Abstract: We present the design of Analog front end (AFE) low noise pre-amplifier implemented in a high voltage 0.18-µm CMOS technology for a three dimensional ultrasound bio microscope (3D UBM) application. The fabricated chip has 4X16 pre-amplifiers implemented to interface a 2-D array of high frequency capacitive micro-machined ultrasound transducers (CMUT). Core AFE cell consists of a high-voltage pulser in the transmit path, and a low-noise transimpedance amplifier in the receive path. Proposed system offers a high image resolution by the use of high frequency CMUTs with associated high performance imaging electronics integrated together. Performance requirements and the design methods of the high bandwidth transimpedance amplifier are described in the paper. A single cell of transimpedance (TIA) amplifier and the bias circuit occupies a silicon area of 250X380 µm2 and the full chip occupies a total silicon area of 10x6.8 mm².
Abstract: Background Contact lens (CL) wear can cause
changes in blinking and corneal staining. Aims and Objectives To
determine the effects of CL materials (HEMA and SiHy) on
spontaneous blink rate, blinking patterns and corneal staining after 2
months of wear. Methods Ninety subjects in 3 groups (control,
HEMA and SiHy) were assessed at baseline and 2-months. Blink rate
was recorded using a video camera. Blinking patterns were assessed
with digital camera and slit lamp biomicroscope. Corneal staining
was graded using IER grading scale Results There were no significant
differences in all parameters at baseline. At 2 months, CL wearers
showed significant increment in average blink rate (F1.626, 47.141 =
7.250, p = 0.003; F2,58 = 6.240, p = 0.004) and corneal staining (χ2
2,
n=30 = 31.921, p < 0.001; χ2
2, n=30 = 26.909, p < 0.001). Conclusion
Blinking characteristics and corneal staining were not influence by
soft CL materials.
Abstract: This paper presents the design and implementation of a fully integrated transimpedance amplifier (TIA) as the analog frontend receiver for Capacitive Micromachined Ultrasound Transducers (CMUTs) for ultrasound biomicroscope imaging application. The amplifier is designed to amplify the received signals from 17.5MHz to 52.5MHz with a center frequency of 35MHz. The TIA was fabricated in GF 0.18μm 1P6M 30V high voltage process. The measurement results show that the designed amplifier can reach a transimpedance gain of 61.08dBΩ and operating frequency from 17.5MHz to 100MHz with 1VP-P output voltage under 6V power supply.