Abstract: The ε4 allele of the ε2, ε3 and ε4 protein isoform polymorphism in the gene encoding apolipoprotein E (Apo E) has previously been associated with increased cardiac artery disease (CAD); therefore to investigate the significance of this polymorphism in pathogenesis of CAD in Iranian patients with stenosis and control subjects. To investigate the association between
Apo E polymorphism and coronary artery disease we performed a comparative case control study of the frequency of Apo E
polymorphism in One hundred CAD patients with stenosis who underwent coronary angiography (>50% stenosis) and 100 control subjects (
Abstract: Atherosclerosis is the condition in which an artery
wall thickens as the result of a build-up of fatty materials such as
cholesterol. It is a syndrome affecting arterial blood vessels, a
chronic inflammatory response in the walls of arteries, in large part
due to the accumulation of macrophage white blood cells and
promoted by low density (especially small particle) lipoproteins
(plasma proteins that carry cholesterol and triglycerides) without
adequate removal of fats and cholesterol from the macrophages by
functional high density lipoproteins (HDL). It is commonly referred
to as a hardening or furring of the arteries. It is caused by the
formation of multiple plaques within the arteries.
Abstract: A registration framework for image-guided robotic
surgery is proposed for three emergency neurosurgical procedures,
namely Intracranial Pressure (ICP) Monitoring, External Ventricular
Drainage (EVD) and evacuation of a Chronic Subdural Haematoma
(CSDH). The registration paradigm uses CT and white light as
modalities. This paper presents two simulation studies for a
preliminary evaluation of the registration protocol: (1) The loci of the
Target Registration Error (TRE) in the patient-s axial, coronal and
sagittal views were simulated based on a Fiducial Localisation Error
(FLE) of 5 mm and (2) Simulation of the actual framework using
projected views from a surface rendered CT model to represent white
light images of the patient. Craniofacial features were employed as
the registration basis to map the CT space onto the simulated
intraoperative space. Photogrammetry experiments on an artificial
skull were also performed to benchmark the results obtained from the
second simulation. The results of both simulations show that the
proposed protocol can provide a 5mm accuracy for these
neurosurgical procedures.
Abstract: This paper presents the automated methods employed
for extracting craniofacial landmarks in white light images as part of
a registration framework designed to support three neurosurgical
procedures. The intraoperative space is characterised by white light
stereo imaging while the preoperative plan is performed on CT scans.
The registration aims at aligning these two modalities to provide a
calibrated environment to enable image-guided solutions. The
neurosurgical procedures can then be carried out by mapping the
entry and target points from CT space onto the patient-s space. The
registration basis adopted consists of natural landmarks (eye corner
and ear tragus). A 5mm accuracy is deemed sufficient for these three
procedures and the validity of the selected registration basis in
achieving this accuracy has been assessed by simulation studies. The
registration protocol is briefly described, followed by a presentation
of the automated techniques developed for the extraction of the
craniofacial features and results obtained from tests on the AR and
FERET databases. Since the three targeted neurosurgical procedures
are routinely used for head injury management, the effect of
bruised/swollen faces on the automated algorithms is assessed. A
user-interactive method is proposed to deal with such unpredictable
circumstances.
Abstract: This paper employs a new approach to regulate the
blood glucose level of type I diabetic patient under an intensive
insulin treatment. The closed-loop control scheme incorporates
expert knowledge about treatment by using reinforcement learning
theory to maintain the normoglycemic average of 80 mg/dl and the
normal condition for free plasma insulin concentration in severe
initial state. The insulin delivery rate is obtained off-line by using Qlearning
algorithm, without requiring an explicit model of the
environment dynamics. The implementation of the insulin delivery
rate, therefore, requires simple function evaluation and minimal
online computations. Controller performance is assessed in terms of
its ability to reject the effect of meal disturbance and to overcome the
variability in the glucose-insulin dynamics from patient to patient.
Computer simulations are used to evaluate the effectiveness of the
proposed technique and to show its superiority in controlling
hyperglycemia over other existing algorithms
Abstract: If a possibility distribution and a probability distribution
are describing values x of one and the same system or process
x(t), can they relate to each other? Though in general the possibility
and probability distributions might be not connected at all, we
can assume that in some particular cases there is an association linked
them.
In the presented paper, we consider distributions of bloodstream
concentrations of physiologically active substances and propose that
the probability to observe a concentration x of a substance X can be
produced from the possibility of the event X = x .
The proposed assumptions and resulted theoretical distributions
are tested against the data obtained from various panel studies of the
bloodstream concentrations of the different physiologically active
substances in patients and healthy adults as well.