Abstract: The need of high frame-rate imaging has been triggered by the new applications of ultrasound imaging to transient elastography and real-time 3D ultrasound. Using plane wave excitation (PWE) is one of the methods to achieve very high frame-rate imaging since an image can be formed with a single insonification. However, due to the lack of transmit focusing, the image quality with PWE is lower compared with those using conventional focused transmission. To solve this problem, we propose a filter-retrieved transmit focusing (FRF) technique combined with cross-correlation weighting (FRF+CC weighting) for high frame-rate imaging with PWE. A restrospective focusing filter is designed to simultaneously minimize the predefined sidelobe energy associated with single PWE and the filter energy related to the signal-to-noise-ratio (SNR). This filter attempts to maintain the mainlobe signals and to reduce the sidelobe ones, which gives similar mainlobe signals and different sidelobes between the original PWE and the FRF baseband data. Normalized cross-correlation coefficient at zero lag is calculated to quantify the degree of similarity at each imaging point and used as a weighting matrix to the FRF baseband data to further suppress sidelobes, thus improving the filter-retrieved focusing quality.
Abstract: Early detection of dementia by testing the spatial
memory can be applied using a virtual environment. This paper
presents guidelines on how to design a virtual environment
specifically for elderly in early detection of dementia. The specific
design needs to be considered because the effectiveness of the
technology relies on the ability of the end user to use it. The primary
goal of these guidelines is to promote accessibility. Based on these
guidelines, a virtual simulation was developed and evaluated. The
results on usability of acceptance and satisfaction that are tested on
young (control group) and elderly participants indicate that these
guidelines are reliable and useful for use with elderly people.
Abstract: We present a label-free biosensor based on
electrochemical impedance spectroscopy for the detection of proinflammatory
cytokine Tumor Necrosis Factor (TNF-α). Secretion of
TNF-α has been correlated to the onset of various diseases including
rheumatoid arthritis, Crohn-s disease etc. Gold electrodes were
patterned on a silicon substrate and self assembled monolayer of
dithiobis-succinimidyl propionate was used to develop the biosensor
which achieved a detection limit of ~57fM. A linear relationship was
also observed between increasing TNF-α concentrations and chargetransfer
resistance within a dynamic range of 1pg/ml – 1ng/ml.
Abstract: Microbubbbles incorporating ultrasound have been used to increase the efficacy of targeted drug delivery, because microstreaming induced by cavitating bubbles affects the drug perfusion into the target cells and tissues. In order to clarify the physical effects of microstreaming on drug perfusion into tissues, a preliminary experimental study of perfusion enhancement by a stably oscillating microbubble was performed. Microstreaming was induced by an oscillating bubble at 15 kHz, and perfusion of dye into an agar phantom was optically measured by histology on agar phantom. Surface color intensity and the penetration length of dye in the agar phantom were increased more than 70% and 30%, respectively, due to the microstreaming induced by an oscillating bubble. The mass of dye perfused into a tissue phantom for 30 s was increased about 80% in the phantom with an oscillating bubble. This preliminary experiment shows the physical effects of steady streaming by an oscillating bubble can enhance the drug perfusion into the tissues while minimizing the biological effects.
Abstract: A lot of recent research have spoken on the relation
between the increase of the homocysteinemia and some kinds of
cancer . For that, our study was based on the research of a possible
relation between the increase of the concentration of this amino-acid
in the plasma and the appearance of the disease of the Acute
Lymphoblastic Leukaemia in a part of Algerian children with Berber
origin in the East of Algeria . The study has done on 47 ill persons
with an average age of (09±06 ) years , with whom the disease has
diagnosed by blood and marrow examination in the hospital of blood
diseases in the CHU of Batna, and on 194 healthy witnesses of the
same age. The two groups were benefited by a dosage of the
concentration of the homocysteine vitamin B9 ,vitamin B12 , and
also of the study of special polymorphisms of indispensable enzymes
in the metabolism of this acid , and that by the use of the method (
Light cycler ) Real time PCR , on the following enzymes : MS (
C2756G ), MSR ( A66G ) ,MTHFR1 ( C677T ) and MTHFR2
(A1298C). The obtained results have revealed that the rate of the
homozygote muted genotype is the less frequent in the two groups ,
and that exist at list one genotype of each enzyme in the ill group and
in which the percentage exceed with remarkable way the same
genotype in the healthy group and we notice specially the muted
genotype GG of -the methionine synthetase-and the form TT of the
enzyme – methyline tetra hydrofolate reductase – We notice the
existence of considerable number of genotypes in the ill group lied
with characteristic increase of this Amino-acid ,and that for the
reduction of the biologic activity of these enzymes which become
inefficient in the transfer of the homocysteine into the methionine
and cause the diminution of the biologic activity of these enzymes
and with consequence the reduction of the percentage of methylic
radicals in the DNA of studied genes and that lead to the increase of
the activity and the capacity of transcription , and it-s so probably
that this last one is one of the factors of this disease especially if we
know that the specific check-up of vitamins is normal and similar in
the two groups , which ovoid the hypothesis of the reduction of
vitamins . We notice also that the heterozygote genotype is the less in
the sick category except the MTHFR2. Wild genotype is more
frequent in the witness group except MSR. Even these results are
partials; they open a new way in the genetic diagnosis of this
malicious disease which allow a precocious diagnosis and the use of
an effective and appropriated treatment in the same time.
Abstract: Recurrence of aneurysm rupture can be attributed to
coil migration and compaction. In order to verify the effects of
hemodynamics on coil compaction and migration, we analyze the
forces and displacements on the coil bundle using a computational
method. Lateral aneurysms partially filled coils are modeled, and
blood flow fields and coil deformations are simulated considering
fluid and solid interaction. Effects of aneurysm neck size and parent
vessel geometry are also investigated. The results showed that coil
deformation was larger in the aneurysms with a wider neck. Parent
vessel geometry and aneurysm neck size also affected mean pressure
force profiles on the coil surface. Pressure forces were higher in wide
neck models with curved parent vessel geometry. Simulation results
showed that coils in the wide neck aneurysm with a curved parent
vessel may be displaced and compacted more easily.
Abstract: This study investigated climatic factors associated
with influenza cases in Southern Thailand. The main aim for use
regression analysis to investigate possible causual relationship of
climatic factors and variability between the border of the Andaman
Sea and the Gulf of Thailand. Southern Thailand had the highest
Influenza incidences among four regions (i.e. north, northeast, central
and southern Thailand). In this study, there were 14 climatic factors:
mean relative humidity, maximum relative humidity, minimum
relative humidity, rainfall, rainy days, daily maximum rainfall,
pressure, maximum wind speed, mean wind speed, sunshine duration,
mean temperature, maximum temperature, minimum temperature,
and temperature difference (i.e. maximum – minimum temperature).
Multiple stepwise regression technique was used to fit the statistical
model. The results indicated that the mean wind speed and the
minimum relative humidity were positively associated with the
number of influenza cases on the Andaman Sea side. The maximum
wind speed was positively associated with the number of influenza
cases on the Gulf of Thailand side.
Abstract: Bionanotechnology deals with nanoscopic interactions between nanostructured materials and biological systems. Polymer nanocomposites with optimized biological activity have attracted great attention. Nanoclay is considered as reinforcing nanofiller in manufacturing of high performance nanocomposites. In current study, organomodified-nanoclay with negatively charged silicate layers was incorporated into biomedical grade silicone rubber. Nanoparticle loading has been tailored to enhance cell behavior. Addition of nanoparticles led to improved mechanical properties of substrate with enhanced strength and stiffness while no toxic effects was observed. Results indicated improved viability and proliferation of cells by addition of nanofillers. The improved mechanical properties of the matrix result in proper cell response through adjustment and arrangement of cytoskeletal fibers. Results can be applied in tissue engineering when enhanced substrates are required for improvement of cell behavior for in vivo applications.
Abstract: In this study, we present an advanced detection
technique for mass type breast cancer based on texture information
of organs. The proposed method detects the cancer areas in three
stages. In the first stage, the midpoints of mass area are determined
based on AHE (Adaptive Histogram Equalization). In the second
stage, we set the threshold coefficient of homogeneity by using
MLE (Maximum Likelihood Estimation) to compute the uniformity
of texture. Finally, mass type cancer tissues are extracted from the
original image. As a result, it was observed that the proposed
method shows an improved detection performance on dense breast
tissues of Korean women compared with the existing methods. It is
expected that the proposed method may provide additional
diagnostic information for detection of mass-type breast cancer.
Abstract: The purpose of this study was to study the practical
delivery room experience of nursing students. The respondents were
6 junior nursing students of Suranaree University of Technology who
had a direct experience from practicing in a delivery room between
January 9 and March 30, 2012 as part of Nursing Care of the Family
and Midwifery 3. The data was collected by using in-depth interview,
observation, and reflective report. The results of the study found that
the practical delivery room experience of nursing students consisted
of three issues: 1) stress and coping with stress during practical
exercise, 2) changes in daily routine, and 3) source during practical
exercise. The results of this study would lead to the understanding of
the meaning of the practical exercise of nursing students.
Abstract: As a part of routine oesophageal HDR Brachytherapy procedure, treatment planning takes about 45 minutes while patients are under light sedation. Some patients may suffer gagging and/or spasms before the 90-minute brachytherapy procedure complete, and the treatment may need to be aborted. A pre-prepared plan generated before patient’s sedation may reduce the brachytherapy procedure time by 40 minutes. This paper reports rationality and evidence of pre-prepared treatment plans. A retrospective study of 28 patients confirms that pre-prepared plans would be acceptable for all reviewed patients. The rationality is further confirmed by a systemic study with a wide range of applicator curvature and treatment volume. Detailed comparison between CT based treatment plans and pre-prepared plans are discussed. The argument holds for endobronchial HDR brachytherapy too. With the above evidence, pre-prepared plans have been used for all oesophageal and endobronchial HDR brachytherapy cases in our clinic.
Abstract: This comparison of valuation techniques for bone age
assessment is a work carried out by the Telemedicine Research Group
of the Military University - TIGUM, as a preliminary to the Design
and development a treatment system of hand and wrist radiological
images for children aged 0-6 years to bone age assessment . In this
paper the techniques mentioned for decades have been the most
widely used and the statistically significant.
Althought, initially with the current project, it wants to work with
children who have limit age, this comparison and evaluation
techniques work will help in the future to expand the study subject in
the system to bone age assessment, implementing more techniques,
tools and deeper analysis to accomplish this purpose.
Abstract: In intensity modulated radiation therapy (IMRT)
treatment planning, beam angles are usually preselected on the basis of
experience and intuition. Therefore, getting an appropriate beam
configuration needs a very long time. Based on the present situation,
the paper puts forward beam orientation optimization using ant colony
optimization (ACO). We use ant colony optimization to select the
beam configurations, after getting the beam configuration using
Conjugate Gradient (CG) algorithm to optimize the intensity profiles.
Combining with the information of the effect of pencil beam, we can
get the global optimal solution accelerating. In order to verify the
feasibility of the presented method, a simulated and clinical case was
tested, compared with dose-volume histogram and isodose line
between target area and organ at risk. The results showed that the
effect was improved after optimizing beam configurations. The
optimization approach could make treatment planning meet clinical
requirements more efficiently, so it had extensive application
perspective.
Abstract: Multidrug resistant organisms have been taunting the
medical world for the last few decades. Even with new antibiotics
developed, resistant strains have emerged soon after. With the
advancement of nanotechnology, we investigated colloidal silver
nanoparticles for its antimicrobial activity against Pseudomonas
aeruginosa. This organism is a multidrug resistant which contributes
to the high morbidity and mortality in immunocompromised patients.
Five multidrug resistant strains were used in this study. The
antimicrobial effect was studied using the disc diffusion and broth
dilution techniques. An inhibition zone of 11 mm was observed with
10 μg dose of the nanoparticles. The nanoparticles exhibited MIC of
50 μg/ml when added at the lag phase and the subinhibitory
concentration was measured as 100 μg/ml. The MIC50 value showed
to be 15 μg/ml. This study suggests that silver nanoparticles can be
further developed as an antimicrobial agent, hence decreasing the
burden of the multidrug resistance phenomena.
Abstract: Sensors possess several properties of physical
measures. Whether devices that convert a sensed signal into an
electrical signal, chemical sensors and biosensors, thus all these
sensors can be considered as an interface between the physical and
electrical equipment. The problem is the analysis of the multitudes of
saved settings as input variables. However, they do not all have the
same level of influence on the outputs. In order to identify the most
sensitive parameters, those that can guide users in gathering
information on the ground and in the process of model calibration
and sensitivity analysis for the effect of each change made.
Mathematical models used for processing become very complex.
In this paper a fuzzy rule-based system is proposed as a solution
for this problem. The system collects the available signals
information from sensors. Moreover, the system allows the study of
the influence of the various factors that take part in the decision
system. Since its inception fuzzy set theory has been regarded as a
formalism suitable to deal with the imprecision intrinsic to many
problems. At the same time, fuzzy sets allow to use symbolic models.
In this study an example was applied for resolving variety of
physiological parameters that define human health state. The
application system was done for medical diagnosis help. The inputs
are the signals expressed the cardiovascular system parameters, blood
pressure, Respiratory system paramsystem was done, it will be able
to predict the state of patient according any input values.
Abstract: It is shown that the relationship of tick-borne
encephalitis virus with the human body comes in two ways, the
development of acute infection with the outcome in convalescence
and long stay by the virus in the body, its persistence in the nervous
tissue with periodic reactivation and prolonged circulating
immunoglobulin M. In spite of the fact that tick-borne encephalitis
virus has a tropism for nerve tissue, involvement in the process of
blood cells is an integral component of the infection. Comprehensive
study of the relation of factors of innate and adaptive immunity in the
tick-borne encephalitis providing insight into the features of chronic
disease.
Abstract: The blood ducts must be occluded to avoid loss of
blood from vessels in laparoscopic surgeries. This paper presents a
locking mechanism to be used in a ligation laparoscopic procedure
(LigLAP I), as an alternative solution for a stapling procedure.
Currently, stapling devices are being used to occlude vessels. Using
these devices may result in some problems, including injury of bile
duct, taking up a great deal of space behind the vessel, and bile leak.
In this new procedure, a two-layer suture occludes a vessel. A
locking mechanism is also required to hold the suture. Since there is
a limited space at the device tip, a Shape Memory Alloy (SMA)
actuator is used in this mechanism. Suitability for cleanroom
applications, small size, and silent performance are among the
advantages of SMA actuators in biomedical applications. An
experimental study is conducted to examine the function of the
locking mechanism. To set up the experiment, a prototype of a
locking mechanism is built using nitinol, which is a nickel-titanium
shape memory alloy. The locking mechanism successfully locks a
polymer suture for all runs of the experiment. In addition, the effects
of various surface materials on the applied pulling forces are studied.
Various materials are mounted at the mechanism tip to compare the
maximum pulling forces applied to the suture for each material. The
results show that the various surface materials on the device tip
provide large differences in the applied pulling forces.
Abstract: Analysis of blood vessel mechanics in normal and
diseased conditions is essential for disease research, medical device
design and treatment planning. In this work, 3D finite element
models of normal vessel and atherosclerotic vessel with 50% plaque
deposition were developed. The developed models were meshed
using finite number of tetrahedral elements. The developed models
were simulated using actual blood pressure signals. Based on the
transient analysis performed on the developed models, the parameters
such as total displacement, strain energy density and entropy per unit
volume were obtained. Further, the obtained parameters were used to
develop artificial neural network models for analyzing normal and
atherosclerotic blood vessels. In this paper, the objectives of the
study, methodology and significant observations are presented.
Abstract: In this paper we used data mining techniques to
identify outlier patients who are using large amount of drugs over a
long period of time. Any healthcare or health insurance system
should deal with the quantities of drugs utilized by chronic diseases
patients. In Kingdom of Bahrain, about 20% of health budget is spent
on medications. For the managers of healthcare systems, there is no
enough information about the ways of drug utilization by chronic
diseases patients, is there any misuse or is there outliers patients. In
this work, which has been done in cooperation with information
department in the Bahrain Defence Force hospital; we select the data
for Cardiac patients in the period starting from 1/1/2008 to
December 31/12/2008 to be the data for the model in this paper. We
used three techniques for finding the drug utilization for cardiac
patients. First we applied a clustering technique, followed by
measuring of clustering validity, and finally we applied a decision
tree as classification algorithm. The clustering results is divided into
three clusters according to the drug utilization, for 1603 patients, who
received 15,806 prescriptions during this period can be partitioned
into three groups, where 23 patients (2.59%) who received 1316
prescriptions (8.32%) are classified to be outliers. The classification
algorithm shows that the use of average drug utilization and the age,
and the gender of the patient can be considered to be the main
predictive factors in the induced model.
Abstract: This paper proposes a method for speckle reduction in
medical ultrasound imaging while preserving the edges with the
added advantages of adaptive noise filtering and speed. A nonlinear
image diffusion method that incorporates local image parameter,
namely, scatterer density in addition to gradient, to weight the
nonlinear diffusion process, is proposed. The method was tested for
the isotropic case with a contrast detail phantom and varieties of
clinical ultrasound images, and then compared to linear and some
other diffusion enhancement methods. Different diffusion parameters
were tested and tuned to best reduce speckle noise and preserve
edges. The method showed superior performance measured both
quantitatively and qualitatively when incorporating scatterer density
into the diffusivity function. The proposed filter can be used as a
preprocessing step for ultrasound image enhancement before
applying automatic segmentation, automatic volumetric calculations,
or 3D ultrasound volume rendering.