Abstract: Background: Breast cancer is the leading cause of death for women around the world. Screening mammography is the reference examination, due to its sensitivity for detecting small lesions and micro-calcifications. Therefore, it is essential to ensure quality mammographic examinations with the most optimal dose. These conditions depend on the choice of exposure parameters. Clinically, practices must be evaluated in order to determine the most appropriate exposure parameters. Material and Methods: We performed our measurements on a mobile mammography unit (PLANMED Sofie-classic.) in Morocco. A solid dosimeter (AGMS Radcal) and a MTM 100 phantom allow to quantify the delivered dose and the image quality. For image quality assessment, scores are defined by the rate of visible inserts (MTM 100 phantom), obtained and compared for each acquisition. Results: The results show that the parameters of the mammography unit on which we have made our measurements can be improved in order to offer a better compromise between image quality and breast dose. The last one can be reduced up from 13.27% to 22.16%, while preserving comparable image quality.
Abstract: In this paper, we report the experimental results on using complementary Golay coded signals at 7.5 MHz to detect breast microcalcifications of 50 µm size. Simulations using complementary Golay coded signals show perfect consistence with the experimental results, confirming the improved signal to noise ratio for complementary Golay coded signals. For improving the success on detecting the microcalcifications, orthogonal complementary Golay sequences having cross-correlation for minimum interference are used as coded signals and compared to tone burst pulse of equal energy in terms of resolution under weak signal conditions. The measurements are conducted using an experimental ultrasound research scanner, Digital Phased Array System (DiPhAS) having 256 channels, a phased array transducer with 7.5 MHz center frequency and the results obtained through experiments are validated by Field-II simulation software. In addition, to investigate the superiority of coded signals in terms of resolution, multipurpose tissue equivalent phantom containing series of monofilament nylon targets, 240 µm in diameter, and cyst-like objects with attenuation of 0.5 dB/[MHz x cm] is used in the experiments. We obtained ultrasound images of monofilament nylon targets for the evaluation of resolution. Simulation and experimental results show that it is possible to differentiate closely positioned small targets with increased success by using coded excitation in very weak signal conditions.
Abstract: Diagnosis of breast cancer at early stages has seen better clinical and survival outcomes. Survival rates in developing countries like India are very low due to accessibility and affordability issues of screening tests such as Mammography. In addition, Mammography is not much effective in younger women with dense breasts. This leaves a gap in current screening methods. Thermalytix is a new technique for detecting breast abnormality in a non-contact, non-invasive way. It is an AI-enabled computer-aided diagnosis solution that automates interpretation of high resolution thermal images and identifies potential malignant lesions. The solution is low cost, easy to use, portable and is effective in all age groups. This paper presents the results of a retrospective comparative analysis of Thermalytix over Mammography and Clinical Breast Examination for breast cancer screening. Thermalytix was found to have better sensitivity than both the tests, with good specificity as well. In addition, Thermalytix identified all malignant patients without palpable lumps.
Abstract: One of the significant and continual public health problems in the world is breast cancer. Early detection is very important to fight the disease, and mammography has been one of the most common and reliable methods to detect the disease in the early stages. However, it is a difficult task, and computer-aided diagnosis (CAD) systems are needed to assist radiologists in providing both accurate and uniform evaluation for mass in mammograms. In this study, a multiresolution statistical method to classify mammograms as normal and abnormal in digitized mammograms is used to construct a CAD system. The mammogram images are represented by wave atom transform, and this representation is made by certain groups of coefficients, independently. The CAD system is designed by calculating some statistical features using each group of coefficients. The classification is performed by using support vector machine (SVM).
Abstract: Cancer affects people globally with breast cancer being a leading killer. Breast cancer is due to the uncontrollable multiplication of cells resulting in a tumour or neoplasm. Tumours are called ‘benign’ when cancerous cells do not ravage other body tissues and ‘malignant’ if they do so. As mammography is an effective breast cancer detection tool at an early stage which is the most treatable stage it is the primary imaging modality for screening and diagnosis of this cancer type. This paper presents an automatic mammogram classification technique using wavelet and Gabor filter. Correlation feature selection is used to reduce the feature set and selected features are classified using different decision trees.
Abstract: Computer aided diagnosis systems provide vital
opinion to radiologists in the detection of early signs of breast cancer
from mammogram images. Architectural distortions, masses and
microcalcifications are the major abnormalities. In this paper, a
computer aided diagnosis system has been proposed for
distinguishing abnormal mammograms with architectural distortion
from normal mammogram. Four types of texture features GLCM
texture, GLRLM texture, fractal texture and spectral texture features
for the regions of suspicion are extracted. Support vector machine
has been used as classifier in this study. The proposed system yielded
an overall sensitivity of 96.47% and an accuracy of 96% for
mammogram images collected from digital database for screening
mammography database.
Abstract: Mammography is widely used technique for breast cancer
screening. There are various other techniques for breast cancer screening
but mammography is the most reliable and effective technique. The
images obtained through mammography are of low contrast which
causes problem for the radiologists to interpret. Hence, a high quality
image is mandatory for the processing of the image for extracting any
kind of information from it. Many contrast enhancement algorithms have
been developed over the years. In the present work, an efficient
morphology based technique is proposed for contrast enhancement of
masses in mammographic images. The proposed method is based on
Multiscale Morphology and it takes into consideration the scale of the
structuring element. The proposed method is compared with other stateof-
the-art techniques. The experimental results show that the proposed
method is better both qualitatively and quantitatively than the other
standard contrast enhancement techniques.
Abstract: Breast cancer is considered as a substantial health
concern and practicing mammography screening [MS] is important in
minimizing its related morbidity. So it is essential to have a better
understanding of breast cancer screening behaviors of women and
factors that influence utilization of them. The aim of this study is to
identify the factors that are linked to MS behaviors among the
Egyptian women. A cross-sectional descriptive design was carried
out to provide a snapshot of the factors that are linked to MS
behaviors. A convenience sample of 311 women was utilized and all
eligible participants admitted to the Women Imaging Unit who are 40
years of age or above, coming for mammography assessment, not
pregnant or breast feeding and who accepted to participate in the
study were included. A structured questionnaire was developed by
the researchers and contains three parts; Socio-demographic data;
Motivating factors associated with MS; and association between MS
and model of behavior change. The analyzed data indicated that most
of the participated women (66.6%) belonged to the age group of 40-
49.A high proportion of participants (58.1%) of group having
previous MS influenced by their neighbors to practice MS, whereas
32.7 % in group not having previous MS were influenced by family
members which indicated significant differences (P
Abstract: Early detection of breast cancer saves many thousands
of lives each year via application of mammography and genetic
screening and many more lives could be saved if nurses are involved
in breast care screening practices. So, the aim of the study was to
identify nurse's role in early detection of breast cancer through
mammography and genetic screening and its impact on patient's
outcome. In order to achieve this aim, 400 women above 40 years,
asymptomatic were recruited for mammography and genetic
screening. In addition, 50 nurses and 6 technologists were involved in
the study. A descriptive analytical design was used. Five tools were
utilized: sociodemographic, mammographic examination and risk
factors, women's before, during and after mammography, items
relaying to technologists, and items related to nurses were also
obtained. The study finding revealed that 3% of women detected for
malignancy and 7.25% for fibroadenoma. Statistically significant
differences were found between mammography results and age,
family history, genetic screening, exposure to smoke, and using
contraceptive pills. Nurses have insufficient knowledge about
screening tests. Based on these findings the present study
recommended involvement of nurses in breast care which is very
important to in force population about screening practices.
Abstract: Mammography has been one of the most reliable
methods for early detection of breast cancer. There are different
lesions which are breast cancer characteristic such as
microcalcifications, masses, architectural distortions and bilateral
asymmetry. One of the major challenges of analysing digital
mammogram is how to extract efficient features from it for accurate
cancer classification. In this paper we proposed a hybrid feature
extraction method to detect and classify all four signs of breast
cancer. The proposed method is based on multiscale surrounding
region dependence method, Gabor filters, multi fractal analysis,
directional and morphological analysis. The extracted features are
input to self adaptive resource allocation network (SRAN) classifier
for classification. The validity of our approach is extensively
demonstrated using the two benchmark data sets Mammographic
Image Analysis Society (MIAS) and Digital Database for Screening
Mammograph (DDSM) and the results have been proved to be
progressive.
Abstract: Clusters of Microcalcifications (MCCs) are most frequent symptoms of Ductal Carcinoma in Situ (DCIS) recognized by mammography. Least-Square Support Vector Machine (LS-SVM) is a variant of the standard SVM. In the paper, LS-SVM is proposed as a classifier for classifying MCCs as benign or malignant based on relevant extracted features from enhanced mammogram. To establish the credibility of LS-SVM classifier for classifying MCCs, a comparative evaluation of the relative performance of LS-SVM classifier for different kernel functions is made. For comparative evaluation, confusion matrix and ROC analysis are used. Experiments are performed on data extracted from mammogram images of DDSM database. A total of 380 suspicious areas are collected, which contain 235 malignant and 145 benign samples, from mammogram images of DDSM database. A set of 50 features is calculated for each suspicious area. After this, an optimal subset of 23 most suitable features is selected from 50 features by Particle Swarm Optimization (PSO). The results of proposed study are quite promising.
Abstract: Breast region segmentation is an essential prerequisite in computerized analysis of mammograms. It aims at separating the breast tissue from the background of the mammogram and it includes two independent segmentations. The first segments the background region which usually contains annotations, labels and frames from the whole breast region, while the second removes the pectoral muscle portion (present in Medio Lateral Oblique (MLO) views) from the rest of the breast tissue. In this paper we propose hybridization of Connected Component Labeling (CCL), Fuzzy, and Straight line methods. Our proposed methods worked good for separating pectoral region. After removal pectoral muscle from the mammogram, further processing is confined to the breast region alone. To demonstrate the validity of our segmentation algorithm, it is extensively tested using over 322 mammographic images from the Mammographic Image Analysis Society (MIAS) database. The segmentation results were evaluated using a Mean Absolute Error (MAE), Hausdroff Distance (HD), Probabilistic Rand Index (PRI), Local Consistency Error (LCE) and Tanimoto Coefficient (TC). The hybridization of fuzzy with straight line method is given more than 96% of the curve segmentations to be adequate or better. In addition a comparison with similar approaches from the state of the art has been given, obtaining slightly improved results. Experimental results demonstrate the effectiveness of the proposed approach.
Abstract: An effective method for the early detection of breast
cancer is the mammographic screening. One of the most important
signs of early breast cancer is the presence of microcalcifications. For
the detection of microcalcification in a mammography image, we
propose to conceive a multiagent system based on a dual irregular
pyramid.
An initial segmentation is obtained by an incremental approach;
the result represents level zero of the pyramid. The edge information
obtained by application of the Canny filter is taken into account to
affine the segmentation. The edge-agents and region-agents cooper
level by level of the pyramid by exploiting its various characteristics
to provide the segmentation process convergence.
Abstract: A typical definition of the Computer Aided Diagnosis
(CAD), found in literature, can be: A diagnosis made by a radiologist
using the output of a computerized scheme for automated image
analysis as a diagnostic aid. Often it is possible to find the expression
Computer Aided Detection (CAD or CADe): this definition
emphasizes the intent of CAD to support rather than substitute the
human observer in the analysis of radiographic images. In this article
we will illustrate the application of CAD systems and the aim of
these definitions.
Commercially available CAD systems use computerized
algorithms for identifying suspicious regions of interest. In this paper
are described the general CAD systems as an expert system
constituted of the following components: segmentation / detection,
feature extraction, and classification / decision making.
As example, in this work is shown the realization of a Computer-
Aided Detection system that is able to assist the radiologist in
identifying types of mammary tumor lesions. Furthermore this
prototype of station uses a GRID configuration to work on a large
distributed database of digitized mammographic images.
Abstract: Mammographic images and data analysis to
facilitate modelling or computer aided diagnostic (CAD) software development should best be done using a common database that can handle various mammographic image file
formats and relate these to other patient information.
This would optimize the use of the data as both primary
reporting and enhanced information extraction of research data could be performed from the single dataset. One desired
improvement is the integration of DICOM file header information into the database, as an efficient and reliable source of supplementary patient information intrinsically
available in the images.
The purpose of this paper was to design a suitable database to link and integrate different types of image files and gather common information that can be further used for research
purposes. An interface was developed for accessing, adding,
updating, modifying and extracting data from the common
database, enhancing the future possible application of the data in CAD processing.
Technically, future developments envisaged include the creation of an advanced search function to selects image files
based on descriptor combinations. Results can be further used for specific CAD processing and other research. Design of a
user friendly configuration utility for importing of the required fields from the DICOM files must be done.
Abstract: A mammography image is composed of low contrast area where the breast tissues and the breast abnormalities such as microcalcification can hardly be differentiated by the medical practitioner. This paper presents the application of active contour models (Snakes) for the segmentation of microcalcification in mammography images. Comparison on the microcalcifiation areas segmented by the Balloon Snake, Gradient Vector Flow (GVF) Snake, and Distance Snake is done against the true value of the microcalcification area. The true area value is the average microcalcification area in the original mammography image traced by the expert radiologists. From fifty images tested, the result obtained shows that the accuracy of the Balloon Snake, GVF Snake, and Distance Snake in segmenting boundaries of microcalcification are 96.01%, 95.74%, and 95.70% accuracy respectively. This implies that the Balloon Snake is a better segmentation method to locate the exact boundary of a microcalcification region.
Abstract: X-ray mammography is the most effective method for
the early detection of breast diseases. However, the typical diagnostic
signs such as microcalcifications and masses are difficult to detect
because mammograms are of low-contrast and noisy. In this paper, a
new algorithm for image denoising and enhancement in Orthogonal
Polynomials Transformation (OPT) is proposed for radiologists to
screen mammograms. In this method, a set of OPT edge coefficients
are scaled to a new set by a scale factor called OPT scale factor. The
new set of coefficients is then inverse transformed resulting in
contrast improved image. Applications of the proposed method to
mammograms with subtle lesions are shown. To validate the
effectiveness of the proposed method, we compare the results to
those obtained by the Histogram Equalization (HE) and the Unsharp
Masking (UM) methods. Our preliminary results strongly suggest
that the proposed method offers considerably improved enhancement
capability over the HE and UM methods.
Abstract: Mammography is the most effective procedure for an
early diagnosis of the breast cancer. Nowadays, people are trying to
find a way or method to support as much as possible to the
radiologists in diagnosis process. The most popular way is now being
developed is using Computer-Aided Detection (CAD) system to
process the digital mammograms and prompt the suspicious region to
radiologist. In this paper, an automated CAD system for detection
and classification of massive lesions in mammographic images is
presented. The system consists of three processing steps: Regions-Of-
Interest detection, feature extraction and classification. Our CAD
system was evaluated on Mini-MIAS database consisting 322
digitalized mammograms. The CAD system-s performance is
evaluated using Receiver Operating Characteristics (ROC) and Freeresponse
ROC (FROC) curves. The archived results are 3.47 false
positives per image (FPpI) and sensitivity of 85%.
Abstract: Breast cancer detection techniques have been reported
to aid radiologists in analyzing mammograms. We note that most
techniques are performed on uncompressed digital mammograms.
Mammogram images are huge in size necessitating the use of
compression to reduce storage/transmission requirements. In this
paper, we present an algorithm for the detection of
microcalcifications in the JPEG2000 domain. The algorithm is based
on the statistical properties of the wavelet transform that the
JPEG2000 coder employs. Simulation results were carried out at
different compression ratios. The sensitivity of this algorithm ranges
from 92% with a false positive rate of 4.7 down to 66% with a false
positive rate of 2.1 using lossless compression and lossy compression
at a compression ratio of 100:1, respectively.
Abstract: In this study, we present an advanced detection
technique for mass type breast cancer based on texture information
of organs. The proposed method detects the cancer areas in three
stages. In the first stage, the midpoints of mass area are determined
based on AHE (Adaptive Histogram Equalization). In the second
stage, we set the threshold coefficient of homogeneity by using
MLE (Maximum Likelihood Estimation) to compute the uniformity
of texture. Finally, mass type cancer tissues are extracted from the
original image. As a result, it was observed that the proposed
method shows an improved detection performance on dense breast
tissues of Korean women compared with the existing methods. It is
expected that the proposed method may provide additional
diagnostic information for detection of mass-type breast cancer.