Abstract: Periventricular Leukomalacia (PVL) is a White Matter
Injury (WMI) of preterm neonatal brain. Objectives of the study were
to assess the neuro-developmental outcome at one year of age and to
determine a good protocol of cranial ultrasonography to detect PVL.
Two hundred and sixty four preterm neonates were included in the
study. Series of cranial ultrasound scans were done by using a
dedicated neonatal head probe 4-10 MHz of Logic e portable
ultrasound scanner. Clinical history of seizures, abnormal head
growth (hydrocephalus or microcephaly) and developmental
milestones were assessed and neurological examinations were done
until one year of age. Among live neonates, 57% who had cystic PVL
(Grades 2 and 3) manifested as cerebral palsy. In conclusion cystic
PVL has permanent neurological disabilities like cerebral palsy.
Good protocol of real time cranial ultrasonography to detect PVL is
to perform scans at least once a week until one month and at term (40
weeks of gestation).
Abstract: Biomechanical properties of infantile aorta in vitro in
cases of different standard anastomoses: end-to-end (ETE), extended
anastomosis end-to-end (EETE) and subclavian flap aortoplasty
(SFA) used for surgical correction of coarctation were analyzed to
detect the influence of the method on the biomechanics of infantile
aorta and possible changes in haemodinamics. 10 specimens of native
aorta, 3 specimens with ETE, 4 EEET and 3 SFA were investigated.
The experiments showed a non-linear relationship between stress and
strain in the infantile aorta, the modulus of elasticity of the aortic wall
increased with the increase of inner pressure. In the case of
anastomosis end-to-end the modulus was almost constant, relevant to
the modulus of elasticity of the aorta with the inner pressure 100-120
mmHg. The anastomoses EETE and SFA showed elastic properties
closer to native aorta, the stiffness of ETE did not change with the
changes in inner pressure.
Abstract: Information regarding early onset neonatal sepsis
(EONS) pathogens may vary between regions. Global perspectives
showed Group B Streptococcal (GBS) as the most common causative
pathogens, but the widespread use of intrapartum antibiotics has
changed the pathogens pattern towards gram negative
microorganisms, especially E. coli. Objective of this study is to
describe the pathogens isolated, to assess current treatment and risk
of EONS. Records of 899 neonates born in three General Hospitals
between 2009 until 2012 were retrospectively reviewed. Proven was
found in 22 (3%) neonates. The majority was isolated with gram
positive organisms, 17 (2.3%). All grams positive and most gram
negative organisms showed sensitivity to the tested antibiotics. Only
two rare gram negative organisms showed total resistant. Male was
possible risk of proven EONS. Although proven EONS remains
uncommon in Malaysia, nonetheless, the effect of intrapartum
antibiotics still required continuous surveillance.