, Srour M (2000). Screening of some Palestinian medicinal
plants for antibacterial activity. J. Ethnopharmacol. 70:343-349.
[11] Fluit, A.C., M.E. Jones, F.J. Schmitz, J. Acar, R. Gupta and J. Verhoef,
2000. Antimicrobial susceptibility and frequency of occurrence of
clinical blood isolates in Europe from the SENTRY antimicrobial
surveillance program, 1997 and 1998. Clin. Infect. Dis., 30: 454- 460.
[12] George M Beringer, 1895. AMERICAN JOURNAL OF PHARMACY.
The APOCYNACEAE in materia medica - Volume 67, #3, March, 1895
- Page 18
[13] Hamil FA, Apio S, Mubiru NK, Bukenya-Ziraba R, Mosango M,
Maganyi OW, Soejarto DD (2003). Traditional herbal drugs of southern
uganda, II : Literature análysis and antimicrobial assays. J.
Ethnopharmacol. 84:57-78.
[14] Hartwell JL. Plants used against cancer (A survey) Quarterman
Publications, Inc. Lawrence, Massachu setts. 1982; pp.408.
[15] Henry AN, Kumeri GR, Chitra V. Flora of Tamil Nadu, India. 1987;
pp.78.
[16] Hooton, T. M., and W. E. Stamm. 1997. Diagnosis and treatment of
uncomplicated urinary tract infection. Infect. Dis. Clin. N. Am. 11:551-
581
[17] Huouinen P.2001.Bacteriotherapy: The time has come.BMJ.323:353-
354.
[18] Ika¨heimo, R., A. Siitonen, T. Heiskanen, U. Karkkainen, P.
Kuosmanen, P. Lipponen, and P. H. Makela. 1996. Recurrence of
urinary tract infection in a primary care setting: analysis of a 1-year
follow-up of 179 women. Clin.Infect. Dis. 22:91-99.
[19] Izzo AA (2004). Drug interactions with St. John-s wort (Hypericum
perforation): A review of the clinical evidence. Int. J. Clin. Pharmacol.
Thera 42:139-148.
[20] Machado T B, Pinto A V, Pinto M C F R, Leal I C R, Silva M G, Amaral
A C F, Kuster R M, Netto - dosSantos K R (2003). Invitro activity of
Brazilian medicinal plants, naturally occurring naphthoqinones and their
analogues, against methicillin-resistant staphylococcus aureus. Int. J. of
Antimicrobial Agents 21:279-284.
[21] Kodera, Y.1997.Ch.11.In: Nutraceuticals: Designer Foods III Garlic,
Soy and Licorice, Trumbell, Ct: Food & Nutrition Press), Paul
Lanchance; ed.,pp.95-105
[22] Julia F. Morton, Director, Morton. Collectanea University of Miami
Coral Gables, Ornamental flowers with toxic and/or irritant
properties,1962
[23] McKeon, D.M., J.P. Calabrese and G.K. Bissonnette, 1995. Antibiotic
resistant gram-negative bacteria in rural ground water supplies. Water
Res., 29: 1902- 1908.
[24] Meng JC, Zhu QX, Tan RX (2000). New antimicrobial mono- and
sesquiterpenes from soroseris hookeriana Subsp.erysimoides. Planta
Medica 66: 541-544.
[25] M.P Darokar , A.Mathur, S. Dwivedi, R. Bhalla, S.P.S Khanuja, Sushil
Kumar, Currents Science Volume, 75, No 3, 1998
[26] Neu, H.C., 1992. The crisis in antibiotic resistance. Sci., 257: 1064-
1073.
[27] New Directions Laboratory of Australia, Certificate of Analysis and
Material Safety Data Sheet, Frangipani Absolute - Batch R1742 -
BCRO1 (2006)
[28] Olaleye, Mary Tolulope (2007). Cytotoxocity and antibacterial activity
of Methanolic extract of Hibiscuss sabdariffa. Journal of Medicinal
Plants Research.1: 009 - 013
[29] Ordonez AA, Cudmani NM, Gomez D, Vattuone MA, Isla MI (2003).
Antimicrobial activity of nine extracts of sechium edule (Jacq) Swartz.
Microbiology Ecology in Health and Disease 15:33-39.
[30] ├ûsterberg E, Hallander HO, Kallner A, Lundin A, Svensson SB, Åberg
H. Female urinary tract infection in primary health care: bacteriological
and clinical characteristics. Scand J Infect Dis 1990; 22: 477-484.
[31] Poyart-Salmeron C, Carlier C, Trieu-cuot P, Courtieu A L, Courvalin P
(1990). Transferable plasmid - mediated antibiotic resistance in Listeria
monocytogenes. The Lancet 335:1422-1426.
[32] Rasool S.N, Jaheerunnisa S, Kumar Chitta and Jayaveera K.N (2008),
Antimicrobial activities of Plmeria acutfolia. Journal of Medicinal Plants
Research; 2: 077 - M. Young, The Techincal Writers Handbook. Mill
Valley, CA: University Science, 1989.
[33] Reid G; Bruce. 2003. Urogenital infection in women: can probiotics
help? Post graduate medical journal.79:428-432.
[34] Salvat A, Antonnacci L, Fartunato RH, Suarez EY, Godoy HM (2001).
Screening of some plants from Northern Argentina for their
antimicrobial activity. Letters in Applied Microbiology 32: 293-297
[35] W. Rizvi, A. Kumar, R. Kumar, N. Haider. 2010. Evaluation of Anti
filarial activity in roots of Plumeria alba.Proceedings of the 6th
Conference of Medicinal and Aromatic Plants of Southeast European
countries. pp 132
@article{"International Journal of Medical, Medicine and Health Sciences:55246", author = "M. H. Syakira and L. Brenda", title = "Antibacterial Capacity of Plumeria alba Petals", abstract = "Antibacterial activity of Plumeria alba (Frangipani)
petals methanolic extracts were evaluated against Escherichia coli,
Proteus vulgaris,Staphylococcus aureus, Klebsiella pneumoniae,
Pseudomonas aeruginosa, Staphylococcus saprophyticus,
Enterococcus faecalis and Serratia marcescens by using disk
diffusion method. Concentration extracts (80 %) showed the highest
inhibition zone towards Escherichia coli (14.3 mm). Frangipani
extract also showed high antibacterial activity against
Staphylococcus saprophyticus, Proteus vulgaris and Serratia
marcescens, but not more than the zones of the positive control used.
Comparison between two broad specrum antibiotics to frangipani
extracts showed that the 80 % concentration extracts produce the
same zone of inhibition as Streptomycin. Frangipani extracts showed
no bacterial activity towards Klebsiella pneumoniae, Pseudomonas
aeruginosa and Enterococcus faecalis. There are differences in the
sensitivity of different bacteria to frangipani extracts, suggesting that
frangipani-s potency varies between these bacteria. The present
results indicate that frangipani showed significant antibacterial
activity especially to Escherichia coli.", keywords = "Frangipani, Plumeria alba, anti microbial,Escherichia coli", volume = "4", number = "8", pages = "324-4", }
