Abstract: Diminished antioxidant defense or increased
production of reactive oxygen species in the biological system can
result in oxidative stress which may lead to various
neurodegenerative diseases including Alzheimer’s disease (AD).
Microglial activation also contributes to the progression of AD by
producing several proinflammatory cytokines, nitric oxide (NO) and
prostaglandin E2 (PGE2). Oxidative stress and inflammation have
been reported to be possible pathophysiological mechanisms
underlying AD. In addition, the cholinergic hypothesis postulates that
memory impairment in patient with AD is also associated with the
deficit of cholinergic function in the brain. Although a number of
drugs have been approved for the treatment of AD, most of these
synthetic drugs have diverse side effects and yield relatively modest
benefits. Marine algae have great potential in pharmaceutical and
biomedical applications as they are valuable sources of bioactive
properties such as anticoagulation, antimicrobial, antioxidative,
anticancer and anti-inflammatory. Hence, this study aimed to provide
an overview of the properties of Malaysian seaweeds (Padina
australis, Sargassum polycystum and Caulerpa racemosa) in
inhibiting oxidative stress, neuroinflammation and cholinesterase
enzymes. These seaweeds significantly exhibited potent DPPH and
moderate superoxide anion radical scavenging ability (P
Abstract: The antimicrobial, antiplasmid and cytotoxic activities of marine algae Halimeda opuntia and Sarconema filiforme were investigated. Antimicrobial bioassay against some human pathogenic bacteria and yeast were conducted using disc diffusion method. Halimeda extract exhibited antibacterial activity against six species of microrganisms, with significant inhibition against Staphylococcus aureus. While Sarconema extract was better potent as antifungal against Candida albicans. Comparative antibacterial studies showed that Halimeda extract showed equivalent or better activity as compared with commercial antibiotic when tested against Staphylococcus aureus. Further tests conducted using dilution method showed both extracts as having bacteriostatic mode of action against the tested microorganisms. Methanol extract of two species showed significant cytotoxicity (LC50
Abstract: In the paper we presented the possibility of application
collagen gels with active principle-s from marine algae extract and chlorhexidine salt in dental medicine. The hydro-alcoholic extracts
from marine algae have been used as they have been obtained. The extracts from marine algae and chlorhexidine salt (digluconate) are
incorporated in type I non-denatured fibrillar collagen matrixes. In order to obtain therapeutic effects at nanostructure level, it is important to know the rheological characteristics of the relevant mixtures of collagen gels and extracts from marine algae selected for use. In this survey we have studied mixtures made of non-denatured
fibrillar collagen hydro-gels where different concentrations of marine
algae have been incorporated. Based on the data obtained for the
shearing tensions, we have traced the rheograms – the diagrams for shearing tensions depending on the shearing speed values – from
which we have calculated the apparent viscosities as ratios between shearing tension and speed values, which have been figured in
relation to the shearing speed values, with a view to levelling
dependency.
Abstract: Characterized as rich mineral substances, low
temperature, few bacteria, and stability with numerous implementation
aspects on aquaculture, food, drinking, and leisure, the deep sea water
(DSW) development has become a new industry in the world. It has
been report that marine algae contain various biologically active
compounds. This research focued on the affections in cultivating
Sagrassum cristaefolium with different concentration of deep sea
water(DSW) and surface sea water(SSW). After two and four weeks,
the total phenolic contents were compared in Sagrassum cristaefolium
culturing with different ways, and the reductive activity of them was
also be tried with potassium ferricyanide. Those fresh seaweeds were
dried with oven and were ground to powder. Progressively, the marine
algae we cultured was extracted by water under the condition with
heating them at 90Ôäâ for 1hr.The total phenolic contents were be
executed using Folin–Ciocalteu method. The results were explaining
as follows: the highest total phenolic contents and the best reductive
ability of all could be observed on the 1/4 proportion of DSW to SSW
culturing in two weeks. Furthermore, the 1/2 proportion of DSW to
SSW also showed good reductive ability and plentiful phenolic
compositions. Finally, we confirmed that difference proportion of
DSW and SSW is the major point relating to ether the total phenolic
components or the reductive ability in the Sagrassum cristaefolium. In
the future, we will use this way to mass production the marine algae or
other micro algae on industry applications.