Abstract: Intravitreal injection (IVI) is the most common treatment for eye posterior segment diseases such as endopthalmitis, retinitis, age-related macular degeneration, diabetic retinopathy, uveitis, and retinal detachment. Most of the drugs used to treat vitreoretinal diseases, have a narrow concentration range in which they are effective, and may be toxic at higher concentrations. Therefore, it is critical to know the drug distribution within the eye following intravitreal injection. Having knowledge of drug distribution, ophthalmologists can decide on drug injection frequency while minimizing damage to tissues. The goal of this study was to develop a computer model to predict intraocular concentrations and pharmacokinetics of intravitreally injected drugs. A finite volume model was created to predict distribution of two drugs with different physiochemical properties in the rabbit eye. The model parameters were obtained from literature review. To validate this numeric model, the in vivo data of spatial concentration profile from the lens to the retina were compared with the numeric data. The difference was less than 5% between the numerical and experimental data. This validation provides strong support for the numerical methodology and associated assumptions of the current study.
Abstract: Public health surveillance system focuses on outbreak detection and data sources used. Variation or aberration in the frequency distribution of health data, compared to historical data is often used to detect outbreaks. It is important that new techniques be developed to improve the detection rate, thereby reducing wastage of resources in public health. Thus, the objective is to developed technique by applying frequent mining and outlier mining techniques in outbreak detection. 14 datasets from the UCI were tested on the proposed technique. The performance of the effectiveness for each technique was measured by t-test. The overall performance shows that DTK can be used to detect outlier within frequent dataset. In conclusion the outbreak detection technique using anomaly-based on frequent-outlier technique can be used to identify the outlier within frequent dataset.
Abstract: In this work a surgical simulator is produced which
enables a training otologist to conduct a virtual, real-time prosthetic
insertion. The simulator provides the Ear, Nose and Throat surgeon
with real-time visual and haptic responses during virtual cochlear
implantation into a 3D model of the human Scala Tympani (ST). The
parametric model is derived from measured data as published in the
literature and accounts for human morphological variance, such as
differences in cochlear shape, enabling patient-specific pre- operative
assessment. Haptic modeling techniques use real physical data and
insertion force measurements, to develop a force model which
mimics the physical behavior of an implant as it collides with the ST
walls during an insertion. Output force profiles are acquired from the
insertion studies conducted in the work, to validate the haptic model.
The simulator provides the user with real-time, quantitative insertion
force information and associated electrode position as user inserts the
virtual implant into the ST model. The information provided by this
study may also be of use to implant manufacturers for design
enhancements as well as for training specialists in optimal force
administration, using the simulator. The paper reports on the methods
for anatomical modeling and haptic algorithm development, with
focus on simulator design, development, optimization and validation.
The techniques may be transferrable to other medical applications
that involve prosthetic device insertions where user vision is
obstructed.
Abstract: Bone remodeling occurs by the balanced action of
bone resorbing osteoclasts (OC) and bone-building osteoblasts.
Increased bone resorption by excessive OC activity contributes
to malignant and non-malignant diseases including osteoporosis.
To study OC differentiation and function, OC formed in
in vitro cultures are currently counted manually, a tedious
procedure which is prone to inter-observer differences. Aiming
for an automated OC-quantification system, classification of
OC and precursor cells was done on fluorescence microscope
images based on the distinct appearance of fluorescent nuclei.
Following ellipse fitting to nuclei, a combination of eight
features enabled clustering of OC and precursor cell nuclei.
After evaluating different machine-learning techniques, LOGREG
achieved 74% correctly classified OC and precursor cell
nuclei, outperforming human experts (best expert: 55%). In
combination with the automated detection of total cell areas,
this system allows to measure various cell parameters and most
importantly to quantify proteins involved in osteoclastogenesis.
Abstract: Musculoskeletal problems are common in high
performance dance population. This study attempts to identify lower
extremity muscle flexibility parameters prevailing among
bharatanatyam dancers and analyze if there is any significant
difference exist between normal and injured dancers in flexibility
parameters. Four hundred and one female dancers and 17 male
dancers were participated in this study. Flexibility parameters
(hamstring tightness, hip internal and external rotation and
tendoachilles in supine and sitting posture) were measured using
goniometer. Results of our study it is evident that injured female
bharathnatyam dancers had significantly (p < 0.05) high hamstring
tightness on left side lower extremity compared to normal female
dancers. The range of motion for left tendoachilles was significantly
(p < 0.05) high for the normal female group when compared to
injured dancers during supine lying posture. Majority of the injured
dancers had high hamstring tightness that could be a possible reason
for pain and MSDs.