In this study, the powders of Ni and Ti with 50.5 at.%
Ni for 12 h were blended and cold pressed at the different pressures
(50, 75 and100 MPa).The porous product obtained after Ni-Ti
compacts were synthesized by SHS (self-propagating hightemperature
synthesis) in the different preheating temperatures (200,
250 and 300oC) and heating rates (30, 60 and 90oC/min). The effects
of the pressure, preheating temperature and heating rate were
investigated on biocompatibility in vivo. The porosity in the
synthesized products was in the range of 50.7–59.7 vol. %. The
pressure, preheating temperature and heating rate were found to have
an important effect on the biocompatibility in-vivo of the synthesized
products. Max. fibrotic tissue within the porous implant was found in
vivo periods (6 months), in which compacting pressure 100MPa.
[1] F. Sarsilmaz, N. Orhan, E. Unsaldi, A. S. Durmus, N.A. Colakoglu, A
polyethylene-high proportion hydroxyapatite implant and its
investigation in vivo Acta Bioeng Biomech, 9, 9-16, 2007.
[2] B.Y.Li, L. J. Rong, Y.Y. Li, V.E. Gjunter, Synthesis of porous Ni-Ti
shape-memory alloys by self-propagating high temperature synthesis:
reaction mechanism and an─▒sotropy ─▒n pore structure, Acta Mater, 48,
3895-904, 2000.
[3] A. Michiardi, C .Aparicio, J.A. Planell, F.J. Gil, Electrochemical
behaviour of oxidized NiTi shape memory alloys for biomedical
applications. Surf Coat Tech. 201,6484-8, 2007.
[4] C.L. Yeh, W.Y. Sung, Synthesis of NiTi intermetallics by selfpropagating
combustion, J Alloy Compd, 376, 79-88, 2004.
[5] C.L. Chu, C.Y. Chung, P.H. Lin, S.D. Wang Fabrication of porous NiTi
shape memory alloy for hard tissue implants by combustion synthesis,
Mat Sci Eng A-Struct., 366,114-9, 2004.
[6] B.Y. Li, L.J. Rong, Y.Y. Li, Stres-strain behavior of porous Ni-Ti shape
memory intermetallics synthesized from powder sintering,
Intermetallics, 8, 643-6, 2000.
[7] D. Bogdanski, M. Koller, D. Muller, G. Muhr, M Bram, H.P.
Buchkremer et al. Easy assessment of the biocompatibility of Ni-Ti
alloys by in vitro cell culture experiments on a functionally graded Ni-
NiTi-Ti material. Biomaterials, 23, 4549-4555, 2002.
[8] A. Kapanen, J. Ilvesaro, A. Danilov, J. Ryhanen, P. Lehenkari, J.
Tuukkanen, Behaviour of Nitinol in osteoblast-like ROS-17 cell
cultures. Biomaterials, 23, 645-650, 2002.
[9] P.K. Chu, Bioactivity of plasma implanted biomaterials Nucl Instrum
Meth B, 24, 1-7, 2006.
[10] C.Y. Li, X.J. Yang, L.Y. Zhang, M. F. Chen, Z. D. Cui, In vivo
histological evaluation of bioactive NiTi alloy after two years
implantation, Mat Sci Eng C-Bio S, 27, 122-126, 2007.
[11] A. Bansiddhi, T.D. Sargeant, S.I. Stupp, D.C. Dunand, Porous NiTi for
bone implants: A review, Acta Biomater, 4, 773-82, 2008.
[12] A. Biswas, Porous NiTi by thermal explosion mode of SHS: processing,
mechanism and generation of single phase microstructure, Acta Mater,
53, 1415-1425, 2005.
[13] C. Shearwood, Y.Q. Fu, L. Yu, K.A. Khor, Spark plasma sintering of
TiNi nano-powder , Scripta Mater, 52, 455-60, 2005.
[14] S. Rhalmi, M. Odin, M. Assad, M. Tabrizian, C.H. Rivard, L.H. Yahia,
Hard. soft tissue and in vitro cell response to porous nickel- titanium: a
biocompatibility evaluation Biomed Mater Eng, 9, 151-62, 1999.
[15] T. Duerig, A. Pelton, D. Stockel, An overview of nitinol medical
applications Mat Sci Eng A-Struct, 273-275, 149-60, 1999.
[16] G. Tosun, L. Ozler, M. Kaya, N. Orhan, A study on microstructure and
porosity of NiTi alloy implants produced by SHS, J Alloys Comp, 487,
605-611, 2009.
[17] D.A. Armitage, T.L. Parker, D.M. Grant, Biocompatibility and
hemocompatibility of surface-modified NiTi alloys J Biomed Mater Res
A, 66, 129-37, 2003.
[18] M.F. Chen, X.J. Yang, R.X. Hu, Z.D. Cui, H.C. Man, Bioactive NiTi
shape memory alloy used as bone bonding implants, Mater. Sci. Eng. C,
24, 497, 2004.
[19] S.L. Zhu, X. J. Yang, M.F. Chen, C.Y. Li, Z.D. Cui, Effect of porous
NiTi alloy on bone formation: A comparative investigation with bulk
NiTi alloy for 15 weeks in vivo, Mat Sci Eng, 28, 1271-1275, 2008.
[1] F. Sarsilmaz, N. Orhan, E. Unsaldi, A. S. Durmus, N.A. Colakoglu, A
polyethylene-high proportion hydroxyapatite implant and its
investigation in vivo Acta Bioeng Biomech, 9, 9-16, 2007.
[2] B.Y.Li, L. J. Rong, Y.Y. Li, V.E. Gjunter, Synthesis of porous Ni-Ti
shape-memory alloys by self-propagating high temperature synthesis:
reaction mechanism and an─▒sotropy ─▒n pore structure, Acta Mater, 48,
3895-904, 2000.
[3] A. Michiardi, C .Aparicio, J.A. Planell, F.J. Gil, Electrochemical
behaviour of oxidized NiTi shape memory alloys for biomedical
applications. Surf Coat Tech. 201,6484-8, 2007.
[4] C.L. Yeh, W.Y. Sung, Synthesis of NiTi intermetallics by selfpropagating
combustion, J Alloy Compd, 376, 79-88, 2004.
[5] C.L. Chu, C.Y. Chung, P.H. Lin, S.D. Wang Fabrication of porous NiTi
shape memory alloy for hard tissue implants by combustion synthesis,
Mat Sci Eng A-Struct., 366,114-9, 2004.
[6] B.Y. Li, L.J. Rong, Y.Y. Li, Stres-strain behavior of porous Ni-Ti shape
memory intermetallics synthesized from powder sintering,
Intermetallics, 8, 643-6, 2000.
[7] D. Bogdanski, M. Koller, D. Muller, G. Muhr, M Bram, H.P.
Buchkremer et al. Easy assessment of the biocompatibility of Ni-Ti
alloys by in vitro cell culture experiments on a functionally graded Ni-
NiTi-Ti material. Biomaterials, 23, 4549-4555, 2002.
[8] A. Kapanen, J. Ilvesaro, A. Danilov, J. Ryhanen, P. Lehenkari, J.
Tuukkanen, Behaviour of Nitinol in osteoblast-like ROS-17 cell
cultures. Biomaterials, 23, 645-650, 2002.
[9] P.K. Chu, Bioactivity of plasma implanted biomaterials Nucl Instrum
Meth B, 24, 1-7, 2006.
[10] C.Y. Li, X.J. Yang, L.Y. Zhang, M. F. Chen, Z. D. Cui, In vivo
histological evaluation of bioactive NiTi alloy after two years
implantation, Mat Sci Eng C-Bio S, 27, 122-126, 2007.
[11] A. Bansiddhi, T.D. Sargeant, S.I. Stupp, D.C. Dunand, Porous NiTi for
bone implants: A review, Acta Biomater, 4, 773-82, 2008.
[12] A. Biswas, Porous NiTi by thermal explosion mode of SHS: processing,
mechanism and generation of single phase microstructure, Acta Mater,
53, 1415-1425, 2005.
[13] C. Shearwood, Y.Q. Fu, L. Yu, K.A. Khor, Spark plasma sintering of
TiNi nano-powder , Scripta Mater, 52, 455-60, 2005.
[14] S. Rhalmi, M. Odin, M. Assad, M. Tabrizian, C.H. Rivard, L.H. Yahia,
Hard. soft tissue and in vitro cell response to porous nickel- titanium: a
biocompatibility evaluation Biomed Mater Eng, 9, 151-62, 1999.
[15] T. Duerig, A. Pelton, D. Stockel, An overview of nitinol medical
applications Mat Sci Eng A-Struct, 273-275, 149-60, 1999.
[16] G. Tosun, L. Ozler, M. Kaya, N. Orhan, A study on microstructure and
porosity of NiTi alloy implants produced by SHS, J Alloys Comp, 487,
605-611, 2009.
[17] D.A. Armitage, T.L. Parker, D.M. Grant, Biocompatibility and
hemocompatibility of surface-modified NiTi alloys J Biomed Mater Res
A, 66, 129-37, 2003.
[18] M.F. Chen, X.J. Yang, R.X. Hu, Z.D. Cui, H.C. Man, Bioactive NiTi
shape memory alloy used as bone bonding implants, Mater. Sci. Eng. C,
24, 497, 2004.
[19] S.L. Zhu, X. J. Yang, M.F. Chen, C.Y. Li, Z.D. Cui, Effect of porous
NiTi alloy on bone formation: A comparative investigation with bulk
NiTi alloy for 15 weeks in vivo, Mat Sci Eng, 28, 1271-1275, 2008.
@article{"International Journal of Medical, Medicine and Health Sciences:49442", author = "Gul Tosun and Emine Ünsaldi Latif Özler and Nuri Orhan and Ali Said Durmus and Hatice Eröksüz", title = "Biocompatibility of NiTi Alloy Implants in vivo", abstract = "In this study, the powders of Ni and Ti with 50.5 at.%
Ni for 12 h were blended and cold pressed at the different pressures
(50, 75 and100 MPa).The porous product obtained after Ni-Ti
compacts were synthesized by SHS (self-propagating hightemperature
synthesis) in the different preheating temperatures (200,
250 and 300oC) and heating rates (30, 60 and 90oC/min). The effects
of the pressure, preheating temperature and heating rate were
investigated on biocompatibility in vivo. The porosity in the
synthesized products was in the range of 50.7–59.7 vol. %. The
pressure, preheating temperature and heating rate were found to have
an important effect on the biocompatibility in-vivo of the synthesized
products. Max. fibrotic tissue within the porous implant was found in
vivo periods (6 months), in which compacting pressure 100MPa.", keywords = "NiTi, biomaterial, SHS, biocompatibility.", volume = "7", number = "6", pages = "221-4", }
