Abstract: The Zung self-depression scale and Beck Anxiety Inventory were used both to study the depression and anxiety levels of Armenian Crohn’s disease patients, and to reveal the relation between emotional status and placebo effect of these patients. On the other hand, the blood cell analyses and gut bacteria investigations were used to assess the placebo effect on ESR, and haemoglobin-s and leukocyte-s levels as well as gut commensal E. coli quantities of these patients. Despite of registered high levels of depression and anxiety, the high placebo effect on psychoemotional status for investigated patients during the investigations was described. On the other hand, no positive effect of placebo on measurements of ESP and hemoglobin-s levels of Crohn’s disease patients was revealed. The importance of use of psychotherapies for optimal outcomes during treatments of Crohn’s disease is discussed.
Abstract: Functional near infrared spectroscopy (fNIRS) is a
practical non-invasive optical technique to detect characteristic of
hemoglobin density dynamics response during functional activation of
the cerebral cortex. In this paper, fNIRS measurements were made in
the area of motor cortex from C4 position according to international
10-20 system. Three subjects, aged 23 - 30 years, were participated in
the experiment.
The aim of this paper was to evaluate the effects of different motor
activation tasks of the hemoglobin density dynamics of fNIRS signal.
The chaotic concept based on deterministic dynamics is an important
feature in biological signal analysis. This paper employs the chaotic
properties which is a novel method of nonlinear analysis, to analyze
and to quantify the chaotic property in the time series of the
hemoglobin dynamics of the various motor imagery tasks of fNIRS
signal. Usually, hemoglobin density in the human brain cortex is
found to change slowly in time. An inevitable noise caused by various
factors is to be included in a signal. So, principle component analysis
method (PCA) is utilized to remove high frequency component. The
phase pace is reconstructed and evaluated the Lyapunov spectrum, and
Lyapunov dimensions. From the experimental results, it can be
conclude that the signals measured by fNIRS are chaotic.
Abstract: In this paper, an automatic detecting algorithm for
QRS complex detecting was applied for analyzing ECG recordings
and five criteria for dangerous arrhythmia diagnosing are applied for a
protocol type of automatic arrhythmia diagnosing system. The
automatic detecting algorithm applied in this paper detected the
distribution of QRS complexes in ECG recordings and related
information, such as heart rate and RR interval. In this investigation,
twenty sampled ECG recordings of patients with different pathologic
conditions were collected for off-line analysis. A combinative
application of four digital filters for bettering ECG signals and
promoting detecting rate for QRS complex was proposed as
pre-processing. Both of hardware filters and digital filters were
applied to eliminate different types of noises mixed with ECG
recordings. Then, an automatic detecting algorithm of QRS complex
was applied for verifying the distribution of QRS complex. Finally,
the quantitative clinic criteria for diagnosing arrhythmia were
programmed in a practical application for automatic arrhythmia
diagnosing as a post-processor. The results of diagnoses by automatic
dangerous arrhythmia diagnosing were compared with the results of
off-line diagnoses by experienced clinic physicians. The results of
comparison showed the application of automatic dangerous
arrhythmia diagnosis performed a matching rate of 95% compared
with an experienced physician-s diagnoses.
Abstract: Brain Computer Interface (BCI) has been recently
increased in research. Functional Near Infrared Spectroscope (fNIRs)
is one the latest technologies which utilize light in the near-infrared
range to determine brain activities. Because near infrared technology
allows design of safe, portable, wearable, non-invasive and wireless
qualities monitoring systems, fNIRs monitoring of brain
hemodynamics can be value in helping to understand brain tasks. In
this paper, we present results of fNIRs signal analysis indicating that
there exist distinct patterns of hemodynamic responses which
recognize brain tasks toward developing a BCI. We applied two
different mathematics tools separately, Wavelets analysis for
preprocessing as signal filters and feature extractions and Neural
networks for cognition brain tasks as a classification module. We
also discuss and compare with other methods while our proposals
perform better with an average accuracy of 99.9% for classification.
Abstract: It is established that the instantaneous heart rate (HR) of healthy humans keeps on changing. Analysis of heart rate variability (HRV) has become a popular non invasive tool for assessing the activities of autonomic nervous system. Depressed HRV has been found in several disorders, like diabetes mellitus (DM) and coronary artery disease, characterised by autonomic nervous dysfunction. A new technique, which searches for pattern repeatability in a time series, is proposed specifically for the analysis of heart rate data. These set of indices, which are termed as pattern repeatability measure and pattern repeatability ratio are compared with approximate entropy and sample entropy. In our analysis, based on the method developed, it is observed that heart rate variability is significantly different for DM patients, particularly for patients with diabetic foot ulcer.
Abstract: A typical definition of the Computer Aided Diagnosis
(CAD), found in literature, can be: A diagnosis made by a radiologist
using the output of a computerized scheme for automated image
analysis as a diagnostic aid. Often it is possible to find the expression
Computer Aided Detection (CAD or CADe): this definition
emphasizes the intent of CAD to support rather than substitute the
human observer in the analysis of radiographic images. In this article
we will illustrate the application of CAD systems and the aim of
these definitions.
Commercially available CAD systems use computerized
algorithms for identifying suspicious regions of interest. In this paper
are described the general CAD systems as an expert system
constituted of the following components: segmentation / detection,
feature extraction, and classification / decision making.
As example, in this work is shown the realization of a Computer-
Aided Detection system that is able to assist the radiologist in
identifying types of mammary tumor lesions. Furthermore this
prototype of station uses a GRID configuration to work on a large
distributed database of digitized mammographic images.
Abstract: Malaria is by far the world-s most persistent tropical parasitic disease and is endemic to tropical areas where the climatic and weather conditions allow continuous breeding of the mosquitoes that spread malaria. A mathematical model for the transmission of malaria with prophylaxis prevention is analyzed. The stability analysis of the equilibria is presented with the aim of finding threshold conditions under which malaria clears or persists in the human population. Our results suggest that eradication of mosquitoes and prophylaxis prevention can significantly reduce the malaria burden on the human population.
Abstract: Diabetes mellitus (DM) is frequently characterized by
autonomic nervous dysfunction. Analysis of heart rate variability
(HRV) has become a popular noninvasive tool for assessing the
activities of autonomic nervous system (ANS). In this paper, changes
in ANS activity are quantified by means of frequency and time
domain analysis of R-R interval variability. Electrocardiograms
(ECG) of 16 patients suffering from DM and of 16 healthy volunteers
were recorded. Frequency domain analysis of extracted normal to
normal interval (NN interval) data indicates significant difference in
very low frequency (VLF) power, low frequency (LF) power and
high frequency (HF) power, between the DM patients and control
group. Time domain measures, standard deviation of NN interval
(SDNN), root mean square of successive NN interval differences
(RMSSD), successive NN intervals differing more than 50 ms (NN50
Count), percentage value of NN50 count (pNN50), HRV triangular
index and triangular interpolation of NN intervals (TINN) also show
significant difference between the DM patients and control group.
Abstract: We present a new method for the fully automatic 3D
reconstruction of the coronary artery centerlines, using two X-ray
angiogram projection images from a single rotating monoplane
acquisition system. During the first stage, the input images are
smoothed using curve evolution techniques. Next, a simple yet
efficient multiscale method, based on the information of the Hessian
matrix, for the enhancement of the vascular structure is introduced.
Hysteresis thresholding using different image quantiles, is used to
threshold the arteries. This stage is followed by a thinning procedure
to extract the centerlines. The resulting skeleton image is then pruned
using morphological and pattern recognition techniques to remove
non-vessel like structures. Finally, edge-based stereo correspondence
is solved using a parallel evolutionary optimization method based on
f symbiosis. The detected 2D centerlines combined with disparity
map information allow the reconstruction of the 3D vessel
centerlines. The proposed method has been evaluated on patient data
sets for evaluation purposes.
Abstract: The functional response of an infective is the relationship
between an infected individual-s infection rate and the abundance
of the number of susceptibles that one can potentially be infected.
In this paper, we consider defensive attitudes for HIV prevention
(primary prevention) while at the same time emphasizing on offensive
attitudes that reduce infection for those infected (secondary prevention).
We look at how defenses can protect an uninfected individual
in the case where high risk groups such as commercial sex workers
and those who deliberately go out to look for partners. We propose
an infection cycle that begins with a search, then an encounter,
a proposal and contact. The infection cycle illustrates the various
steps an infected individual goes through to successfully infect a
susceptible. For heterogeneous transmission of HIV, there will be no
infection unless there is contact. The ability to avoid an encounter,
detection, proposal and contact constitute defense.
Abstract: Heart failure is the most common reason of death
nowadays, but if the medical help is given directly, the patient-s life
may be saved in many cases. Numerous heart diseases can be
detected by means of analyzing electrocardiograms (ECG). Artificial
Neural Networks (ANN) are computer-based expert systems that
have proved to be useful in pattern recognition tasks. ANN can be
used in different phases of the decision-making process, from
classification to diagnostic procedures. This work concentrates on a
review followed by a novel method.
The purpose of the review is to assess the evidence of healthcare
benefits involving the application of artificial neural networks to the
clinical functions of diagnosis, prognosis and survival analysis, in
ECG signals. The developed method is based on a compound neural
network (CNN), to classify ECGs as normal or carrying an
AtrioVentricular heart Block (AVB). This method uses three
different feed forward multilayer neural networks. A single output
unit encodes the probability of AVB occurrences. A value between 0
and 0.1 is the desired output for a normal ECG; a value between 0.1
and 1 would infer an occurrence of an AVB. The results show that
this compound network has a good performance in detecting AVBs,
with a sensitivity of 90.7% and a specificity of 86.05%. The accuracy
value is 87.9%.