Abstract: The goal of this paper is to examine the effects of laser
radiation on the skin wound healing using infrared thermography as
non-invasive method for the monitoring of the skin temperature
changes during laser treatment. Thirty Wistar rats were used in this
study. A skin lesion was performed at the leg on all rats. The animals
were exposed to laser radiation (λ = 670 nm, P = 15 mW, DP = 16.31
mW/cm2) for 600 s. Thermal images of wound were acquired before
and after laser irradiation. The results have demonstrated that the
tissue temperature decreases from 35.5±0.50°C in the first treatment
day to 31.3±0.42°C after the third treatment day. This value is close
to the normal value of the skin temperature and indicates the end of
the skin repair process. In conclusion, the improvements in the
wound healing following exposure to laser radiation have been
revealed by infrared thermography.
Abstract: This study presents design of a carbon silicon electrode
for iontophorsis treatment towards alopecia. The alopecia is a medical
description means loss of hair from the body. For solving this problem,
the drug need to be delivered into the scalp, therefore, the
iontophoresis was chosen to use in this treatment. However, almost
common electrodes of iontophoresis device are made with metal
material, the electrodes could give patients hurt when they using it, and
it is hard to avoid the hair for attaching the hair. For this reason, an
electrode is made with silicon material to decrease the hurt from the
electrodes, and the carbon material is mixed in it for increasing
conductance. The several cones with stainless material on the
electrode make the electrode is able to void hair to attach the affected
part. According to the results of a vivo-experiment, the carbon silicon
electrode showed a good performance and in treatment comfortably.
Abstract: We present a preliminary x-ray study on human-hair
microstructures for a health-state indicator, in particular a cancer
case. As an uncomplicated and low-cost method of x-ray technique,
the human-hair microstructure was analyzed by wide-angle x-ray
diffractions (XRD) and small-angle x-ray scattering (SAXS). The
XRD measurements exhibited the simply reflections at the d-spacing
of 28 Å, 9.4 Å and 4.4 Å representing to the periodic distance of the
protein matrix of the human-hair macrofibrous and the diameter and
the repeated spacing of the polypeptide alpha helixes of the
photofibrils of the human-hair microfibrous, respectively. When
compared to the normal cases, the unhealthy cases including to the
breast- and ovarian-cancer cases obtained higher normalized ratios of
the x-ray diffracting peaks of 9.4 Å and 4.4 Å. This likely resulted
from the varied distributions of microstructures by a molecular
alteration. As an elemental analysis by x-ray fluorescence (XRF), the
normalized quantitative ratios of zinc(Zn)/calcium(Ca) and
iron(Fe)/calcium(Ca) were determined. Analogously, both Zn/Ca and
Fe/Ca ratios of the unhealthy cases were obtained higher than both of
the normal cases were. Combining the structural analysis by XRD
measurements and the elemental analysis by XRF measurements
exhibited that the modified fibrous microstructures of hair samples
were in relation to their altered elemental compositions. Therefore,
these microstructural and elemental analyses of hair samples will be
benefit to associate with a diagnosis of cancer and genetic diseases.
This functional method would lower a risk of such diseases by the
early diagnosis. However, the high-intensity x-ray source, the highresolution
x-ray detector, and more hair samples are necessarily
desired to develop this x-ray technique and the efficiency would be
enhanced by including the skin and fingernail samples with the
human-hair analysis.
Abstract: The research was designed to examine the relationship
between the development of muscle fatigue and the effect it has on
sport performance, specifically during maximal voluntary
contraction. This kind of this investigation using simultaneous
electrophysiological and mechanical recordings, based on advanced
mathematical processing, allows us to get parameters, and indexes in
a short time, and finally, the mapping to use for the thorough
investigation of the muscle contraction force, respectively the
phenomenon of local muscle fatigue, both for athletes and other
subjects.
Abstract: The worldwide prevalence of H3N2 influenza virus
and its increasing resistance to the existing drugs necessitates for the
development of an improved/better targeting anti-influenza drug.
H3N2 influenza neuraminidase is one of the two membrane-bound
proteins belonging to group-2 neuraminidases. It acts as key player
involved in viral pathogenicity and hence, is an important target of
anti-influenza drugs. Oseltamivir is one of the potent drugs targeting
this neuraminidase. In the present work, we have taken subtype N2
neuraminidase as the receptor and probable analogs of oseltamivir as
drug molecules to study the protein-drug interaction in anticipation of
finding efficient modified candidate compound. Oseltamivir analogs
were made by modifying the functional groups using Marvin Sketch
software and were docked using Schrodinger-s Glide. Oseltamivir
analog 10 was detected to have significant energy value (16% less
compared to Oseltamivir) and could be the probable lead molecule. It
infers that some of the modified compounds can interact in a novel
manner with increased hydrogen bonding at the active site of
neuraminidase and it might be better than the original drug. Further
work can be carried out such as enzymatic inhibition studies;
synthesis and crystallizing the drug-target complex to analyze the
interactions biologically.
Abstract: Cast metal inlays can be used on molars requiring a
class II restoration instead amalgam and offer a durable alternative.
Because it is known that class II inlays may increase the
susceptibility to fracture, it is important to ensure optimal
performance in selection of the adequate preparation design to reduce
stresses in teeth structures and also in the restorations. The aim of the
study was to investigate the influence of preparation design on stress
distribution in molars with different class II preparations and in cast
metal inlays. The first step of the study was to achieve 3D models in
order to analyze teeth and cast metal class II inlays. The geometry of
the intact tooth was obtained by 3D scanning using a manufactured
device. With a NURBS modeling program the preparations and the
appropriately inlays were designed. 3D models of first upper molars
of the same shape and size were created. Inlay cavities designs were
created using literature data. The geometrical model was exported
and the mesh structure of the solid 3D model was created for
structural simulations. Stresses were located around the occlusal
contact areas. For the studied cases, the stress values were not
significant influenced by the taper of the preparation. it was
demonstrated stresses are higher in the cast metal restorations and
therefore the strength of the teeth is not affected.
Abstract: Photoplethysmography is a simple measurement of the
variation in blood volume in tissue. It detects the pulse signal of heart
beat as well as the low frequency signal of vasoconstriction and
vasodilation. The transmission type measurement is limited to only a
few specific positions for example the index finger that have a short
path length for light. The reflectance type measurement can be
conveniently applied on most parts of the body surface. This study
analyzed the factors that determine the quality of reflectance
photoplethysmograph signal including the emitter-detector distance,
wavelength, light intensity, and optical properties of skin tissue.
Light emitting diodes (LEDs) with four different visible
wavelengths were used as the light emitters. A phototransistor was
used as the light detector. A micro translation stage adjusts the
emitter-detector distance from 2 mm to 15 mm.
The reflective photoplethysmograph signals were measured on
different sites. The optimal emitter-detector distance was chosen to
have a large dynamic range for low frequency drifting without signal
saturation and a high perfusion index. Among these four wavelengths,
a yellowish green (571nm) light with a proper emitter-detection
distance of 2mm is the most suitable for obtaining a steady and reliable
reflectance photoplethysmograph signal
Abstract: This paper presents a method for the detection of OD in the retina which takes advantage of the powerful preprocessing techniques such as the contrast enhancement, Gabor wavelet transform for vessel segmentation, mathematical morphology and Earth Mover-s distance (EMD) as the matching process. The OD detection algorithm is based on matching the expected directional pattern of the retinal blood vessels. Vessel segmentation method produces segmentations by classifying each image pixel as vessel or nonvessel, based on the pixel-s feature vector. Feature vectors are composed of the pixel-s intensity and 2D Gabor wavelet transform responses taken at multiple scales. A simple matched filter is proposed to roughly match the direction of the vessels at the OD vicinity using the EMD. The minimum distance provides an estimate of the OD center coordinates. The method-s performance is evaluated on publicly available DRIVE and STARE databases. On the DRIVE database the OD center was detected correctly in all of the 40 images (100%) and on the STARE database the OD was detected correctly in 76 out of the 81 images, even in rather difficult pathological situations.
Abstract: In this paper, we propose a new method to distinguish
between arousal and relaxation states by using multiple features
acquired from a photoplethysmogram (PPG) and support vector
machine (SVM). To induce arousal and relaxation states in subjects, 2
kinds of sound stimuli are used, and their corresponding biosignals are
obtained using the PPG sensor. Two features–pulse to pulse interval
(PPI) and pulse amplitude (PA)–are extracted from acquired PPG
data, and a nonlinear classification between arousal and relaxation is
performed using SVM.
This methodology has several advantages when compared with
previous similar studies. Firstly, we extracted 2 separate features from
PPG, i.e., PPI and PA. Secondly, in order to improve the classification
accuracy, SVM-based nonlinear classification was performed.
Thirdly, to solve classification problems caused by generalized
features of whole subjects, we defined each threshold according to
individual features.
Experimental results showed that the average classification
accuracy was 74.67%. Also, the proposed method showed the better
identification performance than the single feature based methods.
From this result, we confirmed that arousal and relaxation can be
classified using SVM and PPG features.
Abstract: Elastic light single-scattering spectroscopy system
with a single optical fiber probe was employed to differentiate cancerous prostate tissue from non-cancerous prostate tissue ex-vivo just after radical prostatectomy. First, ELSSS spectra were acquired
from cancerous prostate tissue to define its spectral features. Then,
spectra were acquired from normal prostate tissue to define difference in spectral features between the cancerous and normal
prostate tissues. Of the total 66 tissue samples were evaluated from
nine patients by ELSSS system. Comparing of histopathology results
and ELSSS measurements revealed that sign of the spectral slopes of
cancerous prostate tissue is negative and non-cancerous tissue is positive in the wavelength range from 450 to 750 nm. Based on the
correlation between histopathology results and sign of the spectral
slopes, ELSSS system differentiates cancerous prostate tissue from
non- cancerous with a sensitivity of 0.95 and a specificity of 0.94.
Abstract: In order to alleviate the mental and physical problems
of persons with disabilities, animal-assisted therapy (AAT) is one of
the possible modalities that employs the merit of the human-animal
interaction. Nevertheless, to achieve the purpose of AAT for persons
with severe disabilities (e.g. spinal cord injury, stroke, and
amyotrophic lateral sclerosis), real-time animal language
interpretation is desirable. Since canine behaviors can be visually
notable from its tail, this paper proposes the automatic real-time
interpretation of canine tail language for human-canine interaction in
the case of persons with severe disabilities. Canine tail language is
captured via two 3-axis accelerometers. Directions and frequencies
are selected as our features of interests. The novel fuzzy rules based
on Gaussian-Trapezoidal model and center of gravity (COG)-based
defuzzification method are proposed in order to interpret the features
into four canine emotional behaviors, i.e., agitate, happy, scare and
neutral as well as its blended emotional behaviors. The emotional
behavior model is performed in the simulated dog and has also been
evaluated in the real dog with the perfect recognition rate.
Abstract: This paper describes an automatic algorithm to restore
the shape of three-dimensional (3D) left ventricle (LV) models created
from magnetic resonance imaging (MRI) data using a geometry-driven
optimization approach. Our basic premise is to restore the LV shape
such that the LV epicardial surface is smooth after the restoration. A
geometrical measure known as the Minimum Principle Curvature (κ2)
is used to assess the smoothness of the LV. This measure is used to
construct the objective function of a two-step optimization process.
The objective of the optimization is to achieve a smooth epicardial
shape by iterative in-plane translation of the MRI slices.
Quantitatively, this yields a minimum sum in terms of the magnitude
of κ
2, when κ2 is negative. A limited memory quasi-Newton algorithm,
L-BFGS-B, is used to solve the optimization problem. We tested our
algorithm on an in vitro theoretical LV model and 10 in vivo
patient-specific models which contain significant motion artifacts. The
results show that our method is able to automatically restore the shape
of LV models back to smoothness without altering the general shape of
the model. The magnitudes of in-plane translations are also consistent
with existing registration techniques and experimental findings.
Abstract: This paper presents the design, implementation and
results related to the storage system of medical information
associated to the ECG (Electrocardiography) signal. The system
includes the signal acquisition modules, the preprocessing and signal
processing, followed by a module of transmission and reception of
the signal, along with the storage and web display system of the
medical platform. The tests were initially performed with this signal,
with the purpose to include more biosignal under the same system in
the future.
Abstract: Background: Tissue Doppler Echocardiography
(TDE) assesses diastolic function more accurately than routine pulse
Doppler echo. Assessment of the effects of dynamic and static
exercises on the heart by using TDE can provides new information
about the athlete-s heart syndrome. Methods: This study was
conducted on 20 elite wrestlers, 14 endurance runners at national
level and 21 non-athletes as the control group. Participants underwent
two-dimensional echocardiography, standard Doppler and TDE.
Results: Wrestlers had the highest left ventricular mass index, enddiastolic
inter-ventricular septum thickness and left ventricular
Posterior wall thickness. Runners had the highest Left ventricular
end-diastolic volume, LV ejection fraction, stroke volume and
cardiac output. In TDE, the early diastolic velocity of mitral annulus
to the late diastolic velocity ratio in athletic groups was greater than
the controls with no significant difference. Conclusion: In spite of
cardiac morphological changes in athletes, TDE shows that cardiac
diastolic function won-t be adversely affected.
Abstract: In this paper we present the modeling, design, and
experimental testing of a nerve cuff multi-electrode system for
diameter-selective vagus nerve stimulation.
The multi-electrode system contained ninety-nine platinum
electrodes embedded within a self-curling spiral silicone sheet. The
electrodes were organized in a matrix having nine parallel groups,
each containing eleven electrodes.
Preliminary testing of the nerve cuff was performed in an isolated
segment of a swinish left cervical vagus nerve. For selective vagus
nerve stimulation, precisely defined current quasitrapezoidal,
asymmetric and biphasic stimulating pulses were applied to
preselected locations along the left vagus segment via appointed
group of three electrodes within the cuff. Selective stimulation was
obtained by anodal block. However, these pulses may not be safe for
a long-term application because of a frequently used high imbalance
between the cathodic and anodic part of the stimulating pulse.
Preliminary results show that the cuff was capable of exciting A
and B-fibres, and, that for a certain range of parameters used in
stimulating pulses, the contribution of A-fibres to the CAP was
slightly reduced and the contribution of B-fibres was slightly larger.
Results also showed that measured CAPs are not greatly
influenced by the imbalance between a charge Qc injected in cathodic
and Qa in anodic phase of quasitrapezoidal, asymmetric and biphasic
pulses.
Abstract: Minor problems arising from optimizations by
welding of fixed prostheses frameworks can be identified by
macroscopic and microscopic visual inspection. The purpose of this
study was to highlight the visible discontinuities present in the laser
welds of dental Ni-Cr alloys. Ni-Cr base metal alloys designated for
fixed prostheses manufacture were selected for the experiments.
Using cast plates, preliminary tests were conducted by laser welding.
Macroscopic visual inspection was done carefully to assess the
defects of the welding rib. Electron microscopy images allowed
visualization of small discontinuities, which escapes visual
inspection. Making comparison to Ni-Cr alloys taken in the
experiment and laser welded, after visual analysis, the best welds
appear for Heraenium NA alloy.
Abstract: Walking and sit to stand are activities carried out by
all the people many times during the day, but physical disabilities due
to age and diseases create needs of assistive devices to help elderly
people during their daily life. This study aims to study the different
types and mechanisms of the assistive devices. We will analyze the
limitations and the challenges faced by the researchers in this field.
We will introduce the Assistive Device developed at the Egypt-Japan
University of Science and Technology, named E-JUST Assistive
Device (EJAD). EJAD will be a low cost intelligent assistive device
to help elders in walking and sit-to-stand activities.
Abstract: The overall penumbra is usually defined as the
distance, p20–80, separating the 20% and 80% of the dose on the beam axis at the depth of interest. This overall penumbra accounts
also for the fact that some photons emitted by the distal parts of the source are only partially attenuated by the collimator. Medulloblastoma is the most common type of childhood brain tumor
and often spreads to the spine. Current guidelines call for surgery to remove as much of the tumor as possible, followed by radiation of the brain and spinal cord, and finally treatment with chemotherapy.
The purpose of this paper was to present results on an Uniformity of dose distribution in radiation fields surrounding the spine using film
dosimetry and comparison with 3D treatment planning software.
Abstract: Thyroid cancer-s overall contribution to the
worldwide cancer burden is relatively small, but incidence rates have increased over the last three decades throughout the world. This trend has been hypothesised to reflect a combination of technological advances enabling increased detection, but also changes in
environmental factors, including population exposure to ionising radiation from fallout, diagnostic tests and treatment for benign and
malignant conditions. The Thyroid dose received apparently shielded
by cerrobend blocks was about 8cGy in 100cGy Expose
Abstract: Segmentation techniques based on Active Contour
Models have been strongly benefited from the use of prior information
during their evolution. Shape prior information is captured from
a training set and is introduced in the optimization procedure to
restrict the evolution into allowable shapes. In this way, the evolution
converges onto regions even with weak boundaries. Although
significant effort has been devoted on different ways of capturing
and analyzing prior information, very little thought has been devoted
on the way of combining image information with prior information.
This paper focuses on a more natural way of incorporating the
prior information in the level set framework. For proof of concept
the method is applied on hippocampus segmentation in T1-MR
images. Hippocampus segmentation is a very challenging task, due
to the multivariate surrounding region and the missing boundary
with the neighboring amygdala, whose intensities are identical. The
proposed method, mimics the human segmentation way and thus
shows enhancements in the segmentation accuracy.