Abstract: The work describes the use of a synthetic transmit
aperture (STA) with a single element transmitting and all elements
receiving in medical ultrasound imaging. STA technique is a novel
approach to today-s commercial systems, where an image is acquired
sequentially one image line at a time that puts a strict limit on the
frame rate and the amount of data needed for high image quality. The
STA imaging allows to acquire data simultaneously from all
directions over a number of emissions, and the full image can be
reconstructed.
In experiments a 32-element linear transducer array with 0.48 mm
inter-element spacing was used. Single element transmission aperture
was used to generate a spherical wave covering the full image region.
The 2D ultrasound images of wire phantom are presented obtained
using the STA and commercial ultrasound scanner Antares to
demonstrate the benefits of the SA imaging.
Abstract: For investigations of electromagnetic field
distributions in biological structures by Finite Element Method
(FEM), a method for automatic 3D model building of human
anatomical objects is developed. Models are made by meshed
structures and specific electromagnetic material properties for each
tissue type. Mesh is built according to specific FEM criteria for
achieving good solution accuracy. Several FEM models of
anatomical objects are built. Formulation using magnetic vector
potential and scalar electric potential (A-V, A) is used for modeling
of electromagnetic fields in human tissue objects. The developed
models are suitable for investigations of electromagnetic field
distributions in human tissues exposed in external fields during
magnetic stimulation, defibrillation, impedance tomography etc.
Abstract: Tumor cells have an invasive and metastatic phenotype
that is the main cause of death for cancer patients. Tumor
establishment and penetration consists of a series of complex
processes involving multiple changes in gene expression. In this study,
intraperitoneal administration of a high concentration of ascorbic acid
inhibited tumor establishment and decreased tumor mass in BALB/C
mice implanted with S-180 sarcoma cancer cells. To identify proteins
involved in the ascorbic acid-mediated inhibition of tumor
progression, changes in the tumor proteome associated with ascorbic
acid treatment of BALB/C mice implanted with S-180 were
investigated using two-dimensional gel electrophoresis and mass
spectrometry. Twenty protein spots were identified whose expression
was different between control and ascorbic acid treatment groups.
Abstract: This paper presents a dominant color descriptor
technique for medical image retrieval. The medical image system
will collect and store into medical database. The purpose of
dominant color descriptor (DCD) technique is to retrieve medical
image and to display similar image using queried image. First, this
technique will search and retrieve medical image based on keyword
entered by user. After image is found, the system will assign this
image as a queried image. DCD technique will calculate the image
value of dominant color. Then, system will search and retrieve again
medical image based on value of dominant color query image.
Finally, the system will display similar images with the queried
image to user. Simple application has been developed and tested
using dominant color descriptor. Result based on experiment
indicates this technique is effective and can be used for medical
image retrieval.
Abstract: In this paper, the construction of a detailed spine
model is presented using the LifeMOD Biomechanics Modeler. The
detailed spine model is obtained by refining spine segments in
cervical, thoracic and lumbar regions into individual vertebra
segments, using bushing elements representing the intervertebral
discs, and building various ligamentous soft tissues between
vertebrae. In the sagittal plane of the spine, constant force will be
applied from the posterior to anterior during simulation to determine
dynamic characteristics of the spine. The force magnitude is
gradually increased in subsequent simulations. Based on these
recorded dynamic properties, graphs of displacement-force
relationships will be established in terms of polynomial functions by
using the least-squares method and imported into a haptic integrated
graphic environment. A thoracolumbar spine model with complex
geometry of vertebrae, which is digitized from a resin spine
prototype, will be utilized in this environment. By using the haptic
technique, surgeons can touch as well as apply forces to the spine
model through haptic devices to observe the locomotion of the spine
which is computed from the displacement-force relationship graphs.
This current study provides a preliminary picture of our ongoing
work towards building and simulating bio-fidelity scoliotic spine
models in a haptic integrated graphic environment whose dynamic
properties are obtained from LifeMOD. These models can be helpful
for surgeons to examine kinematic behaviors of scoliotic spines and
to propose possible surgical plans before spine correction operations.
Abstract: The dental composites are preferably used as filling
materials due to their esthetic appearances. Nevertheless one of the
major problems, during the application of the dental composites, is
shape change named as “polymerisation shrinkage" affecting clinical
success of the dental restoration while photo-polymerisation.
Polymerisation shrinkage of composites arises basically from the
formation of a polymer due to the monomer transformation which
composes of an organic matrix phase. It was sought, throughout this
study, to detect and evaluate the structural polymerisation shrinkage
of prepared dental composites in order to optimize the effects of
various fillers included in hydroxyapatite (HA)-reinforced dental
composites and hence to find a means to modify the properties of
these dental composites prepared with defined parameters. As a
result, the shrinkage values of the experimental dental composites
were decreased by increasing the filler content of composites and the
composition of different fillers used had effect on the shrinkage of
the prepared composite systems.
Abstract: An implant elicits a biological response in the
surrounding tissue which determines the acceptance and long-term
function of the implant. Dental implants have become one of the
main therapy methods in clinic after teeth lose. A successful implant
is in contact with bone and soft tissue represent by fibroblasts. In our
study we focused on the interaction between six different chemically
and physically modified titanium implants (Tis-MALP, Tis-O, Tis-
OA, Tis-OPAAE, Tis-OZ, Tis-OPAE) with alveolar fibroblasts as
well as with five type of microorganisms (S. epidermis, S.mutans, S.
gordonii, S. intermedius, C.albicans). The analysis of microorganism
adhesion was determined by CFU (colony forming unite) and biofilm
formation. The presence of α3β1 and vinculin expression on alveolar
fibroblasts was demonstrated using phospho specific cell based
ELISA (PACE). Alveolar fibroblasts have the highest expression of
these proteins on Tis-OPAAE and Tis-OPAE. It corresponds with
results from bacterial adhesion and biofilm formation and it was
related to the lowest production of collagen I by alveolar fibroblasts
on Tis-OPAAE titanium disc.
Abstract: This paper presents a novel approach to finding a
priori interesting regions in mammograms. In order to delineate those
regions of interest (ROI-s) in mammograms, which appear to be
prominent, a topographic representation called the iso-level contour
map consisting of iso-level contours at multiple intensity levels and
region segmentation based-thresholding have been proposed. The
simulation results indicate that the computed boundary gives the
detection rate of 99.5% accuracy.
Abstract: The structure of retinal vessels is a prominent feature,
that reveals information on the state of disease that are reflected in
the form of measurable abnormalities in thickness and colour.
Vascular structures of retina, for implementation of clinical diabetic
retinopathy decision making system is presented in this paper.
Retinal Vascular structure is with thin blood vessel, whose accuracy
is highly dependent upon the vessel segmentation. In this paper the
blood vessel thickness is automatically detected using preprocessing
techniques and vessel segmentation algorithm. First the capture
image is binarized to get the blood vessel structure clearly, then it is
skeletonised to get the overall structure of all the terminal and
branching nodes of the blood vessels. By identifying the terminal
node and the branching points automatically, the main and branching
blood vessel thickness is estimated. Results are presented and
compared with those provided by clinical classification on 50 vessels
collected from Bejan Singh Eye hospital..
Abstract: There is an ongoing controversy in the literature related
to the biological effects of weak, low frequency electromagnetic
fields. The physical arguments and interpretation of the experimental
evidence are inconsistent, where some physical arguments and
experimental demonstrations tend to reject the likelihood of any
effect of the fields at extremely low level. The problem arises of
explaining, how the low-energy influences of weak magnetic fields
can compete with the thermal and electrical noise of cells at normal
temperature using the theoretical studies. The magnetoreception in
animals involve radical pair mechanism. The same mechanism has
been shown to be involved in the circadian rhythm synchronization in
mammals. These reactions can be influenced by the weak magnetic
fields. Hence, it is postulated the biological clock can be affected
by weak magnetic fields and these disruptions to the rhythm can
cause adverse biological effects. In this paper, likelihood of altering
the biological clock via the radical pair mechanism is analyzed to
simplify these studies of controversy.